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https://www.readbyqxmd.com/read/28453561/a-webgis-platform-for-the-monitoring-of-farm-animal-genetic-resources-genmon
#1
Solange Duruz, Christine Flury, Giona Matasci, Florent Joerin, Ivo Widmer, Stéphane Joost
BACKGROUND: In 2007, the Food and Agriculture Organization of the United Nations (FAO) initiated the Global plan of action for Farm Animal Genetic Resources (FAnGR). The main goal of this plan is to reduce further loss of genetic diversity in farm animals, so as to protect and promote the diversity of farm animal resources. An important step to reach this goal is to monitor and prioritize endangered breeds in the context of conservation programs. METHODOLOGY/WEB PORTAL IMPLEMENTATION: The GENMON WebGIS platform is able to monitor FAnGR and to evaluate the degree of endangerment of livestock breeds...
2017: PloS One
https://www.readbyqxmd.com/read/28453535/plasma-amino-acids-and-metabolic-profiling-of-dairy-cows-in-response-to-a-bolus-duodenal-infusion-of-leucine
#2
Hassan Sadri, Dirk von Soosten, Ulrich Meyer, Jeannette Kluess, Sven Dänicke, Behnam Saremi, Helga Sauerwein
Leucine (Leu), one of the three branch chain amino acids, acts as a signaling molecule in the regulation of overall amino acid (AA) and protein metabolism. Leucine is also considered to be a potent stimulus for the secretion of insulin from pancreatice β-cells. Our objective was to study the effects of a duodenal bolus infusion of Leu on insulin and glucagon secretion, on plasma AA concentrations, and to do a metabolomic profiling of dairy cows as compared to infusions with either glucose or saline. Six duodenum-fistulated Holstein cows were studied in a replicated 3 × 3 Latin square design with 3 periods of 7 days, in which the treatments were applied at the end of each period...
2017: PloS One
https://www.readbyqxmd.com/read/28449412/effects-of-age-gender-and-body-mass-index-on-efficacy-and-hypoglycaemia-outcomes-across-treat-to-target-trials-with-insulin-glargine-100-u-ml-added-to-oral-antidiabetes-agents-in-type-2-diabetes
#3
D Owens, G Bolli, B Charbonnel, T Haak, W Landgraf, F Porcellati, L Traylor, A Kautzky-Willer
AIMS: Analyse effects of patient characteristics and different OAD use on standardised clinical outcomes in type 2 diabetes patients initiating insulin glargine 100 U/ml (Gla-100). MATERIALS AND METHODS: Patient-level data were analysed from 16 randomised, treat-to-target clinical trials that added Gla-100 to existing metformin (MET), sulfonylurea (SU), or metformin plus sulfonylurea (MET+SU) in insulin-naïve patients inadequately controlled on oral therapy and followed for ≥24 weeks...
April 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28449368/a-randomized-placebo-and-sitagliptin-controlled-trial-of-the-safety-and-efficacy-of-omarigliptin-a-once-weekly-dpp-4-inhibitor-in-japanese-patients-with-type-2-diabetes
#4
Ira Gantz, Taro Okamoto, Yuka Ito, Kotoba Okuyama, Edward A O'Neill, Keith D Kaufman, Samuel S Engel, Eseng Lai
AIMS: To assess the safety and efficacy of omarigliptin in Japanese patients with type 2 diabetes (T2D). MATERIALS AND METHODS: In a 24-week double-blind trial, 414 patients with T2D were randomized to omarigliptin 25 mg once-weekly (q.w.), sitagliptin 50 mg once daily (q.d.) or placebo. The double-blind period was followed by a 28-week open-label extension during which all patients received omarigliptin 25 mg q.w. Efficacy endpoints were HbA1c, 2-hour post-meal glucose (PMG) and fasting plasma glucose (FPG)...
April 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28449156/development-of-multiple-unit-floating-drug-delivery-system-of-clarithromycin-formulation-in-vitro-dissolution-by-modified-dissolution-apparatus-in-vivo-radiographic-studies-in-human-volunteers
#5
Arun B Reddy, Narendar D Reddy
Clarithromycin (CM), a broad spectrum macrolide antibiotic used to eradicate H. pylori in peptic ulcer. Clarithromycin (CM) is well absorbed from the gastrointestinal tract, but has a bioavailability of 50% due to rapid biodegradation. The aim of this investigation was to increase the gastric residence time, and to control the drug release of clarithromycin by formulating into multiple unit floating mini-tablets. Floating tablets were prepared by using direct compression method with HPMC K4M and Polyox WSR 1105 as release retarded polymers and sodium bicarbonate as gas generating agent...
April 27, 2017: Drug Research
https://www.readbyqxmd.com/read/28448309/clinical-feasibility-of-3-dimensional-magnetic-resonance-cholangiopancreatography-using-compressed-sensing-comparison-of-image-quality-and-diagnostic-performance
#6
Jeong Hee Yoon, Sang Min Lee, Hyo-Jin Kang, Elisabeth Weiland, Esther Raithel, Yohan Son, Berthold Kiefer, Jeong Min Lee
OBJECTIVE: The aim of this study was to evaluate the clinical feasibility of fast 3-dimensional (3D) magnetic resonance cholangiopancreatography (MRCP) using compressed sensing (CS) in comparison with conventional navigator-triggered 3D-MRCP. MATERIALS AND METHODS: This retrospective study was approved by our institutional review board, and the requirement of informed consent was waived. A total of 84 patients (male-to-female ratio, 41:43; mean age, 47.3 ± 18.8 years) who underwent conventional 3D navigator-triggered T2-weighted MRCP using sampling perfection with application optimized contrasts (SPACE) and fast 3D MRCP using SPACE with high undersampling combined with CS reconstruction (CS SPACE; CS-MRCP) on a 3 T scanner were included...
April 26, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28447440/addition-of-ipragliflozin-to-metformin-treatment-in-korean-patients-with-type-2-diabetes-mellitus-subgroup-analysis-of-a-phase-3-trial
#7
Kyung Wan Min, Bon Jeong Ku, Ji Hyun Lee, Min Seon Kim, Kyu Jeung Ahn, Moon Kyu Lee, Satoshi Kokubo, Satoshi Yoshida, Hyun Ji Cho, Bong Soo Cha
BACKGROUND: This is a subgroup analysis of Korean patients from a phase 3 clinical trial investigating the efficacy and safety of ipragliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin. METHODS: This multicenter, placebo-controlled, double-blind, parallel-group study was carried out between November 2011 and January 2013. Patients entered a 2-week placebo pretreatment period, followed by a 24-week treatment period with either ipragliflozin (50 mg/day) or placebo, while continuing metformin...
April 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28447202/exploring-the-relationship-between-perceived-barriers-to-healthy-eating-and-dietary-behaviours-in-european-adults
#8
M G M Pinho, J D Mackenbach, H Charreire, J-M Oppert, H Bárdos, K Glonti, H Rutter, S Compernolle, I De Bourdeaudhuij, J W J Beulens, J Brug, J Lakerveld
PURPOSE: Dietary behaviours may be influenced by perceptions of barriers to healthy eating. Using data from a large cross-European study (N = 5900), we explored associations between various perceived barriers to healthy eating and dietary behaviours among adults from urban regions in five European countries and examined whether associations differed across regions and socio-demographic backgrounds. METHODS: Frequency of consumption of fruit, vegetables, fish, fast food, sugar-sweetened beverages, sweets, breakfast and home-cooked meals were split by the median into higher and lower consumption...
April 26, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28447132/high-throughput-analysis-of-sub-visible-mab-aggregate-particles-using-automated-fluorescence-microscopy-imaging
#9
Albert Jesuran Paul, Fabian Bickel, Martina Röhm, Lisa Hospach, Bettina Halder, Nina Rettich, René Handrick, Eva Maria Herold, Hans Kiefer, Friedemann Hesse
Aggregation of therapeutic proteins is a major concern as aggregates lower the yield and can impact the efficacy of the drug as well as the patient's safety. It can occur in all production stages; thus, it is essential to perform a detailed analysis for protein aggregates. Several methods such as size exclusion high-performance liquid chromatography (SE-HPLC), light scattering, turbidity, light obscuration, and microscopy-based approaches are used to analyze aggregates. None of these methods allows determination of all types of higher molecular weight (HMW) species due to a limited size range...
April 27, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28446498/diet-quality-of-us-adolescents-during-the-transition-to-adulthood-changes-and-predictors
#10
Leah M Lipsky, Tonja R Nansel, Denise L Haynie, Danping Liu, Kaigang Li, Charlotte A Pratt, Ronald J Iannotti, Katherine W Dempster, Bruce Simons-Morton
Background: Influences on diet quality during the transition from adolescence to adulthood are understudied.Objective: This study examined association of 3 diet-quality indicators-Healthy Eating Index-2010 (HEI), Whole Plant Foods Density (WPF), and Empty Calories (EC; the percentage of calories from discretionary solid fat, added sugar and alcohol)-with lifestyle behaviors, baseline weight status, and sociodemographic characteristics in US emerging adults.Design: Data come from the first 4 waves (annual assessments) of the NEXT Plus Study, a population-based cohort of 10th graders enrolled in 2010 (n = 566)...
April 26, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28446382/compensatory-mechanisms-activated-with-intermittent-energy-restriction-a-randomized-control-trial
#11
Sílvia Ribeiro Coutinho, Eline Holli Halset, Sigrid Gåsbakk, Jens F Rehfeld, Bård Kulseng, Helen Truby, Cátia Martins
BACKGROUND & AIMS: Strong compensatory responses, with reduced resting metabolic rate (RMR), increased exercise efficiency (ExEff) and appetite, are activated when weight loss (WL) is achieved with continuous energy restriction (CER), which try to restore energy balance. Intermittent energy restriction (IER), where short spells of energy restriction are interspaced by periods of habitual energy intake, may offer some protection in minimizing those responses. We aimed to compare the effect of IER versus CER on body composition and the compensatory responses induced by WL...
April 7, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28443702/turmeric-supplementation-improves-serum-glucose-indices-and-leptin-levels-in-patients-with-nonalcoholic-fatty-liver-diseases
#12
Roya Navekar, Maryam Rafraf, Aida Ghaffari, Mohammad Asghari-Jafarabadi, Manouchehr Khoshbaten
OBJECTIVE: Insulin and leptin resistance are important risk factors for non-alcoholic fatty liver disease (NAFLD). There is limited evidence regarding the effects of turmeric on NAFLD. The aim of this study was to investigate the effects of turmeric supplementation on glycemic status and serum leptin levels in patients with NAFLD. METHODS: This double-blind randomized controlled clinical trial was conducted on 46 patients with NAFLD (21males and 25 females) aged 20-60 years old and body mass index (BMI) between 24...
April 26, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28443256/change-in-body-mass-index-and-insulin-resistance-after-1-year-treatment-with-gonadotropin-releasing-hormone-agonists-in-girls-with-central-precocious-puberty
#13
Jina Park, Jae Hyun Kim
PURPOSE: Gonadotropin-releasing hormone agonist (GnRHa) is used as a therapeutic agent for central precocious puberty (CPP); however, increased obesity may subsequently occur. This study compared body mass index (BMI) and insulin resistance during the first year of GnRHa treatment for CPP. METHODS: Patient group included 83 girls (aged 7.0-8.9 years) with developed breasts and a peak luteinizing hormone level of ≥5 IU/L after GnRH stimulation. Control group included 48 prepubertal girls...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28443064/loss-of-vagal-sensitivity-to-cholecystokinin-in-rats-born-with-intrauterine-growth-retardation-and-consequence-on-food-intake
#14
Marième Ndjim, Camille Poinsignon, Patricia Parnet, Gwenola Le Dréan
Perinatal malnutrition is associated with low birth weight and an increased risk of developing metabolic syndrome in adulthood. Modification of food intake (FI) regulation was observed in adult rats born with intrauterine growth retardation induced by maternal dietary protein restriction during gestation and maintained restricted until weaning. Gastrointestinal peptides and particularly cholecystokinin (CCK) play a major role in short-term regulation of FI by relaying digestive signals to the hindbrain via the vagal afferent nerve (VAN)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28443024/low-dose-of-bergamot-derived-polyphenolic-fraction-bpf-did-not-improve-metabolic-parameters-in-second-generation-antipsychotics-treated-patients-results-from-a-60-days-open-label-study
#15
Antonio Bruno, Gianluca Pandolfo, Manuela Crucitti, Massimo Cacciola, Vincenza Santoro, Edoardo Spina, Rocco A Zoccali, Maria R A Muscatello
Objectives: The nutraceutical approach to the management of metabolic syndrome (MetS) might be a promising strategy in the prevention of cardio-metabolic risk. Low-dose bergamot-derived polyphenolic fraction (BPF) has been proven effective in patients with MetS, as demonstrated by a concomitant improvement in lipemic and glycemic profiles. The present study was aimed to further explore, in a sample of subjects receiving second generation antipsychotics (SGAs), the effects on body weight and metabolic parameters of a low dose of BPF (500 mg/day) administered for 60 days...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28440529/-implementation-of-enhanced-recovery-after-surgery-in-nutritional-management-of-patients-undergoing-metabolic-surgery
#16
Tianzi Zhang, Qin Xu, Ningli Yang, Juan Tang, Hui Liang
Metabolic surgery is a gastrointestinal surgical procedure to treat obesity and its related co-morbidities with rapid development in recent years. Patients undergoing metabolic surgery have preoperative nutritional disorders, and the nutrition management for these patients is the key point of perioperative management. During the perioperative period, current research has preliminarily confirmed that perioperative managements including supplementation of micronutrients, preoperative evaluation of the weight loss, preoperative fasting and carbohydrate oral intake based on the full application of ERAS and characteristics of the patients undergoing metabolic surgery, are safe and effective in clinical practice...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440522/-nutrition-management-in-obese-patients-with-type-2-diabetes-mellitus-after-laparoscopic-sleeve-gastrectomy
#17
Weihong Tang, Yuhua Chen, Meizhen Pan, Lihua Chen, Lele Zhang, Tingfeng Wang, Xiong Zhang, Peng Zhang, Chengzhu Zheng, Bo Yu
OBJECTIVE: To explore the value of nutrition management in obese patients with type 2 diabetes mellitus(T2DM) after laparoscopic sleeve gastrectomy(LSG). METHODS: Clinical data of 22 obese T2DM patients undergoing LSG from March 2013 to July 2015 in Fudan University Pudong Medical Center were collected. All the patients strictly followed the specialized instruction by nutritionists: diabetic and low calorie diet 3347.2 to 5020.8 kJ (800 to 1200 kcal) per day before the operation; low calorie liquid diet 2510...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440521/-effect-of-laparoscopic-sleeve-gastrectomy-on-sex-hormone-in-male-severe-obesity
#18
Cuiling Zhu, Yi Zhang, Xingchun Wang, Jingyang Gao, Liesheng Lu, Donglei Zhou, Shen Qu
OBJECTIVE: To investigate the effect of laparoscopic sleeve gastrectomy(LSG) on sex hormone in male patients with severe obesity. METHODS: Retrospective analysis was performed in 31 male patient with severe obese [body mass index(BMI) ≥28 kg/m(2), obesity group] who underwent LSG in Shanghai Tenth People's Hospital of Tongji University from December 2012 to May 2016. The anthropometric parameters(weight, BMI, waist circumference, hip circumference, waist-hip ratio, body fat percentage), glucose metabolic indices [fasting plasma glucose(FPG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), homeostasis model assessment-insulin resistance index(HOMA-IR)], and sex hormone parameters [estradiol(E2), total testosterone (TT), follicle-stimulating hormone (FSH) and luteinizing hormone (LH)] were collected preoperatively and 1, 3, 6 months postoperatively...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440520/-effect-of-laparoscopic-sleeve-gatrectomy-on-type-2-diabetes-mellitus-in-obese-patients-with-body-mass-index-less-than-40-kg-m-2
#19
Yulin Guo, Xiao Xu, Anjian Wu, Jin Du, Guanglong Dong
OBJECTIVE: To evaluate the effect of laparoscopic sleeve gastrectomy(LSG) on type 2 diabetes mellitus (T2DM) in patient with a body mass index(BMI) less than 40 kg/m(2). METHODS: Twenty four obese patients with T2DM and BMI less than 40 kg/m(2) received LSG between 1 January 2011 and 1 September 2013 at the Department of General Surgery in Chinese PLA General Hospital. The clinical data and 3-year follow-up outcomes regarding weight loss and remission of diabetes were retrospectively analyzed...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28439942/assessment-of-motion-of-colonic-contents-in-the-human-colon-using-mri-tagging
#20
S E Pritchard, J Paul, G Major, L Marciani, P A Gowland, R C Spiller, C L Hoad
BACKGROUND: We have previously reported a non-invasive, semi-automated technique to assess motility of the wall of the ascending colon (AC) using Magnetic Resonance Imaging. This study investigated the feasibility of using a tagged MRI technique to visualize and assess the degree of flow within the human ascending colon in healthy subjects and those suffering from constipation. METHODS: An open-labeled study of 11 subjects with constipation and 11 subjects without bowel disorders was performed...
April 25, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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