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Judith Lamb, Karen S Galea, Brian G Miller, Susanne Hesse, Martie Van Tongeren
When applying simple screening (Tier 1) tools to estimate exposure to chemicals in a given exposure situation under the Registration, Evaluation, Authorisation and restriction of CHemicals Regulation 2006 (REACH), users must select from several possible input parameters. Previous studies have suggested that results from exposure assessments using expert judgement and from the use of modelling tools can vary considerably between assessors. This study aimed to investigate the between-user reliability of Tier 1 tools...
October 1, 2017: Annals of Work Exposures and Health
Martin Tischer, Judith Lamb, Susanne Hesse, Martie van Tongeren
No abstract text is available yet for this article.
October 1, 2017: Annals of Work Exposures and Health
Martie van Tongeren, Judith Lamb, John W Cherrie, Laura MacCalman, Ioannis Basinas, Susanne Hesse
Background: Tier 1 exposure tools recommended for use under REACH are designed to easily identify situations that may pose a risk to health through conservative exposure predictions. However, no comprehensive evaluation of the performance of the lower tier tools has previously been carried out. The ETEAM project aimed to evaluate several lower tier exposure tools (ECETOC TRA, MEASE, and EMKG-EXPO-TOOL) as well as one higher tier tool (STOFFENMANAGER®). This paper describes the results of the external validation of tool estimates using measurement data...
October 1, 2017: Annals of Work Exposures and Health
Carrie S Mongle, Abigail C Nishimura, Katherine J Kling, Alicia R Lamb, Marcy Ekanayake-Weber, Dorien de Vries
No abstract text is available yet for this article.
September 2017: Evolutionary Anthropology
Aneesh Gupta, Marie Claire Lamb, John Sisney, Chantel Taylor, Timothy Ziethen, Yvens Laborde
BACKGROUND: Five medical students traveled with 4 doctors and a medical photographer to Mayaya, La Victoire, Haiti, as part of a Medicine in Society rotation to provide medical care to the indigenous population. METHODS: Preparation for the trip involved special study in identifying microbes and using blood analysis equipment; work in a clinic for underserved people in the New Orleans, LA, area; background reading; Haitian dialect classes; and development of ideas for streamlining clinic operations...
2017: Ochsner Journal
Jennifer R Lamb, Jason P Holland
The advent of hybrid cameras that combine magnetic resonance imaging with either single-photon emission computed tomography (SPECT/MRI) or positron-emission tomography (PET/MRI) has stimulated growing interest in developing multi-modality imaging probes. Countless options are available for fusing magnetically active species with positron- or gamma-ray emitting radionuclides. The initial problem is one of choice: which chemical systems are a suitable basis for developing hybrid imaging agents? Any attempt to answer this question must also address how the physical, chemical, and biological properties of a unified imaging agent can be tailored to ensure that optimum specificity and contrast is achieved simultaneously for both imaging modalities...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Lin Sun, Qiang Yin, Ge Gentu, Yanlin Xue, Meiling Hou, Liying Liu, Yushan Jia
A feeding experiment was carried out to determine the effects of different proportions of alfalfa hay and maize stover on the growth performance and carcass characteristics of fattening lambs. Forty-two healthy 3.5-month-old male Small-tail Han lambs of 23.89 ± 0.38 kg body mass were assigned to seven groups, which were fed mixed diets composed of maize stover and alfalfa hay containing 0%, 30%, 40%, 50%, 60%, 70% or 100% maize stover on a dry matter (DM) basis. Each lamb received 1.5 kg DM of forage mixture three times daily and supplementary concentrate (0...
October 11, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
Aigerim Mailybayeva, Bolat Yespembetov, Sholpan Ryskeldinova, Nadezhda Zinina, Abylai Sansyzbay, Gourapura J Renukaradhya, Nikolai Petrovsky, Kaissar Tabynov
We previously developed a potent candidate vaccine against bovine brucellosis caused by Brucella abortus using the influenza viral vector expressing Brucella Omp16 and L7/L12 proteins (Flu-BA). Our success in the Flu-BA vaccine trial in cattle and results of a pilot study in non-pregnant small ruminants prompted us in the current study to test its efficacy against B. melitensis infection in pregnant sheep and goats. In this study, we improved the Flu-BA vaccine formulation and immunization method to achieve maximum efficacy and safety...
2017: PloS One
Alexander Kutschera, Jacob J Lamb
Live monitoring of microorganisms growth in liquid medium is a desired parameter for many research fields. A wildly used approach for determining microbial liquid growth quantification is based on light scattering as the result of the physical interaction of light with microbial cells. These measurements are generally achieved using costly table-top instruments; however, a live, reliable, and straight forward instrument constructed using parts that are inexpensive may provide opportunities for many researchers...
October 11, 2017: Current Microbiology
Tomas Kupcinskas, Inga Stadaliene, Algimantas Paulauskas, Pavelas Trusevicius, Saulius Petkevicius, Johan Höglund, Mindaugas Sarkunas
BACKGROUND: According to targeted treatment (TT), the whole flock is dewormed based on knowledge of the risk, or parameters that quantify the mean level of infection, whereas according to targeted selective treatment (TST), only individual animals within the grazing group are treated, based on parasitological, production and/or morbidity parameters. The aim of this study was to compare two different treatment protocols on sheep farms in Lithuania. The study was conducted from 15 April to 31 October 2014 on three sheep farms...
October 11, 2017: Acta Veterinaria Scandinavica
Srija Moulik, Surya Jyati Chaudhuri, Bikash Sardar, Manab Ghosh, Bibhuti Saha, Nilay Kanti Das, Mitali Chatterjee
Background: The potential reservoirs of Leishmaniasis in South Asia include relapsed cases of visceral leishmaniasis, patients with Post-Kala-azar dermal leishmaniasis (PKDL) and an asymptomatically infected population. Therefore, assessment of cure in terms of parasite clearance, early detection of PKDL and asymptomatic VL are pivotal for ensuring elimination. This study aimed to monitor the efficacy of Miltefosine and Liposomal Amphotericin B (LAmB) in PKDL based on parasite load. Methods: Patients with PKDL were recruited from the Dermatology outpatient departments or during active field surveys...
September 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Hannah Bower, Therese M-L Andersson, Michael J Crowther, Paul W Dickman, Mats Lambe, Paul C Lambert
Expected or reference mortality rates are commonly used in the calculation of measures such as relative survival in population-based cancer survival studies and standardized mortality ratios. These expected rates are usually presented by age, sex and calendar year. In certain situations, stratification of expected rates by other factors is required to avoid potential bias if interest lies in quantifying measures by such factors, for example, socioeconomic status. If data on a population level are not available, information from a control population could be used to adjust expected rates...
August 23, 2017: American Journal of Epidemiology
Christopher R Lamb, Helen Dirrig, Stefano Cortellini
Objectives The objective of this study was to identify the renal ultrasonographic (US) findings most strongly associated with azotaemia in cats. Methods US findings in 238 cats with (serum creatinine >180 μmol/l) and 270 cats without azotaemia were compared in a retrospective case-control study. Cats with pre-renal azotaemia or urethral obstruction were excluded. Data extracted from the medical records included age, body weight and body condition score (BCS). Quantitative and subjective US findings were extracted from archived ultrasound images and contemporaneous reports...
October 1, 2017: Journal of Feline Medicine and Surgery
Maren Bernau, Prisca Valerie Kremer-Rücker, Lena Sophie Kreuzer, Sebastian Schwanitz, Klaus Cussler, Andreas Hoffmann, Armin Manfred Scholz
OBJECTIVES: Vaccination is one of the most effective methods to keep up the health status in humans and in livestock. Therefore, farm animals are vaccinated several times during their lifetime. Although vaccines are being checked regarding their local reactogenicity, side effects occur frequently-especially in the case of the application of adjuvanted products. Many reports exist about local reactions in sheep. The present study aimed at testing MRI as a method to document injection site reactions three-dimensionally...
2017: Veterinary Record Open
Bethan Copsey, Susan Dutton, Ray Fitzpatrick, Sarah E Lamb, Jonathan A Cook
BACKGROUND: A key aspect of the design of randomised controlled trials (RCTs) is determining the sample size. It is important that the trial sample size is appropriately calculated. The required sample size will differ by clinical area, for instance, due to the prevalence of the condition and the choice of primary outcome. Additionally, it will depend upon the choice of target difference assumed in the calculation. Focussing upon the hip and knee osteoarthritis population, this study aims to systematically review how the trial size was determined for trials of osteoarthritis, on what basis, and how well these aspects are reported...
October 10, 2017: Trials
Jacob J Lamb, Martin F Hohmann-Marriott
Manganese is an essential element required by cyanobacteria, as it is an essential part of the oxygen-evolving center of photosystem II. In the presence of atmospheric oxygen, manganese is present as manganese oxides, which have low solubility and consequently provide low bioavailability. It is unknown if cyanobacteria are able to utilize these manganese sources, and what mechanisms may be employed to do so. Recent evidence suggests that type IV pili in non-photosynthetic bacteria facilitate electron donation to extracellular electron acceptors, thereby enabling metal acquisition...
2017: PloS One
Tara A McCannel, EunAh Kim, Mitchell Kamrava, James Lamb, Joseph Caprioli, Dong Yang, Colin A McCannel
PURPOSE: Radiation retinopathy remains incompletely characterized and may cause severe vision loss. Ultra-wide-field fluorescein angiography provides a pan-fundus view of vascular alterations caused by radiation treatment and may predict visual and ocular outcomes. We have developed a grading scheme to describe pan-fundus severity and to predict the progression of radiation retinopathy in patients treated for uveal melanoma with iodine-125 brachytherapy. METHODS: A retrospective review of patients treated with standard iodine-125 brachytherapy for uveal melanoma at the Ophthalmic Oncology Center at the University of California, Los Angeles, who had undergone both baseline and postbrachytherapy ultra-wide-field fluorescein angiography...
October 6, 2017: Retina
Kenneth Kimmel
The survivor of a decade of childhood sexual trauma and violence, perpetrated by a monstrous father, produced a series of dreams in the final year of a ten-year analysis. They illuminated the 'death drive' beneath a lifelong preoccupation with dying and fantasies of submission to death, perpetuated by the promise of hoped-for freedom from pain and release from a life of suffering. The initial dream involved the collapse of a team of white horses drawing him in a pillory cart to his own hanging for a crime he did not commit...
November 2017: Journal of Analytical Psychology
Stefan G Wette, Heather K Smith, Graham D Lamb, Robyn M Murphy
No abstract text is available yet for this article.
October 1, 2017: American Journal of Physiology. Cell Physiology
Jacqueline T Jonker, Paul de Heer, Marten A Engelse, Evelien H van Rossenberg, Celine Q F Klessens, Hans J Baelde, Ingeborg M Bajema, Sietse Jan Koopmans, Paulo G Coelho, Trea C M Streefland, Andrew G Webb, Ilona A Dekkers, Ton J Rabelink, Patrick C N Rensen, Hildo J Lamb, Aiko P J de Vries
Background: Obesity and type 2 diabetes have not only been linked to fatty liver, but also to fatty kidney and chronic kidney disease. Since non-invasive tools are lacking to study fatty kidney in clinical studies, we explored agreement between proton magnetic resonance spectroscopy ( 1 H-MRS) and enzymatic assessment of renal triglyceride content (without and with dietary intervention). We further studied the correlation between fatty kidney and fatty liver. Methods: Triglyceride content in the renal cortex was measured by 1 H-MRS on a 7-Tesla scanner in 27 pigs, among which 15 minipigs had been randomized to a 7-month control diet, cafeteria diet (CAF) or CAF with low-dose streptozocin (CAF-S) to induce insulin-independent diabetes...
September 15, 2017: Nephrology, Dialysis, Transplantation
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