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https://www.readbyqxmd.com/read/29235113/postnatal-effects-of-intrauterine-treatment-of-the-growth-restricted-ovine-fetus-with-intra-amniotic-insulin-like-growth-factor-1
#1
A M Spiroski, M H Oliver, A L Jaquiery, T C R Prickett, E A Espiner, J E Harding, F H Bloomfield
Placental insufficiency-mediated fetal growth restriction (FGR) is associated with altered postnatal growth and metabolism, which are, in turn, associated with increased risk of adult disease. Intra-amniotic insulin-like growth factor-1 (IGF1) treatment of ovine FGR increases growth rate in late gestation, but the effects on postnatal growth and metabolism are unknown. We investigated the effects of intra-amniotic IGF1 administration to ovine fetuses with uteroplacental embolisation-induced FGR on phenotypic and physiologic characteristics in the two weeks after birth...
December 12, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29233079/a-diagnostic-approach-for-rodent-progressive-cardiomyopathy-and-like-lesions-in-toxicology-studies-up-to-28-days-in-the-sprague-dawley-rat-part-2-of-2
#2
James R Hailey, Beverly E Maleeff, Heath C Thomas, Gail Pearse, Jan C Klapwijk, Patrizia G Cristofori, Brian Berridge, Carie L Kimbrough, George A Parker, Daniel Morton, Susan Elmore, Jerry F Hardisty, Noel O Dybdal, David A Rehagen, James D Fikes, Martin Lamb, Kathleen Biddle, Bernard S Buetow, Vinicius Carreira, Abraham Nyska, Niraj K Tripathi, Heather C Workman, Jean-Guy Bienvenu, Ingrid Brees, James R Turk, Rick R Adler
To test the diagnostic approach described in part 1 of this article, 2 exercises were completed by pathologists from multiple companies/agencies. Pathologist's examination of whole slide image (WSI) heart sections from rats using personal diagnostic approaches (exercise #1) corroborated conclusions from study #1. Using the diagnostic approach described in part 1, these pathologists examined the same WSI heart sections (exercise #2) to determine whether that approach increased consistency of diagnosis of rodent progressive cardiomyopathy (PCM) lesions...
December 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29232590/mode-repulsion-of-ultrasonic-guided-waves-in-rails
#3
Philip W Loveday, Craig S Long, Dineo A Ramatlo
Accurate computation of dispersion characteristics of guided waves in rails is important during the development of inspection and monitoring systems. Wavenumber versus frequency curves computed by the semi-analytical finite element method exhibit mode repulsion and mode crossing which can be difficult to distinguish. Eigenvalue derivatives, with respect to the wavenumber, are used to investigate these regions. A term causing repulsion between two modes is identified and a condition for two modes to cross is established...
November 24, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29231848/on-line-corrosion-monitoring-of-plate-structures-based-on-guided-wave-tomography-using-piezoelectric-sensors
#4
Jing Rao, Madis Ratassepp, Danylo Lisevych, Mahadhir Hamzah Caffoor, Zheng Fan
Corrosion is a major safety and economic concern to various industries. In this paper, a novel ultrasonic guided wave tomography (GWT) system based on self-designed piezoelectric sensors is presented for on-line corrosion monitoring of large plate-like structures. Accurate thickness reconstruction of corrosion damages is achieved by using the dispersive regimes of selected guided waves and a reconstruction algorithm based on full waveform inversion (FWI). The system makes use of an array of miniaturised piezoelectric transducers that are capable of exciting and receiving highly dispersive A0 Lamb wave mode at low frequencies...
December 12, 2017: Sensors
https://www.readbyqxmd.com/read/29226751/nordic-cancer-registries-an-overview-of-their-procedures-and-data-comparability
#5
Eero Pukkala, Gerda Engholm, Lise Kristine Højsgaard Schmidt, Hans Storm, Staffan Khan, Mats Lambe, David Pettersson, Elínborg Ólafsdóttir, Laufey Tryggvadóttir, Tiina Hakanen, Nea Malila, Anni Virtanen, Tom Børge Johannesen, Siri Larønningen, Giske Ursin
BACKGROUND: The Nordic Cancer Registries are among the oldest population-based registries in the world, with more than 60 years of complete coverage of what is now a combined population of 26 million. However, despite being the source of a substantial number of studies, there is no published paper comparing the different registries. Therefore, we did a systematic review to identify similarities and dissimilarities of the Nordic Cancer Registries, which could possibly explain some of the differences in cancer incidence rates across these countries...
December 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29225195/strengthening-integration-of-clinical-and-public-health-systems-to-prevent-maternal-child-obesity-in-the-first-1-000days-a-collective-impact-approach
#6
Tiffany Blake-Lamb, Alexy Arauz Boudreau, Sarah Matathia, Etna Tiburcio, Meghan E Perkins, Brianna Roche, Milton Kotelchuck, Derri Shtasel, Sarah N Price, Elsie M Taveras
INTRODUCTION: Obesity interventions may be most effective if they begin in the earliest stages of life, support changes across family, clinical, and public health systems, and address socio-contextual factors. METHODS: The First 1000Days is a systematic program starting in early pregnancy lasting through the first 24months of infancy to prevent obesity among low-income mother-infant pairs in three community health centers in Massachusetts. The program uses a Collective Impact approach to create the infrastructure for sustained, system-wide changes for obesity prevention across early life clinical and public health services, including Obstetrics, Pediatrics, Adult Medicine, Behavioral Health, Nutrition, Community Health, the Women, Infants and Children (WIC) program, and the Maternal, Infant and Childhood Home Visiting program...
December 7, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29225061/crowdsourcing-disease-biomarker-discovery-research-the-ip4ic-study
#7
Michael B Chancellor, Sarah N Bartolone, Andrew Veerecke, Laura E Lamb
PURPOSE: Biomarker discovery is limited by readily assessable, cost efficient, human samples available in large numbers that represent the entire heterogeneity of the disease. We developed a novel active participation crowdsourcing method to develop a Bladder Permeability Defect Risk Score (BP-RS) based on non-invasive urinary cytokines to discriminate Interstitial cystitis/bladder pain syndrome (IC/BPS) with Hunner's lesion (UIC) patients from controls and IC patients without Hunner's lesions...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29224883/utilization-of-protein-in-red-clover-and-alfalfa-silages-by-lactating-dairy-cows-and-growing-lambs
#8
Glen A Broderick
Feeding trials were conducted with lactating cows and growing lambs to quantify effects of replacing dietary alfalfa silage (AS) with red clover silage (RCS) on nutrient utilization. The lactation trial had a 2 × 4 arrangement of treatments: AS or RCS fed with no supplement, rumen-protected Met (RPM), rumen-protected Lys (RPL), or RPM plus RPL. Grass silage was fed at 13% of dry matter (DM) with AS to equalize dietary neutral detergent fiber (NDF) and crude protein contents. All diets contained (DM basis) 5% corn silage and 16% crude protein...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29224699/measuring-physical-capacity-and-performance-in-older-people
#9
REVIEW
Sarah E Lamb, David J Keene
We highlight the important differences between the concepts of capacity and performance and highlight the development of measures and their application in common conditions encountered in health care practice with older people. A number of expert consensus projects have concluded that mobility, balance, muscle strength and dexterity are core domains for capacity measurement in older people. Instruments with evidence of adequate psychometric properties for the evaluation of capacity in response to intervention programmes include the Short Physical Performance Battery, hand grip strength, mini-BEST and 9-hole pegboard test...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29218326/study-protocol-a-multi-centre-double-blind-randomised-placebo-controlled-parallel-group-phase-ii-trial-ridd-to-determine-the-efficacy-of-intra-nodular-injection-of-anti-tnf-to-control-disease-progression-in-early-dupuytren-s-disease-with-an-embedded-dose-response
#10
Jagdeep Nanchahal, Catherine Ball, Jennifer Swettenham, Susan Dutton, Vicki Barber, Joanna Black, Bethan Copsey, Melina Dritsaki, Peter Taylor, Alastair Gray, Marc Feldmann, Sarah Lamb
Dupuytren's disease is a common fibrotic condition of the hand affecting 4% of the population and causes the fingers to curl irreversibly into the palm. It has a strong familial tendency, there is no approved treatment for early stage disease, and patients with established digital contractures are most commonly treated by surgery. This is associated with prolonged recovery, and less invasive techniques have high recurrence rates.The myofibroblasts, the cells responsible for the excessive matrix deposition and contraction, are aggregated in nodules...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29215329/chemotherapeutics-of-visceral-leishmaniasis-present-and-future-developments
#11
Shyam Sundar, Anup Singh
Treatment of Visceral Leishmaniasis (VL), a neglected tropical disease, is very challenging with few treatment options. Long duration of treatment and drug toxicity further limit the target of achieving VL elimination. Chemotherapy remains the treatment of choice. Single dose of liposomal amphotericin B (LAmB) and multidrug therapy (LAmB + miltefosine, LAmB + paromomycin (PM), or miltefosine + PM) are recommended treatment regimen for treatment of VL in Indian sub-continent. Combination therapy of pentavalent antimonials (Sbv) and PM in East Africa and LAmB in the Mediterranean region/South America remains the treatment of choice...
December 7, 2017: Parasitology
https://www.readbyqxmd.com/read/29212808/gestational-age-at-time-of-in-utero-lipopolysaccharide-exposure-influences-the-severity-of-inflammation-induced-diaphragm-weakness-in-lambs
#12
Kanakeswary Karisnan, Tanzila Mahzabin, Anthony J Bakker, Yong Song, Peter B Noble, J Jane Pillow, Gavin Jon Pinniger
The preterm diaphragm is functionally immature compared to its term counterpart. In utero inflammation further exacerbates preterm diaphragm dysfunction. We hypothesized that preterm lambs are more vulnerable to in utero inflammation induced diaphragm dysfunction compared with term lambs. Pregnant ewes received intra-amniotic (IA) injections of saline or 10mg lipopolysaccharide (LPS) 2d or 7d prior to delivery at 121d (preterm) or 145d (term) gestation. Diaphragm contractile function was assessed in vitro. Plasma cytokines and diaphragm myosin heavy chain (MHC) isoforms and oxidative stress were evaluated...
December 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29211751/diffusion-tensor-imaging-detects-ventilation-induced-brain-injury-in-preterm-lambs
#13
Dhafer M Alahmari, Kyra Y Y Chan, Vanesa Stojanovska, Domenic LaRosa, Samantha K Barton, Ilias Nitsos, Valerie Zahra, Jade Barbuto, Michael Farrell, Shigeo Yamaoka, James T Pearson, Graeme R Polglase
PURPOSE: Injurious mechanical ventilation causes white matter (WM) injury in preterm infants through inflammatory and haemodynamic pathways. The relative contribution of each of these pathways is not known. We hypothesised that in vivo magnetic resonance imaging (MRI) can detect WM brain injury resulting from mechanical ventilation 24 h after preterm delivery. Further we hypothesised that the combination of inflammatory and haemodynamic pathways, induced by umbilical cord occlusion (UCO) increases brain injury at 24 h...
2017: PloS One
https://www.readbyqxmd.com/read/29210771/effect-of-inhaled-nitric-oxide-on-hemodynamics-in-lambs-with-1%C3%A2-ventricle-circulation
#14
Hitoshi Kanamitsu, Yasuhiro Fujii, Luca Centola, Katsushi Kinouchi, Liqun Zhu, Robert K Riemer, Olaf Reinhartz
Inhaled nitric oxide (NO) is widely used to treat postoperative pulmonary hypertension in congenital heart disease. It is believed that NO increases cardiac output (CO) by decreasing pulmonary vascular resistance (PVR), leading to increased left ventricular preload. However, the effect of NO on CO in patients with 1½ ventricle circulation remains unclear. To evaluate this, a superior cavopulmonary (SCP) shunt was constructed in 10 juvenile sheep. A PTFE graft was inserted between the superior vena cava (SVC) and the main pulmonary artery (PA)...
November 27, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29208754/proactive-use-of-high-flow-nasal-cannula-with-critically-ill-subjects
#15
Keith D Lamb, Sarah K Spilman, Trevor W Oetting, Julie A Jackson, Matthew W Trump, Sheryl M Sahr
INTRODUCTION: It has been suggested that use of a high-flow nasal cannula (HFNC) could be a first-line therapy for patients with acute hypoxic respiratory failure. The purpose of this study was to determine if protocolized use of HFNC decreases unplanned intubation and adverse outcomes in an ICU population. METHODS: The study was a prospective evaluation of 2 cohorts who received HFNC per protocol. Control groups were retrospective selections of subjects who received HFNC in the pre-protocol period...
December 5, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29208663/haemodynamic-effects-of-umbilical-cord-milking-in-premature-sheep-during-the-neonatal-transition
#16
Douglas A Blank, Graeme R Polglase, Martin Kluckow, Andrew William Gill, Kelly J Crossley, Alison Moxham, Karyn Rodgers, Valerie Zahra, Ishmael Inocencio, Fiona Stenning, Domeic A LaRosa, Peter G Davis, Stuart B Hooper
OBJECTIVE: Umbilical cord milking (UCM) at birth may benefit preterm infants, but the physiological effects of UCM are unknown. We compared the physiological effects of two UCM strategies with immediate umbilical cord clamping (UCC) and physiological-based cord clamping (PBCC) in preterm lambs. METHODS: At 126 days' gestational age, fetal lambs were exteriorised, intubated and instrumented to measure umbilical, pulmonary and cerebral blood flows and arterial pressures...
December 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29207530/characterization-of-ultrasound-energy-diffusion-due-to-small-size-damage-on-an-aluminum-plate-using-piezoceramic-transducers
#17
Guangtao Lu, Qian Feng, Yourong Li, Hao Wang, Gangbing Song
During the propagation of ultrasonic waves in structures, there is usually energy loss due to ultrasound energy diffusion and dissipation. The aim of this research is to characterize the ultrasound energy diffusion that occurs due to small-size damage on an aluminum plate using piezoceramic transducers, for the future purpose of developing a damage detection algorithm. The ultrasonic energy diffusion coefficient is related to the damage distributed in the medium. Meanwhile, the ultrasonic energy dissipation coefficient is related to the inhomogeneity of the medium...
December 4, 2017: Sensors
https://www.readbyqxmd.com/read/29207332/a-model-assessment-method-for-predicting-structural-fatigue-life-using-lamb-waves
#18
Dengjiang Wang, Jingjing He, Xuefei Guan, Jinsong Yang, Weifang Zhang
This paper presents a study on model assessment for predicting structural fatigue life using Lamb waves. Lamb wave coupon testing is performed for model development. Three damage sensitive features, namely normalized energy, phase change, and correlation coefficient are extracted from Lamb wave data and are used to quantify the crack size. Four data-driven models are proposed. The average relative error and the probability of detection (POD) are proposed as two measures to evaluate the performance of the four models...
December 2, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29206355/from-novick-to-the-nhs-the-evolution-of-minimally-invasive-nephron-sparing-surgery
#19
EDITORIAL
Benjamin W Lamb, Daniel A Moon
No abstract text is available yet for this article.
October 2017: BJU International
https://www.readbyqxmd.com/read/29202752/correction-to-integrative-analysis-associates-monocytes-with-insufficient-erythropoiesis-during-acute-plasmodium-cynomolgi-malaria-in-rhesus-macaques
#20
Yan Tang, Chester J Joyner, Monica Cabrera-Mora, Celia L Saney, Stacey A Lapp, Mustafa V Nural, Suman B Pakala, Jeremy D DeBarry, Stephanie Soderberg, Jessica C Kissinger, Tracey J Lamb, Mary R Galinski, Mark P Styczynski
After publication of the article [1], it was brought to our attention that several symbols were missing from Fig. 1, including some cited in the figure's key. The correct version of the figure is shown below and has now been updated in the original article.
December 4, 2017: Malaria Journal
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