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https://www.readbyqxmd.com/read/29444369/rotaviral-non-structural-protein-4-triggers-dynamin-related-protein-1-dependent-mitochondrial-fragmentation-during-infection
#1
Arpita Mukherjee, Upayan Patra, Rahul Bhowmick, Mamta Chawla-Sarkar
Dynamic equilibrium between mitochondrial fission and mitochondrial fusion serves as an important quality control system within cells ensuring cellular vitality and homeostasis. Viruses often target mitochondrial dynamics as a part of their obligatory cellular reprogramming. The present study was undertaken to assess the status and regulation of mitochondrial dynamics during rotavirus (RV) infection. Distinct fragmentation of mitochondrial syncytia was observed during late hours of RV (SA11, Wa, A5-13) infection...
February 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29442453/transcriptomic-analysis-of-the-pi3k-akt-signaling-pathway-reveals-the-dual-role-of-the-c-jun-oncogene-in-cytotoxicity-and-the-development-of-resistance-in-hl-60-leukemia-cells-in-response-to-arsenic-trioxide
#2
Joanna Roszak, Anna Smok-Pieniążek, Maciej Stępnik
BACKGROUND: Arsenic trioxide (ATO) is a well-recognized antileukemic drug used for the treatment of newly diagnosed and relapsed acute promyelocytic leukemia (APL). A major drawback of therapy with ATO is the development of APL cell resistance, the mechanisms of which are still not clear. OBJECTIVES: The aim of this study was to investigate the role of the PI3K/Akt signaling pathway in ATOtreated human acute myeloid leukemia (HL-60) cells and in ATO-resistant clones...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442024/anti-cancer-activity-of-bacillus-amyloliquefaciens-ak-0-through-cyclin-d1-proteasomal-degradation-via-gsk3%C3%AE-dependent-phosphorylation-of-threonine-286
#3
Gwang Hun Park, Hun Min Song, Young Soo Kim, Yongho Jeon, Jin Suk Koo, Hyung Jin Jeong, Jin Boo Jeong
Microorganisms have been regarded as important sources of novel bioactive natural products. In this study, we evaluated the anti-cancer activity and the potential mechanism of Bacillus amyloliquefaciens AK-0 newly isolated from the rhizosphere soil of Korean ginseng. The ethyl acetate fraction from the culture medium of B. amyloliquefaciens AK-0 (EA-AK0) inhibited markedly the proliferation of human colorectal cancer cells such as HCT116, SW480, LoVo and HT-29. EA-AK0 effectively decreased cyclin D1 protein level in human colorectal cancer cells, while cyclin D1 mRNA level was not changed by EA-AK0 treatment...
June 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441982/microrna-17-3p-promotes-keratinocyte-cells-growth-and-metastasis-via-targeting-myot-and-regulating-notch1-nf-%C3%AE%C2%BAb-pathways
#4
Hongshan Yan, Kunxiu Song, Guohui Zhang
Wound healing is a fundamental biological process to restore skin integrity. The role of microRNAs (miRNAs) during this process remains elusive. Thus, our study aimed to investigate the biological functions and its molecular mechanisms of miR-17-3p in cutaneous wound healing. Human keratinocyte cell line HaCaT was transfected with miR-17-3p mimic, antisense oligonucleotides (ASO)-miR-17-3p and corresponding controls respectively. After transfection, MTT, flow cytometry, qRT-PCR and western blot were performed to analyze cell viability, colony-formation and cell cycle...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441884/mir-204-14-3-3%C3%AE-axis-regulates-osteosarcoma-cell-proliferation-through-sata3-pathway
#5
Ruibo Zhao, Hongbo He, Yong Zhu, Jun Wan, Yusheng Li, Shuguang Gao, Can Zhang
Hyperproliferation of cells is a major problem is osteosarcoma (OS). So, further elucidation of the molecular mechanisms underlying hyperproliferation of OS is needed. Western blots results showed that 14-3-3ζ protein was upregulated in OS cell lines; 14-3-3ζ knockdown significantly suppressed OS cell proliferation, as well as the protein levels of p-STAT3, c-Myc and Cyclin D1. MicroRNA-204 (miR-204) has been regarded as an essential regulator in cancer carcinogenesis, including OS. Here, we revealed that miR-204 directly targets the 3'UTR of 14-3-3ζ to inhibit its expression, thus to suppress 14-3-3ζ -induced OS cell hyperproliferation...
October 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441724/prmt5-promotes-cell-proliferation-by-inhibiting-btg2-expression-via-the-erk-signaling-pathway-in-hepatocellular-carcinoma
#6
Hai Jiang, Yue Zhu, Zhenyu Zhou, Junyang Xu, Shaowen Jin, Kang Xu, Heyun Zhang, Qing Sun, Jie Wang, Junyao Xu
Increasing evidence suggests that PRMT5, a protein arginine methyltransferase, has roles in cell growth regulation and cancer development. However, the role of PRMT5 in hepatocellular carcinoma (HCC) progression remains unclear. Here, we showed that PRMT5 expression was frequently upregulated in HCC tissues, and its expression was inversely correlated with overall survival in HCC patients. PRMT5 knockdown markedly inhibited in vitro HCC proliferation and in vivo tumorigenesis. We revealed that the mechanism of PRMT5-induced proliferation was partially mediated by BTG downregulation, leading to cell cycle arrest during the G1 phase in HCC cells...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29441600/berberine-inhibits-experimental-varicocele-induced-cell-cycle-arrest-via-regulating-cyclin-d1-cdk4-and-p21-proteins-expression-in-rat-testicles
#7
M Amin, M Razi, F Sarrafzadeh-Rezaei, A Shalizar Jalali, G Najafi
The aim of this study was to uncover the protective effect of berberine (BBR), an antioxidant chemical, on experimental varicocele (VCL)-induced adverse effects on cell cycle machinery during early germ cells mitosis. To follow-up this study, 30 mature male Wistar rats were divided into control-sham, nontreated VCL, 50 mg kg-1and 100 mg kg-1BBR-treated VCL groups. Following 60 days, histological alterations were analysed by haematoxylin and eosin (H and E) staining, and expressions of cyclin-D1, cyclin-dependent kinase-4 (cdk4) and p21 were investigated by immunohistochemical (IHC) staining technique...
February 14, 2018: Andrologia
https://www.readbyqxmd.com/read/29440639/the-small-gtpase-rhou-lays-downstream-of-jak-stat-signaling-and-mediates-cell-migration-in-multiple-myeloma
#8
Sara Canovas Nunes, Martina Manzoni, Marco Pizzi, Elisa Mandato, Marilena Carrino, Laura Quotti Tubi, Renato Zambello, Fausto Adami, Andrea Visentin, Gregorio Barilà, Livio Trentin, Sabrina Manni, Antonino Neri, Gianpietro Semenzato, Francesco Piazza
Multiple myeloma is a post-germinal center B-cell neoplasm, characterized by the proliferation of malignant bone marrow plasma cells, whose survival and proliferation is sustained by growth factors and cytokines present in the bone marrow microenvironment. Among them, IL-6 triggers the signal downstream of its receptor, leading to the activation of the JAK/STAT pathway. The atypical GTPase RhoU lays downstream of STAT3 transcription factor and could be responsible for mediating its effects on cytoskeleton dynamics...
February 13, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29440396/oncogenic-exon-2-mutations-in-mediator-subunit-med12-disrupt-allosteric-activation-of-cyclin-c-cdk8-19
#9
Min Ju Park, Hailian Shen, Jason M Spaeth, Jaana H Tolvanen, Courtney Failor, Jennifer F Knudtson, Jessica McLaughlin, Sunil K Halder, Qiwei Yang, Serdar E Bulun, Ayman Al-Hendy, Robert S Schenken, Lauri A Aaltonen, Thomas G Boyer
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at high frequency in uterine fibroids (UFs) and breast fibroepithelial tumors as well as recurrently, albeit less frequently, in malignant uterine leimyosarcomas, chronic lymphocytic leukemias, and colorectal cancers. Previously, we reported that UF-linked mutations in MED12 disrupt its ability to activate CycC-dependent kinase 8 (CDK8), implicating impaired Mediator-associated CDK8 activity in the pathogenesis of these clinically significant lesions...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29439259/downregulation-of-prame-suppresses-proliferation-and-promotes-apoptosis-in-hepatocellular-carcinoma-through-the-activation-of-p53-mediated-pathway
#10
Hanzhang Zhu, Jingrui Wang, Junjie Yin, Bei Lu, Qijun Yang, Yafeng Wan, Changku Jia
BACKGROUND/AIMS: The expression of PRAME and its role in hepatocellular carcinoma (HCC) remain unknown. The aim of this study was to examine the functional role of PRAME in HCC development and exploring the molecular mechanism. METHODS: We first detected PRAME expression in 96 human HCC tissue samples and correlated with clinicopathological characteristics and prognosis of the patients. We then established stable HCC cell lines with PRAME overexpression and knockdown followed by functional analysis in vitro...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29438989/mitotic-phosphorylation-of-senp3-regulates-de-sumoylation-of-chromosome-associated-proteins-and-chromosome-stability
#11
Bo Wei, Chao Huang, Bin Liu, Yang Wang, Nansong Xia, Qiuju Fan, Guo-Qiang Chen, Jinke Cheng
Progression of mitotic cell cycle as well as chromosome condensation and segregation are controlled by posttranslational protein modifications such as phosphorylation and SUMOylation. However, how SUMO isopeptidases (SENP) regulate cell mitotic procession is largely unknown. Here we demonstrate that precise phosphorylation of SENP3 during mitosis suppresses SENP3 de-SUMOylation activity towards chromosome-associated proteins including Topoisomerase IIα (Topo IIα). Cyclin B-dependent kinases 1 (CDK1) and protein phosphatase 1α (PP1α) were identified as the kinase and phosphatase in control of mitotic SENP3 phosphorylation, respectively...
February 8, 2018: Cancer Research
https://www.readbyqxmd.com/read/29438988/flavopiridol-inhibits-tgf-%C3%AE-stimulated-biglycan-synthesis-by-blocking-linker-region-phosphorylation-and-nuclear-translocation-of-smad2
#12
Muhamad Ashraf Rostam, Aravindra Shajimoon, Danielle Kamato, Partha Mitra, Terrence Piva, Robel Getachew, Yingnan Cao, Wenhua Zheng, Narin Osman, Peter James Little
Transforming Growth Factor (TGF) β is a pleiotropic growth factor implicated in the development of atherosclerosis for its role in mediating glycosaminoglycan (GAG) chain hyperelongation on the proteoglycan biglycan, a phenomenon that leads to increased binding of atherogenic lipoproteins in the wall of blood vessels. TGF-β signalling pathway components leading to the modification of GAG chains on biglcyan are therefore potential targets for the treatment of atherosclerosis. Phosphorylation of the transcription factor Smad has emerged as a critical step in the signalling pathways that control the synthesis of biglycan, both the core protein and the GAG chains...
February 9, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29438890/flavonoids-from-chinese-bayberry-leaves-induced-apoptosis-and-g1-cell-cycle-arrest-via-erk-pathway-in-ovarian-cancer-cells
#13
Yu Zhang, Shiguo Chen, Chaoyang Wei, Gary O Rankin, Xingqian Ye, Yi Charlie Chen
Ovarian cancer is one of the leading causes of death related to the female reproductive system in western countries. Adverse side effects and resistance to platinum based chemotherapy have become the major obstacles for ovarian cancer treatment. Natural products have gained great attention in cancer treatment in recent years. Chinese bayberry leaves flavonoids (BLF) containing rich content of myricitrin (myricetin 3-O-rhamnoside) and a part of quercetrin (quercetin 3-rhamnoside) inhibited the growth of an ovarian cancer cell line A2780/CP70...
January 31, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29438839/sirtuin7-has-an-oncogenic-potential-via-promoting-the-growth-of-cholangiocarcinoma-cells
#14
Wenzhi Li, Zhe Sun, Chen Chen, Lin Wang, Zhimin Geng, Jie Tao
Accumulating evidence indicates that sirtuin7 (SIRT7) plays an oncogenic role in the main types of liver cancer, hepatocellular carcinoma (HCC). Nevertheless, the clinical significance of SIRT7 and its role in cholangiocarcinoma (CCA) is largely undiscovered. Here, we found that SIRT7 displayed higher expression in CCA tissues compared to intrahepatic normal bile duct and surrounding liver tissues based on The Cancer Genome Atlas (TCGA) data. Our data further confirmed that SIRT7 was overexpressed in CCA patient tissues and cell lines...
February 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29438779/down-regulation-of-mirna-320c-promotes-tumor-growth-and-metastasis-and-predicts-poor-prognosis-in-human-glioma
#15
Qiao-Li Lv, Hui-Ting Zhu, Xiao-Hua Cheng, Hong-Mi Li, Hong-Hao Zhou, Shu-Hui Chen
Emerging studies show that dysregulated miRNAs are implicated in tumorigenesis and progression of various cancers. MiRNA-320c, an important member of miRNA-320 family, was characterized as a new candidate miRNA that suppressed the development of colorectal cancer and bladder cancer. However, the function of miRNA-320c in human glioma remained unclear. Here, we found that miRNA-320c was significantly down-regulated in glioma tissues and cell lines in contrast with normal brain tissues, being tightly related to clinical stage of glioma by qRT-PCR...
February 10, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29438113/morphologic-and-immunohistochemical-appraisal-of-primary-gastric-carcinomas
#16
Gunes Guner, Aynur Isik, Erdem Karabulut, Gokhan Gedikoglu, Cenk Sokmensuer, Aytekin Akyol
Gastric carcinoma management requires adjustments answering their genetic and morphologic heterogeneity. We aim to assess the expression and significance of a myriad of biomarkers (p53, MLH1, MSH2, PMS2, MSH6, Epstein-Barr encoding region-RNA, c-erbB2, E-cadherin, CEA, chromogranin, Ki-67, CDX2, presenilin-1, cathepsin E, MUC5AC, cyclin-dependent kinase 1) in 117 gastric carcinomas, which we have morphologically subclassified with a simple algorithm. Immunohistochemical stains were applied to 3 tissue microarrays of primary gastric carcinomas (n=117) obtained from resection specimens of untreated patients...
February 12, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29437987/cell-cycle-regulation-by-chlamydomonas-cyclin-dependent-protein-kinases
#17
Gregory Bertoni
No abstract text is available yet for this article.
February 5, 2018: Plant Cell
https://www.readbyqxmd.com/read/29437768/fda-approval-ribociclib-for-the-treatment-of-postmenopausal-women-with-hormone-receptor-positive-her2-negative-advanced-or-metastatic-breast-cancer
#18
Anand Shah, Erik Bloomquist, Shenghui Tang, Wentao Fu, Youwei Bi, Qi Liu, Jingyu Yu, Ping Zhao, Todd R Palmby, Kirsten B Goldberg, C J George Chang, Paresma Patel, Elleni Alebachew, Amy Tilley, William F Pierce, Amna Ibrahim, Gideon M Blumenthal, Rajeshwari Sridhara, Julia A Beaver, Richard Pazdur
On March 13, 2017, the U.S. Food and Drug Administration approved ribociclib (KISQALI, Novartis Pharmaceuticals Corp.), a cyclin-dependent kinase 4/6 inhibitor, in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. The approval was based on a randomized, double-blind, placebo-controlled, international clinical trial (MONALEESA-2)...
February 7, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29437706/targeting-cyclin-d-cdk4-6-sensitizes-immune-refractory-cancer-by-blocking-the-scp3-nanog-axis
#19
Se Jin Oh, Hanbyoul Cho, Suhyun Kim, Kyung Hee Noh, Kwon-Ho Song, Hyo-Jung Lee, Seon Rang Woo, Suyeon Kim, Chel Hun Choi, Joon-Yong Chung, Stephen M Hewitt, Jae-Hoon Kim, Seungki Baek, Kyung-Mi Lee, Cassian Yee, Hae-Chul Park, Tae Woo Kim
Immune editing caused by anti-tumor immunity drives tumor cells to acquire refractory phenotypes. We demonstrated previously that tumor antigen-specific T cells edit these cells such that they become resistant to CTL killing and enrich NANOGhigh cancer stem cell-like (CSC-like) cells. In the current study, we show that synaptonemal complex protein 3 (SCP3), a member of the Cor1 family, is overexpressed in immune-edited cells and upregulates NANOG by hyperactivating the Cyclin D1-CDK4/6 axis. The SCP3-Cyclin D1-CDK4/6 axis was preserved across various types of human cancer, and correlated negatively with progression-free survival of cervical cancer patients...
February 6, 2018: Cancer Research
https://www.readbyqxmd.com/read/29436690/effects-of-low-intensity-ultrasound-combined-with-low-dose-carboplatin-in-an-orthotopic-hamster-model-of-tongue-cancer-a-preclinical-study
#20
Hai-Xia Li, Jin-Hua Zheng, Liang Ji, Guan-Yao Liu, Yv-Kun Lv, Dan Yang, Zheng Hu, He Chen, Feng-Min Zhang, Wenwu Cao
Low-intensity ultrasound (LIUS) combined with chemotherapy is an innovative modality for cancer treatment, but its effect on orthotopic carcinoma remains unknown. Our previous study revealed that LIUS enhanced the growth inhibitory effects of several chemotherapeutic drugs in nude mice with transplanted tumors. In the present study, we used 7,12-dimethylbenz(alpha)anthracene to induce orthotopic tongue carcinogenesis in hamsters. We used the first-line chemotherapy drug for tongue cancer, carboplatin (CBP) in combination with LIUS to investigate the synergistic effect...
February 13, 2018: Oncology Reports
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