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https://www.readbyqxmd.com/read/29151187/spatial-distributions-of-hexachlorobutadiene-in-agricultural-soils-from-the-yangtze-river-delta-region-of-china
#1
Jianteng Sun, Lili Pan, Yu Zhan, Lizhong Zhu
Hexachlorobutadiene (HCBD) is one of the persistent organic pollutants (POPs) listed by the Stockholm Convention and poses potential risks to human health and ecosystems. To reveal the regional-scale pollution status of HCBD in agricultural soils from fast-developing areas, an extensive investigation was conducted in the core Yangtze River Delta (YRD), China. The detectable concentrations of HCBD in 241 soil samples ranged from 0.07 to 8.47 ng g(-1) dry weight, with an average value of 0.32 ng g(-1) and a detection rate of 59...
November 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29150756/impact-of-risk-factors-for-gestational-diabetes-gdm-on-pregnancy-outcomes-in-women-with-gdm
#2
T Filardi, F Tavaglione, M Di Stasio, V Fazio, A Lenzi, S Morano
PURPOSE: In this study, we evaluated the impact of risk factors for gestational diabetes on clinical/biochemical parameters and maternal/fetal outcomes. METHODS: One hundred eighty-three (n 183) women (age 33.8 ± 5.5 years, 59% Caucasians, 41% non-Caucasians) with gestational diabetes were included in the study. Anamnestic information, anthropometric and laboratory parameters, and maternal and fetal outcomes at delivery were collected. RESULTS: Insulin therapy prevalence was higher in Asians vs Caucasians (p = 0...
November 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29150012/rethinking-the-accuracy-of-75g-glucose-used-in-the-oral-glucose-tolerance-test-in-the-diagnosis-and-management-of-diabetes
#3
Sun Hee Kim, Tae Sun Park, Heung Yong Jin
AIMS: We investigated the specificity of the 75g oral glucose tolerance test (OGTT) and the clinical usefulness of the 2h post loading glucose (2h PLG) value in the clinical care of diabetes patients. METHODS: The 75g OGTT data of 1755 subjects were analyzed. The relationships and degrees of consistency among 2h PLG, fasting plasma glucose (FPG), and HbA1c values were assessed. We also investigated the degree of contribution of 2h PLG in the prescription of glucose-lowering agents and in the pitfall group for use of 75g OGTT...
December 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/29145418/testosterone-is-protective-against-impaired-glucose-metabolism-in-male-intrauterine-growth-restricted-offspring
#4
Suttira Intapad, John Henry Dasinger, Joel M Fahling, Miles A Backstrom, Barbara T Alexander
Placental insufficiency alters the intrauterine environment leading to increased risk for chronic disease including impaired glucose metabolism in low birth weight infants. Using a rat model of low birth weight, we previously reported that placental insufficiency induces a significant increase in circulating testosterone in male intrauterine growth-restricted offspring (mIUGR) in early adulthood that is lost by 12 months of age. Numerous studies indicate testosterone has a positive effect on glucose metabolism in men...
2017: PloS One
https://www.readbyqxmd.com/read/29144993/evaluate-the-effects-of-antiepileptic-drugs-on-reproductive-endocrine-system-in-newly-diagnosed-female-epileptic-patients-receiving-either-valproate-or-lamotrigine-monotherapy-a-prospective-study
#5
Harpreet Singh Sidhu, R Srinivasa, Akshay Sadhotra
OBJECTIVE: To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy. METHODS: Reproductive hormonal profiles, hirsutism, ovarian morphology by ultrasonography and menstrual cycle data in newly diagnosed women with epilepsy taking VPA (n=34) or LTG (n=32) monotherapy were compared. None of the women were receiving hormonal contraception. Patients gave details of seizure type and frequency, medical and drug history...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29144430/a-correlation-study-of-dha-intake-estimated-by-a-ffq-and-concentrations-in-plasma-and-erythrocytes-in-mid-and-late-pregnancy
#6
Yu-Bo Zhou, Hong-Tian Li, Leonardo Trasande, Lin-Lin Wang, Ya-Li Zhang, Ke-Yi Si, Man-Xi Bai, Jian-Meng Liu
Adequate docosahexaenoic acid (DHA) is essential for the optimal growth and development of the fetus. Maternal DHA content fluctuates during pregnancy. The correlation of DHA content with dietary intake might be varied over the course of pregnancy. We aimed to compare the dietary DHA intake, estimated by a DHA-specific semiquantitative food frequency questionnaire (FFQ) against its blood content, among mid- and late-term pregnant women. A total of 804 Chinese pregnant women completed the tailored FFQ and provided fasting venous blood samples...
November 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29144030/the-role-of-glucagon-in-weight-loss-mediated-metabolic-improvement-a-systematic-review-and-meta-analysis
#7
REVIEW
M P Silvestre, J P Goode, P Vlaskovsky, C McMahon, A Tay, S D Poppitt
Aims This meta-analysis aimed to investigate the role of glucagon suppression in regulating glucose homeostasis following diet or bariatric surgery. Methods A comprehensive search of intervention and observational studies was conducted in Medline, Scopus, Web of Science, PubMed and Embase. Random effects model meta-analysis was performed. Primary outcomes were (i) body weight change, (ii) fasting glucagon, (iii) fasting glucose and (iv) fasting insulin concentrations. Results Twenty articles reporting data from 29 interventions were eligible for analysis...
November 16, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29142651/prevention-of-insulin-resistance-by-dietary-intervention-among-pregnant-mothers-a-randomized-controlled-trial
#8
Masoomeh Goodarzi-Khoigani, Seyed Saeed Mazloomy Mahmoodabad, Mohammad Hossein Baghiani Moghadam, Azadeh Nadjarzadeh, Farahnaz Mardanian, Hossein Fallahzadeh, Azam Dadkhah-Tirani
Background: Chronic insulin resistance (IR) is a basic part of the pathophysiology of gestational diabetes mellitus. Nutrition significantly impacts IR and weight loss reduces insulin levels, whereas weight gain increases the concentrations. Therefore, we surveyed the effect of nutrition intervention on IR in pregnant women and whether this effect is irrespective of weight gaining in accordance with Institute of Medicine limits. Methods: This prospective, randomized clinical trial was carried out among 150 primiparous pregnant mothers in fifteen health centers, five hospitals, and 15 private obstetrical offices in Isfahan...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29142273/a-novel-medium-for-enhancing-callus-growth-of-hazel-corylus-avellana-l
#9
Mina Salehi, Ahmad Moieni, Naser Safaie
Paclitaxel is a powerful antimitotic agent with excellent activity against a range of cancers. Hazel has been described as a paclitaxel-producing species among angiosperms. Fast-growing callus is a prerequisite for the success of callus production and then paclitaxel production. Therefore, optimizing the medium culture for enhancing callus growth is a crucial step for paclitaxel production. In this research, Murashige and Skoog (1962) (MS) medium was optimized for improving callus growth of hazel (Corylus avellana L...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141991/human-sex-hormone-binding-globulin-does-not-provide-metabolic-protection-against-dysglycemia-in-mice
#10
Yael Sofer, Nava Nevo, Michal Vechoropulus, Gabi Shefer, Esther Osher, Nathan Landis, Geoffrey L Hammond, Naftali Stern
BACKGROUND: Sex hormone binding globulin (SHBG) is the main transporter of sex hormones in most vertebrates. Low SHBG levels have been linked to increased propensity for diabetes and metabolic syndrome. Polymorphisms of the SHBG gene linked to low SHBG protein levels, also strongly predicted increased risk of type 2 diabetes, thus raising the possibility that SHBG may play a role in the in the pathogenesis of insulin resistance and diabetes. AIM: To examine whether expression of human SHBG in mice may ameliorate the development of diabetes and metabolic syndrome in response to a high fat diet...
November 15, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29141955/the-constant-threat-from-a-non-native-predator-increases-tail-muscle-and-fast-start-swimming-performance-in-xenopus-tadpoles
#11
Tsukasa Mori, Yukio Yanagisawa, Yoichiro Kitani, Goshi Yamamoto, Naoko Goto-Inoue, Tadashi Kimura, Keiko Kashiwagi, Akihiko Kashiwagi
Predator-induced phenotypic plasticity is the ability of prey to adapt to their native predator. However, owing to environmental changes, encounters with unknown predators are inevitable. Therefore, study of prey and non-native predator interaction will reveal the primary stages of adaptive strategies in prey-predator interactions in the context of evolutionary processes. Here, Xenopus tadpoles exposed to a non-native predator, a larval salamander, showed a significant increase in body weight and tail length to body length ratio...
November 15, 2017: Biology Open
https://www.readbyqxmd.com/read/29141371/-effect-of-recombinant-human-growth-hormone-therapy-on-metabolic-parameters-in-patients-with-craniopharyngioma
#12
J F Mao, X Wang, S Y Xiong, J J Zheng, B Q Yu, M Nie, X Y Wu, S T Qi
Objective: To investigate the effects of recombinant human growth hormone (rhGH) on metabolic parameters in patients with craniopharyngioma surgeries. Methods: Totallys 30 patients with craniopharyngioma were included in this retrospective study. They were divided into growth hormone (GH) group and control group according to whether they received rhGH therapy or not. The following parameters, including body mass index (BMI), weight, waist circumstance, transaminase, fasting blood glucose, lipid profile and high-sensitivity C-reactive protein (hsCRP) were compared after rhGH therapy for 4-6 months...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29140973/a-coupled-oscillator-model-of-olfactory-bulb-gamma-oscillations
#13
Guoshi Li, Thomas A Cleland
The olfactory bulb transforms not only the information content of the primary sensory representation, but also its underlying coding metric. High-variance, slow-timescale primary odor representations are transformed by bulbar circuitry into secondary representations based on principal neuron spike patterns that are tightly regulated in time. This emergent fast timescale for signaling is reflected in gamma-band local field potentials, presumably serving to efficiently integrate olfactory sensory information into the temporally regulated information networks of the central nervous system...
November 15, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29140440/cord-metabolic-profiles-in-obese-pregnant-women-insights-into-offspring-growth-and-body-composition
#14
Nashita Patel, Christian Hellmuth, Olaf Uhl, Keith Godfrey, Annette Briley, Paul Welsh, Dharmintra Pasupathy, Paul Seed, Berthold Koletzko, Lucilla Poston
Context: Offspring exposed in-utero to maternal obesity have an increased risk of later obesity; however, the underlying mechanisms remain unknown. Objective: To assess the effect of an antenatal lifestyle intervention in obese women on the offspring's cord blood metabolic profile, and examine associations of cord blood metabolic profile with maternal clinical characteristics and offspring anthropometry at birth and age 6 months. Design: Randomised controlled trial and cohort study...
November 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29140311/scene-aware-adaptive-updating-for-visual-tracking-via-correlation-filters
#15
Fan Li, Sirou Zhang, Xiaoya Qiao
In recent years, visual object tracking has been widely used in military guidance, human-computer interaction, road traffic, scene monitoring and many other fields. The tracking algorithms based on correlation filters have shown good performance in terms of accuracy and tracking speed. However, their performance is not satisfactory in scenes with scale variation, deformation, and occlusion. In this paper, we propose a scene-aware adaptive updating mechanism for visual tracking via a kernel correlation filter (KCF)...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29139277/tailor-management-to-the-patient-with-fibroids
#16
Marie O'Sullivan, Caroline Overton
Fibroids are benign, hormone-dependent tumours of uterine smooth muscle and connective tissue. They are commonly asymptomatic, but can cause symptoms such as heavy menstrual bleeding and pelvic pressure symptoms. Between 20 to 30% of women with heavy menstrual bleeding have fibroids. Fibroids are most prevalent in women aged 30-50 years and there may be a genetic predisposition. They are more common in black women than white women. Other risk factors include obesity and nulliparity. Asymptomatic women should only be referred if their uterus is palpable abdominally, if fibroids distort the uterine cavity or the uterus is larger than 12 cm in length...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29138452/excessive-fuel-availability-amplifies-the-fto-mediated-obesity-risk-results-from-the-tuef-and-whitehall-ii-studies
#17
Róbert Wagner, Ádám G Tabák, Ellen Fehlert, Louise Fritsche, Benjamin A Jaghutriz, Róbert J Bánhegyi, Sebastian M Schmid, Harald Staiger, Fausto Machicao, Andreas Peter, Hans-Ulrich Häring, Andreas Fritsche, Martin Heni
Variation in FTO is the most important common genetic determinant of body weight. Altered energy metabolism could underlie this association. We hypothesized that higher circulating glucose or triglycerides can amplify the FTO impact on BMI. In 2671 subjects of the TUEF study, we investigated the interaction effect of fasting glucose and triglyceride levels with rs9939609 in FTO on BMI. We analysed the same interaction effect by longitudinally utilizing mixed effect models in the prospective Whitehall II study...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137984/recombinant-human-glp-1-rhglp-1-alleviating-renal-tubulointestitial-injury-in-diabetic-stz-induced-rats
#18
Weiqin Yin, Shiqing Xu, Zai Wang, Honglin Liu, Liang Peng, Qing Fang, Tingting Deng, Wenjian Zhang, Jinning Lou
GLP-1-based treatment improves glycemia through stimulation of insulin secretion and inhibition of glucagon secretion. Recently, more and more findings showed that GLP-1 could also protect kidney from diabetic nephropathy. Most of these studies focused on glomeruli, but the effect of GLP-1 on tubulointerstitial and tubule is not clear yet. In this study, we examined the renoprotective effect of recombinant human GLP-1 (rhGLP-1), and investigated the influence of GLP-1 on inflammation and tubulointerstitial injury using diabetic nephropathy rats model of STZ-induced...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29135251/micellar-thrombin-binding-aptamers-reversible-nanoscale-anticoagulants
#19
Alexander Roloff, Andrea S Carlini, Cassandra E Callmann, Nathan C Gianneschi
Aptamers are nucleic acid-based ligands that exhibit promising features including specific and reversible target binding and inhibition. Aptamers can function as anticoagulants if they are directed against enzymes of the coagulation cascade. However, they typically suffer from nucleolytic digestion and fast clearance from the bloodstream. We present thrombin-binding aptamer amphiphiles that self-assemble into nanoscale polymeric micelles with a densely functionalized aptamer-displaying corona. We show that these micellar aptamers retain their native secondary structure in a crowded environment and are stabilized against degradation by nucleases in human serum...
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29135086/can-mr-enterography-screen-for-perianal-disease-in-pediatric-inflammatory-bowel-disease
#20
Zehour AlSabban, Nicholas Carman, Rahim Moineddin, Ryan T Lo, Sebastian K King, Jacob C Langer, Thomas D Walters, Anne M Griffiths, Peter C Church, Mary-Louise C Greer
BACKGROUND: Pediatric Crohn's disease is associated with perianal disease (PAD). Magnetic resonance enterography (MRE) assesses small bowel involvement in pediatric inflammatory bowel disease (PIBD). Pelvic MRI (P-MRI) is the gold standard for assessing PAD. PURPOSE: To determine if MRE can accurately detect PAD in PIBD, distinguishing perianal fistulae (PAF) from perianal abscesses (PAA), referenced against P-MRI. STUDY TYPE: Retrospective...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
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