keyword
https://read.qxmd.com/read/38488559/growth-hormone-promotes-the-reconstruction-of-injured-axons-in-the-hypothalamo-neurohypophyseal-system
#1
JOURNAL ARTICLE
Kai Li, Zhanpeng Feng, Zhiwei Xiong, Jun Pan, Mingfeng Zhou, Weizhao Li, Yichao Ou, Guangsen Wu, Mengjie Che, Haodong Gong, Junjie Peng, Xingqin Wang, Songtao Qi, Junxiang Peng
JOURNAL/nrgr/04.03/01300535-202410000-00026/figure1/v/2024-02-06T055622Z/r/image-tiff Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38465024/endocrinopathies-in-a-pediatric-patient-post-anatomical-hemispherectomy-for-rasmussen-s-encephalitis-treatment-a-case-report
#2
Jaron C Sanchez, Markeeta T Belmar, Jason C Sanchez, Kenny Nguygen
Hemispherectomy is a neurosurgical procedure that is frequently performed in pediatric patients diagnosed with Rasmussen's encephalitis. Postoperative complications include immediate complications such as hydrocephalus and hemorrhage and behavioral complications such as language impairments and contralateral weakness. However, there are limited studies or case reports that address the potential endocrinopathies associated with this and other pediatric epileptic surgeries. This case report describes the endocrinopathies following an anatomical hemispherectomy procedure...
February 2024: Curēus
https://read.qxmd.com/read/38450501/an-adolescent-with-wolfram-syndrome-and-central-sleep-apnea
#3
Jamie C Harris, Jay D Kenkare, Craig M Schramm
Wolfram syndrome (WS) is a rare autosomal recessive disorder affecting approximately 1:500,000 individuals. The disorder is most commonly caused by mutations in the WFS1 gene, which encodes an endoplasmic reticulum (ER) protein, wolframin, which is thought to protect against ER stress-related apoptosis. The major clinical findings of WS are diabetes mellitus and optic atrophy, both of which usually appear before 16 years of age. Common additional findings include sensorineural hearing impairment, central diabetes insipidus, non-autoimmune hypothyroidism, delayed puberty, neurogenic bladder, cerebellar ataxia, and psychiatric disorders...
March 7, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/38444307/pituitary-stalk-interruption-syndrome-due-to-novel-robo1-mutation-presenting-as-combined-pituitary-hormone-deficiency-and-central-diabetes-insipidus
#4
Raiz Ahmad Misgar, Ankit Chhabra, Ajaz Qadir, Sidharth Arora, Arshad Iqbal Wani, Mir Iftikhar Bashir, Shariq Rashid Masoodi
OBJECTIVES: The genetic causes of pituitary stalk interruption syndrome (PSIS) remain elusive in 95 % of cases. The roundabout receptor-1 gene ( ROBO1 ) plays critical roles in axonal guidance and cell migration. Recently, mutations in the ROBO1 gene have been reported patients with PSIS. CASE PRESENTATION: We report a 2.9-year-old boy with PSIS who presented with combined pituitary hormone deficiency, central diabetes insipidus, and the classical triad of MRI findings...
March 7, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38438767/clinical-characteristics-and-predictive-factors-of-delayed-diagnosis-in-patients-with-sellar-germ-cell-tumors
#5
JOURNAL ARTICLE
Tao Tong, Han Chen, Caiyan Mo, Liyong Zhong
PURPOSE: To investigate the clinical characteristics and predictive factors associated with delayed diagnosis in patients with sellar germ cell tumors (GCTs), aiming for early diagnosis. METHODS: A total of 345 patients with sellar GCTs were retrospectively collected. Patients were classified into a delayed diagnosis group (> 6 months from onset to diagnosis) and a non-delayed diagnosis group (≤ 6 months). We compared general characteristics, clinical symptoms, diagnostic methods, treatment strategies, tumor prognosis, and pituitary function between the two groups...
March 4, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38316255/diabetes-insipidus-vasopressin-deficiency%C3%A2
#6
REVIEW
Fanny Chasseloup, Antoine Tabarin, Philippe Chanson
Diabetes insipidus is a disorder characterized by hypo-osmotic polyuria secondary to abnormal synthesis, regulation, or renal action of antidiuretic hormone. Recently, an expert group, with the support of patient associations, proposed that diabetes insipidus be renamed to avoid confusion with diabetes mellitus. The most common form of diabetes insipidus is secondary to a dysfunction in the neurohypophysis (central diabetes insipidus) and would be therefore termed 'vasopressin deficiency'. The rarer form, which is linked to renal vasopressin resistance (nephrogenic diabetes insipidus), would then be named 'vasopressin resistance'...
February 3, 2024: Annales D'endocrinologie
https://read.qxmd.com/read/38298322/correction-of-in-patient-severe-hypernatremia-in-an-81-year-old-female-with-hypopituitarism
#7
Luke Henwood, Austin Vaughn, Ravish Narvel, Rahil Gour
Hypernatremia has been significantly associated with in-hospital mortality and discharge to long-term care facilities. The appropriate correction of electrolyte disturbances, especially sodium, is important to consider to prevent the addition of central nervous system disturbances, such as cerebral edema and eventual brain injury. The importance of maintaining a proper correction of hypernatremia has been well studied and used in clinical practice. Choosing to use a hypotonic solution is a key principle. It is of utmost importance to adjust the rate of correction based on the patient's symptoms, underlying etiology, and associated comorbidities...
January 2024: Curēus
https://read.qxmd.com/read/38291597/the-diagnostic-performance-of-copeptin-in-clinical-practice-a-prospective-study
#8
JOURNAL ARTICLE
Penelope Trimpou, Ioannis Bounias, Olof Ehn, Ola Hammarsten, Oskar Ragnarsson
OBJECTIVE: Plasma copeptin is a relatively new biomarker for evaluation of arginine vasopressin (AVP) secretion. The aim of this study was to test the diagnostic performance of copeptin in patients with polyuria-polydipsia syndrome. DESIGN, PATIENTS AND MEASUREMENTS: This was a prospective study where 88 patients with polyuria-polydipsia syndrome were evaluated with a water deprivation test (WDT). Weight, urine osmolality, urine specific gravity, and plasma copeptin were collected at baseline, after 8 h, and at termination of the WDT when one of the following had been reached: (i) >3% weight reduction, (ii) urine specific gravity >1...
January 30, 2024: Clinical Endocrinology
https://read.qxmd.com/read/38276973/pediatric-sellar-teratoma-case-report-and-review-of-the-literature
#9
JOURNAL ARTICLE
Katja Kürner, Ladina Greuter, Michel Roethlisberger, Yves Brand, Stephan Frank, Raphael Guzman, Jehuda Soleman
BACKGROUND: Intracranial teratoma represents a rare neoplasm, occurring predominantly during childhood. Characteristic symptoms depend on the location but are mainly hydrocephalus, visual disturbances, hypopituitarism, and diabetes insipidus. Initial diagnosis can be challenging due to similar radiological features in both teratomas and other lesions such as craniopharyngiomas. Gross total resection is recommended if feasible and associated with a good prognosis. CASE DESCRIPTION: A 10-year-old girl presented with newly diagnosed growth retardation, fatigue, cephalgia and bilateral hemianopia...
January 26, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38258733/immune-checkpoint-inhibitors-induced-central-diabetes-insipidus-in-the-course-of-panhypophysitis
#10
JOURNAL ARTICLE
Karolina Cylke-Falkowska, Izabella Czajka-Oraniec, Maria Stelmachowska-Banaś, Wojciech Zgliczyński
No abstract text is available yet for this article.
January 23, 2024: Polish Archives of Internal Medicine
https://read.qxmd.com/read/38243973/transient-central-diabetes-insipidus-arginine-vasopressin-deficiency-following-sars-cov-2-vaccination-a-case-report-and-literature-review
#11
Pierluigi Mazzeo, Filippo Ceccato, Renzo Manara, Cinzia Mazzon, Mattia Barbot
INTRODUCTION: Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people, causing the COVID-19 global pandemic. The use of novel technologies led to the development of different types of SARS-CoV-2 vaccines that have reduced severe disease courses and related deaths. Besides the positive impact of vaccination on the pandemic, local and systemic side effects have been reported; they are usually mild to moderate, although also serious adverse events have been described...
January 12, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/38213880/pituitary-adenoma-coexistent-with-sellar-clear-cell-meningioma-unattached-to-the-dura-case-report-and-treatment-considerations
#12
Grégoire P Chatain, Keanu Chee, Meghan Driscoll, B K Kleinschmidt-DeMasters, Kevin O Lillehei
Collision tumors involving the sella are rare. Intrasellar collision tumors are most commonly composed of a combination of pituitary adenomas and pituitary neuroendocrine tumors; however, collision tumors consisting of a pituitary adenoma and intrasellar meningioma are exceedingly rare. The authors present the case of a 47-year-old man who presented with progressive right eye vision loss. Magnetic resonance imaging showed a large, heterogeneously enhancing sellar mass with suprasellar extension. Using a transcranial approach with a right subfrontal craniotomy, near-total resection of the mass was achieved...
January 2024: Journal of Neurological Surgery Reports
https://read.qxmd.com/read/38171637/severe-osmotic-demyelination-syndrome-with-cortical-involvement-in-the-context-of-severe-hyponatremia-and-central-diabetes-insipidus-an-uncommon-presentation-of-an-unusual-combination
#13
JOURNAL ARTICLE
Andres Giglio, Andres Reccius, Andres Ferre, Jorge Dreyse
BACKGROUND: Osmotic demyelination syndrome (ODS) with cerebral cortical involvement is a rare complication of severe hyponatremia correction. Careful management of hyponatremia is crucial, particularly in patients with risk factors, such as alcohol use disorder and diabetes insipidus. CASE: A patient in his 40s with a history of alcohol use disorder and central diabetes insipidus developed ODS after a 24 mEq/L osmolar increase during the treatment of hyponatremia...
January 3, 2024: BMJ Case Reports
https://read.qxmd.com/read/38155322/the-diagnostic-role-of-arginine-stimulated-copeptin-in-the-differential-diagnosis-of-polyuria-polydipsia-syndrome-pps-in-pediatric-age
#14
JOURNAL ARTICLE
Gerdi Tuli, Jessica Munarin, Luisa De Sanctis
PURPOSE: In recent years, copeptin stimulation through arginine administration has been evaluated as a new potential tool in the differential diagnosis of polyuria-polydipsia syndrome (PPS) in adults; to date very few data, all retrospective, exist in pediatric age. The aim of this prospective study is to evaluate the diagnostic performance of the arginine-stimulation test for copeptin in a cohort of pediatric patients affected by PPS. METHODS: All children (<18 years) referred to the Department of Pediatric Endocrinology of the Regina Margherita Children Hospital for polyuria-polydipsia in the period January 2021-June 2023 were enrolled...
December 28, 2023: Endocrine
https://read.qxmd.com/read/38099068/case-report-invasive-neuromonitoring-in-status-epilepticus-induced-hypoxic-ischemic-brain-injury
#15
Karandeep Singh Bhatti, Swarna Rajagopalan
OBJECTIVES: Literature on invasive neuromonitoring and bilateral decompressive craniectomies (BDC) in patients with refractory status epilepticus (RSE)-mediated hypoxic-ischemic brain injury (HIBI) is limited. Neuromonitoring can guide decision making and treatment escalation. METHODS AND RESULTS: We report a case of a 17 years-old male who was admitted to our hospital's intensive care unit for RSE. HIBI was detected on neuroimaging on this patient's second day of admission after he developed central diabetes insipidus (DI)...
2023: Frontiers in Neurology
https://read.qxmd.com/read/38092289/importance-of-intraoperative-factors-in-postoperative-arginine-vasopressin-deficiency-after-pituitary-adenoma-surgery
#16
JOURNAL ARTICLE
Nasim Alidaei, Guive Sharifi, Zahra Davoudi
OBJECTIVE: Pituitary adenoma is the most frequent tumor in the sellar region. Arginine-vasopressin-deficiency (AVP-D), formerly known as central Diabetes-Insipidus (DI), is a common complication after pituitary surgeries. In this study, we reviewed patients with pituitary adenomas after endoscopic transsphenoidal surgery (ETSS), evaluated the incidence of postoperative AVP-D and determined associated risk-factors. METHOD: We retrospectively studied 520 patients who underwent ETSS for pituitary adenomas, and evaluated perioperative risk factors and their associations with postoperative AVP-D...
December 11, 2023: Endocrine Practice
https://read.qxmd.com/read/38054223/chordoid-gliomas-of-the-third-ventricle
#17
JOURNAL ARTICLE
A N Konovalov, I V Chernov, M V Ryzhova, D I Pitskhelauri, Yu V Kushel, L I Astafieva, O I Sharipov, I S Klochkova, Yu G Sidneva, G P Snigireva, P L Kalinin
BACKGROUND: Chordoid glioma is a rare slow-growing tumor of the central nervous system. Available world experience includes no more than 200 cases (lesion of the third ventricle in absolute majority of cases). Recognition and treatment of chordoid glioma are currently difficult problems due to small incidence of this disease. OBJECTIVE: To describe clinical manifestations and surgical treatment of chordoid glioma of the third ventricle considering literature data and own experience...
2023: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://read.qxmd.com/read/38031464/endocrine-features-of-langerhans-cell-histiocytosis-in-paediatric-patients-a-30-year-review
#18
JOURNAL ARTICLE
Ashley Alexander, Margaret Zacharin
UNLABELLED: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder characterised as an inflammatory myeloid neoplasia. Endocrine manifestations of LCH, particularly central diabetes insipidus (CDI), have been described from the 1940s, through case studies and small cohort analyses. There are limited Australian paediatric data described in recent literature. AIM: To document the incidence of endocrine features in paediatric patients with LCH, treated at a tertiary paediatric centre in Victoria, Australia...
November 29, 2023: Journal of Paediatrics and Child Health
https://read.qxmd.com/read/38029928/clinical-characteristics-of-adipsic-diabetes-insipidus
#19
JOURNAL ARTICLE
Tingjun Yang, Wei Wu, Xiaoyu Liu, Boni Xiang, Quanya Sun, Shuo Zhang, Yuan Zhuang, Zhiwen Yin, Qiongyue Zhang, Yanpei Cao, Hongying Ye
OBJECTIVE: Adipsic diabetes insipidus (ADI) is a life-threatening disease. It is characterized by arginine vasopressin deficiency and thirst absence. Data about clinical characteristics of ADI were scarce. This study investigated the clinical features of hospitalized ADI patients. METHODS: A retrospective study was conducted of hospitalized ADI patients admitted to the Endocrinology Department of Huashan Hospital between January 2014 and December 2021, compared with central diabetes insipidus (CDI) patients with normal thirst...
November 27, 2023: Endocrine Practice
https://read.qxmd.com/read/38021079/hypothalamic-and-pituitary-dysfunction-after-extensive-brain-surgery-there-is-thirst-for-more-knowledge
#20
Francesca Galbiati, George A Stamatiades, Wenya L Bi, Ana Paula Abreu
Craniopharyngiomas are tumors originating from the infundibular stalk, extending to the parasellar and suprasellar region, thereby conferring multiple risks of this region. In particular, hypothalamic and pituitary damage related to its natural history as well as treatment effects of craniopharyngiomas substantially affect life expectancy and quality of life. Here, we describe an adult patient presenting with polyuria, memory, and visual field impairment secondary to concurrent craniopharyngioma and intraventricular glioma...
November 2023: JCEM Case Rep
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