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https://www.readbyqxmd.com/read/29786770/the-extract-of-leonurus-sibiricus-transgenic-roots-with-atpap1-transcriptional-factor-induces-apoptosis-via-dna-damage-and-down-regulation-of-selected-epigenetic-factors-in-human-cancer-cells
#1
Przemysław Sitarek, Tomasz Kowalczyk, Simona Santangelo, Adam J Białas, Monika Toma, Joanna Wieczfinska, Tomasz Śliwiński, Ewa Skała
The aim of this study was to determine the anticancer potential of Leonurus sibiricus extract derived from in vitro transgenic roots transformed by Agrobacetrium rhizogenes with AtPAP1 transcriptional factor, and that of transformed roots without construct, on grade IV human glioma cells and the U87MG cell line, and attempt to characterize the mechanism involved in this process. The anticancer effect induced by the tested extracts was associated with DNA damage, PARP cleavage/increased H2A.X histone levels and UHRF-1/DNMT1 down-regulation of mRNA levels...
May 21, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29786731/regioselective-and-diastereoselective-synthesis-of-two-functionalized-1-5-methanoindeno-1-2-d-azocines-via-a-three-component-reaction
#2
Jun Cao, Jing Sun, Chao-Guo Yan
The morpholine promoted three-component reaction of N-alkylpiperidinone, indane-1,3-dione and 2-arylideneindane-1,3-dione in ethanol at room temperature resulted in the (1H-1,5-methanoindeno[1,2-d]azocin-12-ylidene)-1H-indene-1,3(2H)-dione derivatives in good yields and with exo-configuration. Under similar conditions, the reaction of N-alkylpiperidinone with 2-arylideneindane-1,3-dione afforded 7H-1,5-methanoindeno[1,2-d]azocine-7,12-diones with endo-configuration. The domino reaction is believed to proceed with domino Knoevenagel condensation, Michael addition and aldol condensation reaction...
May 22, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29786576/the-histological-and-electron-microscopic-study-of-the-parotid-salivary-gland-in-dehydrated-rats-of-different-ages
#3
Denys P Biletskyy, Oleg A Ustiansky, Olena S Maksymova, Pavel A Moskalenko, Alexey A Tymoshenko, Anna S Degtyarenko, Viktoriia Yu Harbuzova, Yevhen I Dubovyk, Andrii P Voznyi, Gennadii F Tkach
OBJECTIVE: Introduction: Water-salt metabolism disorders is one of the main factor of salivary gland pathology development. The aim: To study the morphological structure of the parotid salivary gland of young, mature and old rats at micro- and ultrastructural levels under water deprivation. PATIENTS AND METHODS: Materials and methods: The experiment was carried out on thirty six laboratory male rats of different ages (young, mature and old). The rats of the control group received normal volume of drinking water...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29785848/the-total-synthesis-of-tetarimycin-a-%C3%A2-naphthacemycin-a-9-and-%C3%A2-fasamycin-a-structure-activity-relationship-studies-against-drug-resistant-bacteria
#4
Jing-Kai Huang, Tsai-Ling Yang Lauderdale, Chun-Cheng Lin, Kak-Shan Shia
Making use of a reductive olefin coupling reaction and Michael-Dieckmann condensation as two key operations, we have completed a concise total synthesis of tetarimycin A, (±)-naphthacemycin A9 and (±)-fasamycin A in a highly convergent and practical protocol. Synthetic procedures thus developed have also been applied to providing related analogues for structure-activity relationship studies, thereof coming to a conclusion that the free hydroxyl group at C-10 is essential for exerting inhibitory activities against a panel of Gram-positive bacteria, including drug-resistant strains VRE and MRSA...
May 22, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29785431/slow-magnetic-relaxation-and-luminescence-properties-in-lanthanide-iii-anil-complexes
#5
Diamantoula Maniaki, Ioannis Mylonas-Margaritis, Julia Mayans, Aikaterini Savvidou, Catherine P Raptopoulou, Vlasoula Bekiari, Vassilis Psycharis, Albert Escuer, Spyros P Perlepes
The initial use of anils, i.e. bidentate Schiff bases derived from the condensation of anilines with salicylaldehyde or its derivatives, in 4f-metal chemistry is described. The 1 : 1 reactions between Ln(NO3)3·xH2O (Ln = lanthanide) or Y(NO3)3·6H2O and N-(5-bromosalicylidene)aniline (5BrsalanH) in MeCN has provided access to complexes [Ln(NO3)3(5BrsalanH)2(H2O)]·MeCN (Ln = Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb) and [Y(NO3)3(5BrsalanH)2(H2O)]·MeCN, respectively, in good yields. The structures of the isomorphous complexes with Ln = Pr(1·MeCN), Sm(3·MeCN), Gd(5·MeCN), Dy(7·MeCN) and Er(9·MeCN) have been determined by single-crystal X-ray crystallography...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29785032/solvents-can-control-solute-molecular-identity
#6
Devon R Widmer, Benjamin J Schwartz
For solution-phase chemical reactions, the solvent is often considered simply as a medium to allow the reactants to encounter each other by diffusion. Although examples of direct solvent effects on molecular solutes exist, such as the compression of solute bonding electrons due to Pauli repulsion interactions, the solvent is not usually considered a part of the chemical species of interest. We show, using quantum simulations of Na2 , that when there are local specific interactions between a solute and solvent that are energetically on the same order as a hydrogen bond, the solvent controls not only the bond dynamics but also the chemical identity of the solute...
May 21, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29784922/special-temperatures-in-frustrated-ferromagnets
#7
L Bovo, M Twengström, O A Petrenko, T Fennell, M J P Gingras, S T Bramwell, P Henelius
The description and detection of unconventional magnetic states, such as spin liquids, is a recurring topic in condensed matter physics. While much of the efforts have traditionally been directed at geometrically frustrated antiferromagnets, recent studies reveal that systems featuring competing antiferromagnetic and ferromagnetic interactions are also promising candidate materials. We find that this competition leads to the notion of special temperatures, analogous to those of gases, at which the competing interactions balance, and the system is quasi-ideal...
May 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29784461/stability-and-reactivity-of-%C3%AE-%C3%AE-ptms-silane-in-some-commercial-primer-and-adhesive-formulations
#8
Maria Dimitriadi, Angeliki Panagiotopoulou, Maria Pelecanou, Konstantina Yannakopoulou, George Eliades
OBJECTIVES: To evaluate the stability and reactivity of γ-methacryloxypropyl trimethoxysilane (MPTMS) in commercially available primers and adhesives. METHODS: Four representative primer formulations [Calibra Silane Coupling Agent/Dentsply (CLB), G-Multi Primer/GC (GMP), Kerr Silane Primer/Kerr (KSP), Monobond Plus/Ivoclar Vivadent (MBP)] and a universal adhesive [Scotchbond Universal/3M ESPE (SBU)] containing MPTMS were analyzed spectroscopically. For the stability study, the silanol content was evaluated in bulk solutions as received (reference-RE) and after aging (AG, 48°C/1month) by 1 H, 13 C, 31 P NMR and in fresh films by transmission FTIR analysis (TIR, films applied on Ge windows after solvent evaporation)...
May 18, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29784316/structural-profile-of-soluble-and-bound-phenolic-compounds-in-teff-eragrostis-tef-reveals-abundance-of-distinctly-different-flavones-in-white-and-brown-varieties
#9
Shreeya Ravisankar, Kebede Abegaz, Joseph M Awika
Reliable data on polyphenol in teff, an increasingly important food crop, is currently lacking. This study investigated the structural and quantitative profile of soluble and bound polyphenols in white and brown teff grown in Ethiopia and USA using LC-tandem quadrupole mass spectrometry. Thirty-four phenolic compounds (32 newly identified in teff), mostly flavones and phenolic acid derivatives, were characterized. Unusually high levels of flavones were present in both white (1398-2049 μg/g), and brown (1720-1847 μg/g) teff soluble fractions...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29783842/spin-direction-controlled-electronic-band-structure-in-two-dimensional-ferromagnetic-cri-3
#10
Peiheng Jiang, Lei Li, Zhaoliang Liao, Y X Zhao, Zhicheng Zhong
Manipulating physical properties using the spin degree of freedom constitutes a major part of modern condensed matter physics and is a key aspect for spintronics devices. Using the newly discovered two-dimensional van der Waals ferromagnetic CrI3 as a prototype material, we theoretically demonstrated a giant magneto band-structure (GMB) effect whereby a change of magnetization direction significantly modifies the electronic band structure. Our density functional theory calculations and model analysis reveal that rotating the magnetic moment of CrI3 from out-of-plane to in-plane causes a direct-to-indirect bandgap transition, inducing a magnetic field controlled photoluminescence...
May 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29783755/a-miniaturized-extruder-to-prototype-amorphous-solid-dispersions-selection-of-plasticizers-for-hot-melt-extrusion
#11
Matthias E Lauer, Reto Maurer, Anne T De Paepe, Cordula Stillhart, Laurence Jacob, Rajesh James, Yuki Kojima, Rene Rietmann, Tom Kissling, Joost A van den Ende, Sabine Schwarz, Olaf Grassmann, Susanne Page
Hot-melt extrusion is an option to fabricate amorphous solid dispersions and to enhance oral bioavailability of poorly soluble compounds. The selection of suitable polymer carriers and processing aids determines the dissolution, homogeneity and stability performance of this solid dosage form. A miniaturized extrusion device (MinEx) was developed and Hypromellose acetate succinate type L (HPMCAS-L) based extrudates containing the model drugs neurokinin-1 (NK1) and cholesterylester transfer protein (CETP) were manufactured, plasticizers were added and their impact on dissolution and solid-state properties were assessed...
May 19, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29782662/spoof-plasmonics-from-metamaterial-concept-to-topological-description
#12
REVIEW
Zhen Gao, Lin Wu, Fei Gao, Yu Luo, Baile Zhang
Advances in metamaterials have offered the opportunity of engineering electromagnetic properties beyond the limits of natural materials. A typical example is "spoof" surface plasmon polaritons (SPPs), which mimic features of SPPs without penetrating into metal, but only with periodic corrugations on metal surfaces. They hold considerable promise in device applications from microwaves to the far infrared, where real SPP modes do not exist. The original spoof SPP concept is derived from the description of corrugated surfaces by a metamaterial that hosts an effective plasma frequency...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782168/rapid-aqueous-phase-hydrolysis-of-ester-hydroperoxides-arising-from-criegee-intermediates-and-organic-acids
#13
Ran Zhao, Christopher M Kenseth, Yuanlong Huang, Nathan F Dalleska, Xiaobi Michelle Kuang, Jierou Chen, Suzanne E Paulson, John H Seinfeld
Stabilized Criegee intermediates react with organic acids in the gas phase and at the air-water interface to form a class of ester hydroperoxides, α-acyloxyalkyl hydroperoxides (αAAHPs). A number of recent studies have proposed the importance of αAAHPs to the formation and growth of secondary organic aerosol (SOA). The chemistry of αAAHPs has not been investigated due to a lack of commercially available chemical standards. In this work, the behavior of αAAHPs in condensed phases is investigated for the first time...
May 21, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29782155/a-narrow-gap-semiconducting-germanium-allotrope-from-the-oxidation-of-a-layered-zintl-phase-in-ionic-liquids
#14
Zhongjia Tang, Alexander P Litvinchuk, Melissa Gooch, Arnold M Guloy
A metastable germanium allotrope, Ge(oP32), was synthe-sized as polycrystalline powders and single crystals from the mild-oxidation/delithiation of Li7Ge12 in ionic liquids. Its crystal structure, from single crystal X-ray diffraction (P bcm, a = 8.1527(4) Å, b = 11.7572(5) Å, c = 7.7617(4) Å), features a complex covalent network of 4-bonded Ge, resulting from a well-ordered topotactic oxidative condensation of [Ge12 ]7- layers. It is a diamagnetic semiconductor (Eg = 0.33 eV), and transforms exothermically and irreversibly to α-Ge at 363 °C...
May 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29781246/determination-of-pesticide-dermal-transfer-to-operators-agricultural-workers-through-contact-with-sprayed-hard-surfaces
#15
Angelos N Tsakirakis, Konstantinos M Kasiotis, Pelagia Anastasiadou, Agathi N Charistou, Rianda Gerritsen-Ebben, C Richard Glass, Kyriaki Machera
BACKGROUND: In the present study, the dermal transfer rate of pesticides to agricultural workers occurring via contact with sprayed hard surfaces was investigated. Cotton gloves were used as dosimeters to collect residues from hard surfaces contaminated by pesticides in greenhouses. Dosimeters, either dry or moistened, were in contact with wood, metal and plastic surfaces previously sprayed. The experimental approach applied mimicked the typical hand contact. Moistened cotton gloves were used to simulate hand moisture from dew/condensation or rainfall...
May 20, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29781047/a-survey-on-coronary-atherosclerotic-plaque-tissue-characterization-in-intravascular-optical-coherence-tomography
#16
REVIEW
Alberto Boi, Ankush D Jamthikar, Luca Saba, Deep Gupta, Aditya Sharma, Bruno Loi, John R Laird, Narendra N Khanna, Jasjit S Suri
PURPOSE OF REVIEW: Atherosclerotic plaque deposition within the coronary vessel wall leads to arterial stenosis and severe catastrophic events over time. Identification of these atherosclerotic plaque components is essential to pre-estimate the risk of cardiovascular disease (CVD) and stratify them as a high or low risk. The characterization and quantification of coronary plaque components are not only vital but also a challenging task which can be possible using high-resolution imaging techniques...
May 21, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29780544/the-enhancement-and-suppression-of-immersion-mode-heterogeneous-ice-nucleation-by-solutes
#17
Thomas F Whale, Mark A Holden, Theodore W Wilson, Daniel O'Sullivan, Benjamin J Murray
Heterogeneous nucleation of ice from aqueous solutions is an important yet poorly understood process in multiple fields, not least the atmospheric sciences where it impacts the formation and properties of clouds. In the atmosphere ice-nucleating particles are usually, if not always, mixed with soluble material. However, the impact of this soluble material on ice nucleation is poorly understood. In the atmospheric community the current paradigm for freezing under mixed phase cloud conditions is that dilute solutions will not influence heterogeneous freezing...
May 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779367/tandem-aza-michael-addition-vinylogous-nitroaldol-condensation-construction-of-highly-substituted-n-fused-3-nitropyrazolopyridines
#18
Owk Obulesu, V Murugesh, Battu Harish, Surisetti Suresh
A base-mediated tandem aza-Michael addition-vinylogous nitroaldol condensation has been described between 3,5-dialkyl 4-nitropyrazoles and alkynyl ketones/aldehydes. This transition metal-free atom economical transformation occurred via C-N and C=C bond formations in one step with the elimination of water. The construction of a variety of highly substituted N-fused 3-nitro-pyrazolopyridine derivatives has been demonstrated with good yields. Good to excellent regioselectivities have been achieved with unsymmetrically substituted 4-nitropyrazoles...
May 21, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29779241/visible-light-driven-chemoselective-hydrogenation-of-nitroarenes-to-anilines-in-water-via-graphitic-carbon-nitride-metal-free-photocatalysis
#19
Gang Xiao, Peifeng Li, Yilin Zhao, Shengnan Xu, Haijia Su
Green and efficient procedures are highly required for the chemoselective hydrogenation of functionalized nitroarenes to industrially important anilines. Here, we show that visible-light-driven, chemoselective hydrogenation of functionalized nitroarenes bearing the sensitive groups to anilines can be achieved in good to excellent yields (82-100%) in water under relatively mild conditions, catalyzed by low-cost and recyclable graphitic carbon nitride. It is also applicable in gram-scale reaction with 86% yield of aniline...
May 20, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29777989/synthesis-antiproliferative-activity-and-mechanism-of-gallium-iii-thiosemicarbazone-complexes-as-potential-anti-breast-cancer-agents
#20
Jinxu Qi, Qian Yao, Kun Qian, Liang Tian, Zhen Cheng, Dongmei Yang, Yihong Wang
Five thiosemicarbazone ligands were synthesized and characterized by condensation with different aldehydes or ketones by 4-phenylthiosemicarbazone. The representative dichlorido[2-(Di-2-pyridinylmethylene)-Nphenylhydrazinecarbothioamide-N,N,S]-gallium(III) (Ga4) was characterized by X-ray single crystal diffraction, which was 1:1 ligand/Ga(III) complexes. The structure-activity relationship of these ligands and Ga (III) complexes have been investigated, and the results demonstrate that the formation of Ga (III) complexes have significant antiproliferative activity over the corresponding ligands...
May 14, 2018: European Journal of Medicinal Chemistry
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