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Mycoplasma gallisepticum

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https://www.readbyqxmd.com/read/29131864/comparison-of-histone-like-hu-protein-dna-binding-properties-and-hu-ihf-protein-sequence-alignment
#1
Dmitri Kamashev, Yulia Agapova, Sergey Rastorguev, Anna A Talyzina, Konstantin M Boyko, Dmitry A Korzhenevskiy, Anna Vlaskina, Raif Vasilov, Vladimir I Timofeev, Tatiana V Rakitina
BACKGROUND: The structure and function of bacterial nucleoid are controlled by histone-like proteins of HU/IHF family, omnipresent in bacteria and also founding archaea and some eukaryotes.HU protein binds dsDNA without sequence specificity and avidly binds DNA structures with propensity to be inclined such as forks, three/four-way junctions, nicks, overhangs and DNA bulges. Sequence comparison of thousands of known histone-like proteins from diverse bacteria phyla reveals relation between HU/IHF sequence, DNA-binding properties and other protein features...
2017: PloS One
https://www.readbyqxmd.com/read/29115156/development-and-evaluation-of-novel-recombinant-adenovirus-based-vaccine-candidates-for-infectious-bronchitis-virus-and-mycoplasma-gallisepticum-in-chickens
#2
Dongchao Zhang, Yuqing Long, Meng Li, Jianfang Gong, Xiaohui Li, Jing Lin, Jiali Meng, Keke Gao, Ruili Zhao, Tianming Jin
Avian infectious bronchitis (IB) caused by the infectious bronchitis virus (IBV) and mycoplasmosis caused by Mycoplasma gallisepticum (MG) are two major respiratory diseases in chickens that have resulted in severe economic losses in the poultry industry. We constructed a recombinant adenovirus that simultaneously expresses the S1 spike glycoprotein of IBV and the TM-1 protein of MG (pBH-S1-TM-1-EGFP). For comparison, we constructed two recombinant adenoviruses (pBH-S1-EGFP and pBH-TM-1-EGFP) that express either the S1 spike glycoprotein or the TM-1 protein alone...
November 8, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29102105/cholesterol-exacerbates-mycoplasma-hyopneumoniae-induced-apoptosis-via-stimulating-proliferation-and-adhesion-to-porcine-alveolar-macrophages
#3
Maojun Liu, Gaimei Du, Beibei Liu, Yun Hu, Jie Liu, Yimin Jia, F Chris Minion, Guoqing Shao, Ruqian Zhao
Mycoplasma hyopneumoniae (M. hyo) is the agent of porcine enzootic pneumonia, a disease that causes considerable economic losses in the swine industry. Induction of apoptosis in porcine alveolar macrophages is an important pathogenic mechanism of M. hyo. Cholesterol has been reported to influence cell adherence and cell invasion of Mycoplasma gallisepticum and Mycoplasma fermentans leading to apoptosis, but the role of cholesterol on the apoptotic inducing activity of M. hyo remains unknown. In this study, we found a positive correlation between cholesterol level and M...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29070657/core-genome-multilocus-sequence-typing-cgmlst-a-standardized-approach-for-molecular-typing-of-mycoplasma-gallisepticum
#4
Mostafa Ghanem, Leyi Wang, Yan Zhang, Scott Edwards, Amanda Lu, David Ley, Mohamed El-Gazzar
Mycoplasma gallisepticum (MG) is the most virulent and economically important Mycoplasma species for poultry worldwide. Currently, MG strain differentiation based on sequence analysis of 5 loci remains insufficient for accurate outbreak investigation. Recently, whole genome sequences (WGS) of many human and animal pathogens have been successfully used for microbial outbreak investigations. However, the massive sequence data and the diverse properties of different genes within bacterial genomes results in the lack of standard reproducible methods for comparisons among MG whole genomes...
October 25, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29053429/house-finch-haemorhous-mexicanus-associated-mycoplasma-gallisepticum-identified-in-lesser-goldfinch-spinus-psaltria-and-western-scrub-jay-aphelocoma-californica-using-strain-specific-quantitative-pcr
#5
Catherine R Allen, Arlind Mara, Edan R Tulman, David H Ley, Steven J Geary
In 1994 Mycoplasma gallisepticum was found to be the etiologic agent of House Finch (Haemorhous mexicanus) conjunctivitis, a rapidly expanding epidemic caused by a genetically discrete, House Finch-associated strain of M. gallisepticum (HFMG). While most prominent in House Finches, HFMG has been reported in other members of the family Fringillidae, including American Goldfinches (Spinus tristis), Purple Finches (Haemorhous purpureus), Pine Grosbeaks (Pinicola enucleator), and Evening Grosbeaks (Coccothraustes vespertinus)...
October 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29050407/layer-chicken-embryo-survival-to-hatch-when-administered-an-in-ovo-vaccination-of-strain-f-mycoplasma-gallisepticum-and-locations-of-bacteria-prevalence-in-the-newly-hatched-chick
#6
K E C Elliott, S L Branton, J D Evans, P D Gerard, E D Peebles
Mycoplasma gallisepticum (MG) is a bacterial pathogen that causes production losses in layer chickens. To combat MG, multiage layer facilities vaccinate pullets by either spray or eye-drop vaccination. The objective in this study was to evaluate the use of in ovo vaccination as a potential alternative for MG vaccination. Layer embryos at 18 d of incubation were either not-injected (control), or were hand-injected with either commercial Marek's disease vaccine diluent alone or with a high, medium, low, or very low dosage of a live attenuated strain F (FMG) vaccine suspended in the commercial diluent...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29034329/comparative-metabolomics-of-mycoplasma-bovis-and-mycoplasma-gallisepticum-reveals-fundamental-differences-in-active-metabolic-pathways-and-suggests-novel-gene-annotations
#7
Y Masukagami, D P De Souza, S Dayalan, C Bowen, S O'Callaghan, K Kouremenos, B Nijagal, D Tull, K A Tivendale, P F Markham, M J McConville, G F Browning, F M Sansom
Mycoplasmas are simple, but successful parasites that have the smallest genome of any free-living cell and are thought to have a highly streamlined cellular metabolism. Here, we have undertaken a detailed metabolomic analysis of two species, Mycoplasma bovis and Mycoplasma gallisepticum, which cause economically important diseases in cattle and poultry, respectively. Untargeted gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry analyses of mycoplasma metabolite extracts revealed significant differences in the steady-state levels of many metabolites in central carbon metabolism, while (13)C stable isotope labeling studies revealed marked differences in carbon source utilization...
September 2017: MSystems
https://www.readbyqxmd.com/read/28941621/safety-and-efficacy-of-a-mycoplasma-gallisepticum-oppd-knockout-mutant-as-a-vaccine-candidate
#8
Chi-Wen Tseng, Chien-Ju Chiu, Anna Kanci, Amir H Noormohammadi, Glenn F Browning, Philip F Markham
Control of the important poultry pathogen Mycoplasma gallisepticum is highly dependent on safe and efficacious attenuated vaccines. In order to assess a novel vaccine candidate we evaluated the safety and efficacy of the M. gallisepticum mutant 26-1. The oppD1 gene in this mutant has been interrupted by a signature-tagged transposon and previous studies have shown that it can colonise the respiratory tract of chickens without inducing significant disease. The capacity of the oppD1 mutant to induce protective immunity in the respiratory tract after vaccination by eye-drop was assessed by challenging vaccinated birds with an aerosol of the virulent M...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28900116/response-induced-in-mycoplasma-gallisepticum-under-heat-shock-might-be-relevant-to-infection-process
#9
Ivan Butenko, Anna Vanyushkina, Olga Pobeguts, Daria Matyushkina, Sergey Kovalchuk, Alexey Gorbachev, Nicolay Anikanov, Gleb Fisunov, Vadim Govorun
Despite the fact the term "proteome" was proposed to characterize a set of proteins in one of mycoplasma species, proteome response to various exposures in this bacteria are still obscure. Commonly, authors studying proteomic response on perturbation models in mycoplasmas use single approach and do not confirm their findings by alternative methods. Consequently, the results of proteomic analysis should be validated by complementary techniques. In this study we utilized three complementary approaches (SWATH, MRM, 2D-DIGE) to assess response of Mycoplasma gallisepticum under heat stress on proteomic level and combined these findings with metabolic response and the results of transcriptional profiling...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28895509/mycoplasma-tullyi-sp-nov-isolated-from-penguins-of-the-genus-spheniscus
#10
Christine A Yavari, Ana S Ramírez, Robin A J Nicholas, Alan D Radford, Alistair C Darby, Janet M Bradbury
A mycoplasma isolated from the liver of a dead Humboldt penguin (Spheniscus humboldti) and designated strain 56A97(T), was investigated to determine its taxonomic status. Complete 16S rRNA gene sequence analysis indicated that the organism was most closely related to Mycoplasma gallisepticum and Mycoplasma imitans(99.7 and 99.9 % similarity, respectively). The average DNA-DNA hybridization values between strain 56A97(T) and M. gallisepticum and M. imitans were 39.5 and 30 %, respectively and the Genome to Genome Distance Calculator gave results of 29...
October 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28889017/mycoplasmas-brain-invaders
#11
REVIEW
Rubén S Rosales, Roberto Puleio, Guido R Loria, Salvatore Catania, Robin A J Nicholas
Mycoplasmas of humans and animals are usually associated with respiratory, autoimmune, genital and joint diseases. Human mycoplasmas have also been known to affect the brain. Severe central nervous system (CNS) diseases, such as encephalitis, have been linked to Mycoplasma pneumoniae and ureaplasma infections. Less well known is the sheep and goat pathogen, Mycoplasma agalactiae, which has been found in large quantities in the brain where it may be responsible for non-purulent encephalitis as well as ataxia in young animals...
September 5, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28854912/development-and-validation-of-a-house-finch-interleukin-1%C3%AE-hfil-1%C3%AE-elisa-system
#12
Sungwon Kim, Myeongseon Park, Ariel E Leon, James S Adelman, Dana M Hawley, Rami A Dalloul
BACKGROUND: A unique clade of the bacterium Mycoplasma gallisepticum (MG), which causes chronic respiratory disease in poultry, has resulted in annual epidemics of conjunctivitis in North American house finches since the 1990s. Currently, few immunological tools have been validated for this songbird species. Interleukin-1β (IL-1β) is a prototypic multifunctional cytokine and can affect almost every cell type during Mycoplasma infection. The overall goal of this study was to develop and validate a direct ELISA assay for house finch IL-1β (HfIL-1β) using a cross-reactive chicken antibody...
August 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28768998/synthesis-and-biological-evaluation-of-novel-thioether-pleuromutilin-derivatives
#13
Shuhua Mu, Huixian Liu, Lifang Zhang, Xiaoyang Wang, Feiqun Xue, Yue Zhang
To develop new pleuromutilin derivatives as veterinary antibiotic medicines, we designed and synthesized a series of new thioether pleuromutilin derivatives possessing acylthiazolyl moiety based on previously designed derivatives. The antibacterial properties of the prepared pleuromutilin derivatives were assessed in vitro by the broth dilution method against five kinds of bacteria and the mycoplasma Mycoplasma gallisepticum (MG). All of the tested compounds displayed moderate to good antibacterial activity to methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-sensitive Staphylococcus epidermidis (MSSE), methicillin-resistant S...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28766063/host-responses-to-pathogen-priming-in-a-natural-songbird-host
#14
Ariel E Leon, Dana M Hawley
Hosts in free-living populations can experience substantial variation in the frequency and dose of pathogen exposure, which can alter disease progression and protection from future exposures. In the house finch-Mycoplasma gallisepticum (MG) system, the pathogen is primarily transmitted via bird feeders, and some birds may be exposed to frequent low doses of MG while foraging. Here we experimentally determined how low dose, repeated exposures of house finches to MG influence host responses and protection from secondary high-dose challenge...
August 1, 2017: EcoHealth
https://www.readbyqxmd.com/read/28739827/transcriptional-profiling-of-the-chicken-tracheal-response-to-virulent-mycoplasma-gallisepticum-strain-rlow
#15
J Beaudet, E R Tulman, K Pflaum, X Liao, G F Kutish, S M Szczepanek, L K Silbart, S J Geary
Mycoplasma gallisepticum, the primary etiologic agent of chronic respiratory disease (CRD) in poultry, leads to prolonged recruitment and activation of inflammatory cells in the respiratory mucosa. This is consistent with the current model of immune dysregulation that ostensibly allows the organism to evade clearance mechanisms and establish chronic infection. To date, studies using quantitative reverse transcription-PCR (qRT-PCR) and microarrays have shown a significant transient upregulation of cytokines and chemokines from tracheal epithelial cells (TECs) in vitro and tracheal tissue ex vivo in response to virulent strain Rlow that contributes to the infiltration of inflammatory cells into the tracheal mucosa...
October 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28675463/pharmacokinetic-depletion-phase-of-doxycycline-in-healthy-and-mycoplasma-gallisepticum-infected-chicken-broilers-after-coadministration-of-enrofloxacin-traces
#16
M Gbylik-Sikorska, A Gajda, A Posyniak
The objective of this study was to investigate the influence of enrofloxacin (ENR) traces on doxycycline (DC) pharmacokinetic depletion phase parameters in plasma and lungs of healthy and Mycoplasma gallisepticum (MG)-infected chicken broilers. The multiple-dose oral administration of DC to chickens which were permanently exposed on ENR traces significantly increased concentration of DC in plasma and lung. It also prolonged the DC elimination time in both healthy and infected animals after final dose. The obtained result indicated that simultaneous administration of DC and ENR in chicken broilers therapy should be avoided...
July 4, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28652181/gga-mir-99a-targets-smarca5-to-regulate-mycoplasma-gallisepticum-hs-strain-infection-by-depressing-cell-proliferation-in-chicken
#17
REVIEW
Yabo Zhao, Zaiwei Wang, Yue Hou, Kang Zhang, Xiuli Peng
Mycoplasma gallisepticum (MG), one of the primary etiological agents of poultry chronic respiratory disease, has caused significant economic losses worldwide, and increasing evidence has recently indicated that miRNAs are involved in its microbial pathogenesis. gga-miR-99a, a member of the miR-99 family, plays an essential role in a variety of diseases. Through miRNA Solexa sequencing, we previously found that gga-miR-99a is significantly down-regulated in the lungs of MG-infected chicken embryos. In this study, we further verified that the expression of gga-miR-99 was significantly down-regulated in both MG-infected lungs and a chicken embryonic fibroblast cell line (DF-1) by qPCR...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28649082/short-communication-study-on-quality-and-efficacy-of-commercial-tylosin-and-doxycycline-products-against-local-isolates-of-mycoplasma-in-broilers
#18
- Riazuddin, Sarzamin Khan, Naila Imtiaz, Saima Aslam, Shakoor Ahmad, Hamayun Khan, Masood Rabbani, Javed Muhammad, Zafar Iqbal Tanveer, Sakhawat Ali
The present study was conducted to investigate the quality and efficacy of commercially available preparations of tylosin and doxycycline available in the local market at Peshawar for poultry. In vitro and in vivo, tests were conducted to check the quality of these antimicrobial drugs. In vitro quality control test was performed by High performance liquid chromatographic (HPLC) and micro dilution method. In vivo, efficacy of the test drugs was checked in broilers infected with Mycoplasma gallisepticum. Results of HPLC indicated that test drug-2 contains doxycycline hydrochloride within specified limits but contain high quantity of active ingredient (Tylosin tartrate 120%)...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28616387/biosecurity-and-geospatial-analysis-of-mycoplasma-infections-in-poultry-farms-at-al-jabal-al-gharbi-region-of-libya
#19
Abdulwahab Kammon, Paolo Mulatti, Monica Lorenzetto, Nicola Ferre, Monier Sharif, Ibrahim Eldaghayes, Abdunaser Dayhum
Geospatial database of farm locations and biosecurity measures are essential to control disease outbreaks. A study was conducted to establish geospatial database on poultry farms in Al-Jabal Al-Gharbi region of Libya, to evaluate the biosecurity level of each farm and to determine the seroprevalence of mycoplasma and its relation to biosecurity level. A field team of 7 Veterinarians belongs to the National Center of Animal Health was assigned for data recording and collection of blood samples. Personal information of the producers, geographical locations, biosecurity measures and description of the poultry farms were recorded...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28611739/the-pk-pd-relationship-and-resistance-development-of-danofloxacin-against-mycoplasma-gallisepticum-in-an-in-vivo-infection-model
#20
Nan Zhang, Yuzhi Wu, Zilong Huang, Lihua Yao, Longfei Zhang, Qinren Cai, Xiangguang Shen, Hongxia Jiang, Huanzhong Ding
Mycoplasma gallisepticum is the causative agent of chronic respiratory disease (CRD), a prevalent disease of poultry, which is responsible for significant economic losses in farms. Although several antimicrobial agents are currently recommended for the treatment and prevention of M. gallisepticum infections, investigations of M. gallisepticum have been hampered by their fastidious growth requirements and slow growth rate. As such, little work has been conducted concerning the PK/PD relationship and mechanisms of antibiotic resistance between antimicrobials against M...
2017: Frontiers in Microbiology
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