keyword
MENU ▼
Read by QxMD icon Read
search

Disorder of sex development

keyword
https://www.readbyqxmd.com/read/29222403/common-pathophysiology-in-multiple-mouse-models-of-pitt-hopkins-syndrome
#1
Courtney Thaxton, Alexander D Kloth, Ellen P Clark, Sheryl S Moy, Raymond A Chitwood, Benjamin D Philpot
Mutations or deletions of the transcription factor TCF4 are linked to Pitt-Hopkins syndrome (PTHS) and schizophrenia, suggesting that the precise pathogenic mutations dictate cellular, synaptic, and behavioral consequences. Here we generated two novel mouse models of PTHS-one that mimics the most common pathogenic TCF4 point mutation (human R580W, mouse R579W) and one that deletes three pathogenic arginines-and explored phenotypes of these lines alongside models of pan-cellular or CNS-specific heterozygous Tcf4 disruption...
December 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29220746/testing-bidirectional-relationships-between-alcohol-use-and-depressive-symptoms-what-is-the-role-of-the-serotonin-transporter-gene
#2
Roy Otten, Carmen S van der Zwaluw, Rutger C Engels
Alcohol abuse often co-exists with a major depressive disorder. In order to understand the development of this comorbidity, it is important to concentrate on the preceding process. It has been suggested that the link between alcohol use and depressive symptoms is a result of an interaction with genetic factors. The aim of this study was to longitudinally examine the effect of the 5-HTTLPR genotype on the association between depressive symptoms and alcohol use in a Dutch community sample. Following a stepwise approach, bivariate correlations, longitudinal regression analyses, and latent growth curve analyses were separately conducted for 316 males and 321 females...
August 13, 2017: Alcohol
https://www.readbyqxmd.com/read/29220612/coexistence-of-trisomy-13-and-sry-xx-ovotesticular-disorder-of-sex-development
#3
Gizem Ürel Demir, Özlem Akgün Doğan, Pelin Özlem Şimşek Kiper, Gülen Eda Utine, Koray Boduroğlu, Safak Gucer, Mehmet Alikaşifoğlu
INTRODUCTION: Ovotesticular disorder of sex development (OT-DSD) is a rare disorder of sexual differentiation characterized by the presence of both testicular and ovarian tissue in an individual and the majority of cases have been reported with 46,XX karyotype. In 46,XX cases, testicular differentiation may occur due to the translocation of SRY to the X chromosome or to an autosome. CASE REPORT: Herein, we present a female newborn with a combination of trisomy 13 and SRY (-) XX OT-DSD...
December 8, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29217656/anti-inflammatory-effects-of-omega-3-fatty-acids-in-the-brain-physiological-mechanisms-and-relevance-to-pharmacology
#4
REVIEW
Sophie Layé, Agnès Nadjar, Corinne Joffre, Richard P Bazinet
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert structural components of brain, largely important for the formation of cellular membranes. Over the past 10 years, a host of bioactive lipid mediators that are enzymatically derived from arachidonic acid, the main n-6 PUFA, and docosahexaenoic acid, the main n-3 PUFA in the brain, known to regulate peripheral immune function, have been detected in the brain and shown to regulate microglia activation. Recent advances have focused on how PUFA regulate the molecular signaling of microglia, especially in the context of neuroinflammation and behavior...
January 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29216570/the-effects-of-alcohol-hangover-on-future-drinking-behavior-and-the-development-of-alcohol-problems
#5
Kelly E Courtney, Matthew Worley, Norma Castro, Susan F Tapert
INTRODUCTION: Alcohol hangover experiences in young adulthood have been shown to predict more subsequent alcohol problems. Hangover susceptibility appears to be partially heritable and related to family history of alcohol use disorders. However, very little is known about the developmental course of these associations and whether they are accounted for by an individual's drinking history. The goal of this study is to investigate the prospective and unique relationships between family history of alcohol use disorders, severity of alcohol hangover experiences in adolescence, and later alcohol use and related problems measured over 13years...
November 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29215750/questionnaire-based-problematic-relationship-to-eating-and-food-is-associated-with-25-year-body-mass-index-trajectories-during-midlife-the-coronary-artery-risk-development-in-young-adults-cardia-study
#6
Cynthia Yoon, David R Jacobs, Daniel A Duprez, Gareth Dutton, Cora E Lewis, Dianne Neumark-Sztainer, Lyn M Steffen, Delia S West, Susan M Mason
OBJECTIVE: Problematic eating behaviors and attitudes are of public health concern. Questionnaire-based assessment of these behaviors is important for large-scale research on eating behaviors. The questionnaire on eating and weight patterns-revised (QEWP-R) measures potential problematic behaviors and attitudes toward food (including anxieties, compensatory actions, overeating and loss of control, dieting, and shape concerns) that in aggregate may indicate diagnosable eating disorders...
December 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29212532/delivery-of-screening-and-brief-intervention-for-unhealthy-alcohol-use-in-an-urban-academic-federally-qualified-health-center
#7
Marcus A Bachhuber, Megan A O'Grady, Henry Chung, Charles J Neighbors, Joseph DeLuca, Elenita M D'Aloia, Arelis Diaz, Chinazo O Cunningham
BACKGROUND: Screening and brief intervention (SBI) for unhealthy drinking has not been widely implemented in primary care partly due to reliance on physicians to perform it. METHODS: We implemented a model of nursing staff-delivered SBI for unhealthy drinking for adult patients receiving primary care at an academically-affiliated Federally Qualified Health Center in the Bronx, NY. Our model consisted of nursing staff screening all patients with the alcohol use disorders identification test consumption questions (AUDIT-C) and, if screening positive, providing BI or referral to specialty services...
December 7, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29211317/neurobiology-of-gender-identity-and-sexual-orientation
#8
REVIEW
Charles E Roselli
Sexual identity and sexual orientation are independent components of a person's sexual identity. These dimensions are most often in harmony with each other and with an individual's genital sex, but not always. This review discusses the relationship of sexual identity and sexual orientation to prenatal factors that act to shape the development of the brain and the expression of sexual behaviors in animals and humans. One major influence discussed relates to organizational effects that the early hormone environment exerts on both gender identity and sexual orientation...
December 6, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29210144/adolescent-impulsivity-as-a-sex-dependent-and-subtype-dependent-predictor-of-impulsivity-alcohol-drinking-and-dopamine-d2-receptor-expression-in-adult-rats
#9
Lindsey R Hammerslag, Amogh P Belagodu, Olubankole A Aladesuyi Arogundade, Angela G Karountzos, Qingrou Guo, Roberto Galvez, Brent W Roberts, Joshua M Gulley
Impulsivity is a personality trait associated with a heightened risk for drug use and other psychiatric conditions. Because impulsivity-related disorders typically emerge during adolescence, there has been interest in exploring methods for identifying adolescents that will be at risk to develop substance use disorders in adulthood. Here, we used a rodent model to assess inhibitory control (impulsive action) and impulsive decision making (impulsive choice) during adolescence (43-50 days old) or adulthood (93-100 days old) and then examined the impact of development on these impulsivity traits by re-testing rats 50 days later...
December 5, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29203521/persistent-opioid-use-among-pediatric-patients-after-surgery
#10
Calista M Harbaugh, Jay S Lee, Hsou Mei Hu, Sean Esteban McCabe, Terri Voepel-Lewis, Michael J Englesbe, Chad M Brummett, Jennifer F Waljee
BACKGROUND: Despite efforts to reduce nonmedical opioid misuse, little is known about the development of persistent opioid use after surgery among adolescents and young adults. We hypothesized that there is an increased incidence of prolonged opioid refills among adolescents and young adults who received prescription opioids after surgery compared with nonsurgical patients. METHODS: We performed a retrospective cohort study by using commercial claims from the Truven Health Marketscan research databases from January 1, 2010, to December 31, 2014...
December 4, 2017: Pediatrics
https://www.readbyqxmd.com/read/29203443/examination-of-emotion-induced-changes-in-eating-a-latent-profile-analysis-of-the-emotional-appetite-questionnaire
#11
L Bourdier, Y Morvan, G Kotbagi, L Kern, L Romo, S Berthoz
It is now recognized that emotions can influence food intake. While some people report eating less when distressed, others report either no change of eating or eating more in the same condition. The question whether this interindividual variability also occurs in response to positive emotions has been overlooked in most studies on Emotional Eating (EE). Using the Emotional Appetite Questionnaire (EMAQ) and Latent Profile Analysis, this study aimed to examine the existence of latent emotion-induced changes in eating profiles, and explore how these profiles differ by testing their relations with 1) age and sex, 2) BMI and risk for eating disorders (ED) and 3) factors that are known to be associated with EE such as perceived positive/negative feelings, depression, anxiety, stress symptoms and impulsivity...
December 1, 2017: Appetite
https://www.readbyqxmd.com/read/29201068/gender-identity-in-patients-with-congenital-adrenal-hyperplasia
#12
Maryam Razzaghy-Azar, Sakineh Karimi, Elham Shirazi
Background: Sex assignment in infancy for patients with disorder of sex development (DSD) is a challenging problem. Some of the patients with congenital adrenal hyperplasia (CAH) have DSD that may affect their gender identity. Objectives: The study aimed to assess gender identity in patients with CAH. Methods: In this study, 52 patients with CAH, including 22 prepubertal children and 30 adolescents and adults, were assessed using two separate gender identity questionnaires for children and adults based on the criteria of diagnostic and statistical manual of mental disorders, 5th edition...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29200555/erectile-dysfunction-an-underestimated-presentation-in-patients-with-diabetes-mellitus
#13
Zeeshan Anwar, Vishal Sinha, Sayantanava Mitra, Ashwani Kumar Mishra, Mahboobul Hasan Ansari, Abhishek Bharti, Vipin Kumar, Ashwini Kumar Nigam
Introduction: Erectile dysfunction (ED) is a common complication of diabetes mellitus. ED, like other sexual disorders, is often under-reported and under-diagnosed, as talking about sex is considered a taboo in our society. Methodology: All the male patients with diabetes mellitus (with or without active complaints of ED) attending Medicine or Psychiatry OPD of the institute during the study period were enrolled in the study. They were investigated for their body-mass index (BMI), blood sugar and lipid profile; and were assessed on HAM-D, General Health Questionnaire-30, IIEF, sex myth checklist and QOL Instrument for Indian Diabetes Patients (QOLID)...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29198504/female-sexual-dysfunction-medical-and-psychological-treatments-committee-14
#14
Sheryl A Kingsberg, Stanley Althof, James A Simon, Andrea Bradford, Johannes Bitzer, Joana Carvalho, Kathryn E Flynn, Rossella E Nappi, Jennifer B Reese, Roya L Rezaee, Leslie Schover, Jan L Shifrin
INTRODUCTION: Since the millennium we have witnessed significant strides in the science and treatment of female sexual dysfunction (FSD). This forward progress has included (i) the development of new theoretical models to describe healthy and dysfunctional sexual responses in women; (ii) alternative classification strategies of female sexual disorders; (iii) major advances in brain, hormonal, psychological, and interpersonal research focusing on etiologic factors and treatment approaches; (iv) strong and effective public advocacy for FSD; and (v) greater educational awareness of the impact of FSD on the woman and her partner...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29197983/reduced-sensitivity-to-reinforcement-in-adolescent-compared-to-adult-sprague-dawley-rats-of-both-sexes
#15
Emily R Hankosky, Sara R Westbrook, Rachel M Haake, Michela Marinelli, Joshua M Gulley
RATIONALE: Adolescence is a period of considerable development of brain and behavior and is the time during which most drug use is initiated. OBJECTIVE: Age-dependent differences in motivated behaviors may be one of the factors that contribute to heightened vulnerability to developing substance use disorders, so we sought to compare age differences in methamphetamine (METH) and saccharin seeking. METHODS: Beginning during adolescence or adulthood, male and female Sprague-Dawley rats were trained to self-administer 0...
December 2, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29197507/association-between-a-functional-interleukin-6-receptor-genetic-variant-and-risk-of-depression-and-psychosis-in-a-population-based-birth-cohort
#16
Golam M Khandaker, Stanley Zammit, Stephen Burgess, Glyn Lewis, Peter B Jones
OBJECTIVE: Interleukin 6 (IL-6) levels are commonly elevated in patients with depression and psychosis and in people who are at risk of developing these disorders. A common, functional variant in the IL6R gene (IL6R Asp358Ala; rs2228145 A>C) is known to dampen down inflammation by impairing IL6R signaling. We have examined the association of Asp358Ala with diagnosis of depression and psychosis, serum IL-6, CRP levels, and a number of risk factors commonly linked with inflammation, depression or psychosis...
November 29, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29197324/altered-phosphorylation-electrophysiology-and-behavior-on-attenuation-of-pde4b-action-in-hippocampus
#17
Susan L Campbell, Thomas van Groen, Inga Kadish, Lisa High Mitchell Smoot, Graeme B Bolger
BACKGROUND: PDE4 cyclic nucleotide phosphodiesterases regulate 3', 5' cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions. The PDE4 isoform PDE4B1 also interacts with the DISC1 protein, implicated in neural development and behavioral disorders. The cellular functions of PDE4B1 have been investigated extensively, but its function(s) in the intact organism remained unexplored...
December 2, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/29196732/human-crmp4-mutation-and-disrupted-crmp4-expression-in-mice-are-associated-with-asd-characteristics-and-sexual-dimorphism
#18
Atsuhiro Tsutiya, Yui Nakano, Emily Hansen-Kiss, Benjamin Kelly, Masugi Nishihara, Yoshio Goshima, Don Corsmeier, Peter White, Gail E Herman, Ritsuko Ohtani-Kaneko
Autism spectrum disorders (ASD) are more common among boys than girls. The mechanisms responsible for ASD symptoms and their sex differences remain mostly unclear. We previously identified collapsin response mediator protein 4 (CRMP4) as a protein exhibiting sex-different expression during sexual differentiation of the hypothalamic sexually dimorphic nucleus. This study investigated the relationship between the sex-different development of autistic features and CRMP4 deficiency. Whole-exome sequencing detected a de novo variant (S541Y) of CRMP4 in a male ASD patient...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29194807/prevalence-of-the-amhr2-mutation-in-miniature-schnauzers-and-genetic-investigation-of-a-belgian-malinois-with-persistent-m%C3%A3-llerian-duct-syndrome
#19
M M Smit, K J Ekenstedt, K M Minor, C K Lim, Paj Leegwater, E Furrow
Persistent Müllerian duct syndrome (PMDS) is a sex-limited disorder in which males develop portions of the female reproductive tract. Important consequences of PMDS are cryptorchidism and its sequelae of infertility and increased risk of testicular cancer. Anti-Müllerian hormone (AMH) and its receptor (AMHR2) induce the regression of the Müllerian ducts in male embryos. In Miniature Schnauzer dogs, the genetic basis has been identified as an autosomal recessive nonsense mutation in AMHR2, but the allele frequency of the mutation is unknown...
December 1, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29193493/the-sleep-condition-indicator-reference-values-derived-from-a-sample-of-200%C3%A2-000-adults
#20
Colin A Espie, Pedro Farias Machado, Jenna R Carl, Simon D Kyle, John Cape, A Niroshan Siriwardena, Annemarie I Luik
The Sleep Condition Indicator (SCI) is an eight-item rating scale that was developed to screen for insomnia disorder based on DSM-5 criteria. It has been shown previously to have good psychometric properties among several language translations. We developed age- and sex-referenced values for the SCI to assist the evaluation of insomnia in everyday clinical practice. A random sample of 200 000 individuals (58% women, mean age: 31 ± 13 years) was selected from those who had completed the SCI via several internet platforms...
November 29, 2017: Journal of Sleep Research
keyword
keyword
85264
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"