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https://www.readbyqxmd.com/read/28317482/nutraceuticals-as-an-important-part-of-combination-therapy-in-dyslipidaemia
#1
Angelo Maria Patti, Peter P Toth, Rosaria Vincenza Giglio, Maciej Banach, Marcello Noto, Dragana Nikolic, Giuseppe Montalto, Manfredi Rizzo
Several risk factors such as abnormality of lipid metabolism (e.g. high levels of low-density lipoprotein cholesterol (LDL-C), elevated triglycerides and low levels of high-density lipoprotein cholesterol (HDL-C)) play a central role in the aetiology of cardiovascular disease (CVD). Nutraceutical combination together with a cholesterol-lowering action, when associated with suitable lifestyle, should furnish an alternative to pharmacotherapy in patients reporting statin-intolerance and in subjects at low cardiovascular risk...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28208159/two-previously-unknown-phytophthora-species-associated-with-brown-rot-of-pomelo-citrus-grandis-fruits-in-vietnam
#2
Ivana Puglisi, Alessandro De Patrizio, Leonardo Schena, Thomas Jung, Maria Evoli, Antonella Pane, Nguyen Van Hoa, Mai Van Tri, Sandra Wright, Mauritz Ramstedt, Christer Olsson, Roberto Faedda, Gaetano Magnano di San Lio, Santa Olga Cacciola
Two distinct Phytophthora taxa were found to be associated with brown rot of pomelo (Citrus grandis), a new disease of this ancestral Citrus species, in the Vinh Long province, Mekong River Delta area, southern Vietnam. On the basis of morphological characters and using the ITS1-5.8S-ITS2 region of the rDNA and the cytochrome oxidase subunit 1 (COI) as barcode genes, one of the two taxa was provisionally named as Phytophthora sp. prodigiosa, being closely related to but distinct from P. insolita, a species in Phytophthora Clade 9, while the other one, was closely related to but distinct from the Clade 2 species P...
2017: PloS One
https://www.readbyqxmd.com/read/28182421/encapsulation-of-polymethoxyflavones-in-citrus-oil-emulsion-based-delivery-systems
#3
Ying Yang, Chengying Zhao, Jingjing Chen, Guifang Tian, David Julian McClements, Hang Xiao, Jinkai Zheng
The purpose of this work was to elucidate the effects of citrus oil type on polymethoxyflavone (PMF) solubility and on the physicochemical properties of PMF-loaded emulsion-based delivery systems. Citrus oils were extracted from mandarin, orange, sweet orange, and bergamot. The major constituents were determined by GC/MS: sweet orange oil (97.4% d-limonene); mandarin oil (72.4% d-limonene); orange oil (67.2% d-limonene); and bergamot oil (34.6% linalyl acetate and 25.3% d-limonene). PMF-loaded emulsions were fabricated using 10% oil phase (containing 0...
February 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28117581/tyramine-pathways-in-citrus-plant-defense-glycoconjugates-of-tyramine-and-its-n-methylated-derivatives
#4
Luigi Servillo, Domenico Castaldo, Alfonso Giovane, Rosario Casale, Nunzia D'Onofrio, Domenico Cautela, Maria Luisa Balestrieri
Glucosylated forms of tyramine and some of its N-methylated derivatives are here reported for the first time to occur in Citrus genus plants. The compounds tyramine-O-β-d-glucoside, N-methyltyramine-O-β-d-glucoside, and N,N-dimethyltyramine-O-β-d-glucoside were detected in juice and leaves of sweet orange, bitter orange, bergamot, citron, lemon, mandarin, and pomelo. The compounds were identified by mass spectrometric analysis, enzymatic synthesis, and comparison with extracts of Stapelia hirsuta L., a plant belonging to the Apocynaceae family in which N,N-dimethyltyramine-O-β-d-glucoside was identified by others...
February 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28058251/evaluation-of-the-antibacterial-activity-of-bergamot-essential-oils-on-different-listeria-monocytogenes-strains
#5
Stefania M Marotta, Filippo Giarratana, Alessio Parco, Domenico Neri, Graziella Ziino, Alessandro Giuffrida, Antonio Panebianco
Essential oils are aromatic and volatile substances extracted from plants and characterized by antimicrobial activity. The aim of the present study was to evaluate the antibacterial activity (agar disc-diffusion method) of seven different bergamot essential oils (BEOs) on eight Listeria monocytogenes strains. Minimal inhibitory concentration (MIC) of most efficient BEOs was estimated. Extremely variable results for agar disc-diffusion method for L. monocytogenes strains were reported. One of the tested microorganisms resulted insensible to all the BEOs; 3 strains showed an inhibition from weak to null and the remaining 4 a variable susceptibility...
September 20, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27975482/bergamot-orange-phytochemical-screening-and-antioxidant-activity-of-fruit-parts-and-hydrodistillation-waste-products-of-species-cultivated-in-western-greece-and-southern-italy
#6
N Tsafantakis, E Tsiokanos, C D Kanakis, L A Skaltsounis, N Fokialakis
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27882320/mediterrasian-diet-products-that-could-raise-hdl-cholesterol-a-systematic-review
#7
REVIEW
Mariangela Rondanelli, Attilio Giacosa, Paolo Morazzoni, Davide Guido, Mario Grassi, Gabriella Morandi, Chiara Bologna, Antonella Riva, Pietro Allegrini, Simone Perna
Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjects. Methods. A systematic review has been done involving all the English written studies published from the 1st of January 1958 to the 31st of March 2016. Results. The results of this systematic review indicate that the dietary supplementation with red yeast rice, bergamot, artichoke, and virgin olive oil has promising effects on the increase of HDL-C serum levels...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27877148/changes-in-mood-states-are-induced-by-smelling-familiar-and-exotic-fragrances
#8
Orly Sarid, Michele Zaccai
Familiar fragrances usually induce positive mood states and elicit favorable evaluation. Relaxation is also widely thought to improve mood state. Yet experimental evidence on the effect of two different stimuli, fragrance smelling and breathing relaxation, on mood state, and fragrance evaluation is lacking. This study aimed to test (1) the effect of two familiar fragrances, lavender and myrtle, and two exotic fragrances, bergamot and ravensara, on perceived mood states before and after relaxation, (2) the effect of relaxation on perceived mood states for each fragrance, and (3) the effect of relaxation on fragrance evaluation as defined by adjectives...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27857849/in-vitro-effect-of-seven-essential-oils-on-the-reproduction-of-the-cattle-tick-rhipicephalus-microplus
#9
Rafael Pazinato, Andréia Volpato, Matheus D Baldissera, Roberto C V Santos, Dilmar Baretta, Rodrigo A Vaucher, Janice L Giongo, Aline A Boligon, Lenita Moura Stefani, Aleksandro Schafer Da Silva
The acaricidal effect of seven essential oils was examined in vitro against the cattle tick (Rhipicephalus microplus). Engorged female ticks were manually collected in farms of Southern Brazil and placed into petri dishes (n = 10) in order to test the following oils: juniper (Juniperus communis), palmarosa (Cymbopogon martinii), cedar (Cedrus atlantica), lemon grass (Cymbopogon citratus), ginger (Zingiber officinale), geranium (Pelargonium graveolens) and bergamot (Citrus aurantium var bergamia) at concentrations of 1%, 5%, and 10% each...
November 2016: Journal of Advanced Research
https://www.readbyqxmd.com/read/27846426/metabolic-outcomes-of-bergamot-polyphenolic-fraction-administration-in-patients-treated-with-second-generation-antipsychotics-a-pilot-study
#10
Antonio Bruno, Gianluca Pandolfo, Manuela Crucitti, Antonino Maisano, Rocco A Zoccali, Maria Rosaria Anna Muscatello
Second-generation antipsychotics (SGAs) are notoriously associated with a marked increase in body weight and with a wide range of metabolic adverse effects, and their chronic use is related with an increased risk for the development of metabolic syndrome (MS). Different adjunctive treatments have been proposed to reduce SGAs-induced weight gain and/or metabolic abnormalities with inconsistent or too limited evidence to support their regular clinical use, thus suggesting the need to find new possible treatments...
October 22, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27845763/the-chemistry-and-pharmacology-of-citrus-limonoids
#11
REVIEW
Roberta Gualdani, Maria Maddalena Cavalluzzi, Giovanni Lentini, Solomon Habtemariam
Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach...
November 13, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27755863/adverse-phototoxic-effect-of-essential-plant-oils-on-nih-3t3-cell-line-after-uv-light-exposure
#12
Svatopluk Binder, Adéla Hanáková, Kateřina Tománková, Klára Pížová, Robert Bajgar, Barbora Manišová, Kristina Kejlová, Hana Bendová, Dagmar Jírová, Hana Kolářová
AIM: Natural or artificial substances have become an inseparable part of our lives. It is questionable whether adequate testing has been performed in order to ensure these substances do not pose a serious health risk. The principal aim of our research was to clarify the potential risk of adding essential oils to food, beverages and cosmetic products. METHODS: The toxicity of substances frequently employed in cosmetics, aromatherapy and food industry (bergamot oil, Litsea cubeba oil, orange oil, citral) were investigated using cell line NIH3T3 (mouse fibroblasts) with/without UV irradiation...
September 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/27747942/clinical-pharmacology-of-citrus-bergamia-a-systematic-review
#13
REVIEW
Carmen Mannucci, Michele Navarra, Fabrizio Calapai, Raffaele Squeri, Sebastiano Gangemi, Gioacchino Calapai
Citrus bergamia Risso et Poiteau ("Bergamot") originated from the Mediterranean ecoregion (southern Italy, Calabria). Bergamot essential oil (BEO) is used in perfumes, cosmetics, and for stress reduction. Juice from C. bergamia has been used for hyperlipidemia. We evaluated literature published on C. bergamia clinical applications. Clinical trials on C. bergamia not combined with other substances, published in English, were searched. We selected ten articles, six describing BEO effects on stress, three reporting effects of polyphenolic fraction of C...
January 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27669206/anti-inflammatory-activity-of-citrus-bergamia-derivatives-where-do-we-stand
#14
REVIEW
Nadia Ferlazzo, Santa Cirmi, Gioacchino Calapai, Elvira Ventura-Spagnolo, Sebastiano Gangemi, Michele Navarra
Inflammatory diseases affect a large portion of the worldwide population, and chronic inflammation is a major risk factor for several dangerous pathologies. To limit the side effects of both synthetic and biological anti-inflammatory drugs, the use of herbal medicines, nutraceuticals and food supplements has increased tremendously as alternative and/or complementary medicine to treat several pathologies, including inflammation. During the last decades, the biological properties of Citrus bergamia (bergamot) derivatives have obtained important scientific achievements, and it has been suggested their use in a context of a multitarget pharmacological strategy...
September 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27570269/effect-of-uv-c-radiation-and-vapor-released-from-a-water-hyacinth-root-absorbent-containing-bergamot-oil-to-control-mold-on-storage-of-brown-rice
#15
Sumethee Songsamoe, Narumol Matan, Nirundorn Matan
The aims of this study were to develop absorbent material from a water hyacinth root containing bergamot oil and to improve its antifungal activity by using ultraviolet C (UV-C) against the growth of A. flavus on the brown rice. Process optimization was studied by the immersion of a water hyacinth root into a water and bergamot oil (300, 500 and 700 μl ml(-1)). The root (absorbent material) was dried at 50, 70, and 90 °C for 10 min. Then, ultraviolet C (UV-C) was used for enhancing the antifungal activity of bergamot oil for 10, 15, and 20 min...
March 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27471464/anti-inflammatory-and-antioxidant-effects-of-flavonoid-rich-fraction-of-bergamot-juice-bje-in-a-mouse-model-of-intestinal-ischemia-reperfusion-injury
#16
Daniela Impellizzeri, Marika Cordaro, Michela Campolo, Enrico Gugliandolo, Emanuela Esposito, Filippo Benedetto, Salvatore Cuzzocrea, Michele Navarra
The flavonoid-rich fraction of bergamot juice (BJe) has demonstrated anti-inflammatory and antioxidant activities. The aim of work was to test the beneficial effects of BJe on the modulation of the ileum inflammation caused by intestinal ischemia/reperfusion (I/R) injury in mice. To understand the cellular mechanisms by which BJe may decrease the development of intestinal I/R injury, we have evaluated the activation of signaling transduction pathways that can be induced by reactive oxygen species production...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27463949/synergistic-in-vitro-antioxidant-activity-and-observational-clinical-trial-of-f105-a-phytochemical-formulation-including-citrus-bergamia-in-subjects-with-moderate-cardiometabolic-risk-factors
#17
John G Babish, Clinton J Dahlberg, Joseph J Ou, William J Keller, Wei Gao, Mohan R Kaadige, Holly Brabazon, Joseph Lamb, Hani C Soudah, Xiaolan Kou, Zhe Zhang, Linda M Pacioretty, Matthew L Tripp
We examined the clinical safety and efficacy of F105 in 11 subjects with moderate dyslipidemia. F105 is a combination of bergamot fruit extract (Citrus bergamia, BFE) and 9 phytoextracts selected for their ability to improve the antioxidant and anti-inflammatory activity of BFE. In vitro F105 exhibited a synergistic inhibition of oxygen radical absorbing capacity, peroxynitrite formation, and myeloperoxidase activity. Following 12 weeks of F105 daily, no treatment-related adverse events or changes in body mass were seen...
December 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27460885/rapid-discrimination-of-bergamot-essential-oil-by-paper-spray-mass-spectrometry-and-chemometric-analysis
#18
Domenico Taverna, Leonardo Di Donna, Fabio Mazzotti, Antonio Tagarelli, Anna Napoli, Emilia Furia, Giovanni Sindona
A novel approach for the rapid discrimination of bergamot essential oil from other citrus fruits oils is presented. The method was developed using paper spray mass spectrometry (PS-MS) allowing for a rapid molecular profiling coupled with a statistic tool for a precise and reliable discrimination between the bergamot complex matrix and other similar matrices, commonly used for its reconstitution. Ambient mass spectrometry possesses the ability to record mass spectra of ordinary samples, in their native environment, without sample preparation or pre-separation by creating ions outside the instrument...
September 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/27246183/multimodal-interaction-in-the-insect-brain
#19
Anna Balkenius, Christian Balkenius
BACKGROUND: The magnitude of multimodal enhancement in the brain is believed to depend on the stimulus intensity and timing. Such an effect has been found in many species, but has not been previously investigated in insects. RESULTS: We investigated the responses to multimodal stimuli consisting of an odour and a colour in the antennal lobe and mushroom body of the moth Manduca sexta. The mushroom body shows enhanced responses for multimodal stimuli consisting of a general flower odour and a blue colour...
2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27227548/inhibition-of-spinal-oxidative-stress-by-bergamot-polyphenolic-fraction-attenuates-the-development-of-morphine-induced-tolerance-and-hyperalgesia-in-mice
#20
Filomena Lauro, Luigino Antonio Giancotti, Sara Ilari, Concetta Dagostino, Micaela Gliozzi, Chiara Morabito, Valentina Malafoglia, William Raffaeli, Maurizio Muraca, Bianca M Goffredo, Vincenzo Mollace, Carolina Muscoli
Citrus Bergamia Risso, commonly known as Bergamot, is a fruit whose Essential Oil and Bergamot Polyphenolic Fraction have numerous medicinal properties. It is also an excellent antioxidant and in this study, for the first time, its potential effect on morphine induced tolerance in mice has been investigated. Our studies revealed that development of antinociceptive tolerance to repeated doses of morphine in mice is consistently associated with increased formation of superoxide, malondialdehyde and tyrosine-nitrated proteins in the dorsal horn of the spinal cord such as the enzyme glutamine synthase...
2016: PloS One
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