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Mycoplasma gallisepticum

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https://www.readbyqxmd.com/read/28900116/response-induced-in-mycoplasma-gallisepticum-under-heat-shock-might-be-relevant-to-infection-process
#1
Ivan Butenko, Anna Vanyushkina, Olga Pobeguts, Daria Matyushkina, Sergey Kovalchuk, Alexey Gorbachev, Nicolay Anikanov, Gleb Fisunov, Vadim Govorun
Despite the fact the term "proteome" was proposed to characterize a set of proteins in one of mycoplasma species, proteome response to various exposures in this bacteria are still obscure. Commonly, authors studying proteomic response on perturbation models in mycoplasmas use single approach and do not confirm their findings by alternative methods. Consequently, the results of proteomic analysis should be validated by complementary techniques. In this study we utilized three complementary approaches (SWATH, MRM, 2D-DIGE) to assess response of Mycoplasma gallisepticum under heat stress on proteomic level and combined these findings with metabolic response and the results of transcriptional profiling...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28895509/mycoplasma-tullyi-sp-nov-isolated-from-penguins-of-the-genus-spheniscus
#2
Christine A Yavari, Ana S Ramírez, Robin A J Nicholas, Alan D Radford, Alistair C Darby, Janet M Bradbury
A mycoplasma isolated from the liver of a dead Humboldt penguin (Spheniscus humboldti) and designated strain 56A97T, was investigated to determine its taxonomic status. Complete 16S rRNA gene sequence analysis indicated that the organism was most closely related to Mycoplasma gallisepticum and Mycoplasma imitans(99.7 and 99.9 % similarity, respectively). The average DNA-DNA hybridization values between strain 56A97T and M. gallisepticum and M. imitans were 39.5 and 30 %, respectively and the Genome to Genome Distance Calculator gave results of 29...
September 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28889017/mycoplasmas-brain-invaders
#3
REVIEW
Rubén S Rosales, Roberto Puleio, Guido R Loria, Salvatore Catania, Robin A J Nicholas
Mycoplasmas of humans and animals are usually associated with respiratory, autoimmune, genital and joint diseases. Human mycoplasmas have also been known to affect the brain. Severe central nervous system (CNS) diseases, such as encephalitis, have been linked to Mycoplasma pneumoniae and ureaplasma infections. Less well known is the sheep and goat pathogen, Mycoplasma agalactiae, which has been found in large quantities in the brain where it may be responsible for non-purulent encephalitis as well as ataxia in young animals...
September 5, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28854912/development-and-validation-of-a-house-finch-interleukin-1%C3%AE-hfil-1%C3%AE-elisa-system
#4
Sungwon Kim, Myeongseon Park, Ariel E Leon, James S Adelman, Dana M Hawley, Rami A Dalloul
BACKGROUND: A unique clade of the bacterium Mycoplasma gallisepticum (MG), which causes chronic respiratory disease in poultry, has resulted in annual epidemics of conjunctivitis in North American house finches since the 1990s. Currently, few immunological tools have been validated for this songbird species. Interleukin-1β (IL-1β) is a prototypic multifunctional cytokine and can affect almost every cell type during Mycoplasma infection. The overall goal of this study was to develop and validate a direct ELISA assay for house finch IL-1β (HfIL-1β) using a cross-reactive chicken antibody...
August 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28768998/synthesis-and-biological-evaluation-of-novel-thioether-pleuromutilin-derivatives
#5
Shuhua Mu, Huixian Liu, Lifang Zhang, Xiaoyang Wang, Feiqun Xue, Yue Zhang
To develop new pleuromutilin derivatives as veterinary antibiotic medicines, we designed and synthesized a series of new thioether pleuromutilin derivatives possessing acylthiazolyl moiety based on previously designed derivatives. The antibacterial properties of the prepared pleuromutilin derivatives were assessed in vitro by the broth dilution method against five kinds of bacteria and the mycoplasma Mycoplasma gallisepticum (MG). All of the tested compounds displayed moderate to good antibacterial activity to methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-sensitive Staphylococcus epidermidis (MSSE), methicillin-resistant S...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28766063/host-responses-to-pathogen-priming-in-a-natural-songbird-host
#6
Ariel E Leon, Dana M Hawley
Hosts in free-living populations can experience substantial variation in the frequency and dose of pathogen exposure, which can alter disease progression and protection from future exposures. In the house finch-Mycoplasma gallisepticum (MG) system, the pathogen is primarily transmitted via bird feeders, and some birds may be exposed to frequent low doses of MG while foraging. Here we experimentally determined how low dose, repeated exposures of house finches to MG influence host responses and protection from secondary high-dose challenge...
August 1, 2017: EcoHealth
https://www.readbyqxmd.com/read/28739827/transcriptional-profiling-of-the-chicken-tracheal-response-to-virulent-mycoplasma-gallisepticum-strain-rlow
#7
J Beaudet, E R Tulman, K Pflaum, X Liao, G F Kutish, S M Szczepanek, L K Silbart, S J Geary
Mycoplasma gallisepticum, the primary etiologic agent of Chronic Respiratory Disease (CRD) in poultry, leads to prolonged recruitment and activation of inflammatory cells in the respiratory mucosa. This is consistent with the current model of immune dysregulation that ostensibly allows the organism to evade clearance mechanisms and establish chronic infection. To date, studies using qRT-PCR and microarrays have shown a significant transient up-regulation of cytokines and chemokines from tracheal epithelial cells (TECs) in vitro and tracheal tissue ex vivo in response to virulent strain Rlow, that contributes to the infiltration of inflammatory cells into the tracheal mucosa...
July 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28675463/pharmacokinetic-depletion-phase-of-doxycycline-in-healthy-and-mycoplasma-gallisepticum-infected-chicken-broilers-after-coadministration-of-enrofloxacin-traces
#8
M Gbylik-Sikorska, A Gajda, A Posyniak
The objective of this study was to investigate the influence of enrofloxacin (ENR) traces on doxycycline (DC) pharmacokinetic depletion phase parameters in plasma and lungs of healthy and Mycoplasma gallisepticum (MG)-infected chicken broilers. The multiple-dose oral administration of DC to chickens which were permanently exposed on ENR traces significantly increased concentration of DC in plasma and lung. It also prolonged the DC elimination time in both healthy and infected animals after final dose. The obtained result indicated that simultaneous administration of DC and ENR in chicken broilers therapy should be avoided...
July 4, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28652181/gga-mir-99a-targets-smarca5-to-regulate-mycoplasma-gallisepticum-hs-strain-infection-by-depressing-cell-proliferation-in-chicken
#9
REVIEW
Yabo Zhao, Zaiwei Wang, Yue Hou, Kang Zhang, Xiuli Peng
Mycoplasma gallisepticum (MG), one of the primary etiological agents of poultry chronic respiratory disease, has caused significant economic losses worldwide, and increasing evidence has recently indicated that miRNAs are involved in its microbial pathogenesis. gga-miR-99a, a member of the miR-99 family, plays an essential role in a variety of diseases. Through miRNA Solexa sequencing, we previously found that gga-miR-99a is significantly down-regulated in the lungs of MG-infected chicken embryos. In this study, we further verified that the expression of gga-miR-99 was significantly down-regulated in both MG-infected lungs and a chicken embryonic fibroblast cell line (DF-1) by qPCR...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28649082/short-communication-study-on-quality-and-efficacy-of-commercial-tylosin-and-doxycycline-products-against-local-isolates-of-mycoplasma-in-broilers
#10
- Riazuddin, Sarzamin Khan, Naila Imtiaz, Saima Aslam, Shakoor Ahmad, Hamayun Khan, Masood Rabbani, Javed Muhammad, Zafar Iqbal Tanveer, Sakhawat Ali
The present study was conducted to investigate the quality and efficacy of commercially available preparations of tylosin and doxycycline available in the local market at Peshawar for poultry. In vitro and in vivo, tests were conducted to check the quality of these antimicrobial drugs. In vitro quality control test was performed by High performance liquid chromatographic (HPLC) and micro dilution method. In vivo, efficacy of the test drugs was checked in broilers infected with Mycoplasma gallisepticum. Results of HPLC indicated that test drug-2 contains doxycycline hydrochloride within specified limits but contain high quantity of active ingredient (Tylosin tartrate 120%)...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28616387/biosecurity-and-geospatial-analysis-of-mycoplasma-infections-in-poultry-farms-at-al-jabal-al-gharbi-region-of-libya
#11
Abdulwahab Kammon, Paolo Mulatti, Monica Lorenzetto, Nicola Ferre, Monier Sharif, Ibrahim Eldaghayes, Abdunaser Dayhum
Geospatial database of farm locations and biosecurity measures are essential to control disease outbreaks. A study was conducted to establish geospatial database on poultry farms in Al-Jabal Al-Gharbi region of Libya, to evaluate the biosecurity level of each farm and to determine the seroprevalence of mycoplasma and its relation to biosecurity level. A field team of 7 Veterinarians belongs to the National Center of Animal Health was assigned for data recording and collection of blood samples. Personal information of the producers, geographical locations, biosecurity measures and description of the poultry farms were recorded...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28611739/the-pk-pd-relationship-and-resistance-development-of-danofloxacin-against-mycoplasma-gallisepticum-in-an-in-vivo-infection-model
#12
Nan Zhang, Yuzhi Wu, Zilong Huang, Lihua Yao, Longfei Zhang, Qinren Cai, Xiangguang Shen, Hongxia Jiang, Huanzhong Ding
Mycoplasma gallisepticum is the causative agent of chronic respiratory disease (CRD), a prevalent disease of poultry, which is responsible for significant economic losses in farms. Although several antimicrobial agents are currently recommended for the treatment and prevention of M. gallisepticum infections, investigations of M. gallisepticum have been hampered by their fastidious growth requirements and slow growth rate. As such, little work has been conducted concerning the PK/PD relationship and mechanisms of antibiotic resistance between antimicrobials against M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28433919/identification-of-differentially-expressed-mirnas-through-high-throughput-sequencing-in-the-chicken-lung-in-response-to-mycoplasma-gallisepticum-hs
#13
Yabo Zhao, Yue Hou, Kang Zhang, Bo Yuan, Xiuli Peng
Mycoplasma gallisepticum (MG) infects chickens, causes chronic respiratory diseases (CRD) and severely damages the poultry industry. It has been suggested that micro-ribonucleic acids (miRNAs) are involved in microbial pathogenesis. Here, we identified miRNAs that are associated with MG infection in chicken lungs at 3 and 10days post-infection by deep sequencing. Thirty-six down-regulated and 9 up-regulated miRNAs belonging to 31 miRNA families were detected at 3days post-infection, whereas 50 down-regulated and 18 up-regulated miRNAs belonging to 41 miRNA families were found at 10days post-infection...
June 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28431183/efficacy-of-tiamulin-alone-or-in-combination-with-chlortetracycline-against-experimental-mycoplasma-gallisepticum-infection-in-chickens
#14
A Garmyn, M Vereecken, K Degussem, W Depondt, F Haesebrouck, A Martel
Mycoplasma gallisepticum (M. gallisepticum) remains one of the most important diseases in poultry production. Controlling the impact of the disease is done by eradication of positive breeder flocks or by vaccination and medication. A widely used molecule in medication programs is tiamulin, a pleuromutilin antibiotic. Since recent data on the in vivo efficacy of this molecule are scarce, 2 challenge studies were conducted using a recently isolated M. gallisepticum strain belonging to the wildtype population with regard to its tiamulin and tetracycline minimum inhibitory concentration (MIC)...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28396323/attenuated-phenotype-of-a-recent-house-finch-associated-mycoplasma-gallisepticum-isolate-in-domestic-poultry
#15
K Pflaum, E R Tulman, J Beaudet, X Liao, K V Dhondt, A A Dhondt, D M Hawley, D H Ley, K M Kerr, S J Geary
Mycoplasma gallisepticum, known primarily as a respiratory pathogen of domestic poultry, has emerged since 1994 as a significant pathogen of the house finch (Haemorhousmexicanus) causing severe conjunctivitis and mortality. House finch-associated M. gallisepticum (HFMG) spread rapidly and increased in virulence for the finch host in the eastern United States. In the current study, we assessed virulence in domestic poultry with two temporally distant, and yet geographically consistent, HFMG isolates which differ in virulence for house finches-Virginia 1994 (VA1994), the index isolate of the epidemic, and Virginia 2013 (VA2013), a recent isolate of increased house finch virulence...
June 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28348959/apparent-effect-of-chronic-plasmodium-infections-on-disease-severity-caused-by-experimental-infections-with-mycoplasma-gallisepticum-in-house-finches
#16
André A Dhondt, Keila V Dhondt, Sophie Nazeri
An epidemic caused by a successful host jump of the bacterial pathogen Mycoplasma gallisepticum from poultry to house finches in the 1990s has by now spread across most of North America. M. gallisepticum causes severe conjunctivitis in house finches. We experimentally show that M. gallisepticum transmission to birds with or without chronic Plasmodium infection does not differ. However, once infected with M. gallisepticum house finches chronically infected with Plasmodium develop more severe clinical disease than birds without such infection...
August 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28348054/the-oppd-gene-and-putative-peptidase-genes-may-be-required-for-virulence-in-mycoplasma-gallisepticum
#17
Chi-Wen Tseng, Chien-Ju Chiu, Anna Kanci, Christine Citti, Renate Rosengarten, Glenn F Browning, Philip F Markham
Relatively few virulence genes have been identified in pathogenic mycoplasmas, so we used signature-tagged mutagenesis to identify mutants of the avian pathogen Mycoplasma gallisepticum with a reduced capacity to persist in vivo and compared the levels of virulence of selected mutants in experimentally infected chickens. Four mutants had insertions in one of the two incomplete oppABCDF operons, and a further three had insertions in distinct hypothetical genes, two containing peptidase motifs and one containing a member of a gene family...
June 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28345962/immune-responses-to-vaccination-and-infection-with-mycoplasma-gallisepticum-in-turkeys
#18
Dinidu S Wijesurendra, Anna Kanci, Kelly A Tivendale, Joanne M Devlin, Nadeeka K Wawegama, Barbara Bacci, Amir H Noormohammadi, Philip F Markham, Glenn F Browning
Infection with Mycoplasma gallisepticum induces severe lymphoproliferative lesions in multiple sites along the respiratory tract in chickens and turkeys. These immunopathological responses have been well-characterized in chickens, but have not been studied closely in turkeys. The aim of the study described here was to examine the immune responses of turkeys after live vaccination and infection with M. gallisepticum. In a strain comparison study, the mean log10 antibody titre of birds exposed to an aerosol culture of M...
October 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28243629/serological-screening-suggests-extensive-presence-of-mycoplasma-gallisepticum-and-mycoplasma-synoviae-in-backyard-chickens-in-southern-mozambique
#19
Augusto Messa Júnior, Paula Taunde, Ana Felicidade Zandamela, Alberto Pondja Junior, Abel Chilundo, Rosa Costa, Custódio Gabriel Bila
A total of 459 serum samples from unvaccinated backyard chickens originating from 4 villages in Mandlakazi district, Southern Mozambique, were tested for the presence of Mycoplasma gallisepticum and Mycoplasma synoviae antibodies through commercial enzyme-linked immunoabsorbent assay [ELISA] kits. Anti-MG and anti-MS antibodies were detected in all villages surveyed and the overall seroprevalence was 48.8% [95% CI 39.1-57.8] and 84.5% [95% CI 76.8-90.4], respectively. The risk of being seropositive for both diseases was higher [P < 0...
2017: Journal of veterinary medicine
https://www.readbyqxmd.com/read/28143392/binding-site-of-restriction-modification-system-controller-protein-in-mollicutes
#20
Gleb Y Fisunov, Daria V Evsyutina, Valentin A Manuvera, Vadim M Govorun
BACKGROUND: Bacteria of the class Mollicutes underwent extreme reduction of genomes and gene expression control systems. Only a few regulators are known to date. In this work, we describe a novel group of transcriptional regulators that are distributed within different Mollicutes and control the expression of restriction-modification systems (RM-systems). RESULTS: We performed cross-species search of putative regulators of RM-systems (C-proteins) and respective binding sites in Mollicutes...
January 31, 2017: BMC Microbiology
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