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Normal physiologic birth

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https://www.readbyqxmd.com/read/28292683/lower-inflammatory-markers-in-women-with-antenatal-depression-brings-the-m1-m2-balance-into-focus-from-a-new-direction
#1
Åsa Edvinsson, Emma Bränn, Charlotte Hellgren, Eva Freyhult, Richard White, Masood Kamali-Moghaddam, Jocelien Olivier, Jonas Bergquist, Adrian E Boström, Helgi B Schiöth, Alkistis Skalkidou, Janet L Cunningham, Inger Sundström-Poromaa
BACKGROUND: Antenatal depression and use of serotonin reuptake inhibitors (SSRI) in pregnancy have both been associated with an increased risk of poor pregnancy outcomes, such as preterm birth and impaired fetal growth. While the underlying biological pathways for these complications are poorly understood, it has been hypothesized that inflammation may be a common physiological pathway. The aim of the present study was to assess peripheral inflammatory markers in healthy women, women with antenatal depression, and in women using SSRI during pregnancy...
February 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28278287/a-comparative-study-of-the-characterization-of-mir-155-in-knockout-mice
#2
Dong Zhang, Yongchun Cui, Bin Li, Xiaokang Luo, Bo Li, Yue Tang
miR-155 is one of the most important miRNAs and plays a very important role in numerous biological processes. However, few studies have characterized this miRNA in mice under normal physiological conditions. We aimed to characterize miR-155 in vivo by using a comparative analysis. In our study, we compared miR-155 knockout (KO) mice with C57BL/6 wild type (WT) mice in order to characterize miR-155 in mice under normal physiological conditions using many evaluation methods, including a reproductive performance analysis, growth curve, ultrasonic estimation, haematological examination, and histopathological analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28215177/cutaneous-changes-in-neonates-in-the-first-72-hours-of-birth-an-observational-study
#3
Nayantara R Gandra, Harshita B Reddy, Tina P Katta
BACKGROUND: Variation in neonatal skin changes and presentation is a frequent occurrence. We studied the pattern of cutaneous manifestations in new-borns <72 hours of birth. METHOD: We included all live babies delivered in our hospital; Babies were categorised according to age, birth weight and gestational age. Neonates were examined within 24 hrs of birth and daily for skin lesions for 72 hrs. Skin lesions were categorised into physiological, transient eruptions, due to infections, congenital anomalies and miscellaneous...
February 16, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28208849/finger-length-ratio-2d-4d-in-central-india-and-an-attempt-to-verify-fraternal-birth-order-effect-a-population-based-cross-sectional-study
#4
Arjun Maitra, Chaitali Maitra, Dilip Kumar Jha, Rakesh Biswas
INTRODUCTION: A normal physiology of a human being is not mere a series of functions occurring with specific intensities and timing. There are lot of factors that may change the normal physiological activity within normal limits. Finger length ratio is one of the markers of intrauterine androgen exposure and it is debated and contradicted by many authors. Digit ratio varies among the ethnicities. Many Indian studies show that there is considerable difference in finger length ratio in different population...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28178926/framework-for-the-establishment-of-a-feasible-tailored-and-effective-perinatal-education-programme
#5
Isabel Artieta-Pinedo, Carmen Paz-Pascual, Gonzalo Grandes, Maite Espinosa
BACKGROUND: Antenatal education needs to be renewed and adapted to the needs of women. OBJECTIVES: to assess women needs, identify factors that influence the desired outcomes, and propose a framework for developing new perinatal education based on the guidance published by the UK Medical Research Council for the development and evaluation of complex interventions in primary care. METHODS: For this study: (a) four focus group sessions were held from October to November 2010 in Bizkaia (Spain) with 30 women exploring their needs during pregnancy and postpartum; (b) two literature reviews were conducted on women's needs at these times and theoretical models of healthcare education; and (c) seven discussion and consensus sessions were run with a group of experts composed of midwifes, gynaecologists, paediatricians, and paediatric and postpartum nurses...
February 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28178039/rap1-in-endothelial-biology
#6
Magdalena Chrzanowska-Wodnicka
PURPOSE OF REVIEW: Ubiquitously-expressed small GTPase Rap1 is a key modulator of integrin- and cadherin-regulated processes. In endothelium, Rap1 promotes angiogenesis and endothelial barrier function, acting downstream from cAMP-activated Rap1GEF, Epac. Recent in-vivo studies in mouse models have provided more information about the physiological role of Rap1 in vessel development and after birth under normal and pathologic conditions. Important molecular details of dynamic regulation of endothelial barrier are uncovered...
February 7, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28165176/cardiotocographic-parameters-in-small-for-gestational-age-fetuses-how-do-they-vary-from-normal-at-different-gestational-ages-a-study-of-11687-fetuses-from-25-to-40-weeks-of-pregnancy
#7
Célia Amorim-Costa, Diogo Ayres de Campos, João Bernardes
AIM: The aim of this study was to assess how cardiotocographic (CTG) parameters differ between small-for-gestational-age (SGA) and normal fetuses at different gestational ages. METHODS: This was a retrospective cross-sectional study using the first antepartum tracing of singleton pregnancies with no malformations. Fetuses with birthweight ≥10th percentile for gestational age and other normal pregnancy outcome criteria (term birth, normal umbilical artery pH and Apgar scores, no intensive care unit admission) were compared with fetuses with birthweight <10th and <3rd percentiles for gestational age (SGA < p10 and SGA < p3, a subgroup of the latter)...
February 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28144955/hypothyroidism-in-utero-stimulates-pancreatic-beta-cell-proliferation-and-hyperinsulinaemia-in-the-ovine-fetus-during-late-gestation
#8
Shelley E Harris, Miles J De Blasio, Melissa A Davis, Amy C Kelly, Hailey M Davenport, F B Peter Wooding, Dominique Blache, David Meredith, Miranda Anderson, Abigail L Fowden, Sean W Limesand, Alison J Forhead
Development of pancreatic beta cell mass before birth is essential for normal growth of the fetus and for long-term control of carbohydrate metabolism in postnatal life. Thyroid hormones are also important regulators of fetal growth, and the present study tested the hypotheses that thyroid hormones promote beta cell proliferation in the fetal ovine pancreatic islets, and that growth retardation in hypothyroid fetal sheep is associated with reductions in pancreatic beta cell mass and circulating insulin concentration in utero...
January 31, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28101112/effect-of-training-preparation-for-childbirth-on-fear-of-normal-vaginal-delivery-and-choosing-the-type-of-delivery-among-pregnant-women-in-hamadan-iran-a-randomized-controlled-trial
#9
Seyedeh Zahra Masoumi, Farideh Kazemi, Khodayar Oshvandi, Mozhgan Jalali, Ali Esmaeili-Vardanjani, Hossein Rafiei
Objective: To examine effect of an educational program on pregnant women's fear of normal vaginal delivery. Fear of natural childbirth during pregnancy may increase the risk of caesarean section. Educational programs may be effective in reducing women fear of natural childbirth. Materials and methods: This randomized controlled trial conducted from September 2012 to January 2013 in Hamadan, Iran. One hundred fifty eligible women were randomly assigned to group "A" (Intervention group, n = 75) or group "B" (Control group, n = 75)...
September 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28099786/labor-intervention-and-outcomes-in-women-who-are-nulliparous-and-obese-comparison-of-nurse-midwife-to-obstetrician-intrapartum-care
#10
Nicole S Carlson, Elizabeth J Corwin, Nancy K Lowe
BACKGROUND: Women who are obese have slower labors than women of normal weight, and show reduced response to interventions designed to speed labor progress like oxytocin augmentation and artificial rupture of membranes. The optimal labor management for these women has not been described. METHODS: This retrospective cohort study compared 2 propensity score-matched groups of women (N = 360) who were healthy, nulliparous, spontaneously laboring, and obese (body mass index ≥ 30 kg/m(2) )...
January 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28077073/student-midwives-perceptions-on-the-organisation-of-maternity-care-and-alternative-maternity-care-models-in-the-netherlands-a-qualitative-study
#11
J Catja Warmelink, T Paul de Cock, Yvonne Combee, Marloes Rongen, Therese A Wiegers, Eileen K Hutton
BACKGROUND: A major change in the organisation of maternity care in the Netherlands is under consideration, going from an echelon system where midwives provide primary care in the community and refer to obstetricians for secondary and tertiary care, to a more integrated maternity care system involving midwives and obstetricians at all care levels. Student midwives are the future maternity care providers and they may be entering into a changing maternity care system, so inclusion of their views in the discussion is relevant...
January 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28073296/the-microbiome-and-complement-activation
#12
Alexis B Dunn, Anne L Dunlop, Carol J Hogue, Andrew Miller, Elizabeth J Corwin
Preterm birth (PTB, <37 completed weeks' gestation) is one of the leading obstetrical problems in the United States, affecting approximately one of every nine births. Even more concerning are the persistent racial disparities in PTB, with particularly high rates among African Americans. There are several recognized pathophysiologic pathways to PTB, including infection and/or exaggerated systemic or local inflammation. Intrauterine infection is a causal factor linked to PTB thought to result most commonly from inflammatory processes triggered by microbial invasion of bacteria ascending from the vaginal microbiome...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28009336/hypocortisolism-and-preterm-birth
#13
S D Karakash, N Tschankoshvili, J Weedon, R M Schwartz, C Kirschbaum, H Minkoff
OBJECTIVE: We sought to determine whether hypocortisolism is associated with preterm birth, using hair cortisol as a marker of long term hypothalamic-pituitary-adrenal axis activity. STUDY DESIGN: In a prospective, matched, case-control study, 29 women who had a preterm birth at 24-36w5d gestation were compared to 29 women who delivered at term, matched for maternal age, gestational age, and ethnicity. Cases' samples were collected within 72 h of preterm birth and controls at the same gestational age as the corresponding case...
2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28008608/increasing-pulmonary-blood-flow-at-birth-the-nerve-of-the-baby
#14
Noah H Hillman
No abstract text is available yet for this article.
March 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28002805/expression-of-psma-in-tumor-neovasculature-of-high-grade-sarcomas-including-synovial-sarcoma-rhabdomyosarcoma-undifferentiated-sarcoma-and-mpnst
#15
Birthe Heitkötter, Marcel Trautmann, Inga Grünewald, Martin Bögemann, Kambiz Rahbar, Heidrun Gevensleben, Eva Wardelmann, Wolfgang Hartmann, Konrad Steinestel, Sebastian Huss
AIMS: PSMA (prostate specific membrane antigen) is physiologically expressed in normal prostate tissue. It is overexpressed in prostate cancer cells and has been suggested as a target for antibody-based radioligand therapy. As PSMA expression so far has not been systematically analyzed in soft tissue tumors, the current study aims at investigating a large cohort of different subtypes. METHODS AND RESULTS: Immunohistochemistry was used to detect PSMA expression in 779 samples of soft tissue tumors and Ewing sarcoma as a primary bone malignancy...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/28002412/piezo2-senses-airway-stretch-and-mediates-lung-inflation-induced-apnoea
#16
Keiko Nonomura, Seung-Hyun Woo, Rui B Chang, Astrid Gillich, Zhaozhu Qiu, Allain G Francisco, Sanjeev S Ranade, Stephen D Liberles, Ardem Patapoutian
Respiratory dysfunction is a notorious cause of perinatal mortality in infants and sleep apnoea in adults, but the mechanisms of respiratory control are not clearly understood. Mechanical signals transduced by airway-innervating sensory neurons control respiration; however, the physiological significance and molecular mechanisms of these signals remain obscured. Here we show that global and sensory neuron-specific ablation of the mechanically activated ion channel Piezo2 causes respiratory distress and death in newborn mice...
January 12, 2017: Nature
https://www.readbyqxmd.com/read/27988927/cardiac-remodelling-in-a-baboon-model-of-intrauterine-growth-restriction-mimics-accelerated-ageing
#17
Anderson H Kuo, Cun Li, Jinqi Li, Hillary F Huber, Peter W Nathanielsz, Geoffrey D Clarke
KEY POINTS: Rodent models of intrauterine growth restriction (IUGR) successfully identify mechanisms that can lead to short-term and long-term detrimental cardiomyopathies but differences between rodent and human cardiac physiology and placental-fetal development indicate a need for models in precocial species for translation to human development. We developed a baboon model for IUGR studies using a moderate 30% global calorie restriction of pregnant mothers and used cardiac magnetic resonance imaging to evaluate offspring heart function in early adulthood...
February 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/27974134/setting-the-stage-for-health-salutogenesis-in-midwifery-professional-knowledge-in-three-european-countries
#18
Claudia Meier Magistretti, Soo Downe, Bengt Lindstrøm, Marie Berg, Katharina Tritten Schwarz
There is a lack of systematic evidence concerning health orientation in maternity practice in the current climate of risk avoidance. The midwifery professional project is orientated toward the preservation of normal physiological processes during the maternity episode. This study investigates accounts of midwives who were working in health-orientated birth settings, to examine if and how they frame a health orientation in professional practice. Twenty-seven narrative interviews were conducted with midwives working in pre-, peri-, and postnatal care in different maternity care settings in Switzerland, Austria, and Germany...
2016: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/27940961/imps-an-rna-binding-protein-family-that-provides-a-link-between-stem-cell-maintenance-in-normal-development-and-cancer
#19
REVIEW
Nils Degrauwe, Mario-Luca Suvà, Michalina Janiszewska, Nicolo Riggi, Ivan Stamenkovic
IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that regulate RNA processing at several levels, including localization, translation, and stability. Three mammalian IMP paralogs (IMP1-3) have been identified that are expressed in most organs during embryogenesis, where they are believed to play an important role in cell migration, metabolism, and stem cell renewal. Whereas some IMP2 expression is retained in several adult mouse organs, IMP1 and IMP3 are either absent or expressed at very low levels in most tissues after birth...
November 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27939485/postpartum-physiology-psychology-and-paediatric-follow-up-study-p4-study-study-protocol
#20
Gregory K Davis, Lynne Roberts, George Mangos, Amanda Henry, Franziska Pettit, Anthony O'Sullivan, Caroline S E Homer, Maria Craig, Samuel B Harvey, Mark A Brown
BACKGROUND: Women who have had hypertension in pregnancy are at greater risk of long term cardiovascular disease (CVD). Little is known about their cardiovascular risk postpartum or the effects on the woman's mental health and the outcomes of their infants. In this project we will study the physiological and psychological health of women and the physical health and development of their infants six months, two years and five years after birth. We will establish normal blood pressure (BP) and metabolic function for women who were normotensive in pregnancy and use these to assess women who had gestational hypertension (GH) or preeclampsia (PE)...
October 2016: Pregnancy Hypertension
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