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https://www.readbyqxmd.com/read/29909499/immune-checkpoint-inhibitors-and-radiosurgery-for-newly-diagnosed-melanoma-brain-metastases
#1
Tyler P Robin, Robert E Breeze, Derek E Smith, Chad G Rusthoven, Karl D Lewis, Rene Gonzalez, Amanda Brill, Robin Saiki, Kelly Stuhr, Laurie E Gaspar, Sana D Karam, David Raben, Brian D Kavanagh, Sameer K Nath, Arthur K Liu
INTRODUCTION: Brain metastases are common in metastatic melanoma and radiosurgery is often utilized for local control. Immune checkpoint inhibitors (CPIs) play a central role in contemporary melanoma management; however, there is limited data exploring outcomes and potential toxicities for patients treated with CPIs and radiosurgery. METHODS: We retrospectively identified all consecutive cases of newly diagnosed melanoma brain metastases (MBM) treated with Gamma Knife radiosurgery at a single institution between 2012 and 2017, and included only patients that initiated CPIs within 8 weeks before or after radiosurgery...
June 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29909496/transplantation-of-macroencapsulated-insulin-producing-cells
#2
REVIEW
Albert J Hwa, Gordon C Weir
PURPOSE OF REVIEW: There is considerable interest in using macroencapsulation devices as a delivery strategy for transplanting insulin-producing cells. This review aims to summarize recent advances, to highlight remaining challenges, and to provide recommendations for the field. RECENT FINDINGS: A variety of new device designs have been reported to improve biocompatibility and to provide protection for islet/beta cells from immune destruction while allowing continuous secretion of insulin...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29909486/probiotics-l-acidophilus-and-b-clausii-modulate-gut-microbiota-in-th1-and-th2-biased-mice-to-ameliorate-salmonella-typhimurium-induced-diarrhea
#3
Biswaranjan Pradhan, Dipanjan Guha, Aman Kumar Naik, Arka Banerjee, Subodh Tambat, Saurabh Chawla, Shantibhusan Senapati, Palok Aich
Gut microbiota play important role in maintaining health. Probiotics are believed to augment it further. We aimed at comparing effects of probiotics, Lactobacillus acidophilus (LA) and Bacillus clausii (BC) (a) on the gut microbiota abundance and diversity and (b) their contributions to control intestinal dysbiosis and inflammation in Th1- and Th2-biased mice following Salmonella infection. We report how could gut microbiota and the differential immune bias (Th1 or Th2) of the host regulate host responses when challenged with Salmonella typhimurium in the presence and absence of either of the probiotics...
June 16, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29909435/photobiomodulation-therapy-pbmt-on-acute-pain-and-inflammation-in-patients-who-underwent-total-hip-arthroplasty-a-randomized-triple-blind-placebo-controlled-clinical-trial
#4
Luciana Gonçalves Langella, Heliodora Leão Casalechi, Shaiane Silva Tomazoni, Douglas Scott Johnson, Regiane Albertini, Rodney Capp Pallotta, Rodrigo Labat Marcos, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior
When conservative treatments fail, hip osteoarthritis (OA), a chronic degenerative disease characterized by cartilage wear, progressive joint deformity, and loss of function, can result in the need for a total hip arthroplasty (THA). Surgical procedures induced tissue trauma and incite an immune response. Photobiomodulation therapy (PBMt) using low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) has proven effective in tissue repair by modulating the inflammatory process and promoting pain relief...
June 16, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29909388/lymphedema-secondary-to-limited-cutaneous-systemic-sclerosis
#5
Sónia Moreira, Jorge Crespo, Lèlita Santos
Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by vascular abnormalities, immune system activation and fibrosis. Lymphatic involvement in SSc was described more recently and starts in early stages. This report describes a 46-year-old patient who developed over the last 2 years asymmetric lymphedema in lower extremities. Compromise in lymphatic drainage was confirmed by lymphoscintigraphy. She also presented Raynaud's phenomenon, a scleroderma pattern in nailfold capillaroscopy, cutaneous thickening and anticentromere antibodies, which together resulted in a new diagnosis of limited cutaneous SSc...
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29908976/effects-of-methylene-blue-mediated-photodynamic-therapy-on-a-mouse-model-of-squamous-cell-carcinoma-and-normal-skin
#6
Ana Paula da Silva, Camila Lima Neves, Elizangela Dos Anjos Silva, Tania Cristina Lima Portela, Renata Stecca Iunes, Bruno Cogliati, Divinomar Severino, Maurício da Silva Baptista, Maria Lúcia Zaidan Dagli, Francisco Javier Hernandez Blazquez, José Roberto Machado Cunha da Silva
BACKGROUND: Photodynamic therapy is used to treat a variety of cancers and skin diseases by inducing apoptosis, necrosis, immune system activation, and/or vascular damage. Here, we describe the effects of a single photodynamic therapy session using methylene blue on a mouse model of squamous cell carcinoma and normal skin. METHODS: The photodynamic therapy protocol comprised application of a 1% methylene blue solution, followed by irradiation with a diode laser for 15 min at 74 mW/cm2 , for a total dose of 100 J/cm2 ...
June 14, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29908975/differential-effect-of-hydroxyapatite-nano-particle-versus-nano-rod-decorated-titanium-micro-surface-on-osseointegration
#7
Long Bai, Yanlian Liu, Zhibin Du, Zeming Weng, Wei Yao, Xiangyu Zhang, Xiaobo Huang, Xiaohong Yao, Ross Crawford, Ruiqiang Hang, Di Huang, Bin Tang, Yin Xiao
Coating materials applied for intraosseous implants must be optimized to stimulate osseointegration. Osseointegration is a temporal and spatial physiological process that not only requires interactions between osteogenesis and angiogenesis but also necessitates a favorable immune microenvironment. It is now well-documented that hierarchical nano-micro surface structures promote the long-term stability of implants, the interactions between nano-micro structure and the immune response are largely unknown. Here, we report the effects of microporous titanium (Ti) surfaces coated with nano-hydroxyapatite (HA) produced by micro-arc oxidation and steam-hydrothermal treatment (SHT) on multiple cell behavior and osseointegration...
June 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29908864/longitudinal-cohort-study-of-serum-antibody-responses-towards-giardia-lamblia-variant-specific-surface-proteins-in-a-non-endemic-area
#8
Torunn Hjøllo, Eirik Bratland, Hans Steinsland, Matej Radunovic, Nina Langeland, Kurt Hanevik
INTRODUCTION/AIMS: The long-term humoral immune response after a natural giardiasis infection is not well understood. The aim of this study was to evaluate longitudinal serum IgA and IgG/M responses towards conserved regions of two Giardia variant-specific surface proteins (VSP) and whether these responses differ between Giardia assemblages and durations of infection. METHODS: We recruited thirty Giardia-positive patients, mainly returning travellers, and eighteen healthy adults presumed to be Giardia unexposed...
June 14, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29908806/preweaned-heifer-management-on-us-dairy-operations-part-ii-factors-associated-with-colostrum-quality-and-passive-transfer-status-of-dairy-heifer-calves
#9
C B Shivley, J E Lombard, N J Urie, D M Haines, R Sargent, C A Kopral, T J Earleywine, J D Olson, F B Garry
Passive transfer of immunity is essential for the short- and long-term health of dairy calves. The objective of this study was to evaluate factors associated with colostrum quality and passive transfer status of US heifer calves. This study included 104 operations in 13 states that participated in the calf component of the National Animal Health Monitoring System's Dairy 2014 study. This 18-mo longitudinal study included 1,972 Holstein heifer calves from birth to weaning. Multivariable mixed linear regression models were selected using backward elimination model selection after univariate screening to determine which factors were associated with colostrum IgG and serum IgG concentrations...
June 13, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29908638/gadd45a-knockdown-alleviates-oxidative-stress-through-suppressing-the-p38-mapk-signaling-pathway-in-the-pathogenesis-of-preeclampsia
#10
Fa-Hong Li, Na Han, Yong Wang, Qian Xu
OBJECTIVE: Preeclampsia (PE) is a hypertensive disease associated with vascular oxidative stress (OS). Besides, cell response to OS triggers growth arrest and DNA damage inducible alpha (Gadd45a). Herein, we investigated the effect of Gadd45a on OS in PE. METHODS: Umbilical cord tissues and peripheral blood samples were collected from PE patients and normal pregnant women. Immunohistochemistry was applied to identify Gadd45a level and extent of p38 phosphorylation...
May 2018: Placenta
https://www.readbyqxmd.com/read/29908564/a-rare-case-of-type-1-leprosy-reactions-following-tetanus-infection-in-a-borderline-tuberculoid-leprosy-patient-and-a-literature-review
#11
Chao Shi, Zhi-Chun Jing, De-Gang Yang, Jian-Yu Zhu
BACKGROUND: Type 1 leprosy reaction, also known as "reversal reaction", is related to cellular immune responses to Mycobacterium leprae antigens. The risk factors that trigger type 1 leprosy reactions are poorly understood. Leprosy with concurrent tetanus is rare, and there are no publicly available reports of a leprosy patient infected with tetanus that induced type 1 leprosy reactions. CASE PRESENTATION: A 56-year-old Chinese Han female presented to our hospital with symptoms of erythematous plaques and pain over her left upper limb for 2 days and foreign object sensation in her throat for 3 days...
June 17, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29908541/construction-of-a-recombinant-phage-vaccine-capable-of-reducing-the-growth-rate-of-an-established-ll2-tumor-model
#12
Majid Asadi-Ghalehni, Mohamad Javad Rasaee, Nabiollah Namvar Asl, Masood Khosravani, Masoumeh Rajabibazl, Saeed Khalili, Helmout Modjtahedi, Esmaeil Sadroddiny
Over expression of the epidermal growth factor receptor (EGFR) in many human epithelial tumors has been correlated with disease progression and poor prognosis. EGFR-inhibiting immunotherapy has already been introduced in cancer therapy. Peptide displaying phage particles in eukaryotic hosts can behave as antigen carriers, able to activate the innate immune system and to elicit adaptive immunity. Herein, the M13-pAK8-VIII phagemid plasmid was engineered to contain the sequences for an EGFR mimotope along with the L2 extracellular domain of EGFR (EM-L2) which would produce the final peptide-phage vaccine...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29908359/statin-therapy-does-not-reduce-liver-fat-scores-in-patients-receiving-antiretroviral-therapy-for-hiv-infection
#13
Vanessa El Kamari, Corrilynn O Hileman, Pierre M Gholam, Manjusha Kulkarni, Nicholas Funderburg, Grace A McComsey
BACKGROUND & AIMS: Therapies are needed to limit progression of fatty liver diseases in patients with HIV infection. We analyzed data from a prospective study of the effects of rosuvastatin (a statin) on hepatic steatosis in HIV-positive adults. METHODS: We performed secondary analysis of data from a double-blind trial of adult patients with HIV infection (78% male; 68% African American; mean age, 46 years; body mass index, 29 kg/m2 ; HIV1 RNA<1000 copies/mL; LDL-cholesterol <130 mg/dL) receiving antiretroviral therapy...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908324/pd-1-blockade-with-nivolumab-in-patients-with-recurrent-malignant-pleural-mesothelioma
#14
Josine Quispel-Janssen, Vincent van der Noort, Jeltje F de Vries, Marion Zimmerman, Ferry Lalezari, Erik Thunnissen, Kim Monkhorst, Robert Schouten, Laurel Schunselaar, Maria Disselhorst, Houke Klomp, Koen Hartemink, Sjaak Burgers, Wieneke Buikhuisen, Paul Baas
BACKGROUND: Malignant Pleural Mesothelioma (MPM) has limited treatment options and a poor outcome. PD-1/PD-L1 checkpoint inhibitors have proven efficacious in several cancer types. Nivolumab is a fully humanized monoclonal antibody against PD-1 with a favorable toxicity profile. In MPM, the immune system is considered to play an important role. We therefore tested nivolumab in recurrent MPM. METHODS: In this single center trial, patients with MPM received nivolumab 3mg/kg i...
June 13, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29908322/chitooligosaccharide-supplementation-in-low-fish-meal-diets-for-pacific-white-shrimp-litopenaeus-vannamei-effects-on-growth-innate-immunity-gut-histology-and-immune-related-genes-expression
#15
Samad Rahimnejad, Xiangli Yuan, Ling Wang, Kangle Lu, Kai Song, Chunxiao Zhang
This study evaluated the effects of supplementing chitooligosaccharide (COS) in low fish meal (FM) diets on growth, immune response, intestine and hepatopancrease histology, and expression of inflammatory and immune-related genes in Pacific white shrimp (Litopenaeus vannamei). A basal diet was formulated using FM and soybean meal (SM) as primary protein sources and considered as a high FM (HFM) diet, then a low FM (LFM) diet was prepared by substituting 50% of FM with SM and supplemented with 0, 3, 6, 9, 12 or 15 g COS kg-1 diet (LFM, COS3, COS6, COS9, COS12 and COS15 diets)...
June 13, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29908231/haploidentical-bone-marrow-transplantation-with-post-transplant-cyclophosphamide-bendamustine-in-pediatric-and-young-adult-patients-with-hematologic-malignancies
#16
Emmanuel Katsanis, Lauren N Sapp, Nicole Varner, Shannon Koza, Baldassarre Stea, Yi Zeng
More than half of patients undergoing hematopoietic cell transplantation at our institution are ethnic or racial minorities, making the search for matched unrelated donors more challenging. Since the introduction of haploidentical bone marrow transplant (haplo-BMT) into our pediatric BMT program in 2015, 69.2% of the recipients have been minorities. Herein, we describe our experience with the first thirteen pediatric and young adult patients with hematologic malignancies who have undergone T-cell replete haplo-BMT following myeloablative conditioning (MAC) at our institution...
June 13, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29908076/diabetes-associated-with-immune-checkpoint-inhibition-presentation-and-management-challenges
#17
A Galligan, W Xu, S Fourlanos, A Nankervis, C Chiang, A M Mant, P Parente, D Rischin, B Krishnamurthy, S Sandhu, P G Colman
BACKGROUND: In recent years, immune checkpoint blockade has become a standard therapy for a wide range of cancers. Adverse events including endocrinopathies result from the induction of autoimmunity. CASE REPORT: We report a case series of nine individuals who presented with immunotherapy-induced type 1 diabetes between 2015-2017. DISCUSSION: Onset of diabetes occurred within 12 weeks of commencing therapy. Anti- GAD antibodies were present in six people...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29907890/impact-of-mast-cells-in-depression-disorder-inhibitory-effect-of-il-37-new-frontiers
#18
REVIEW
Pio Conti, Alessandro Caraffa, Gianpaolo Ronconi, Chiara M Conti, Spiros K Kritas, Filiberto Mastrangelo, Lucia Tettamanti, Theoharis C Theoharides
The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and thoughts is a major risk factor for several metabolic diseases and may influence the physiology of the body leading to depression. Depression, present in mastocytosis, is an important endogenous process that promotes the activation of meningeal cell receptors through a low-grade neurogenic chronic inflammation, and MCs...
June 16, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29907877/electroporation-mediated-delivery-of-fer-gene-enhances-innate-immune-response-and-improves-survival-in-a-murine-model-of-pneumonia
#19
Vladislav Dolgachev, Sreehari Panicker, Sanjay Balijepalli, Lane Kelly McCandless, Yue Yin, Samantha Swamy, M V Suresh, Matthew J Delano, Mark R Hemmila, Krishnan Raghavendran, David Machado-Aranda
Previously, we reported that electroporation-mediated (EP) delivery of the FER gene improved survival in a combined trauma-pneumonia model. The mechanism of this protective effect is unknown. In this paper, we performed a pneumonia model in C57/BL6 mice with 500 CFU of Klebsiella pneumoniae. After inoculation, a plasmid encoding human FER was delivered by EP into the lung (PNA/pFER-EP). Survival of FER-treated vs. controls (PNA; PNA/EP-pcDNA) was recorded. In parallel cohorts, bronchial alveolar lavage (BAL) and lung were harvested at 24 and 72 h with markers of infection measured...
June 15, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29907869/bves-is-required-for-maintenance-of-colonic-epithelial-integrity-in-experimental-colitis-by-modifying-intestinal-permeability
#20
Yash A Choksi, Vishruth K Reddy, Kshipra Singh, Caitlyn W Barrett, Sarah P Short, Bobak Parang, Cody E Keating, Joshua J Thompson, Thomas G Verriere, Rachel E Brown, M Blanca Piazuelo, David M Bader, M Kay Washington, Mukul K Mittal, Thomas Brand, Alain P Gobert, Lori A Coburn, Keith T Wilson, Christopher S Williams
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. There have been no in vivo studies investigating the role of BVES in colitis. We hypothesized that BVES is critical for maintaining colonic epithelial integrity. At baseline, Bves -/- mouse colons demonstrate increased crypt height, elevated proliferation, decreased apoptosis, altered intestinal lineage allocation, and dysregulation of tight junctions with functional deficits in permeability and altered intestinal immunity...
June 15, 2018: Mucosal Immunology
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