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etanercept in alzheimers disease

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https://www.readbyqxmd.com/read/27470609/treatment-for-rheumatoid-arthritis-and-risk-of-alzheimer-s-disease-a-nested-case-control-analysis
#1
Richard C Chou, Michael Kane, Sanjay Ghimire, Shiva Gautam, Jiang Gui
INTRODUCTION: It is increasingly becoming accepted that inflammation may play an important role in the pathogenesis of Alzheimer's disease (AD), as several immune-related genes have been associated with AD. Among these is tumor necrosis factor (TNF)-α, a proinflammatory cytokine known to play an important role in autoimmune disorders, including rheumatoid arthritis (RA). Although AD and RA appear to involve similar pathological mechanisms through the production of TNF-α, the relationship between AD and RA remains unknown...
July 28, 2016: CNS Drugs
https://www.readbyqxmd.com/read/26644054/etanercept-in-alzheimer-disease-a-randomized-placebo-controlled-double-blind-phase-2-trial
#2
(no author information available yet)
No abstract text is available yet for this article.
December 8, 2015: Neurology
https://www.readbyqxmd.com/read/26644053/etanercept-in-alzheimer-disease-a-randomized-placebo-controlled-double-blind-phase-2-trial
#3
LETTER
Ayse N Tufan, Fatih Tufan
No abstract text is available yet for this article.
December 8, 2015: Neurology
https://www.readbyqxmd.com/read/26560086/central-delivery-of-iodine-125-labeled-cetuximab-etanercept-and-anakinra-after-perispinal-injection-in-rats-possible-implications-for-treating-alzheimer-s-disease
#4
Megan E Roerink, Rob Jm Groen, Gerben Franssen, Bianca Lemmers-van de Weem, Otto C Boerman, Jos Wm van der Meer
INTRODUCTION: Alzheimer's disease is a debilitating condition, and the search for an effective treatment is ongoing. Inflammation, in reaction to amyloid deposition, is thought to accelerate cognitive decline. With tumor necrosis factor α being an important proinflammatory cytokine, a recent trial investigated the effect of the tumor necrosis factor α inhibitor etanercept after peripheral administration in patients with Alzheimer's disease. Although there was no significant effect, others have claimed spectacular effects of etanercept after perispinal injection...
2015: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/25934853/etanercept-in-alzheimer-disease-a-randomized-placebo-controlled-double-blind-phase-2-trial
#5
RANDOMIZED CONTROLLED TRIAL
Joseph Butchart, Laura Brook, Vivienne Hopkins, Jessica Teeling, Ursula Püntener, David Culliford, Richard Sharples, Saif Sharif, Brady McFarlane, Rachel Raybould, Rhodri Thomas, Peter Passmore, V Hugh Perry, Clive Holmes
OBJECTIVES: To determine whether the tumor necrosis factor α inhibitor etanercept is well tolerated and obtain preliminary data on its safety in Alzheimer disease dementia. METHODS: In a double-blind study, patients with mild to moderate Alzheimer disease dementia were randomized (1:1) to subcutaneous etanercept (50 mg) once weekly or identical placebo over a 24-week period. Tolerability and safety of this medication was recorded including secondary outcomes of cognition, global function, behavior, and systemic cytokine levels at baseline, 12 weeks, 24 weeks, and following a 4-week washout period...
May 26, 2015: Neurology
https://www.readbyqxmd.com/read/25596877/effects-of-systemic-thalidomide-and-intracerebroventricular-etanercept-and-infliximab-administration-in-a-streptozotocin-induced-dementia-model-in-rats
#6
H Kübra Elçioğlu, Levent Kabasakal, Fatih Tufan, Ömer H Elçioğlu, Seyhun Solakoglu, Tugba Kotil, Mehmet Akif Karan
Tumor necrosis factor-alpha (TNF-α) upregulation enhances amyloid β (Aβ) induced neurotoxicity in Alzheimer's disease (AD). Intracerebroventricular streptozotocin (STZ) administration causes pathological changes and cognitive deficits similar to those seen in AD by causing impairment of brain glucose and energy metabolism. Recent reports indicate a protective role of Thalidomide, Etanercept, and Infliximab, all of which have anti-TNF-α activity, against cognitive and neuropathological changes in experimental and clinical studies...
March 2015: Acta Histochemica
https://www.readbyqxmd.com/read/22191562/deciphering-the-physiology-underlying-the-rapid-clinical-effects-of-perispinal-etanercept-in-alzheimer-s-disease
#7
REVIEW
Edward Tobinick
Excess tumor necrosis factor (TNF) plays a pivotal role in the pathogenesis of Alzheimer's disease(AD). Clinical improvement following perispinal administration of etanercept in patients with Alzheimer's disease and other forms of dementia and brain dysfunction is characteristically evident within minutes. The rapidity and constellation of the clinical effects across multiple domains (cognition, mood, memory, motor function, and attention) suggest they are mediated by non-synaptic signaling mechanisms previously unrecognized for etanercept...
January 2012: Current Alzheimer Research
https://www.readbyqxmd.com/read/21504126/neuroinflammation-in-alzheimer-s-disease-are-nsaids-and-selective-cox-2-inhibitors-the-next-line-of-therapy
#8
REVIEW
Catherine H Trepanier, Norton W Milgram
Alzheimer's disease (AD) is currently treated with cholinergic and glutamatergic therapies, which provide symptomatic benefit but do not reverse the underlying pathology or cognitive deficits. The prevalence of AD is expected to triple over the next 50 years, creating an urgency to develop effective "disease-modifying" therapies to reduce the economic burden of this devastating disorder. One of the main areas of therapeutic focus has been an antiinflammatory strategy based on an inflammatory hypothesis of AD...
2010: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/21254790/rapid-improvement-of-chronic-stroke-deficits-after-perispinal-etanercept-three-consecutive-cases
#9
Edward Tobinick
BACKGROUND: Thrombolytic therapy reduces stroke size and disability by reperfusion and salvage of ischaemic penumbra. Emerging evidence suggests that retrieved penumbra may be the site of ongoing inflammatory pathology that includes extensive microglial activation. Microglial activation may be associated with excessive levels of tumour necrosis factor (TNF) and resultant neurotoxicity. Etanercept, a potent biologic TNF antagonist, reduces microglial activation in experimental models and has been therapeutically effective in models of brain and neuronal injury...
February 2011: CNS Drugs
https://www.readbyqxmd.com/read/21155625/alzheimer-s-disease-the-pros-and-cons-of-pharmaceutical-nutritional-botanical-and-stimulatory-therapies-with-a-discussion-of-treatment-strategies-from-the-perspective-of-patients-and-practitioners
#10
REVIEW
Keith A Wollen
Alzheimer's disease (AD) is characterized by dysfunctional intracellular and extracellular biochemical processes that result in neuron death. This article summarizes hypotheses regarding cell dysfunction in AD and discusses the effectiveness of, and problems with, different therapies. Pharmaceutical therapies discussed include cholinesterase inhibitors, memantine, antihypertensive drugs, anti-inflammatory drugs, secretase inhibitors, insulin resistance drugs, etanercept, brain-derived neurotrophic factor, and immunization...
September 2010: Alternative Medicine Review: a Journal of Clinical Therapeutic
https://www.readbyqxmd.com/read/20926740/investigational-medications-for-treatment-of-patients-with-alzheimer-disease
#11
REVIEW
Pamela E Potter
Development of effective treatments for patients with Alzheimer disease has been challenging. Currently approved treatments include acetylcholinesterase inhibitors and the N-methyl-D-aspartate receptor antagonist memantine hydrochloride. To investigate treatments in development for patients with Alzheimer disease, the author conducted a review of the literature. New approaches for treatment or prevention focus on several general areas, including cholinergic receptor agonists, drugs to decrease β-amyloid and tau levels, antiinflammatory agents, drugs to increase nitric oxide and cyclic guanosine monophosphate levels, and substances to reduce cell death or promote cellular regeneration...
September 2010: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/20704555/involvement-of-rat-hippocampal-astrocytes-in-%C3%AE-amyloid-induced-angiogenesis-and-neuroinflammation
#12
L Fioravanzo, M Venturini, R Di Liddo, R D Liddo, F Marchi, C Grandi, P P Parnigotto, M Folin
Although Alzheimer's disease (AD) is considered a neurodengenerative disorders, in the last few years a large amount of evidence has suggested that it is also a vascular pathology characterized by increased capillary density and expression of angiogenic factors. In AD the endothelium degenerates, promoting local neuroinflammation and activation of brain endothelium, perivascular microglia, pericytes, astrocytes. Excess tumor necrosis factor (TNF) in the cerebrospinal fluid (CSF), at a concentration of 25 times higher than in the control group, has been demonstrated in AD...
November 2010: Current Alzheimer Research
https://www.readbyqxmd.com/read/20586508/beneficial-neurological-effects-observed-in-a-patient-with-psoriasis-treated-with-etanercept
#13
Elisa Bassi, Claudia De Filippi
A 53-year-old woman with a history of psoriasis presented with severe cutaneous lesions associated with psoriasis. The woman was mentally handicapped; she was able to converse monosyllabically with her mother only and was very limited in social interactions. After preliminary investigations, a biological treatment was proposed. Etanercept was started in October 2006. The patient responded rapidly and, after 3 months, achieved a 75% improvement in the psoriasis area and severity index (PASI 75) score. Most notable, however, was that she began interacting with other people, even if they were not familiar to her...
2010: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/20518613/perispinal-etanercept-a-new-therapeutic-paradigm-in-neurology
#14
REVIEW
Edward Tobinick
Etanercept is a potent antagonist of TNF, a pleotropic immune signaling molecule that is also a pivotal regulator of synaptic function. Excess TNF is centrally involved in the pathogenesis of a variety of inflammatory neurological disorders, including Alzheimer's disease, sciatica, traumatic brain injury and spinal cord injury. Perispinal etanercept produces rapid improvement in both Alzheimer's disease and sciatica and in other forms of disc-related pain. Basic research and the observed clinical effects suggest that etanercept has the surprising ability to penetrate into the cerebrospinal fluid after perispinal administration...
June 2010: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/20097590/creutzfeldt-jakob-disease-in-a-patient-treated-by-etanercept-for-rheumatoid-arthritis-ra-just-a-coincidence
#15
Martin Soubrier, Stéphane Haïk, Jean-Jacques Hauw, Jean Christophe Corvol, Olivier Lyon-Caen, Maxime Dougados
We describe a patient in whom sporadic Creutzfeldt-Jakob disease (sCJD) occurred one year after the onset of etanercept therapy for rheumatoid arthritis (RA). This association could be a chance occurrence. However, TNF-alpha has been implicated in the pathogenesis of neurodegeneration in sCJD and etanercept might worsen the disease. Such an aggravation has been observed in multiple sclerosis, in which TNF-alpha is the key mediator of demyelination. It may be of interest studying the impact of treatment with TNF-alpha antagonists on prevalence and incidence of those neurodegenerative diseases involving TNF-alpha mediation, such as Alzheimer disease...
March 2010: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/19742190/the-prevention-and-treatment-of-cognitive-decline-and-dementia-an-overview-of-recent-research-on-experimental-treatments
#16
Chittaranjan Andrade, Rajiv Radhakrishnan
The prevention and treatment of cognitive impairment in the elderly has assumed increasing importance in an aging population. This article presents a qualitative review of recent research on experimental interventions for the prevention and treatment of mild cognitive impairment and Alzheimer's disease in elderly subjects. Interventions addressed range from lifestyle measures to pharmacological treatments. Epidemiological studies suggest that dietary measures, physical exercise, and mental activity may reduce the risk of cognitive impairment and Alzheimer's disease in elderly subjects...
January 2009: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/19689163/tumour-necrosis-factor-modulation-for-treatment-of-alzheimer-s-disease-rationale-and-current-evidence
#17
REVIEW
Edward Tobinick
Tumour necrosis factor (TNF), a key regulator of varied physiological mechanisms in multiple organ systems, is an immune signalling molecule produced by glia, neurons, macrophages and other immune cells. In the brain, among other functions, TNF serves as a gliotransmitter, secreted by glial cells that envelope and surround synapses, which regulates synaptic communication between neurons. The role of TNF as a gliotransmitter may help explain the profound synaptic effects of TNF that have been demonstrated in the hippocampus, in the spinal cord and in a variety of experimental models...
September 2009: CNS Drugs
https://www.readbyqxmd.com/read/19284700/rapid-intracerebroventricular-delivery-of-cu-dota-etanercept-after-peripheral-administration-demonstrated-by-pet-imaging
#18
Edward L Tobinick, Kai Chen, Xiaoyuan Chen
BACKGROUND: The cytokines interleukin-1 and tumor necrosis factor (TNF), and the cytokine blocker interleukin-1 receptor antagonist, all have been demonstrated to enter the cerebrospinal fluid (CSF) following peripheral administration. Recent reports of rapid clinical improvement in patients with Alzheimer's disease and related forms of dementia following perispinal administration of etanercept, a TNF antagonist, suggest that etanercept also has the ability to reach the brain CSF. To investigate, etanercept was labeled with a positron emitter to enable visualization of its intracranial distribution following peripheral administration by PET in an animal model...
February 27, 2009: BMC Research Notes
https://www.readbyqxmd.com/read/19027875/perispinal-etanercept-for-neuroinflammatory-disorders
#19
REVIEW
Edward Tobinick
Excess TNF is centrally involved in the pathogenesis of a variety of neuroinflammatory disorders, including Alzheimer's disease, other forms of dementia, intervertebral disc-related pain, and related disorders. TNF causes neuronal dysfunction, regulates synaptic mechanisms, and mediates amyloid-induced disruption of molecular mechanisms involved in memory. Perispinal administration of etanercept, a potent anti-TNF fusion protein, is a treatment modality whose rapid clinical effects may be related to modulation of these TNF-related mechanisms, particularly the role of TNF as a gliotransmitter capable of regulating synaptic transmission...
February 2009: Drug Discovery Today
https://www.readbyqxmd.com/read/18679537/perispinal-etanercept-produces-rapid-improvement-in-primary-progressive-aphasia-identification-of-a-novel-rapidly-reversible-tnf-mediated-pathophysiologic-mechanism
#20
Edward Tobinick
Primary progressive aphasia (PPA) is an uncommon form of progressive dementia for which there exists no established treatment. The underlying pathology may be that of either frontotemporal dementia or Alzheimer's disease. Increasing evidence suggests that excess tumor necrosis factor (TNF) may play a central role in Alzheimer's disease. Additionally, excess TNF has been documented in patients with frontotemporal dementia. Excess TNF may therefore represent a therapeutic target in PPA. Etanercept, an anti-TNF fusion protein, binds to TNF, thereby reducing its biologic effect...
2008: Medscape Journal of Medicine
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