keyword
MENU ▼
Read by QxMD icon Read
search

Normal physiologic birth

keyword
https://www.readbyqxmd.com/read/28770443/how-to-proceed-with-examination-of-a-child
#1
REVIEW
Sonia Makhija, Poornima Tiwari
The assessment of a child is quite different from that of adults and requires knowledge of normal variations in anatomy and physiology with growth and development. An important part of initial assessment includes triage and recognizing children with emergency signs so that they can be managed at the earliest to prevent death and referred timely to the specialist. After ruling out emergency signs, the children with priority signs require prompt assessment, management and referral to the specialist. In addition to normal history as in adults, prenatal and birth history, developmental history, immunization history, feeding history and social history are important for complete assessment of the child...
August 3, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28759177/breastfeeding-outcomes-after-oxytocin-use-during-childbirth-an-integrative-review
#2
REVIEW
Elise N Erickson, Cathy L Emeis
INTRODUCTION: Despite widespread use of exogenous synthetic oxytocin during the birth process, few studies have examined the effect of this drug on breastfeeding. Based on neuroscience research, endogenous oxytocin may be altered or manipulated by exogenous administration or by blocking normal function of the hormone or receptor. Women commonly cite insufficient milk production as their reason for early supplementation, jeopardizing breastfeeding goals. Researchers need to consider the role of birth-related medications and interventions on the production of milk...
July 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28731586/pregnancy-in-women-with-non-classic-congenital-adrenal-hyperplasia-time-to-conceive-and-outcome
#3
Ori Eyal, Irit Ayalon-Dangur, Anat Segev-Becker, Anita Schachter-Davidov, Shoshana Israel, Naomi Weintrob
OBJECTIVE: Non-classic congenital adrenal hyperplasia (NCAH) is common among Ashkenazi Jews (1:400). It is associated with various degrees of postnatal virilization, irregular menses and infertility. Therapy of symptomatic subjects consists of physiologic doses of glucocorticoids. The objective of this study was to evaluate the effect of glucocorticoid treatment on fertility and on pregnancy outcome in women with NCAH. DESIGN, SETTING AND PATIENTS: This retrospective study included 75 women diagnosed with NCAH who were followed in our clinic and sought fertility between 2008 and 2015...
July 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28727004/physiology-and-endocrinology-symposium-postnatal-reproductive-development-and-the-lactocrine-hypothesis
#4
F F Bartol, A A Wiley, A F George, D J Miller, C A Bagnell
Maternal effects on development can program cell fate and dictate offspring phenotype. Such effects do not end at birth, but extend into postnatal life through signals communicated from mother to offspring in first milk (colostrum). Transmission of bioactive factors from mother to offspring as a specific consequence of nursing defines a lactocrine mechanism. The female reproductive tract is not fully formed at birth (postnatal day = PND 0). Data for ungulates and mice indicate that disruption of development during neonatal life can have lasting effects on the form and function of uterine tissues...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28708527/artificially-extended-photoperiod-administered-to-pre-partum-mares-via-blue-light-to-a-single-eye-observations-on-gestation-length-foal-birth-weight-and-foal-hair-coat-at-birth
#5
Margaret B Nolan, Caroline M Walsh, Noelle Duff, Conor McCrarren, Ralph L Prendergast, Barbara A Murphy
In seasonally breeding animals, photoperiod perception is crucial for timing of important physiological events. In the horse, long day photoperiod influences the onset of ovulation and cyclicity, shedding of the heavier winter coat and the timing of parturition. In this compilation of studies, conducted across three breeding seasons and two countries, the impact of artificially extended day length was investigated on gestation length, foal birth weight and foal hair coat at birth. The light therapy was administered to pre-partum mares via mobile head worn masks which provided short wavelength blue light to a single eye...
June 9, 2017: Theriogenology
https://www.readbyqxmd.com/read/28701011/action-plan-for-prolongation-of-nephrogenesis-in-preterm-and-growth-restricted-babies-explore-ultrastructure-of-the-nephrogenic-zone-identify-a-molecular-target-select-a-viable-drug-and-find-a-path-for-administration
#6
Will W Minuth
A large amount of investigations informs about primary steps of mammalian kidney development such as anlage of the organ and initial nephron formation, while only few data exists about the late phase of human kidney development. In particular, little attention was up to date addressed to the decrease of morphogenic activity in the nephrogenic zone short before birth and the vanishing of all stem cell niches aligned beyond the organ capsule. There is evidence that molecular controlling of this normal but degenerative developmental process also plays a decisive role in the kidneys of preterm and growth restricted babies...
July 12, 2017: Drug Research
https://www.readbyqxmd.com/read/28695270/maternal-use-of-prednisolone-is-unlikely-to-be-associated-with-neonatal-adrenal-suppression-a-single-center-study-of-16-cases
#7
Leanne de Vetten, Margriet van Stuijvenberg, Ido P Kema, Gianni Bocca
The use of supra-physiological, exogenous corticosteroids in pregnancy may lead to neonatal adrenal suppression. We report on a single-center, case series study carried out between 2006 and 2014, which included all newborns (n = 16) of mothers using prednisolone ≥10 mg/day during pregnancy. Newborns were routinely assessed according to hospital protocol, with follow-up until 6 weeks after birth. We investigated the clinical symptoms and biochemical findings of adrenal suppression occurring in the newborns...
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28674490/what-the-spectrum-of-microglial-functions-can-teach-us-about-fetal-alcohol-spectrum-disorder
#8
REVIEW
Elissa L Wong, Rianne D Stowell, Ania K Majewska
Alcohol exposure during gestation can lead to severe defects in brain development and lifelong physical, behavioral and learning deficits that are classified under the umbrella term fetal alcohol spectrum disorder (FASD). Sadly, FASD is diagnosed at an alarmingly high rate, affecting 2%-5% of live births in the United States, making it the most common non-heritable cause of mental disability. Currently, no standard therapies exist that are effective at battling FASD symptoms, highlighting a pressing need to better understand the underlying mechanisms by which alcohol affects the developing brain...
2017: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/28662821/the-role-of-matrix-metalloproteinases-in-development-repair-and-destruction-of-the-lungs
#9
Amanda Y Hendrix, Farrah Kheradmand
Normal gas exchange after birth requires functional lung alveolar units that are lined with epithelial cells, parts of which are intricately fused with microvascular capillaries. A significant phase of alveolar lung development occurs in the perinatal period, continues throughout early stages in life, and requires activation of matrix-remodeling enzymes. Failure to achieve an optimum number of alveoli during lung maturation can cause several untoward medical consequences including disabling obstructive and/or restrictive lung diseases that limit physiological endurance and increase mortality...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28644347/age-and-sex-normalization-of-intestinal-permeability-measures-for-the-improved-assessment-of-enteropathy-in-infancy-and-early-childhood-results-from-the-mal-ed-study
#10
Margaret N Kosek, Gwenyth O Lee, Richard L Guerrant, Rashidul Haque, Gagandeep Kang, Tahmeed Ahmed, Pascal Bessong, Asad Ali, Estomih Mduma, Pablo Peñataro Yori, William A Faubion, Aldo A M Lima, Maribel Paredes Olortegui, Carl Mason, Sudhir Babji, Ravinder Singh, Shahida Qureshi, Peter S Kosek, Amidou Samie, John Pascal, Sanjaya Shrestha, Benjamin J J McCormick, Jessica C Seidman, Dennis R Lang, Anita Zaidi, Laura E Caulfield, Michael Gottlieb
OBJECTIVES: The aim of the study was to describe changes in intestinal permeability in early childhood in diverse epidemiologic settings. METHODS: In a birth cohort study, the lactulose:mannitol (L:M) test was administered to 1980 children at 4 time points in the first 24 months of life in 8 countries. Data from the Brazil site with an incidence of diarrhea similar to that seen in the United States and no growth faltering was used as an internal study reference to derive age- and sex-specific z scores for mannitol and lactulose recoveries and the L:M ratio...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28569783/damage-induced-neuronal-endopeptidase-dine-enhances-axonal-regeneration-potential-of-retinal-ganglion-cells-after-optic-nerve-injury
#11
Aoi Kaneko, Sumiko Kiryu-Seo, Sakiko Matsumoto, Hiroshi Kiyama
Damage-induced neuronal endopeptidase (DINE)/endothelin-converting enzyme-like 1 (ECEL1) is a membrane-bound metalloprotease that we identified as a nerve regeneration-associated molecule. The expression of DINE is upregulated in response to nerve injury in both the peripheral and central nervous systems, while its transcription is regulated by the activating transcription factor 3 (ATF3), a potent hub-transcription factor for nerve regeneration. Despite its unique hallmark of injury-induced upregulation, the physiological relevance of DINE in injured neurons has been unclear...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28554805/genomics-of-sex-hormone-receptor-signaling-in-hepatic-sexual-dimorphism
#12
Daoshan Zheng, Xiao Wang, Per Antonson, Jan-Åke Gustafsson, Zhaoyu Li
The liver plays a crucial role in a variety of physiological processes. Sexual dimorphism is markedly defined in liver disorders, such as fatty liver diseases and liver cancer, but barely addressed in the normal liver. Distinct sex hormone signaling between male and female livers is the major driving factor for hepatic sexual dimorphism. Over 6000 genes are differently expressed between male and female livers in mice. Here we address how sex hormone receptors, estrogen receptor alpha (ERα) and androgen receptor (AR), mediate sexually dimorphic gene expression in mouse livers...
May 26, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28532827/hepatoma-derived-growth-factor-protein-quantification-in-uterine-fluid-gene-expression-in-endometrial-cell-culture-and-effects-on-in%C3%A2-vitro-embryo-development-pregnancy-and-birth
#13
E Gómez, S Carrocera, D Martin, M J Sánchez-Calabuig, A Gutiérrez-Adán, A Murillo, M Muñoz
Hepatoma-derived growth factor (HDGF) is present in the endometrium of cows and other mammals. Recombinant HDGF (rHDGF) improves bovine blastocyst development in vitro. However, specific culture conditions and essential aspects of HDGF uterine physiology are yet unknown. In this work we quantified total HDGF protein in uterine fluid (UF) by multiple reaction monitoring (MRM), and analyzed effects of rHDGF on specific embryonic stages with Day-6 bovine embryos cultured in vitro with and without BSA, and on pregnancy viability and calf phenotypes after embryo transfer to recipients...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28506993/mapk-pathway-control-of-stem-cell-proliferation-and-differentiation-in-the-embryonic-pituitary-provides-insights-into-the-pathogenesis-of-papillary-craniopharyngioma
#14
Scott Haston, Sara Pozzi, Gabriela Carreno, Saba Manshaei, Leonidas Panousopoulos, Jose Mario Gonzalez-Meljem, John R Apps, Alex Virasami, Selvam Thavaraj, Alice Gutteridge, Tim Forshew, Richard Marais, Sebastian Brandner, Thomas S Jacques, Cynthia L Andoniadou, Juan Pedro Martinez-Barbera
Despite the importance of the RAS-RAF-MAPK pathway in normal physiology and disease of numerous organs, its role during pituitary development and tumourigenesis remains largely unknown. Here, we show that the over-activation of the MAPK pathway, through conditional expression of the gain-of-function alleles BrafV600E and KrasG12D in the developing mouse pituitary, results in severe hyperplasia and abnormal morphogenesis of the gland by the end of gestation. Cell-lineage commitment and terminal differentiation are disrupted, leading to a significant reduction in numbers of most of the hormone-producing cells before birth, with the exception of corticotrophs...
June 15, 2017: Development
https://www.readbyqxmd.com/read/28498553/fundamentals-of-clinical-pharmacology-with-application-for-pregnant-women
#15
REVIEW
Avinash S Patil, Jessica Sheng, Sarah K Dotters-Katz, Maria S Schmoll, Mitchell Onslow, Rebecca C Pierson
Medication use is common in pregnancy, yet for most medications the optimal formulation and dosage have not been described specifically for pregnant women. Often, adverse effects are only discovered anecdotally or after extensive off-label use occurs. Since pharmacologic research that includes pregnant women is sparse and animal studies are often not applicable to the human fetus, providers must use knowledge of drug behavior and normal physiologic changes of pregnancy to personalize treatment for pregnant women...
May 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28481226/neonatal-expression-of-rna-binding-protein-igf2bp3-regulates-the-human-fetal-adult-megakaryocyte-transition
#16
Kamaleldin E Elagib, Chih-Huan Lu, Goar Mosoyan, Shadi Khalil, Ewelina Zasadzińska, Daniel R Foltz, Peter Balogh, Alejandro A Gru, Deborah A Fuchs, Lisa M Rimsza, Els Verhoeyen, Miriam Sansó, Robert P Fisher, Camelia Iancu-Rubin, Adam N Goldfarb
Hematopoietic transitions that accompany fetal development, such as erythroid globin chain switching, play important roles in normal physiology and disease development. In the megakaryocyte lineage, human fetal progenitors do not execute the adult morphogenesis program of enlargement, polyploidization, and proplatelet formation. Although these defects decline with gestational stage, they remain sufficiently severe at birth to predispose newborns to thrombocytopenia. These defects may also contribute to inferior platelet recovery after cord blood stem cell transplantation and may underlie inefficient platelet production by megakaryocytes derived from pluripotent stem cells...
June 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28471910/age-and-sex-normalization-of-intestinal-permeability-measures-for-the-improved-assessment-of-enteropathy-in-infancy-and-early-childhood-results-from-the-mal-ed-study
#17
Margaret N Kosek, Gwenyth O Lee, Richard L Guerrant, Rashidul Haque, Gagandeep Kang, Tahmeed Ahmed, Pascal Bessong, Asad Ali, Estomih Mduma, Pablo Peñataro Yori, William A Faubion, Aldo A M Lima, Maribel Paredes Olortegui, Carl Mason, Sudhir Babji, Ravinder Singh, Shahida Qureshi, Peter S Kosek, Amidou Samie, John Pascal, Sanjaya Shrestha, Benjamin J J McCormick, Jessica C Seidman, Dennis R Lang, Anita Zaidi, Laura E Caulfield, Michael Gottlieb
OBJECTIVES: To describe changes in intestinal permeability in early childhood in diverse epidemiologic settings. METHODS: In a birth cohort study the lactulose:mannitol (LM) test was administered to 1,980 children at four time points in the first 24 months of life in eight countries. Data from the Brazil site with an incidence of diarrhea similar to that seen in the U.S. and no growth faltering was used as an internal study reference to derive age- and sex-specific Z-scores for mannitol and lactulose recoveries and the lactulose mannitol ratio...
May 3, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28467149/is-preterm-placental-calcification-related-to-adverse-maternal-and-foetal-outcome
#18
Ashraf Jamal, Maryam Moshfeghi, Saeedreza Moshfeghi, Nooshin Mohammadi, Elahe Zarean, Nadia Jahangiri
This prospective cohort study aimed to evaluate the role of premature placental calcification in adverse pregnancy outcomes and identify its associated potential risk factors. We consecutively enrolled 293 women who presented to three academic medical centres from September 2011 to March 2013. Participants underwent transabdominal sonographies between 28-36 weeks of gestation in an attempt to determine placental maturity. We compared maternal and foetal outcomes between two groups of women, those with grade III placenta (n = 69) and those without grade III placenta (n = 224)...
May 3, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28450702/complement-factors-c4-and-c3-are-down-regulated-in-response-to-short-term-overfeeding-in-healthy-young-men
#19
Caroline Foghmar, Charlotte Brøns, Katrine Pilely, Allan Vaag, Peter Garred
Insulin resistance is associated with high circulating level of complement factor C3. Animal studies suggest that improper complement activation mediates high-fat-diet-induced insulin resistance. Individuals born with low birth weight (LBW) are at increased risk of developing insulin resistance. We hypothesized that high-fat overfeeding (HFO) increase circulating C3 and induce complement activation in a birth weight differential manner. Twenty LBW and 26 normal birth weight (NBW) young men were studied using a randomised crossover design...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429366/analysis-of-transcriptional-activities-of-angiogenic-biomarkers-during-intrauterine-complications-leading-to-preterm-birth
#20
M Rabajdová, R Dudič, P Urban, V Dudičová, P Urdzík, M Mareková
OBJECTIVE: Pre-eclampsia, growth retardation and preterm delivery are the most common reasons leading to increased maternal and perinatal mortality. The increased expression of hypoxia induced factors, such as HIF-1, triggers the overexpression of anti-angiogenic genes. The aim of this study was to determine the transcriptional activity of individual pro- and anti-angiogenic markers (VEGF, HIF-1, sEng, Flt-1, PlGF-1) in maternal blood samples from patients with spontaneous preterm labor, preterm labor in combination with pre-eclampsia and fetal growth restriction in comparison with physiologically terminated pregnancies...
April 2017: European Review for Medical and Pharmacological Sciences
keyword
keyword
85277
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"