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Mycoplasma gallisepticum

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https://www.readbyqxmd.com/read/28143392/binding-site-of-restriction-modification-system-controller-protein-in-mollicutes
#1
Gleb Y Fisunov, Daria V Evsyutina, Valentin A Manuvera, Vadim M Govorun
BACKGROUND: Bacteria of the class Mollicutes underwent extreme reduction of genomes and gene expression control systems. Only a few regulators are known to date. In this work, we describe a novel group of transcriptional regulators that are distributed within different Mollicutes and control the expression of restriction-modification systems (RM-systems). RESULTS: We performed cross-species search of putative regulators of RM-systems (C-proteins) and respective binding sites in Mollicutes...
January 31, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28070539/data-on-genome-analysis-of-mycoplasmagallisepticum-during-intracellular-infection
#2
Daria Matyushkina, Olga Pobeguts, Irina Garanina, Vladislav Babenko, Maria Vakhitova, Gleb Fisunov, Vadim Govorun
The genus Mycoplasma relates to Gram-positive bacteria that lack a cell wall and are capable to cause chronic disease in humans and animals. Among the agents of infection and disease in domestic poultry and wild birds, Mycoplasma gallisepticum is the most important mycoplasma species, causing considerable losses in the poultry industry. In the present paper, we provide data on adaptation of M. gallisepticum to the eukaryotic host cells on the genomic level. The major changes were predominantly localized in the VlhA-hemagglutinin genes which are important components of pathogenesis...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28062003/identification-of-genes-involved-in-mycoplasma-gallisepticum-biofilm-formation-using-mini-tn4001-sgm-transposon-mutagenesis
#3
Yang Wang, Li Yi, Fanqing Zhang, Xusheng Qiu, Lei Tan, Shengqing Yu, Xiangchao Cheng, Chan Ding
Mycoplasma gallisepticum (MG) is an important pathogen that can cause chronic respiratory disease in chickens and infectious sinusitis in turkeys. MG has the ability to form biofilms. The molecular mechanisms underlying MG biofilm formation are complex and poorly understood. To better understand the mechanisms involved in biofilm formation, mini-Tn4001-SGM, a novel transposon vector containing the gentamicin gene was constructed and electroporated into MG strain Rlow. Of the 738 mutants obtained, 12 had significantly reduced capacity to form biofilms in a polystyrene microtiter-plate biofilm assay...
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28052123/determination-of-the-mutant-selection-window-and-evaluation-of-the-killing-of-mycoplasma-gallisepticum-by-danofloxacin-doxycycline-tilmicosin-tylvalosin-and-valnemulin
#4
Nan Zhang, Xiaomei Ye, Yuzhi Wu, Zilong Huang, Xiaoyan Gu, Qinren Cai, Xiangguang Shen, Hongxia Jiang, Huanzhong Ding
Mycoplasma gallisepticum is a common etiological cause of a chronic respiratory disease in chickens; its increasing antimicrobial resistance compromises the use of tetracyclines, macrolides and quinolones in the farm environment. Mutant selection window (MSW) determination was used to investigate the propensity for future resistance induction by danofloxacin, doxycycline, tilmicosin, tylvalosin and valnemulin. Killing of M. gallisepticum strain S6 by these antimicrobials was also studied by incubating M. gallisepticum into medium containing the compounds at the minimal concentration that inhibits colony formation by 99% (MIC99) and the mutant prevention concentration (MPC)...
2017: PloS One
https://www.readbyqxmd.com/read/27999573/reconstruction-of-transcription-control-networks-in-mollicutes-by-high-throughput-identification-of-promoters
#5
Gleb Y Fisunov, Irina A Garanina, Daria V Evsyutina, Tatiana A Semashko, Anastasia S Nikitina, Vadim M Govorun
Bacteria of the class Mollicutes have significantly reduced genomes and gene expression control systems. They are also efficient pathogens that can colonize a broad range of hosts including plants and animals. Despite their simplicity, Mollicutes demonstrate complex transcriptional responses to various conditions, which contradicts their reduction in gene expression regulation mechanisms. We analyzed the conservation and distribution of transcription regulators across the 50 Mollicutes species. The majority of the transcription factors regulate transport and metabolism, and there are four transcription factors that demonstrate significant conservation across the analyzed bacteria...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27984202/ribosome-profiling-reveals-an-adaptation-strategy-of-reduced-bacterium-to-acute-stress
#6
Gleb Y Fisunov, Daria V Evsyutina, Irina A Garanina, Alexander A Arzamasov, Ivan O Butenko, Ilya A Altukhov, Anastasia S Nikitina, Vadim M Govorun
Bacteria of class Mollicutes (mycoplasmas) feature significant genome reduction which makes them good model organisms for systems biology studies. Previously we demonstrated, that drastic transcriptional response of mycoplasmas to stress results in a very limited response on the level of protein. In this study we used heat stress model of M. gallisepticum and ribosome profiling to elucidate the process of genetic information transfer under stress. We found that under heat stress ribosomes demonstrate selectivity towards mRNA binding...
January 2017: Biochimie
https://www.readbyqxmd.com/read/27942460/transcription-profiling-data-set-of-different-states-of-mycoplasma-gallisepticum
#7
Tatiana A Semashko, Alexander A Arzamasov, Gleb Y Fisunov, Vadim M Govorun
Mycoplasma gallisepticum belongs to class Mollicutes and causes chronic respiratory disease in birds. It has a reduced genome, lack of cell wall and many metabolic pathways, and also easy to culture and non-pathogenic to humans. Aforementioned made it is a convenient model for studying of systems biology of minimal cell. Studying the transcriptomic level of M. gallisepticum is interesting for both understanding of common principles of transcription regulation of minimal cell and response to definite influence for pathogen bacteria...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/27924415/detection-of-infectious-bronchitis-virus-793b-avian-metapneumovirus-mycoplasma-gallisepticum-and-mycoplasma-synoviae-in-poultry-in-ethiopia
#8
S Hutton, J Bettridge, R Christley, T Habte, K Ganapathy
A survey was conducted into respiratory infectious diseases of poultry on a chicken breeder farm run by the Ethiopian Institute of Agricultural Research (EIAR), located in Debre Zeit, Ethiopia. Oropharyngeal swabs were collected from 117 randomly selected birds, and blood was taken from a subset of 73 of these birds. A combination of serological and molecular methods was used for detection of pathogens. For the first time in Ethiopia, we report the detection of variant infectious bronchitis virus (793B genotype), avian metapneumovirus subtype B and Mycoplasma synoviae in poultry...
February 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27902896/the-efficacy-of-chitosan-adjuvanted-mycoplasma-gallisepticum-bacterin-in-chickens
#9
Arithat Limsatanun, Jiroj Sasipreeyajan, Somsak Pakpinyo
Mycoplasma gallisepticum (MG) is one of the major pathogens that cause respiratory signs in the poultry industry. To control MG infection, vaccination is the useful procedure. In this study, MG vaccine was developed by using the local Thai MG isolate (AHRL 20/52). Chitosan, a polysaccharide adjuvant derived from crustaceans, has been successfully used in various vaccines. The objectives of this study were to prepare MG bacterins by using chitosan, serving as an adjuvant, to determine protection against the field Thai MG isolate and to evaluate tissue reaction at the injection site...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27884082/enhanced-conformational-flexibility-of-the-histone-like-hu-protein-from-mycoplasma-gallisepticum
#10
Dmitry A Altukhov, Anna A Talyzina, Yulia K Agapova, Anna V Vlaskina, Dmitry A Korzhenevskiy, Eduard V Bocharov, Tatiana V Rakitina, Vladimir I Timofeev, Vladimir O Popov
The histone-like (HU) protein is one of the major nucleoid-associated proteins involved in DNA supercoiling and compaction into bacterial nucleoid as well as in all DNA-dependent transactions. This small positively charged dimeric protein binds DNA in a non-sequence specific manner promoting DNA super-structures. The majority of HU proteins are highly conserved among bacteria; however, HU protein from Mycoplasma gallisepticum (HUMgal) has multiple amino acid substitutions in the most conserved regions, which are believed to contribute to its specificity to DNA targets unusual for canonical HU proteins...
December 29, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27871125/eye-of-the-finch-characterization-of-the-ocular-microbiome-of-house-finches-in-relation-to-mycoplasmal-conjunctivitis
#11
Courtney A Thomason, Ariel Leon, Laila T Kirkpatrick, Lisa K Belden, Dana M Hawley
Vertebrate ocular microbiomes are poorly characterized and virtually unexplored in wildlife species. Pathogen defense is considered a key function of microbiomes, but determining microbiome stability during disease is critical for understanding the role of resident microbial communities in infectious disease dynamics. Here, we characterize the ocular bacterial microbiome of house finches (Haemorhous mexicanus), prior to and during experimental infection with an inflammatory ocular disease, Mycoplasmal conjunctivitis, caused by Mycoplasma gallisepticum...
November 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27847370/identification-of-strain-specific-sequences-that-distinguish-a-mycoplasma-gallisepticum-vaccine-strain-from-field-isolates
#12
Camir Ricketts, Larissa Pickler, John Maurer, Saravanaraj Ayyampalayam, Maricarmen García, Naola M Ferguson-Noel
Despite attempts to control avian mycoplasmosis through management, vaccination, and surveillance, Mycoplasma gallisepticum continues to cause significant morbidity, mortality, and economic losses in poultry production. Live attenuated vaccines are commonly used in the poultry industry to control avian mycoplasmosis; unfortunately, some vaccines may revert to virulence and vaccine strains are generally difficult to distinguish from natural field isolates. In order to identify genome differences among vaccine revertants, vaccine strains, and field isolates, whole-genome sequencing of the M...
January 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27796116/health-evaluation-of-african-penguins-i-spheniscus-demersus-i-in-southern-africa
#13
Nola J Parsons, Tertius A Gous, Adam M Schaefer, Ralph E T Vanstreels
The African penguin (Spheniscus demersus) is an endangered seabird that breeds along the coast of Namibia and South Africa, and disease surveillance was identified as a priority for its conservation. Aiming for the establishment of baseline data on the presence of potential pathogens in this species, a comprehensive health assessment (blood smear examination, haematology, biochemistry and serology) was conducted on samples obtained from 578 African penguins at 11 breeding colonies and a rehabilitation centre...
September 20, 2016: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/27775027/phase-transition-of-the-bacterium-upon-invasion-of-a-host-cell-as-a-mechanism-of-adaptation-a-mycoplasma-gallisepticum-model
#14
Daria Matyushkina, Olga Pobeguts, Ivan Butenko, Anna Vanyushkina, Nicolay Anikanov, Olga Bukato, Daria Evsyutina, Alexandra Bogomazova, Maria Lagarkova, Tatiana Semashko, Irina Garanina, Vladislav Babenko, Maria Vakhitova, Valentina Ladygina, Gleb Fisunov, Vadim Govorun
What strategies do bacteria employ for adaptation to their hosts and are these strategies different for varied hosts? To date, many studies on the interaction of the bacterium and its host have been published. However, global changes in the bacterial cell in the process of invasion and persistence, remain poorly understood. In this study, we demonstrated phase transition of the avian pathogen Mycoplasma gallisepticum upon invasion of the various types of eukaryotic cells (human, chicken, and mouse) which was stable during several passages after isolation of intracellular clones and recultivation in a culture medium...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27738118/egg-quality-in-laying-hens-exposed-to-mycoplasma-gallisepticum-f-strain-attenuated-vaccine
#15
L D S Machado, F F D Santos, C K Togashi, D L D C Abreu, J C Pimentel, L Sesti, V L D A Pereira, E R D Nascimento
Mycoplasma gallisepticum causes coughing, ocular and nasal discharge, reduction in feed intake, lower and uneven growth, decline in egg production and quality, and increase in mortality. Among the attenuated vaccination strains, MGF can reduce clinical signs and lesions in layer hens, stimulate immune responses of cellular and humoral basis, act as an instrument of competitive exclusion in relation to field strains, and reduce the use of antimicrobials. This study aimed to investigate the effects of attenuated MG F-strain vaccination on egg quality in 3 groups of 30 hens each, being one control and 2 vaccinated...
October 12, 2016: Poultry Science
https://www.readbyqxmd.com/read/27699194/data-on-translatome-analysis-of-mycoplasma-gallisepticum
#16
G Y Fisunov, D V Evsyutina, V M Govorun
Mycoplasma gallisepticum is a bacterium of class Mollicutes which encompasses wall-less bacteria with significantly reduced genomes. Due to their overall reduction and simplicity mycoplasmas serve as a model of minimal cell and are used for systems biology studies. Here we present raw data on translatome (ribosome-bound mRNA) analysis of Mycoplasma gallisepticum under logarithm growth and heat stress. The data supports the publication of "Ribosomal profiling of Mycoplasma gallisepticum" (G. Y. Fisunov, D. V Evsyutina, A...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27683641/chicken-gga-mir-19a-targets-zmynd11-and-plays-an-important-role-in-host-defense-against-mycoplasma-gallisepticum-hs-strain-infection
#17
Qingchang Hu, Yabo Zhao, Zaiwei Wang, Yue Hou, Dingren Bi, Jianjun Sun, Xiuli Peng
Mycoplasma gallisepticum (MG), one of the most pathogenic Mycoplasmas, can cause chronic respiratory disease (CRD) in chickens. It has been suggested that micro-ribonucleic acids (miRNAs) are involved in microbial pathogenesis. However, little is known about the roles of miRNAs in MG infection. Previously, we found by deep sequencing that gga-miR-19a was significantly up-regulated in the lungs of MG-infected chicken embryos. In this work, we confirmed that gga-miR-19a was up-regulated in both MG-infected chicken embryonic lungs and MG-infected DF-1 (chicken embryo fibroblast) cells...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27600955/in-vitro-antimicrobial-activities-of-animal-used-quinoxaline-1-4-di-n-oxides-against-mycobacteria-mycoplasma-and-fungi
#18
Yan Zhao, Guyue Cheng, Haihong Hao, Yuanhu Pan, Zhenli Liu, Menghong Dai, Zonghui Yuan
BACKGROUND: The quinoxaline 1,4-di-N-oxides (QdNOs) were known as potent antibacterial agents. For the purpose of evaluating the bioactivity of existing animal-used QdNOs drugs against representative pathogenic microorganism, the representative drugs of quinoxalines including cyadox, mequindox, quinocetone and their metabolites were submitted to the in vitro evaluation for antituberculosis, antimycoplasma, antifungal and antiviral activities. RESULTS: In antituberculosis assays, the prototype compounds were active (MIC = 4 ~ 8 μg/mL) against Mycobacterium tuberculosis H37Rv and M...
September 6, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27580325/mutations-of-domain-v-in-23s-ribosomal-rna-of-macrolide-resistant-mycoplasma-gallisepticum-isolates-in-egypt
#19
Ahmed M Ammar, Norhan K Abd El-Aziz, Ahlam A Gharib, Hanaa K Ahmed, Amira E Lameay
INTRODUCTION: Avian mycoplasmas impose a significant economic burden to the poultry industry. In recent years, macrolide-resistant Mycoplasma gallisepticum have occasionally been encountered in Egypt. METHODOLOGY: This study was designed to document the involvement of macrolide-resistant M. gallisepticum in respiratory organs of chickens suffering respiratory problems. Concurrently, an exhaustive molecular characterization of the intrinsic resistance of recovered isolates to macrolides was done...
August 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27550334/tickborne-fever-associated-with-abortion-outbreak-in-dairy-cows
#20
(no author information available yet)
Anaplasma phagocytophilum detected in aborting cows on rough grazingLead poisoning in bullocksPersistent bovine viral diarrhoea virus infection and colisepticaemia in a 20-hour-old calfAbortion due to bovine herpesvirus 1 in a four-year-old cowTickborne fever in lambsInfectious sinusitis due to Mycoplasma gallisepticum in pheasants These are among matters discussed in the disease surveillance report for May 2016 from SAC Consulting: Veterinary Services (SAC C VS).
August 20, 2016: Veterinary Record
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