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Tests and Measures Spine

Chao Dong, Ji-Chun Zhang, Wei Yao, Qian Ren, Min Ma, Chun Yang, Shigeyuki Chaki, Kenji Hashimoto
BACKGROUND: Similar to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, the metabotropic glutamate 2/3 (mGlu2/3) receptor antagonist, MGS0039 shows antidepressant effects. However, there are no reports comparing these two compounds in the social defeat stress model of depression. METHODS: We examined the effects of MGS0039 (1 mg/kg) and ketamine (10 mg/kg) on depression-like behavior in susceptible mice, after repeated social defeat stress. Protein levels of brain-derived neurotrophic factor (BDNF), TrkB, phospho-TrkB (p-TrkB), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (GluA1) and postsynaptic density protein 95 (PSD-95), and dendritic spine density in selected brain regions were measured...
October 7, 2016: International Journal of Neuropsychopharmacology
Dennis Hey, Eugene Tze Chun Lau, Joel-Louis Lim, Denise Choong, Chuen-Seng Tan, Gabriel Ka-Po Liu, Hee-Kit Wong
BACKGROUND CONTEXT: Flexion radiographs have been used to identify cases of spinal instability. However, current methods are not standardized and are not sufficiently sensitive/specific to identify instability. PURPOSE: Introduction of a new slump sitting method for performing lumbar spine flexion radiographs and comparison of the angular range of motions and displacements between the conventional method and this new method. STUDY DESIGN: Prospective study on radiologic evaluation of the lumbar spine flexion range of motions and displacements using dynamic radiographs PATIENT SAMPLE: 60 patients were recruited from a single spine tertiary centre...
October 17, 2016: Spine Journal: Official Journal of the North American Spine Society
Daniel Niederer, Lutz Vogt, Pia-Maria Wippert, Anne-Katrin Puschmann, Ann-Christin Pfeifer, Marcus Schiltenwolf, Winfried Banzer, Frank Mayer
BACKGROUND: Arising from the relevance of sensorimotor training in the therapy of nonspecific low back pain patients and from the value of individualized therapy, the present trial aims to test the feasibility and efficacy of individualized sensorimotor training interventions in patients suffering from nonspecific low back pain. METHODS AND STUDY DESIGN: A multicentre, single-blind two-armed randomized controlled trial to evaluate the effects of a 12-week (3 weeks supervised centre-based and 9 weeks home-based) individualized sensorimotor exercise program is performed...
October 20, 2016: Trials
Nam-Su Chung, Chang-Hoon Jeon, Han-Dong Lee, Suk-Hyeong Won
STUDY DESIGN: This was a radiographic validity and reliability study. OBJECTIVE: We assessed the validity and reliability of measurements made on standing lateral lumbar radiographs, compared with lateral whole-spine radiographs, for evaluating spinopelvic parameters and lumbar lordosis (LL). SUMMARY OF BACKGROUND DATA: A lateral whole-spine radiograph is the gold standard image for measurement of spinopelvic parameters. However, little evidence is available on the reliability of measurements made on such radiograph...
October 19, 2016: Clinical Spine Surgery
Saulo de Tarso de Sá Pereira Segundo, Edgar Santiago Valesin, Mario Lenza, Durval do Carmo Barros Santos, Laercio Alberto Rosemberg, Mario Ferretti
Objective: To measure the interobserver reproducibility of the radiographic evaluation of lumbar spine instability. Methods: Measurements of the dynamic radiographs of the lumbar spine in lateral view were performed, evaluating the anterior translation and the angulation among the vertebral bodies. The tests were evaluated at workstations of the organization, through the Carestream Health Vue RIS (PACS), version Inc. 2009© system. Results: Agreement in detecting cases of radiographic instability among the observers varied from 88...
July 2016: Einstein
Brett T Allaire, M Clara DePaolis Kaluza, Alexander G Bruno, Elizabeth J Samelson, Douglas P Kiel, Dennis E Anderson, Mary L Bouxsein
PURPOSE: Current standard methods to quantify disc height, namely distortion compensated Roentgen analysis (DCRA), have been mostly utilized in the lumbar and cervical spine and have strict exclusion criteria. Specifically, discs adjacent to a vertebral fracture are excluded from measurement, thus limiting the use of DCRA in studies that include older populations with a high prevalence of vertebral fractures. Thus, we developed and tested a modified DCRA algorithm that does not depend on vertebral shape...
October 18, 2016: European Spine Journal
Nima Toosizadeh, Homayoon Harati, Tzu-Chuan Yen, Cindy Fastje, Jane Mohler, Bijan Najafi, Michael Dohm
BACKGROUND: This study examined short- and long-term improvements in motor performance, quantified using wearable sensors, in response to facet spine injection in degenerative facet osteoarthropathy patients. METHODS: Adults with confirmed degenerative facet osteoarthropathy were recruited and were treated with medial or intermediate branch block injection. Self-report pain, health condition, and disability (Oswestry), as well as objective motor performance measures (gait, balance, and timed-up-and-go) were obtained in five sessions: pre-surgery (baseline), immediately after the injection, one-month, three-month, and 12-month follow-ups...
October 11, 2016: Clinical Biomechanics
Wendy B Katzman, Neeta Parimi, Ziba Mansoori, Lorenzo Nardo, Deborah M Kado, Peggy M Cawthon, Lynn M Marshall, John T Schousboe, Nancy E Lane
OBJECTIVE: Investigate cross-sectional and longitudinal associations of Diffuse Idiopathic Skeletal Hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS: DISH and kyphosis were assessed in 1500 men from the Osteoporosis in Men (MrOS) study and 1267 women from the Study of Osteoporotic Fractures (SOF). DISH was assessed in baseline lateral spine radiographs, and Cobb angle of kyphosis was measured from baseline and follow-up radiographs, mean 4.6 years later in men, and 3...
October 9, 2016: Arthritis Care & Research
Lan T Ho-Pham, Thai Q Lai, Uyen D T Nguyen, Quoc V Bui, Tuan V Nguyen
To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20-89 years who were randomly sampled from Ho Chi Minh City (Vietnam). BMD at the femoral neck (FN), lumbar spine (LS), and whole body (WB) was measured by DXA. Lean mass and FM were derived from the WB DXA scan. Leptin was measured by ELISA (DRG Diagnostics, Germany). The regression method was used to partition the variance of leptin and FM on BMD...
October 8, 2016: Calcified Tissue International
Hal D Martin, Anthony N Khoury, Ricardo Schröder, Eric Johnson, Juan Gómez-Hoyos, Salvador Campos, Ian J Palmer
PURPOSE: To determine the isolated function of the pubofemoral ligament of the hip capsule and its contribution to hip stability in external/internal rotational motion during flexion greater than 30° and abduction. METHODS: Thirteen hips from 7 fresh-frozen pelvis-to-toe cadavers were skeletonized from the lumbar spine to the distal femur with the capsular ligaments intact. Computed tomographic imaging was performed to ensure no occult pathological state existed, and assess bony anatomy...
October 5, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
A I Macfarlane, D Rudd, E Knight, L A G Marshman, E P Guazzo, D S Anderson
: Prior studies have suggested that elevated serum Troponin-I (TnI) levels immediately after non-cardiac surgical procedures (8-40%) represent subclinical cardiac stress which independently predicts increased 30-day mortality. Routine post-operative TnI monitoring has therefore been suggested as a standard of care. However, no prior studies have focussed on elective degenerative spine surgery, whilst few have measured pre-op TnI. Further, prolonged prone positioning could represent an additional, independent, cardiac stress...
October 1, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Arnaud Dubory, Lotfi Miladi, Brice Ilharreborde, Jean-Marie Gennari, Jihane Rouissi, Christophe Glorion, Charles Henri Flouzat Lachaniette, Thierry Odent
PURPOSE: Anterior fusion is a well-established procedure for the treatment of Lenke 5C adolescent idiopathic scoliosis (AIS). This retrospective study aimed to assess preoperative and postoperative radiographic differences between the conventional anterior fusion and anterior short fusions (ASF) in Lenke 5C AIS. METHODS: Radiographic data of 42 consecutive cases of Lenke 5C AIS, which were surgically treated through anterior segmental fusion, were analyzed retrospectively...
October 4, 2016: European Spine Journal
Donita I Bylski-Austrow, David L Glos, Anne C Bonifas, Max F Carvalho, Matthew C Coombs, Peter F Sturm
BACKGROUND: Surgical treatments for early onset scoliosis (EOS) correct curvatures and improve respiratory function but involve many complications. A distractible, or 'growing rod,' implant construct that is more flexible than current metal rod systems may sufficiently correct curves in small children and reduce complications due to biomechanical factors. The purpose of this pilot study was to determine ranges of motion (ROM) after implantation of simulated growing rod constructs with a range of clinically relevant structural properties...
2016: Scoliosis and Spinal Disorders
Niloofar Hajizadeh, Mehryar Mehrkash, Daryoosh Fahimi, Mostafa Qorbani, Nina Shafa
INTRODUCTION: Although some descriptive and cross-sectional studies have been reported about bone mass in chronic kidney disease (CKD) children, only a few studies investigated markers of bone turnover and the bone mass measurements. OBJECTIVES: The aim of this study was to evaluate the association between bone mineral density (BMD) and biochemical markers of bone turnover in hemodialysis (HD) children. PATIENTS AND METHODS: The children who had received dialysis for at least the preceding 6-month were included...
2016: Journal of Renal Injury Prevention
Fatih Cesme, Sina Esmaeilzadeh, Aydan Oral
OBJECTIVES: The aim of this case-control study was to compare the discriminatory ability of bone mineral density (BMD) measurements and calcaneal quantitative ultrasound (QUS) parameters for fractures and to determine fracture thresholds for each variable in men with hip or distal forearm fractures. PATIENTS AND METHODS: A total of 20 men with hip and 18 men with distal forearm fractures and 38 age-matched controls were included in this study. Dual-energy X-ray absorptiometry (DXA) BMD (spine and hip) and calcaneal QUS measurements were made...
September 25, 2016: Acta Orthopaedica et Traumatologica Turcica
C I Leichtle, A Lorenz, S Rothstock, J Happel, F Walter, T Shiozawa, U G Leichtle
OBJECTIVES: Cement augmentation of pedicle screws could be used to improve screw stability, especially in osteoporotic vertebrae. However, little is known concerning the influence of different screw types and amount of cement applied. Therefore, the aim of this biomechanical in vitro study was to evaluate the effect of cement augmentation on the screw pull-out force in osteoporotic vertebrae, comparing different pedicle screws (solid and fenestrated) and cement volumes (0 mL, 1 mL or 3 mL)...
September 2016: Bone & Joint Research
S Indhavivadhana, M Rattanachaiyanont, S Angsuwathana, K Techatraisak, P Tanmahasamut, P Leerasiri
OBJECTIVES: To validate osteoporosis risk assessment tools in middle-aged Thai women. METHODS: A total of 1038 women who had bone mineral density (BMD) measurements using dual-energy X-ray absorptiometry were reviewed. Clinical data were used to validate the diagnostic test performance of various osteoporosis risk assessment tools, including ABONE, FRAX(®), ORAI, OSIRIS, SCORE, SOFSURF, and OSTA. The following parameters were evaluated: sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy; those with 95% confidence interval (CI) of the receiver operator characteristics area under the curve (ROC-AUC) > 0...
September 24, 2016: Climacteric: the Journal of the International Menopause Society
D B Amin, I M Lawless, D Sommerfeld, R M Stanley, B Ding, J J Costi
The complex, direction-dependent, poro-viscoelastic properties of the intervertebral disc (disc) suggest that investigations of the six degree of freedom (6DOF) behaviour may be susceptible to inter-test variation in mechanical response if the disc does not return to initial conditions between loading directions. No studies have quantified the effects of sequential multi-directional loading on the consistency of the compressive response of the disc throughout a 6DOF testing protocol. Therefore, the objective of this study was to determine the effect of 6DOF loading on the compressive properties (stiffness and phase angle) of human discs, as evaluated by a reference compression test performed after each single DOF test...
October 3, 2016: Journal of Biomechanics
Md Abu Bakar Siddiq, Md Shawkat Hossain, Mohammad Moin Uddin, Israt Jahan, Moshiur Rahman Khasru, Neaz Mahmud Haider, Johannes J Rasker
AIMS: To describe a series of piriformis syndrome patient among Bangladesh people with literature review. METHODS: Consecutive 31 piriformis syndrome patients were enrolled. Besides history and clinical examination, piriformis muscle thickness was also measured with diagnostic ultrasound (3.5 MHZ). MRI of lumbar spine, X-rays of lumbo-sacral spine, and pelvis were performed in all patients. Statistical Package for the Social Sciences (SPSS), Windows 8.0, was used for statistical calculation, and univariate analysis of primary data was done...
September 19, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Virginie Poortmans, Jean-Michel Brismée, Bernard Poortmans, Omer C Matthijs, Pierre-Michel Dugailly, Stéphane Sobczak
OBJECTIVES: The purpose of this study was to correlate sitting height measured by stadiometry with lumbar spine height (LSH) modifications measured by musculoskeletal ultrasonography (MSU). METHODS: Eighteen healthy young adults were recruited for this study (mean age: 21.5 ± 1.5 years). All subjects were tested in the following sequence: (1) lying supine for 10 minutes, (2) sitting under loaded (9.5 kg) and unloaded conditions for 5 minutes each, (3) lying supine for 15 minutes with passive lumbar extension, and (4) sitting unloaded for 5 minutes...
September 13, 2016: Journal of Manipulative and Physiological Therapeutics
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