Jianyu Wang, Xing Liu, Zhen Dou, Liang Chen, Hao Jiang, Chuanhai Fu, Guosheng Fu, Dan Liu, Jiancun Zhang, Tongge Zhu, Jingwen Fang, Jianye Zang, Jinke Cheng, Maikun Teng, Xia Ding, Xuebiao Yao
The centromere is essential for precise and equal segregation of the parental genome into two daughter cells during mitosis. CENP-A is a unique histone H3 variant conserved in eukaryotic centromeres. The assembly of CENP-A to the centromere is mediated by Holliday junction recognition protein (HJURP) in early G1 phase. However, it remains elusive how HJURP governs CENP-A incorporation into the centromere. Here we show that human HJURP directly binds to Mis18β, a component of the Mis18 complex conserved in the eukaryotic kingdom...
March 21, 2014: Journal of Biological Chemistry