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https://www.readbyqxmd.com/read/29244129/dolutegravir-reshapes-the-genetic-diversity-of-hiv-1-reservoirs
#1
Pierre Gantner, Guinevere Q Lee, David Rey, Thibault Mesplede, Marialuisa Partisani, Christine Cheneau, Geneviève Beck-Wirth, Jean-Pierre Faller, Mahsa Mohseni-Zadeh, Martin Martinot, Mark A Wainberg, Samira Fafi-Kremer
Objectives: Better understanding of the dynamics of HIV reservoirs under ART is a critical step to achieve a functional HIV cure. Our objective was to assess the genetic diversity of archived HIV-1 DNA over 48 weeks in blood cells of individuals starting treatment with a dolutegravir-based regimen. Methods: Eighty blood samples were prospectively and longitudinally collected from 20 individuals (NCT02557997) including: acutely (n = 5) and chronically (n = 5) infected treatment-naive individuals, as well as treatment-experienced individuals who switched to a dolutegravir-based regimen and were either virologically suppressed (n = 5) or had experienced treatment failure (n = 5)...
December 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29243807/microrna-as-a-systemic-intervention-in-the-specific-breast-cancer-subtypes-with-c-myc-impacts-introducing-subtype-based-appraisal-tool
#2
REVIEW
Vida Pourteimoor, Mahdi Paryan, Samira Mohammadi-Yeganeh
Breast cancer is indisputably a heterogeneous disease, in which a formidable combination of definitely dis-regulated C-MYC and microRNA (miRNA) profiles along with other factors are responsible to generate a specific type of breast cancer. C-MYC as a master regulator of more than 20,000 genes can modify the expression of genes underlying to perform diverse conflicting functional frameworks. The functional spectra of miRNA in the new areas of the evolution of cell behaviors are identified. Here, we endeavor to summarize some recent advances of miRNA applications that can be recruited as combinatorial targeted therapy for patients with breast cancer...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29241475/israeli-national-policy-for-carbapenem-resistant-enterobacteriaceae-screening-carrier-isolation-and-discontinuation-of-isolation
#3
Ester Solter, Amos Adler, Bina Rubinovitch, Elizabeth Temkin, David Schwartz, Debby Ben-David, Samira Masarwa, Yehuda Carmeli, Mitchell J Schwaber
Since 2006, Israel has been confronting an outbreak of carbapenem-resistant Enterobacteriaceae (CRE), and in 2007 Israel implemented a national strategy to contain spread. The intervention was initially directed toward acute-care hospitals and later expanded to include an established reservoir of carriage in long-term-care hospitals. It included regular reporting of CRE cases to a central registry and daily oversight of management of the outbreak at the institutional level. Microbiological methodologies were standardized in clinical laboratories nationwide...
December 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29237046/exposure-to-contrast-media-in-the-perioperative-period-confers-no-additional-risk-of-acute-kidney-injury-in-surgical-patients
#4
Ian Zealley, Huan Wang, Peter T Donnan, Samira Bell
Background: Iodinated contrast media (CM) used in angiography and computed tomography (CT) scans is an important cause of acute kidney injury (AKI) in hospitalized patients undergoing surgery. Contrast-induced nephropathy leads to AKI soon after CM administration. The aim of the study was to determine whether the timing of contrast media exposure related to diagnostic imaging during the immediate perioperative period influences the risk of post-operative AKI. Methods: All patients aged 18 years or above who underwent diagnostic imaging within 7 days of non-cardiac surgery between 1 January 2003 and 31 December 2013 in the Tayside region of Scotland, UK were included in the analysis...
December 9, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29236204/the-burden-of-pure-anisometropic-amblyopia-a-cross-sectional-study-on-2800-iranians
#5
Siamak Akbarzadeh, Reihaneh Vahabi, Nooshin Bazzazi, Ghodratollah Roshanaei, Samira Heydarian, Daniel F Fouladi
PURPOSE: To assess the proportion of pure anisometropic amblyopia in a sample Iranian (white) population. METHODS: A total of 2800 consecutive individuals who presented at a referral eye clinic for any reason were examined for the presence of pure anisometropic amblyopia. Anisometropia was reported when a spherical equivalent refraction difference of at least 1.0 D with or without a cylinder refraction difference of at least 1.0 D was present between the two eyes...
December 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29235196/influence-of-particle-and-air-abrasion-moment-on-y-tzp-surface-characterization-and-bond-strength
#6
Samira Branco Martins, Filipe de Oliveira Abi-Rached, Gelson Luis Adabo, Paolo Baldissara, Renata Garcia Fonseca
PURPOSE: To evaluate the influence of particle and air-abrasion on the surface characterization and shear bond strength (SBS) of a Y-TZP ceramic with a resin cement. MATERIALS AND METHODS: Y-TZP specimens were air-abraded with 50 μm alumina particles; 120 μm alumina particles; 30 μm silica-coated alumina particles (Rocatec Soft); 110 μm silica-coated alumina particles (Rocatec Plus). Air-abrasion was performed before (BS); after (AS); before and after (BAS) zirconia sintering...
December 13, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29234163/clarifying-the-relationship-between-metformin-acute-kidney-injury-and-lactic-acidosis
#7
Samira Bell, Enrique Soto-Pedre, Paul Connelly, Shona Livingstone, Ewan Pearson
No abstract text is available yet for this article.
December 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29233074/-you-have-to-take-action-changing-knowledge-and-attitudes-towards-newborn-care-practices-during-crisis-in-south-sudan
#8
Samira Sami, Kate Kerber, Barbara Tomczyk, Ribka Amsalu, Debra Jackson, Elaine Scudder, Alexander Dimiti, Janet Meyers, Kemish Kenneth, Solomon Kenyi, Caitlin E Kennedy, Kweku Ackom, Luke C Mullany
Highest rates of neonatal mortality occur in countries that have recently experienced conflict. International Medical Corps implemented a package of newborn interventions in June 2016, based on the Newborn health in humanitarian settings: field guide, targeting community- and facility-based health workers in displaced person camps in South Sudan. We describe health workers' knowledge and attitudes toward newborn health interventions, before and after receiving clinical training and supplies, and recommend dissemination strategies for improved uptake of newborn guidelines during crises...
December 13, 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29230399/role-of-protein-kinase-c-in-bipolar-disorder-a-review-of-the-current-literature
#9
REVIEW
Ashwini Saxena, Giselli Scaini, Daniela V Bavaresco, Camila Leite, Samira S Valvassoria, André F Carvalho, João Quevedo
Bipolar disorder (BD) is a major health problem. It causes significant morbidity and imposes a burden on the society. Available treatments help a substantial proportion of patients but are not beneficial for an estimated 40-50%. Thus, there is a great need to further our understanding the pathophysiology of BD to identify new therapeutic avenues. The preponderance of evidence pointed towards a role of protein kinase C (PKC) in BD. We reviewed the literature pertinent to the role of PKC in BD. We present recent advances from preclinical and clinical studies that further support the role of PKC...
November 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29229628/nationwide-multicenter-study-on-the-management-of-pulmonary-neuroendocrine-carcinoid-tumors
#10
Samira Mercedes Sadowski, Emanuel Christ, Benoit Bedat, Attila Kollar, Wolfram Karenovics, Aurel Perren, Frederic Triponez
Background/ Aim: To analyze the management and outcome of patients with primary typical (TC) and atypical lung carcinoids (AC) in Switzerland. METHODS: Retrospective analysis of patients selected from a neuroendocrine tumor (NET) registry. Patients were divided into TC and AC according to pathology reports, and surgical procedures were grouped as wedge/ segmentectomy, lobectomy/ bi-lobectomy and pneumectomy. Survival analysis was performed using the Kaplan-Meier method and log-rank test...
December 11, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29225853/a-clinical-picture-of-pulmonary-embolism-revealing-light-chain-myeloma
#11
Badia Belarj, Amine El Alaoui, Souhail Dahraoui, Jean Uwingabiye, Emmanuel Millbank Owusu, Anas Rochdi, Asmaa Biaz, Abdellah Dami, Sanae Bouhsain, Zohra Ouzzif, Nawfel Doghmi, Samira El Machtani Idrissi
We are highlighting on the particularity of a clinical picture of pulmonary embolism revealing light-chain myeloma in a 56-year-old male patient. Myeloma remains a rare affection. Even though its revelation through pulmonary embolism remains rare, it can be explained by hyperviscosity syndrome accompanying it.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29225645/the-effects-of-different-ionic-liquid-coatings-and-the-length-of-alkyl-chain-on-antimicrobial-and-cytotoxic-properties-of-silver-nanoparticles
#12
Abbas Abbaszadegan, Ahmad Gholami, Sara Abbaszadegan, Zeynab Sadat Aleyasin, Yasamin Ghahramani, Samira Dorostkar, Bahram Hemmateenejad, Younes Ghasemi, Hashem Sharghi
Introduction: The antibacterial efficacy and toxicity of silver nanoparticles (AgNPs) depends on their physicochemical properties including size, shape, surface charge and surface coatings. The Objectives of this study were: i) To synthesize and characterize positively charged AgNPs coated by different ionic-liquids with different alkyl chain lengths, ii) To evaluate the antimicrobial activity of these nanoparticles against Enterococcus faecalis compared to sodium hypochlorite (NaOCl) and chlorhexidine (CHX), iii) To compare the cytocompatibility of these solutions against L929 mouse fibroblasts...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29225347/accelerated-epigenetic-aging-and-mitochondrial-dna-copy-number-in-bipolar-disorder
#13
Gabriel R Fries, Isabelle E Bauer, Giselli Scaini, Mon-Ju Wu, Iram F Kazimi, Samira S Valvassori, Giovana Zunta-Soares, Consuelo Walss-Bass, Jair C Soares, Joao Quevedo
Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the mechanisms underlying this association are largely unknown. The epigenetic clock has been increasingly recognized as a valuable aging marker, although its association with other biological clocks in BD patients and high-risk subjects, such as telomere length and mitochondrial DNA (mtDNA) copy number, has never been investigated. We included 22 patients with BD I, 16 siblings of BD patients, and 20 healthy controls in this analysis...
December 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29221764/regulation-of-autophagy-by-polyphenols-paving-the-road-for-treatment-of-neurodegeneration
#14
REVIEW
Seyed Fazel Nabavi, Antoni Sureda, Ahmad Reza Dehpour, Samira Shirooie, Ana Sanches Silva, Kasi Pandima Devi, Touqeer Ahmed, Nafeesa Ishaq, Rabia Hashim, Eduardo Sobarzo-Sánchez, Maria Daglia, Nady Braidy, Mariateresa Volpicella, Rosa Anna Vacca, Seyed Mohammad Nabavi
In the present paper, we will discuss on the importance of autophagy in the central nervous system, and outline the relation between autophagic pathways and the pathogenesis of neurodegenerative disorders. The potential therapeutic benefits of naturally occurring phytochemicals as pharmacological modulators of autophagy will also be addressed. Our findings provide renewed insight on the molecular modes of protection by polyphenols, which is likely to be at least in part mediated not only by their potent antioxidant and anti-inflammatory effects, but also through modulation of autophagic processes to remove the aberrant protein aggregates...
December 5, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29221731/white-adipose-tissue-is-a-reservoir-for-memory-t-cells-and-promotes-protective-memory-responses-to-infection
#15
Seong-Ji Han, Arielle Glatman Zaretsky, Vinicius Andrade-Oliveira, Nicholas Collins, Amiran Dzutsev, Jahangheer Shaik, Denise Morais da Fonseca, Oliver J Harrison, Samira Tamoutounour, Allyson L Byrd, Margery Smelkinson, Nicolas Bouladoux, James B Bliska, Jason M Brenchley, Igor E Brodsky, Yasmine Belkaid
White adipose tissue bridges body organs and plays a fundamental role in host metabolism. To what extent adipose tissue also contributes to immune surveillance and long-term protective defense remains largely unknown. Here, we have shown that at steady state, white adipose tissue contained abundant memory lymphocyte populations. After infection, white adipose tissue accumulated large numbers of pathogen-specific memory T cells, including tissue-resident cells. Memory T cells in white adipose tissue expressed a distinct metabolic profile, and white adipose tissue from previously infected mice was sufficient to protect uninfected mice from lethal pathogen challenge...
November 30, 2017: Immunity
https://www.readbyqxmd.com/read/29219744/n-nitrosamines-migrating-from-food-contact-materials-into-food-simulants-analysis-and-quantification-by-means-of-hplc-apci-ms-ms
#16
Friederike Kühne, Oliver Kappenstein, Samira Straβgütl, Florian Weese, Jürgen Weyer, Karla Pfaff, Andreas Luch
It was the aim of the work described here to develop a validated analytical method for the determination N-nitrosamines in food simulants. Here, we present the validation of a liquid chromatography-atmospheric pressure chemical ionisation-tandem mass spectrometry (LC-APCI-MS/MS) method for the determination of thirteen N-nitrosamines in the food simulants deionised water, 3 % acetic acid and 10 % ethanol. Method validation encompassed linearity, limit of detection (LOD), limit of quantification (LOQ), recovery, precision and stability of the N-nitrosamines...
December 8, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29218583/promising-antibacterial-effects-of-silver-nanoparticle-loaded-tea-tree-oil-nanoemulsion-a-synergistic-combination-against-resistance-threat
#17
Roqya Najafi-Taher, Behnaz Ghaemi, Sharmin Kharazi, Samira Rasoulikoohi, Amir Amani
Highly resistant pathogens may be developed in patients with immune disorders after prolonged exposure to antibiotics, a growing threat worldwide. In order to overcome these problems, this study introduces a new class of engineered nanosystems comprising of tea tree oil nanoemulsion (TTO NE) loaded with Ag nanoparticles (NPs). Silver shows a strong toxicity towards a wide range of microorganisms. Also, TTO NE could be employed as a promising and safe antimicrobial agent for local therapies of bacterial infections...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29217624/applying-a-vernix-caseosa-based-formulation-accelerates-skin-barrier-repair-by-modulating-lipid-biosynthesis
#18
Walter A Boiten, Tineke Berkers, Samira Absalah, Jeroen van Smeden, Adriana P M Lavrijsen, Joke A Bouwstra
Restoring the lipid homeostasis of the stratum corneum (SC) is a common strategy to enhance the skin barrier function. Here, we used a ceramide containing vernix caseosa (VC) based formulation and were able to accelerate barrier recovery in healthy volunteers. The recovery was examined over 16 days by monitoring trans-epidermal water loss (TEWL) after barrier disruption by tape-stripping. Four skin sites were used to examine the effects of both treatment and barrier recovery. After 16 days, samples were harvested at these sites to examine the SC ceramide composition and the lipid organization...
December 7, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29217167/potential-protective-effect-of-pistacia-lentiscus-oil-against-chlorpyrifos-induced-hormonal-changes-and-oxidative-damage-in-ovaries-and-thyroid-of-female-rats
#19
Samira Chebab, Fatiha Mekircha, Essaid Leghouchi
The purpose of this study was to evaluate the protective effect of Pistacia lentiscus oil (PLO), known for its antioxidant properties, on chlorpyrifos (CPF)-induced alterations in the thyroid, reproductive hormone levels, and oxidative damage in the ovaries and thyroid of adult Wistar rats. The animals were treated with orally administered PLO (2 mL/kg), CPF (6.75 mg/kg), and a combination of CPF and PLO for 30 days. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (Pg), estradiol (E2), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were assessed using chemiluminescence assay...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29215686/are-desensitizing-toothpastes-equally-biocompatible-and-effective-against-microorganisms
#20
Samira Esteves Afonso Camargo, Noala Vicensoto Moreira Milhan, Fernanda de Oliveira Saraiva, Jonatas Rafael de Oliveira, Luciane Dias de Oliveira, Carlos Henrique Ribeiro Camargo
The aims of this study were evaluate cytotoxicity, genotoxicity, antimicrobial activity of desensitizing toothpastes compared to a common one and the surface roughness of tooth enamel submitted to brushing with these toothpastes. Samples of three desensitizing toothpastes (Colgate Sensitive, Sensodyne and Oral B Sensitive) and common toothpaste (Colgate) were placed in contact with gingival human fibroblasts. Cytotoxicity and genotoxocity were measured by MTT assay and micronucleus test. Antimicrobial activity of the toothpastes extracts against C...
September 2017: Brazilian Dental Journal
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