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Tests and Measures Spine

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https://www.readbyqxmd.com/read/28437350/biomechanical-effects-of-a-dynamic-topping-off-instrumentation-in-a-long-rigid-pedicle-screw-construct
#1
Michael Reichl, Rebecca A Kueny, Reza Danyali, Peter Obid, Hüseyin Übeyli, Klaus Püschel, Michael M Morlock, Gerd Huber, Thomas Niemeyer, Alexander Richter
STUDY DESIGN: Biomechanical ex vivo study. OBJECTIVE: To determine if topping off instrumentation can reduce the hypermobility in the adjacent segments when compared with the classic rigid spinal instrumentation. SUMMARY OF THE BACKGROUND DATA: Long rigid instrumentation might increase the mechanical load in the adjacent segments, the resulting hypermobility, and the risk for adjacent segment disease. Topping off instrumentation intends to reduce the hypermobility at the adjacent level by more evenly distributing segmental motion and, thereby, potentially mitigating adjacent level disease...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437340/proximal-junctional-kyphosis-following-posterior-hemivertebra-resection-and-short-fusion-in-children-younger-than-10-years
#2
Yingsong Wang, Noriaki Kawakami, Taichi Tsuji, Tetsuya Ohara, Yoshitaka Suzuki, Toshiki Saito, Ayato Nohara, Ryoji Tauchi, Kazuki Kawakami
STUDY DESIGN: A retrospective study. OBJECTIVE: To investigate whether proximal junctional kyphosis (PJK) or obvious proximal junctional angle (PJA) changes in the sagittal plane develops following short fusion in children younger than 10 years of age with congenital scoliosis, and to investigate the possible risk factors. SUMMARY OF BACKGROUND DATA: PJK following long spinal fusion in adolescents and adults is a serious postoperative complication...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437336/both-bilateral-breast-volume-discrepancy-and-asymmetric-anterior-chest-wall-shape-contribute-to-the-unsightly-breast-contour-in-female-right-thoracic-idiopathic-scoliosis
#3
Benlong Shi, Saihu Mao, Xu Sun, Leilei Xu, Feng Zhu, Zezhang Zhu, Bangping Qian, Weijun Wang, Yong Qiu
STUDY DESIGN: A retrospective radiographic study. OBJECTIVE: To evaluate the asymmetry of breast volume (BV) and shape in female adolescent idiopathic scoliosis (AIS) patients and to define their relationship with deformed components of the anterior chest wall and curved spine. SUMMARY OF BACKGROUND DATA: The higher incidence of asymmetric breast development in AIS was described by prior studies. However, the interplay between scoliosis curve magnitude and severity of breast asymmetry (BA) are unknown...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437331/do-the-position-and-orientation-of-the-crosslink-influence-the-stiffness-of-spinal-instrumentation
#4
Zhuo Wang, Toshihiko Sakakibara, Takamasa Yoshikawa, Tadashi Inaba, Yuichi Kasai
STUDY DESIGN: Biomechanical study of double-level pedicle screw constructs with or without crosslinks (CL) in an unstable model. OBJECTIVES: The purpose of this study is to investigate the optimal position and orientation of the CL. SUMMARY OF BACKGROUND DATA: Several reports have described biomechanical research on such CL, but no definite consensus has been reached regarding the effects. Very few studies have examined the position and orientation of the CL...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28434682/a-proposed-linear-skeletal-distance-to-predict-occlusal-vertical-dimension-a-cephalometric-study
#5
Mohammed Nasser Alhajj, Ammar A Daer
STATEMENT OF PROBLEM: Establishing a correct occlusal vertical dimension is considered one of the most important aspects of facial esthetics for patients in need of oral rehabilitation. PURPOSE: The purpose of this retrospective study was to evaluate the use of a proposed linear skeletal distance to predict the appropriate occlusal vertical dimension. MATERIAL AND METHODS: A total of 93 digital cephalometric radiographs were collected in Joint Photographic Experts Group (JPEG) format (51 men, 42 women) from the archive of the orthodontics department at the Faculty of Dentistry, Sana'a University, Yemen...
April 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28430052/predicting-complication-risk-in-spine-surgery-a-prospective-analysis-of-a-novel-risk-assessment-tool
#6
Anand Veeravagu, Amy Li, Christian Swinney, Lu Tian, Adrienne Moraff, Tej D Azad, Ivan Cheng, Todd Alamin, Serena S Hu, Robert L Anderson, Lawrence Shuer, Atman Desai, Jon Park, Richard A Olshen, John K Ratliff
OBJECTIVE The ability to assess the risk of adverse events based on known patient factors and comorbidities would provide more effective preoperative risk stratification. Present risk assessment in spine surgery is limited. An adverse event prediction tool was developed to predict the risk of complications after spine surgery and tested on a prospective patient cohort. METHODS The spinal Risk Assessment Tool (RAT), a novel instrument for the assessment of risk for patients undergoing spine surgery that was developed based on an administrative claims database, was prospectively applied to 246 patients undergoing 257 spinal procedures over a 3-month period...
April 21, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28429640/spinal-alterations-of-reil-insula-in-alzheimer-s-disease
#7
Foivos E Petrides, Ioannis A Mavroudis, Martha Spilioti, Fotios G Chatzinikolaou, Vasiliki G Costa, Stavros J Baloyannis
Alzheimer's disease (AD) is a progressive neurodegenerative disease that involves numerous cellular and biochemical mechanisms resulting in synaptic alterations and extensive neuronal loss. It is primarily characterized by impairment of memory, associated frequently with mood disorders. Continuous studies have shown that insula may be an important target of AD, but neuropathological alterations have not been described extensively. In the present study, we attempted to describe the morphometric and morphological changes of the spines of Reil insula in AD in comparison with normal aging using a silver impregnation technique...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28427472/optimising-conservative-management-of-chronic-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#8
Katherine J Simson, Clint T Miller, Jon Ford, Andrew Hahne, Luana Main, Timo Rantalainen, Wei-Peng Teo, Megan Teychenne, David Connell, Guy Trudel, Guoyan Zheng, Gary Thickbroom, Daniel L Belavy
BACKGROUND: Lower back pain is a global health issue affecting approximately 80% of people at some stage in their life. The current literature suggests that any exercise is beneficial for reducing back pain. However, as pain is a subjective evaluation and physical deficits are evident in low back pain, using it as the sole outcome measure to evaluate superiority of an exercise protocol for low back pain treatment is insufficient. The overarching goal of the current clinical trial is to implement two common, conservative intervention approaches and examine their impact on deficits in chronic low back pain...
April 20, 2017: Trials
https://www.readbyqxmd.com/read/28419292/design-and-testing-of-2-novel-scores-that-predict-global-sagittal-alignment-utilizing-cervical-or-lumbar-plain-radiographs
#9
Ezequiel Goldschmidt, Federico Angriman, Bruno Ferreyro, Nitin Agarwal, James Zhou, Katherine Chen, Zachary J Tempel, Peter C Gerszten, Adam S Kanter, David O Okonkwo, Peter Passias, Justin Scheer, Themistocles Protopsaltis, Virginie Lafage, Renaud Lafage, Frank Schwab, Shay Bess, Chris Ames, Justin S Smith, Douglas Burton, D Kojo Hamilton
BACKGROUND: Global sagittal deformity is an established cause of disability. However, measurements of sagittal alignment are often ignored when patients present with symptoms localizing to the cervical or lumbar spine. OBJECTIVE: To develop scoring scales to predict the risk of sagittal malalignment in patients with only cervical or lumbar spine radiographs. METHODS: A retrospective review of a prospectively maintained multicenter adult spinal deformity database was performed...
April 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28418508/validation-method-for-motion-segments-of-the-lower-cervical-spine-kinematic-and-kinetic-response-for-quasi-static-and-dynamic-loading
#10
Jeffrey B Barker, Duane S Cronin, Roger W Nightingale
Advanced computational human body models enabling enhanced occupant safety require verification and validation at different levels or scales. Specifically, the motion segments, which are the building blocks of a detailed neck model, must be validated with representative experimental data to have confidence in segment and, ultimately, full neck model response. In this study, we demonstrate the importance of objective validation for quasi-static and dynamic loading. Finite element segment models at all levels in the lower human cervical spine were developed from scans of a 26 year old male subject...
April 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28415680/long-term-neurocognitive-dysfunction-in-offspring-via-ngf-erk-creb-signaling-pathway-caused-by-ketamine-exposure-during-the-second-trimester-of-pregnancy-in-rats
#11
Yanan Li, Xinran Li, Cen Guo, Lina Li, Yuxin Wang, Yiming Zhang, Yu Chen, Wenhan Liu, Li Gao
Early life exposure to ketamine caused neurohistopathologic changes and persistent cognitive dysfunction. For this study, a pregnant rat model was developed to investigate neurocognitive effects in the offspring, following ketamine exposure during the second trimester. Pregnant rats on gestational day 14 (equal to midtrimester pregnancy in humans), intravenously received 200 mg/kg ketamine for 3 h. Their behavior was tested (Morris water maze, odor recognition test, and fear conditioning) at postnatal days (P25-30)...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414169/a-biomechanical-investigation-of-different-screw-head-designs-for-vertebral-derotation-in-scoliosis-surgery
#12
Po-Yi Liu, Po-Liang Lai, Chun-Li Lin
BACKGROUND CONTEXT: The posterior pedicle screw-rod system, which is widely used to correct spinal deformities, achieves a good correction rate in the frontal and coronal planes but not in the axial plane. Direct vertebral derotation (DVD) was developed to correct axial plane deformities. However, the design of screw head and body connection, in terms of monoaxial, polyaxial, and uniplanar screw, may influence the efficiency of DVD. PURPOSE: This study compared the efficiency of a newly designed uniplanar screw to that of monoaxial and polyaxial screws in the DVD maneuver...
April 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28414168/decompression-alone-versus-fusion-for-pyogenic-spondylodiscitis
#13
Sung Hyun Noh, Ho Yeol Zhang, Hyun Sun Lim, Hyeon Jin Song, Kyung Hwa Yang
BACKGROUND CONTEXT: A spinal infection is a serious problem for a spine surgeon, and there is currently much debate regarding how best to treat pyogenic spondylodiscitis using antibiotics and the instrumentations that have been developed to date. PURPOSE: The purpose of this study was to determine which is better method for treating pyogenic spondylodiscitis. STUDY DESIGN/SETTING: A retrospective chart review was performed. PATIENT SAMPLE: Thirty-one patients with pyogenic spondylodiscitis underwent surgical treatment between 2000 and 2016 at the authors' institution...
April 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28413736/targeted-intraspinal-radiofrequency-ablation-for-lumbar-spinal-stenosis
#14
Robert E Jacobson, Michelle Granville, Jesse Hatgis DO
INTRODUCTION: By using a combination of magnetic resonance imaging (MRI) and computed tomography (CT) of the lumbar spine, it is possible to distinguish between spinal stenosis caused by bone compression and specific soft tissue epidural intraspinal lesions that cause localized spinal canal stenosis and neural compression. Examples include facet cysts and yellow ligament hypertrophy. Many of these patients are elderly with medical comorbidities that make open surgery problematic. MATERIALS & METHODS: This is a study of patients with predominantly soft tissue stenosis being treated with targeted intraspinal radiofrequency (RF) heat ablation...
March 10, 2017: Curēus
https://www.readbyqxmd.com/read/28408260/evaluation-of-bioabsorbable-multiamino-acid-copolymer-nano-hydroxyapatite-calcium-sulphate-cage-in-a-goat-spine-model
#15
Chunpeng Ren, Yueming Song, Youdi Xue, Xi Yang, Chunguang Zhou
BACKGROUND: Recently, polylactide is the most popular material used to made bioabsorbable cages, but too fast degradation and osteolysis around the cage have been reported in the literature. This study evaluated the fusion effect, biomechanical stability and histological characteristics of a novel bioabsorbable multi-amino acid copolymer/nano-hydroxyapatite/calcium sulphate (MAACP/n-HA/CS) interbody cage in a goat model of anterior cervical discectomy and fusion (ACDF). METHODS: A total of 24 goats underwent C3/C4 discectomy and fusion with three groups of intervertebral implants: MAACP/n-HA/CS cage group (n = 8), titanium cage group (n = 8) and autologous tricortical iliac crest bone group (n = 8)...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28394688/distance-between-the-malleoli-and-the-grounda-new-clinical-method-to-measure-leg-length-discrepancy
#16
Estela Gomez Aguilar, Águeda Gómez Domínguez, Carolina Peña-Algaba, José M Castillo-López
BACKGROUND: The aim of this work is to introduce a useful method for the clinical diagnosis of leg-length inequality: distance between the malleoli and the ground (DMG). METHODS: A transversal observational study was performed on 17 patients with leg-length discrepancy. Leg-length inequality was determined with different clinical methods: with a tape measure in a supine position from the anterior superior iliac spine (ASIS) to the internal and external malleoli, as the difference between the iliac crests when standing (pelvimeter), and as asymmetry between ASISs (PALpation Meter [PALM]; A&D Medical Products Healthcare, San Jose, California)...
March 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28394087/epigenome-wide-association-of-dna-methylation-in-whole-blood-with-bone-mineral-density
#17
John A Morris, Pei-Chien Tsai, Roby Joehanes, Jie Zheng, Katerina Trajanoska, Mette Soerensen, Vincenzo Forgetta, Juan Edgar Castillo-Fernandez, Morten Frost, Tim D Spector, Kaare Christensen, Lene Christiansen, Fernando Rivadeneira, Jonathan H Tobias, David M Evans, Douglas P Kiel, Yi-Hsiang Hsu, J Brent Richards, Jordana T Bell
Genetic and environmental determinants of skeletal phenotypes such as bone mineral density (BMD) may converge through the epigenome, providing a tool to better understand osteoporosis pathophysiology. As the epigenetics of BMD have been largely unexplored in humans, we performed an epigenome wide association study (EWAS) of BMD. We undertook a large-scale BMD EWAS using the Infinium HumanMethylation450 array to measure site-specific DNA methylation in up to 5,515 European descent individuals (NDiscovery  = 4,614, NValidation  = 901)...
April 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28391382/insufficient-stability-of-pedicle-screws-in-osteoporotic-vertebrae-biomechanical-correlation-of-bone-mineral-density-and-pedicle-screw-fixation-strength
#18
Lukas Weiser, Gerd Huber, Kay Sellenschloh, Lennart Viezens, Klaus Püschel, Michael M Morlock, Wolfgang Lehmann
PURPOSE: Loosening of pedicle screws is one major complication of posterior spinal stabilisation, especially in the patients with osteoporosis. Augmentation of pedicle screws with cement or lengthening of the instrumentation is widely used to improve implant stability in these patients. However, it is still unclear from which value of bone mineral density (BMD) the stability of pedicle screws is insufficient and an additional stabilisation should be performed. The aim of this study was to investigate the correlation of bone mineral density and pedicle screw fatigue strength as well as to define a threshold value for BMD below which an additional stabilisation is recommended...
April 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28391381/osseointegration-improves-bone-implant-interface-of-pedicle-screws-in-the-growing-spine-a-biomechanical-and-histological-study-using-an-in-vivo-immature-porcine-model
#19
Kanako Shiba, Hiroshi Taneichi, Takashi Namikawa, Satoshi Inami, Daisaku Takeuchi, Yutaka Nohara
PURPOSE: Implant failure is a frequent complication in corrective surgery for early onset scoliosis, since considerable forces are acting on small and fragile vertebrae. Osseointegration showing biomechanical and histological improvement in bone-implant interface (BII) after dental implant placement has been well investigated. However, there are no studies regarding osseointegration in immature vertebral bone. The purpose was to evaluate the timecourse of biomechanical and histological changes at BII after pedicle screw placement using in vivo immature porcine model...
April 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28377978/long-term-treatment-with-odanacatib-maintains-normal-trabecular-biomechanical-properties-in-ovariectomized-adult-monkeys-as-demonstrated-by-micro-ct-based-finite-element-analysis
#20
Antonio Cabal, Donald S Williams, Richa Y Jayakar, Jingru Zhang, Swanand Sardesai, Le T Duong
The cathepsin K inhibitor odanacatib (ODN) is a potent and reversible inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. Previously, we described data on the treatment efficacy of ODN in a preclinical estrogen-deficient model of an ovariectomized (OVX) rhesus monkey using HR-pQCT based finite element analysis (FEA) in vivo estimates of bone strength on the distal radius. To support the bone safety profile of ODN, we report ex vivo data on the apparent and hard tissue biomechanical properties of the trabecular bone of vertebrae of animals after 20 months of dosing in three treatment groups: Vehicle (VEH), ODN (2 mg/kg/day), and ALN (30 μg/kg/week)...
June 2017: Bone Reports
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