Isabella Maria Mayer, Eszter Doma, Thorsten Klampfl, Michaela Prchal-Murphy, Sebastian Kollmann, Alessia Schirripa, Lisa Scheiblecker, Markus Zojer, Natalia Kunowska, Lea Gebrail, Lisa E Shaw, Ulrike Mann, Alex Farr, Reinhard Grausenburger, Gerwin Heller, Eva Zebedin-Brandl, Matthias Farlik, Marcos Malumbres, Veronika Sexl, Karoline Kollmann
Hematopoietic stem cells (HSCs) are characterized by the ability to self-renew and to replenish the hematopoietic system. The cell-cycle kinase cyclin dependent-kinase 6 (CDK6) regulates transcription, whereby it has both kinase-dependent and kinase-independent functions. We here describe the complex role of CDK6, balancing quiescence, proliferation, self-renewal and differentiation in activated HSCs. Mouse HSCs expressing kinase-inactivated CDK6 show enhanced long-term repopulation and homing, whereas HSCs lacking CDK6 have impaired functionality...
April 29, 2024: Blood