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Plasmalyte

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https://www.readbyqxmd.com/read/28685297/hemodynamic-effects-of-lipid-based-oxygen-microbubbles-via-rapid-intravenous-injection-in-rodents
#1
Katherine J Black, Andrew T Lock, Lindsay M Thomson, Alexis R Cole, Xiaoqi Tang, Brian D Polizzotti, John N Kheir
PURPOSE: Low oxygen levels, or hypoxemia, is a common cause of morbidity and mortality in critically ill patients. Hypoxemia is typically addressed by increasing the fraction of inspired oxygen, the use of mechanical ventilation, or more invasive measures. Recently, the injection of oxygen gas directly into the bloodstream by packaging it within lipid-based oxygen microbubbles (LOMs) has been explored. The purpose of this work is to examine the acute hemodynamic effects of intravenous injections of LOMs...
July 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28676074/immunoregulatory-effects-of-multipotent-adult-progenitor-cells-in-a-porcine-ex-vivo-lung-perfusion-model
#2
An Martens, Sofie Ordies, Bart M Vanaudenaerde, Stijn E Verleden, Robin Vos, Dirk E Van Raemdonck, Geert M Verleden, Valerie D Roobrouck, Sandra Claes, Dominique Schols, Eric Verbeken, Catherine M Verfaillie, Arne P Neyrinck
BACKGROUND: Primary graft dysfunction (PGD) is considered to be the end result of an inflammatory response targeting the new lung allograft after transplant. Previous research has indicated that MAPC cell therapy might attenuate this injury by its paracrine effects on the pro-/anti-inflammatory balance. This study aims to investigate the immunoregulatory capacities of MAPC cells in PGD when administered in the airways. METHODS: Lungs of domestic pigs (n = 6/group) were subjected to 90 minutes of warm ischemia...
July 5, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28616838/assessment-of-renal-hemodynamic-toxicity-of-fluid-challenge-with-0-9-nacl-compared-to-balanced-crystalloid-plasmalyte-%C3%A2-in-a-rat-model-with-severe-sepsis
#3
Pierre-Yves Olivier, François Beloncle, Valérie Seegers, Maher Tabka, Mathilde Renou de La Bourdonnaye, Alain Mercat, Paul Cales, Daniel Henrion, Peter Radermacher, Lise Piquilloud, Nicolas Lerolle, Pierre Asfar
BACKGROUND: According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, PlasmaLyte(®) (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28553873/does-fluid-resuscitation-with-balanced-solutions-induce-electrolyte-and-metabolic-abnormalities-an-in-vitro-assessment
#4
Łukasz J Krzych, Piotr F Czempik
BACKGROUND: Popular intravenous fluids in clinical use may have an impact on electrolyte concentration and metabolic balance and should be considered as powerful pharmacological agents. There is a growing body of evidence that fluid therapy should be more individualised and preferably based on balanced solutions. AIM: We sought to investigate the impact of three commonly used balanced fluids on electrolytes and metabolic equilibrium in an in vitro setting. METHODS: Study group comprised 32 healthy male volunteers (without history of any acute/chronic disorder or known metabolic abnormality), aged 21-35 (29 ± 4) years, weight 59-103 (81...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28497841/effect-of-fluid-resuscitation-with-balanced-solutions-on-platelets-in-vitro-simulation-of-20-volume-substitution
#5
Łukasz J Krzych, Piotr F Czempik
BACKGROUND: Fluid resuscitation in massive bleeding may cause coagulation disorders by dilution of platelets and clotting factors or by the definite influence on theirfunction. The aim of this study was to investigate the effects of balanced crystalloid and colloid solutions on platelets (PLT) in vitro using complex assessment of coagulation. METHODS: The study group was comprised of 32 American Society of Anesthesiologists physical status class I male volunteers, aged 21-35 (29 ± 4) years, weighting 59-103 (81...
May 12, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28077541/the-role-of-bicarbonate-precursors-in-balanced-fluids-during-haemorrhagic-shock-with-and-without-compromised-liver-function
#6
B Ergin, A Kapucu, P Guerci, C Ince
BACKGROUND: Lactate, acetate, and gluconate are anions used in balanced resuscitation fluids, of which lactate and acetate are considered bicarbonate precursors. This study investigated the role of the liver in the ability of balanced and unbalanced solutions to correct acid-base alterations and renal haemodynamics and microvascular oxygenation in a rat model of resuscitated haemorrhagic shock. METHODS: Ringer's lactate, Ringer's acetate, PlasmaLyte, or normal saline were administered following haemorrhagic shock in the presence or absence of a 70% partial liver resection...
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27896148/plasma-lyte-148-a-clinical-review
#7
Laurence Weinberg, Neil Collins, Kiara Van Mourik, Chong Tan, Rinaldo Bellomo
AIM: To outline the physiochemical properties and specific clinical uses of Plasma-Lyte 148 as choice of solution for fluid intervention in critical illness, surgery and perioperative medicine. METHODS: We performed an electronic literature search from Medline and PubMed (via Ovid), anesthesia and pharmacology textbooks, and online sources including studies that compared Plasma-Lyte 148 to other crystalloid solutions. The following keywords were used: "surgery", "anaesthesia", "anesthesia", "anesthesiology", "anaesthesiology", "fluids", "fluid therapy", "crystalloid", "saline", "plasma-Lyte", "plasmalyte", "hartmann's", "ringers" "acetate", "gluconate", "malate", "lactate"...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/26276005/storage-effect-on-viability-and-biofunctionality-of-human-adipose-tissue-derived-stromal-cells
#8
Mizied Falah, Anwar Rayan, Samer Srouji
BACKGROUND AIMS: In our recent studies, the transplantation of human adipose tissue-derived stromal cells (ASCs) has shown promise for treatment of diseases related to bone and joint disorders. METHODS: For the current clinical applications, ASCs were formulated and suspended in PlasmaLyte A supplemented with heparin, glucose and human serum albumin, balanced to pH 7.4 with sodium bicarbonate. This cell solution constitutes 20% of the overall transplanted mixture and is supplemented with hyaluronic acid (60%) and OraGraft particles (20%)...
September 2015: Cytotherapy
https://www.readbyqxmd.com/read/26123384/the-effect-of-0-9-saline-versus-plasmalyte-on-coagulation-in-patients-undergoing-lumbar-spinal-surgery-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Jong Wook Song, Jae-Kwang Shim, Na Young Kim, Jaewon Jang, Young-Lan Kwak
INTRODUCTION: In multi-level lumbar spinal fusion surgery yielding a large amount of blood loss, choice of fluid for volume resuscitation is an important issue since it can influence acid-base status, coagulation, and patients' outcome. This study compared the effect of plasmalyte to 0.9% saline on coagulation assessed by rotation thromboelastometry (ROTEM) and acid-base balance in the aforementioned patients. METHODS: Fifty patients were randomly allocated to receive either 0...
August 2015: International Journal of Surgery
https://www.readbyqxmd.com/read/25768968/0-9-saline-induced-hyperchloremic-acidosis
#10
REVIEW
Megan E Barker
In the acute care setting, the type and amount of fluid administered has a significant impact on patient outcomes. In particular, 0.9% saline infusions are known to cause or exacerbate hyperchloremia. The studies presented evaluate possible complications from 0.9% saline infusions. These studies compared administration of 0.9% saline with lactated ringer or plasmalyte in the acute care setting. In each trial, the patients who were randomized to receive 0.9% saline infusions had a more severe acidosis from increased serum chloride levels...
March 2015: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/25699349/acute-hypervolemic-hemodilution-effect-on-oxygen-metabolism-and-blood-pharmacokinetics-in-patients-undergoing-acute-laparotomy-during-induction-of-general-anesthesia
#11
RANDOMIZED CONTROLLED TRIAL
Ping Wang, Chun-Yan Yan, Xiu-Jun Cai
BACKGROUND/AIMS: To investigate acute hypervolemic hemodilution effect on oxygen metabolism and blood pharmacokinetics in patients undergoing acute laparotomy during Induction of general anesthesia. METHODOLOGY: Forty ASA I-II patients undergoing acute laparotomy were randomly divided into 2 groups (n=20 each): Patients of group A received Voluven 7 ml/kg in 20 mins before induction and 8 ml/kg after induction. Patients of group B received 6 ml/kg/h Plasmalyte A...
November 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25407026/the-effects-of-plasmalyte-148-vs-hartmann-s-solution-during-major-liver-resection-a-multicentre-double-blind-randomized-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
L Weinberg, B Pearce, R Sullivan, L Siu, N Scurrah, C Tan, M Backstrom, M Nikfarjam, L McNicol, D Story, C Christophi, R Bellomo
BACKGROUND: The acid-base, biochemical and hematological effects of crystalloid solutions have not been comprehensively evaluated in patients with liver resection. METHODS: HASH(0x40eafb0) DESIGN: multicenter, prospective, double-blind randomized controlled trial investigating the biochemical effects of Hartmann's solution (HS) or Plasmalyte-148 (PL) in 60 patients undergoing major liver resection. PRIMARY OUTCOME: base excess immediately after surgery...
December 2015: Minerva Anestesiologica
https://www.readbyqxmd.com/read/24891325/human-mesenchymal-stem-cells-reduce-the-severity-of-acute-lung-injury-in-a-sheep-model-of-bacterial-pneumonia
#13
Sven Asmussen, Hiroshi Ito, Daniel L Traber, Jae W Lee, Robert A Cox, Hal K Hawkins, Daniel F McAuley, David H McKenna, Lillian D Traber, Hanjing Zhuo, Jennifer Wilson, David N Herndon, Donald S Prough, Kathleen D Liu, Michael A Matthay, Perenlei Enkhbaatar
BACKGROUND: Human bone marrow-derived mesenchymal stem (stromal) cells (hMSCs) improve survival in mouse models of acute respiratory distress syndrome (ARDS) and reduce pulmonary oedema in a perfused human lung preparation injured with Escherichia coli bacteria. We hypothesised that clinical grade hMSCs would reduce the severity of acute lung injury (ALI) and would be safe in a sheep model of ARDS. METHODS: Adult sheep (30-40 kg) were surgically prepared. After 5 days of recovery, ALI was induced with cotton smoke insufflation, followed by instillation of live Pseudomonas aeruginosa (2...
September 2014: Thorax
https://www.readbyqxmd.com/read/24719128/effect-of-6-hydroxyethyl-starch-130-0-4-as-a-priming-solution-on-coagulation-and-inflammation-following-complex-heart-surgery
#14
RANDOMIZED CONTROLLED TRIAL
Jang-Eun Cho, Jae-Kwang Shim, Jong-Wook Song, Jong-Won Song, Hye-Won Lee, Dong-Hwan Kim, Young-Lan Kwak
PURPOSE: Prolonged duration of cardiopulmonary bypass aggravates the degree of inflammation and coagulopathy. We investigated the influence of 6% hydroxyethyl starch (HES) 130/0.4 on coagulation and inflammation compared with albumin when used for both cardiopulmonary bypass priming and perioperative fluid therapy in patients undergoing complex valvular heart surgery. MATERIALS AND METHODS: Fifty four patients were randomly allocated into albumin-HES, albumin-nonHES, and HES-HES groups...
May 2014: Yonsei Medical Journal
https://www.readbyqxmd.com/read/24673482/extended-storage-of-buffy-coat-platelet-concentrates-in-plasma-or-a-platelet-additive-solution
#15
Sherrill J Slichter, Doug Bolgiano, Jill Corson, Mary Kay Jones, Todd Christoffel, S Lawrence Bailey, Esther Pellham
BACKGROUND: Platelet (PLT) concentrates (PCs) prepared from whole blood in the United States are made using the PLT-rich plasma method. The PCs must be made within 8 hours of blood collection and stored for only 5 days. In Europe and Canada, PCs are made using the buffy coat (BC) method from whole blood held overnight at 22 °C and storage times may be up to 7 days. Our studies were designed to determine how long BC PLTs can be stored in plasma or Plasmalyte while meeting the FDA's poststorage viability criteria...
September 2014: Transfusion
https://www.readbyqxmd.com/read/24299660/fluid-homeostasis-in-the-neonate
#16
REVIEW
Frances O'Brien, Isabeau A Walker
The physiology of the neonate is ideally suited to the transition to extrauterine life followed by a period of rapid growth and development. Intravenous fluids and electrolytes should be prescribed with care in the neonate. Sodium and water requirements in the first few days of life are low and should be increased after the postnatal diuresis. Expansion of the extracellular fluid volume prior to the postnatal diuresis is associated with poor outcomes, particularly in preterm infants. Newborn infants are prone to hypoglycemia and require a source of intravenous glucose if enteral feeds are withheld...
January 2014: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/23953528/comparison-of-the-effects-of-normal-saline-versus-plasmalyte-on-acid-base-balance-during-living-donor-kidney-transplantation-using-the-stewart-and-base-excess-methods
#17
RANDOMIZED CONTROLLED TRIAL
S Y Kim, K H Huh, J R Lee, S H Kim, S H Jeong, Y S Choi
BACKGROUND: Ischemia-reperfusion injury is an inevitable consequence of kidney transplantation, leading to metabolic acidosis. This study compared the effects of normal saline (NS) and Plasmalyte on acid-base balance and electrolytes during living donor kidney transplantation using the Stewart and base excess (BE) methods. METHODS: Patients were randomized to an NS group (n = 30) or a Plasmalyte group (n = 30). Arterial blood samples were collected for acid-base analysis after induction of anesthesia (T0), prior to clamping the iliac vein (T1), 10 minutes after reperfusion of the donated kidney (T2), and at the end of surgery (T3)...
July 2013: Transplantation Proceedings
https://www.readbyqxmd.com/read/23865445/the-dynamic-observation-of-plasma-concentration-of-antimicrobial-agents-during-balanced-ultrafiltration-in-vitro
#18
Yinghui Fang, Yulong Guan, Caihong Wan, Zhida Fu, Juanjuan Jiang, Chunfu Wu, Ju Zhao, Peng Sun, Cun Long
Routine perioperative intravenous antimicrobial agents are administered as surgical prophylaxis. However, whether balanced ultrafiltration during extracorporeal circulation has substantial effect on the concentration of antimicrobial agents remains unclear. The concentrations of antimicrobial agents in plasma and ultrafiltrate samples were measured in this pseudo-extracorporeal circulation model. Extracorporeal circulation consisted of cardiotomy reservoir, membrane oxygenator, and pediatric arterial line filter...
January 2014: Artificial Organs
https://www.readbyqxmd.com/read/23758736/a-double-blind-randomized-placebo-controlled-phase-i-ii-study-assessing-the-safety-and-efficacy-of-allogeneic-bone-marrow-derived-mesenchymal-stem-cell-in-critical-limb-ischemia
#19
RANDOMIZED CONTROLLED TRIAL
Pawan K Gupta, Anoop Chullikana, Rajiv Parakh, Sanjay Desai, Anjan Das, Sanjay Gottipamula, Sagar Krishnamurthy, Naveen Anthony, Arun Pherwani, Anish S Majumdar
BACKGROUND: Peripheral vascular disease of the lower extremities comprises a clinical spectrum that extends from no symptoms to presentation with critical limb ischemia (CLI). Bone marrow derived Mesenchymal Stem Cells (BM- MSCs) may ameliorate the consequences of CLI due to their combinatorial potential for inducing angiogenesis and immunomodulatory environment in situ. The primary objective was to determine the safety of BM- MSCs in patients with CLI. METHODS: Prospective, double blind randomized placebo controlled multi-center study was conducted in patients with established CLI as per Rutherford classification in category II-4, III-5, or III-6 with infra-inguinal arterial occlusive disease and were not suitable for or had failed revascularization treatment...
June 10, 2013: Journal of Translational Medicine
https://www.readbyqxmd.com/read/23598288/cognitive-changes-after-saline-or-plasmalyte-infusion-in-healthy-volunteers-a-multiple-blinded-randomized-cross-over-trial
#20
RANDOMIZED CONTROLLED TRIAL
David A Story, Lucy Lees, Laurence Weinberg, Soon-Yee Teoh, Katherine J Lee, Sarah Velissaris, Rinaldo Bellomo, Sarah J Wilson
BACKGROUND: In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann's (Ringer's lactate) solution. The authors tested the hypothesis that saline infusion would produce greater adverse cognitive changes than Plasmalyte infusion. METHODS: The authors conducted a randomized, cross-over, multiple blinded study of healthy adult volunteers...
September 2013: Anesthesiology
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