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https://www.readbyqxmd.com/read/28338219/human-orf-complicated-by-epidermolysis-bullosa-acquisita
#1
E Zuelgaray, C Salle de Chou, J Gottlieb, M Battistella, M D Vignon-Pennamen, M Bagot, F Guibal, J D Bouaziz
Orf is a DNA parapoxvirus transmitted to humans by contact with infected goats and sheep. Many complications have been reported after Orf infection including erythema multiforme. A few cases of auto-immune bullous dermatosis complicating Orf disease have been reported to date, usually characterized by tense blisters eruptions with or without mucosal involvement, linear deposition of C3, IgG and/or IgA along the basement membrane and negativity of indirect immunofluorescence analysis and ELISA assays (performed in 4 of 11 reported cases) against target antigens of bullous pemphigoid, mucous membrane pemphigoid or epidermolysis bullosa acquisita, except one case of mucosal pemphigoid with antilaminin-332 antibodies...
March 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28337572/genetic-appraisal-of-serological-response-post-vaccination-against-enterotoxaemia-et-in-malpura-and-avikalin-sheep
#2
G R Gowane, Najif Akram, L L L Prince, Ved Prakash, Arun Kumar
Enterotoxaemia (ET) is a fatal enteric disease of small ruminants attributable to a toxigenic type of Clostridium perfringens. The key strategy for prevention of ET is the management and vaccination. Present study aimed at identifying the sources of variation for ET vaccine response especially against epsilon toxin in 173 sheep that included 83 Avikalin and 90 Malpura lambs raised at the institute flock in the semi-arid region of India. The mean age at vaccination was 90 days. Sera were tested by blocking ELISA...
March 23, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28337571/effects-of-feeding-ground-pods-of-enterolobium-cyclocarpum-jacq-griseb-on-dry-matter-intake-rumen-fermentation-and-enteric-methane-production-by-pelibuey-sheep-fed-tropical-grass
#3
S Albores-Moreno, J A Alayón-Gamboa, A J Ayala-Burgos, F J Solorio-Sánchez, C F Aguilar-Pérez, L Olivera-Castillo, J C Ku-Vera
An experiment was carried out to determine the effect of supplementing ground pods of Enterolobium cyclocarpum in a basal ration of Pennisetum purpureum grass on feed intake, rumen volatile fatty acids (VFAs), and protozoa and methane (CH4) production by hair sheep. Four male sheep (Pelibuey × Katahdin) with a mean live weight of 27.0 kg (SD ± 0.5) were supplemented with 0.00, 0.15, 0.30, and 0.45 kg of dry matter (DM) of E. cyclocarpum pods daily; equivalent to 0.00, 4.35, 8.70, and 13.05 g of crude saponins, respectively...
March 23, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28337414/pheochromocytoma-with-negative-metanephrines-a-rarity-and-the-significance-of-dopamine-secreting-tumors
#4
Michael Bozin, Alastair Lamb, Lydia Johns Putra
We describe a case of a 25-year-old female with a dopamine secreting PPGL diagnosed retrospectively with biochemical analysis. This finding resulted in change in approach to investigation and management, given their important clinical implications. There are important differences in management of dopamine secreting PPGL compared to classical noradrenaline and adrenaline-secreting PPGL. This includes the risk of peri-operative cardiovascular collapse peri-operatively with alpha/beta blockade, risk of malignancy/recurrence, and associated genetic abnormalities...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28336079/re-radiation-with-or-without-antiandrogen-therapy-in-recurrent-prostate-cancer
#5
Benjamin W Lamb, John Violet, Shankar Siva, Declan G Murphy
No abstract text is available yet for this article.
March 20, 2017: European Urology
https://www.readbyqxmd.com/read/28332559/the-immunogenetics-of-narcolepsy-associated-with-a-h1n1-pdm09-vaccination-pandemrix-supports-a-potent-gene-environment-interaction
#6
I L Bomfim, F Lamb, K Fink, A Szakács, A Silveira, L Franzén, V Azhary, M Maeurer, N Feltelius, N Darin, T Hallböök, L Arnheim-Dahlström, I Kockum, T Olsson
The influenza A(H1N1)pdm09 vaccination campaign from 2009 to 2010 was associated with a sudden increase in the incidence of narcolepsy in several countries. Narcolepsy with cataplexy is strongly associated with the human leukocyte antigen (HLA) class II DQB1*06:02 allele, and protective associations with the DQB1*06:03 allele have been reported. Several non-HLA gene loci are also associated, such as common variants of the T-cell receptor-α (TRA), the purinergic receptor P2RY11, cathepsin H (CTSH) and TNFSF4/OX40L/CD252...
March 23, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28330965/greater-sympathoadrenal-activation-with-longer-pre-ventilation-intervals-after-immediate-cord-clamping-increases-hemodynamic-lability-at-birth-in-preterm-lambs
#7
Joseph J Smolich, Kelly R Kenna, Murray David Esler, Sarah E Phillips, Gavin W Lambert
This study tested the hypothesis that varying degrees of hemodynamic fluctuations seen after birth following immediate cord clamping were related to development of asphyxia with longer cord clamp-to-ventilation intervals, resulting in higher perinatal circulating levels of the catecholamines norepinephrine (NE) and epinephrine (Epi), and thus increased heart rate, blood pressures and cardiac contractility after birth. Anesthetized preterm fetal lambs were instrumented with 1) aortic (AoT) and pulmonary trunk (PT) micromanometers to obtain pressures and the maximal rate of pressure rise (dP/dtmax) as a surrogate measure of ventricular contractility, and 2) an AoT catheter to obtain samples for blood gas and catecholamine analyses...
March 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28328561/does-orientation-of-the-femoral-head-affect-acetabular-development-an-experimental-study-in-lamb
#8
Luis Moraleda, Christian Bravo, Francisco Forriol, Javier Albiñana
BACKGROUND: Derotational osteotomy of the proximal femur has proved to be effective in the treatment of residual acetabular dysplasia. However, the reason why this osteotomy is effective remains debatable. The purpose of this study is to investigate if an alteration of femoral head orientation affects acetabular growth. METHODS: A proximal femoral osteotomy was performed in 21 lambs aged 3 months: 5 varus osteotomies (110 degrees), 4 valgus osteotomies (150 degrees), and 12 derotation osteotomies...
March 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28328155/does-dynorphin-play-a-role-in-the-onset-of-puberty-in-female-sheep
#9
J A Lopez, M N Bedenbaugh, R B McCosh, P W Weems, L J Meadows, B Wisman, L M Coolen, R L Goodman, S M Hileman
Puberty onset involves increased gonadotrophin-release (GnRH) release as a result of decreased sensitivity to oestrogen (E2 )-negative feedback. Because GnRH neurones lack E2 receptor α, this pathway must contain interneurones. One likely candidate is KNDy neurones (kisspeptin, neurokinin B, dynorphin). The overarching hypothesis of the present study was that the prepubertal hiatus in luteinising hormone (LH) release involves reduced kisspeptin and/or heightened dynorphin input. We first tested the specific hypothesis that E2 would reduce kisspeptin-immunopositive cell numbers and increase dynorphin-immunopositive cell numbers...
December 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28327253/the-wolf-will-live-with-the-lamb
#10
Richard Ronay, Joshua M Tybur
Maestripieri et al. pit evolutionary psychology against social psychological and economic perspectives in a winner-take-all empirical battle. In doing so, they risk positioning evolutionary psychology as an antagonistic subdisciplinary enterprise. We worry that such a framing may exacerbate tensions between "competing" scientific perspectives and limit evolutionary psychology's potential to serve as a unifying core theory.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28324778/measurement-of-weld-penetration-depths-in-thin-structures-using-transmission-coefficients-of-laser-generated-lamb-waves-and-neural-network
#11
Lei Yang, I Charles Ume
The Laser/EMAT ultrasonic (LEU) technique has shown the capability to measure weld penetration depths in thick structures based on ray-tracing of laser-generated bulk and surface waves. The ray-tracing method is not applicable to laser-generated Lamb waves when the LEU technique is used to measure weld penetration depths in thin structures. In this work, transmission coefficients of Lamb waves present in the LEU signals are investigated against varying weld penetration depths. An artificial neural network is developed to use transmission coefficients of sensitive Lamb waves and LEU signal energy to predict weld penetration depths accurately...
February 28, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28321847/antenatal-corticosteroids-for-accelerating-fetal-lung-maturation-for-women-at-risk-of-preterm-birth
#12
REVIEW
Devender Roberts, Julie Brown, Nancy Medley, Stuart R Dalziel
BACKGROUND: Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed...
March 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28320715/experimental-models-of-short-courses-of-liposomal-amphotericin-b-for-induction-therapy-for-cryptococcal-meningitis
#13
Jodi Lestner, Laura McEntee, Adam Johnson, Joanne Livermore, Sarah Whalley, Julie Schwartz, John R Perfect, Thomas Harrison, William Hope
Cryptococcal meningoencephalitis is a rapidly lethal infection in immunocompromised patients. Induction regimens are usually administered for 2-weeks. The shortest effective period of induction therapy with liposomal amphotericin B (LAmB) is unknown. The pharmacodynamics of LAmB were studied in murine and rabbit models of cryptococcal meningoencephalitis. The concentrations of LAmB in plasma and brain of mice were measured using HPLC. Histopathological changes were determined. The penetration of LAmB into the brain was determined by immunohistochemistry using an antibody directed to amphotericin B...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28319073/ex-vivo-t-cell-depletion-in-allogeneic-hematopoietic-stem-cell-transplant-past-present-and-future
#14
REVIEW
A Saad, L S Lamb
The most common cause of post-transplant mortality in patients with hematological malignancy is relapse, followed by GvHD, infections, organ toxicity and second malignancy. Immune-mediated complications such as GvHD continue to be challenging, yet amenable to control through manipulation of the T-cell compartment of the donor graft with subsequent immunomodulation after transplant. However, risk of both relapse and infection increase concomitantly with T-cell depletion (TCD) strategies that impair immune recovery...
March 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28317104/contact-and-contagion-bighorn-sheep-demographic-states-vary-in-probability-of-transmission-given-contact
#15
Kezia R Manlove, E Frances Cassirer, Raina K Plowright, Paul C Cross, Peter J Hudson
1.Understanding both contact and probability of transmission given contact are key to managing wildlife disease. However, wildlife disease research tends to focus on contact heterogeneity, in part because probability of transmission given contact is notoriously difficult to measure. Here we present a first step toward empirically investigating probability of transmission given contact in free-ranging wildlife. 2.We used measured contact networks to test whether bighorn sheep demographic states vary systematically in infectiousness or susceptibility to Mycoplasma ovipneumoniae, an agent responsible for bighorn sheep pneumonia...
March 20, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28316610/integrative-approaches-for-studying-mitochondrial-and-nuclear-genome-co-evolution-in-oxidative-phosphorylation
#16
Paul Sunnucks, Hernán E Morales, Annika M Lamb, Alexandra Pavlova, Chris Greening
In animals, interactions among gene products of mitochondrial and nuclear genomes (mitonuclear interactions) are of profound fitness, evolutionary, and ecological significance. Most fundamentally, the oxidative phosphorylation (OXPHOS) complexes responsible for cellular bioenergetics are formed by the direct interactions of 13 mitochondrial-encoded and ∼80 nuclear-encoded protein subunits in most animals. It is expected that organisms will develop genomic architecture that facilitates co-adaptation of these mitonuclear interactions and enhances biochemical efficiency of OXPHOS complexes...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28315490/neutralization-of-both-il-1%C3%AE-il-1%C3%AE-plays-a-major-role-in-suppressing-combined-cigarette-smoke-virus-induced-pulmonary-inflammation-in-mice
#17
Hannes Bucher, Samuel Mang, Martina Keck, Michèl Przibilla, David Lamb, Felix Schiele, Mareike Wittenbrink, Klaus Fuchs, Birgit Jung, Klaus J Erb, Daniel Peter
Smoking is an important risk factor for the development of chronic obstructive pulmonary disease (COPD) and viral infections are believed to be major triggers of exacerbations, which periodically lead to a worsening of symptoms. The pro-inflammatory IL-1 family members IL-1α and IL-1β are increased in COPD patients and might contribute to disease pathology. We investigated whether individual or combined inhibition of these cytokines reduced lung inflammation in cigarette smoke (CS)-exposed and H1N1-infected BALB/c mice...
March 15, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28314980/ex-post-assessment-of-genetically-modified-low-level-presence-in-canadian-flax
#18
Helen M Booker, Eric G Lamb, Stuart J Smyth
Canada is the world's largest producer and exporter of flaxseed. In 2009, DNA from deregistered genetically modified (GM) CDC Triffid was detected in a shipment of Canadian flaxseed exported to Europe, causing a large decrease in the amount of flax planted in Canada and a major shift in export markets. The flax industry in Canada undertook major changes to ensure the removal of transgenic flax from the supply chain. To demonstrate compliance, Canada adopted a protocol involving testing grain samples (post-harvest) using an RT-PCR test for the construct found in CDC Triffid...
March 17, 2017: Transgenic Research
https://www.readbyqxmd.com/read/28303741/weight-of-the-evidence-evaluation-of-2-4-d-potential-for-interactions-with-the-estrogen-androgen-and-thyroid-pathways-and-steroidogenesis
#19
B H Neal, J Bus, M S Marty, K Coady, A Williams, J Staveley, J C Lamb
A comprehensive weight-of-the-evidence evaluation of 2,4-dichlorophenoxyacetic acid (2,4-D) was conducted for potential interactions with the estrogen, androgen and thyroid pathways and with steroidogenesis. This assessment was based on an extensive database of high quality in vitro, in vivo ecotoxicological and in vivo mammalian toxicological studies. Epidemiological studies were also considered. Toxicokinetic data provided the basis for determining rational cutoffs above which exposures were considered irrelevant to humans based on exceeding thresholds for saturation of renal clearance (TSRC); extensive human exposure and biomonitoring data support that these boundaries far exceed human exposures and provide ample margins of exposure...
March 2, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28302366/the-cf-cares-primary-palliative-care-model-a-cf-specific-structured-assessment-of-symptoms-distress-and-coping
#20
Deborah Friedman, Rachel W Linnemann, Lily L Altstein, Suhayla Islam, Kieu-Tram Bach, Chelsea Lamb, John Volpe, Caitlin Doolittle, Anita St John, Patricia J O'Malley, Gregory S Sawicki, Anna M Georgiopoulos, Lael M Yonker, Samuel M Moskowitz
BACKGROUND: Current palliative care tools do not address distressing chronic symptoms that are most relevant to cystic fibrosis. METHODS: A CF-specific structured assessment based on a primary palliative care framework was administered to 41 adolescents and adults with CF. Descriptive and correlational analyses were conducted. RESULTS: Patients reported numerous physical and psychological symptoms (mean of 10 per patient), with psychological symptoms rated as more distressing...
March 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
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