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Abdominal aortic aneurysms

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https://www.readbyqxmd.com/read/29221957/endovascular-repair-of-complex-juxtarenal-aortic-aneurysm-using-a-combined-fenestrated-endograft-and-chimney-technique
#1
REVIEW
Zaher Fanari, Nilesh J Goswami
Chimney EVAR (CHEVAR) and Fenestrated EVAR (FEVAR) are two options for management of very complex abdominal aortic aneurysm (AAA). While some anatomical factors may favor one strategy over the other, there are some cases where the anatomical challenges may require using a hybrid approach. We are reporting the case of an 84-year-old male with a 6.8×5.7cm infrarenal abdominal aortic aneurysm that arises immediately below the level of the renal arteries and extends down to just above the iliac bifurcation with occluded celiac and inferior mesenteric arteries and severe bilateral renal artery stenosis with caudally oriented right renal and cranially oriented left renal artery...
November 22, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29217508/il-1%C3%AE-interleukin-1%C3%AE-and-tnf-%C3%AE-tumor-necrosis-factor-%C3%AE-impact-abdominal-aortic-aneurysm-formation-by-differential-effects-on-macrophage-polarization
#2
Rishi Batra, Melissa K Suh, Jeffrey S Carson, Matthew A Dale, Trevor M Meisinger, Matthew Fitzgerald, Patrick J Opperman, Jiangtao Luo, Iraklis I Pipinos, Wanfen Xiong, B Timothy Baxter
OBJECTIVE: Abdominal aortic aneurysms are inflammatory in nature and are associated with some risk factors that also lead to atherosclerotic occlusive disease, most notably smoking. The purpose of our study was to identify differential cytokine expression in patients with abdominal aortic aneurysm and those with atherosclerotic occlusive disease. Based on this analysis, we further explored and compared the mechanism of action of IL (interleukin)-1β versus TNF-α (tumor necrosis factor-α) in abdominal aortic aneurysm formation...
December 7, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29217447/early-experience-with-fenestrated-endovascular-compared-to-open-repair-of-complex-abdominal-aortic-aneurysms-in-a-high-volume-open-aortic-center
#3
Sarah E Deery, Robert T Lancaster, Anna M Gubala, Thomas F X O'Donnell, Christopher J Kwolek, Mark F Conrad, Richard P Cambria, Virendra I Patel
OBJECTIVE: Early data suggest that FEVAR is feasible but may have higher morbidity and unclear durability compared to open surgical repair (OSR) of complex abdominal aortic aneurysms (CAAA). We compared the early experience following elective FEVAR to traditional OSR of CAAA in a high-volume open aortic center. METHODS: All patients undergoing FEVAR and OSR for elective CAAA from 1/2010-7/2015 were identified. Univariate, multivariable logistic, and Cox hazards modeling were used to compare perioperative and intermediate outcomes...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29217411/ct-after-endovascular-repair-of-abdominal-aortic-aneurysms-diagnostic-accuracy-of-diameter-measurements-for-the-detection-of-aneurysm-sac-enlargement
#4
Michael Schnitzbauer, Oliver Güntner, Walter A Wohlgemuth, Florian Zeman, Michael Haimerl, Christian Stroszczynski, René Müller-Wille
PURPOSE: To evaluate the diagnostic accuracy of diameter measurements for the detection of aneurysm volume increase during follow-up after endovascular aortic repair (EVAR) of abdominal aortic aneurysms (AAAs). MATERIALS AND METHODS: This retrospective study analyzed 100 pairs of follow-up computed tomography scans randomly selected from an EVAR database (male/female ratio, 91/9; mean age, 71 y; bifurcated and aortouniiliac stent grafts, 96% and 4%, respectively; mean interval, 359 d)...
December 4, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29211214/hybrid-approach-of-aortic-diseases-zone-1-delivery-and-volumetric-analysis-on-the-descending-aorta
#5
José Augusto Duncan, Ricardo Ribeiro Dias, Fabrício José Dinato, Fábio Fernandes, Félix José Álvares Ramirez, Charles Mady, Fabio Biscegli Jatene
INTRODUCTION: Conventional techniques of surgical correction of arch and descending aortic diseases remains as high-risk procedures. Endovascular treatments of abdominal and descending thoracic aorta have lower surgical risk. Evolution of both techniques - open debranching of the arch and endovascular approach of the descending aorta - may extend a less invasive endovascular treatment for a more extensive disease with necessity of proximal landing zone in the arch. OBJECTIVE: To evaluate descending thoracic aortic remodeling by means of volumetric analysis after hybrid approach of aortic arch debranching and stenting the descending aorta...
September 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29210916/acute-inflammatory-responses-to-exercise-in-patients-with-abdominal-aortic-aneurysm
#6
Mark T Windsor, Tom G Bailey, Maria Perissiou, Kim Greaves, Pankaj Jha, Anthony S Leicht, Fraser D Russell, Jonathan Golledge, Christopher D Askew
PURPOSE: Inflammation and extracellular matrix degeneration contribute to abdominal aortic aneurysm (AAA) development. We aimed to assess the effect of exercise intensity on circulating biomarkers of inflammation and extracellular matrix degeneration in patients with AAA and healthy older adults. METHODS: Twenty patients with AAA (74±6y) and twenty healthy males (72±5y) completed moderate-intensity cycling at 40% peak power output (PPO), higher-intensity intervals at 70% PPO, and control (rest) on separate days...
November 27, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29206004/outcomes-of-endovascular-aortic-repair-in-the-modern-era
#7
Jacob Budtz-Lilly, Anders Wanhainen, Kevin Mani
Monitoring outcomes following endovascular aortic repair (EVAR) is critical. Although evidence from randomized controlled trials has solidified the role of EVAR, the analysis of outcomes and "real-world" data has uncovered limitations, improved the selection of appropriate patients, and underscored the importance of instructions for use. Subsequent studies demonstrated the learning curve of EVAR and gradual improvement of outcomes over time. Outcomes analyses will continue to play an important role, particularly as technological growth of endovascular therapy has enabled treatment of more complex aneurysm pathologies and patients...
December 4, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29206003/outcomes-and-challenges-in-modern-abdominal-aortic-aneurysm-repair
#8
Kevin Mani
No abstract text is available yet for this article.
December 4, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29205995/volume-and-health-outcomes-evidence-from-systematic-reviews-and-from-evaluation-of-italian-hospital-data
#9
Laura Amato, Danilo Fusco, Anna Acampora, Katia Bontempi, Alessandro Cesare Rosa, Paola Colais, Fabio Cruciani, Mariangela D'Ovidio, Francesca Mataloni, Silvia Minozzi, Zuzana Mitrova, Luigi Pinnarelli, Rosella Saulle, Salvatore Soldati, Chiara Sorge, Simona Vecchi, Martina Ventura, Marina Davoli
BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29204794/thoracic-aortic-aneurysm-unlocking-the-silent-killer-secrets
#10
Ayman A Saeyeldin, Camilo A Velasquez, Syed Usman B Mahmood, Adam J Brownstein, Mohammad A Zafar, Bulat A Ziganshin, John A Elefteriades
Thoracic aortic aneurysm (TAA) is an increasingly recognized condition that is often diagnosed incidentally. This review discusses ten of the most relevant epidemiological and clinical secrets of this disease; (1) the difference in pathogenesis between ascending and descending TAAs. TAAs at these two sites act as different diseases, which is related to the different embryologic origins of the ascending and descending aorta. (2) The familial pattern and genetics of thoracic aneurysms. Syndromic TAAs only explain 5% of the pattern of inheritance...
December 4, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29202650/increasing-the-elective-endovascular-to-open-repair-ratio-of-popliteal-artery-aneurysm
#11
Axel Wrede, Frans Wiberg, Stefan Acosta
BACKGROUND: Open repair (OR) for popliteal artery aneurysm (PAA) has recently been challenged by endovascular repair (ER) as the primary choice of treatment. The aim of the present study was to evaluate time trends in treatment modality and compare outcomes between OR and ER among electively operated patients after start of screening in 2010 for abdominal aortic aneurysm (AAA), a disease highly associated with PAA. METHODS: Between January 1, 2009, and April 30, 2017, 102 procedures and 36 acute and 66 elective repairs for PAA were identified...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29197893/management-of-concurrent-thoracic-and-abdominal-aortic-aneurysms
#12
S T Saw, S J Feona, B D K Leong
Concurrent thoracic and abdominal aortic aneurysm is uncommon. It remains a formidable surgical challenge to vascular surgeons, as decision to treat in staged or simultaneous setting still debatable. We present, here, a case of a 62-year-old-man with asymptomatic concurrent thoracic and abdominal aortic aneurysms, which was successfully treated with two-stage hybrid endovascular repair. The aim of this case report is to discuss the treatment options available, possible associated complications and measures to prevent them...
October 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29197609/comparison-of-two-sample-processing-methods-and-nine-commercial-immunoassays-for-the-detection-of-interleukin-il-1%C3%AE-in-the-serum-of-patients-with-abdominal-aortic-aneurysm-aaa
#13
Mehtab Ahmad, Rajiv Vohra, Andrew Bradbury
BACKGROUND: For a cytokine to have a role as a clinically useful biomarker it must be measureable in a practical, reliable and reproducible manner. Furthermore, assays from different manufacturers should produce comparable results. AIM: To examine the effect of two sample processing methodologies and compare nine commercially available immunoassays for their measurement of serum interleukin (IL)-1α in patients with abdominal aortic aneurysm (AAA). METHODS: Two sample processing methodologies and nine manufacturers' immunoassays were compared...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29197602/continuous-flow-perfused-cadaver-model-for-endovascular-training-research-and-development
#14
Amrita Sarkar, Richa Kalsi, Joseph D Ayers, Charles B Drucker, Vaidehi Kaushal, William Sutton, Robert S Crawford
BACKGROUND: Endovascular simulation employing computer, animal, and static models are common and useful adjuncts for teaching endovascular procedures and developing novel, complex endovascular techniques. Unfortunately, these models lack realistic haptic feedback and thus do not faithfully replicate many of the technical challenges associated with clinical endovascular procedures (e.g., arterial calcification, rigidity, and stenosis). We sought to develop a realistic and reproducible perfused cadaver model for endovascular training, device development and research...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29195736/a-novel-reproducible-model-of-aortic-aneurysm-rupture
#15
Anna Z Fashandi, Robert B Hawkins, Morgan D Salmon, Michael D Spinosa, William G Montgomery, J Michael Cullen, Guanyi Lu, Gang Su, Gorav Ailawadi, Gilbert R Upchurch
INTRODUCTION: Given the unknown biologic antecedents before aortic aneurysm rupture, the purpose of this study was to establish a reproducible model of aortic aneurysm rupture. METHODS: We fed 7-week-old apolipoprotein E deficient mice a high-fat diet for 4 weeks and osmotic infusion pumps containing Angiotensin II were implanted. Angiotensin II was delivered continuously for 4 weeks at either 1,000 ng/kg/min (n = 25) or 2,000 ng/kg/min (n = 29). A third group (n = 14) were given Angiotensin II at 2,000 ng/kg/min and 0...
November 28, 2017: Surgery
https://www.readbyqxmd.com/read/29191809/molecular-fingerprint-for-terminal-abdominal-aortic-aneurysm-disease
#16
Gabor Gäbel, Bernd H Northoff, Irina Weinzierl, Stefan Ludwig, Irene Hinterseher, Wolfgang Wilfert, Daniel Teupser, Stefan A Doderer, Hendrik Bergert, Frank Schönleben, Jan H N Lindeman, Lesca M Holdt
BACKGROUND: Clinical decision making in abdominal aortic aneurysms (AAA) relies completely on diameter. At this point, improved decision tools remain an unmet medical need. Our goal was to identify changes at the molecular level specifically leading up to AAA rupture. METHODS AND RESULTS: Aortic wall tissue specimens were collected during open elective (eAAA; n=31) or emergency repair of ruptured AAA (rAAA; n=17), and gene expression was investigated using microarrays...
November 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29190959/effect-of-ampk-signal-pathway-on-pathogenesis-of-abdominal-aortic-aneurysms
#17
Le Yang, Lin Shen, Peixian Gao, Gang Li, Yuxiang He, Maohua Wang, Hua Zhou, Hai Yuan, Xing Jin, Xuejun Wu
Background and aims: Determine the effect of AMPK activation and inhibition on the development of AAA (abdominal aortic aneurysm). Methods: AAA was induced in ApoE-/- mice by Ang II (Angiotensin II)-infusion. AICAR (5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside) was used as AMPK activator and Compound C was used as AMPK inhibitor. We further investigate the effect of metformin, a widely used anti-diabetic drug which could activate AMPK signal pathway, on the pathogenesis of aneurysm...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29188294/genetic-association-of-lipids-and-lipid-drug-targets-with-abdominal-aortic-aneurysm-a-meta-analysis
#18
Seamus C Harrison, Michael V Holmes, Stephen Burgess, Folkert W Asselbergs, Gregory T Jones, Annette F Baas, F N van 't Hof, Paul I W de Bakker, Jan D Blankensteijn, Janet T Powell, Athanasios Saratzis, Gert J de Borst, Daniel I Swerdlow, Yolanda van der Graaf, Andre M van Rij, David J Carey, James R Elmore, Gerard Tromp, Helena Kuivaniemi, Robert D Sayers, Nilesh J Samani, Matthew J Bown, Steve E Humphries
Importance: Risk factors for abdominal aortic aneurysm (AAA) are largely unknown, which has hampered the development of nonsurgical treatments to alter the natural history of disease. Objective: To investigate the association between lipid-associated single-nucleotide polymorphisms (SNPs) and AAA risk. Design, Setting, and Participants: Genetic risk scores, composed of lipid trait-associated SNPs, were constructed and tested for their association with AAA using conventional (inverse-variance weighted) mendelian randomization (MR) and data from international AAA genome-wide association studies...
November 29, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29187677/prevention-of-kinked-stent-graft-limb-due-to-severe-angulated-proximal-neck-during-endovascular-repair-for-abdominal-aortic-aneurysm
#19
Pyung Chun Oh, Minsu Kim, Eak Kyun Shin, Woong Chol Kang
Although the technology of endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA) is evolving that make it appealing for challenging anatomy, proximal aortic neck morphology, especially severe angulation, is still one of the most determinants for a successful procedure. We describe a patient of AAA with severely angulated proximal neck, in whom kinked stent graft limb occurred against severe angulation of proximal neck. Then, we suggested how to prevent this complication in the second patient...
November 29, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29182987/lipoprotein-a-and-abdominal-aortic-aneurysm-risk-the-atherosclerosis-risk-in-communities-study
#20
Yasuhiko Kubota, Aaron R Folsom, Christie M Ballantyne, Weihong Tang
BACKGROUND AND AIMS: No prospective study has investigated whether elevated lipoprotein(a) concentrations are associated with an increased risk of abdominal aortic aneurysm (AAA). We aimed to prospectively investigate this association. METHODS: In 1987-1989, the Atherosclerosis Risk in Communities study measured plasma lipoprotein(a) in 13,683 participants aged 45-64 years, without a history of AAA surgery. We followed them for incident, clinical AAA events through 2011...
November 25, 2017: Atherosclerosis
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