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https://www.readbyqxmd.com/read/29443647/system-level-health-care-integration-and-the-costs-of-cancer-care-across-the-disease-continuum
#1
Deborah R Kaye, Hye Sung Min, Edward C Norton, Zaojun Ye, Jonathan Li, James M Dupree, Chad Ellimoottil, David C Miller, Lindsey A Herrel
PURPOSE: Policy reforms in the Affordable Care Act encourage health care integration to improve quality and lower costs. We examined the association between system-level integration and longitudinal costs of cancer care. METHODS: We used linked SEER-Medicare data to identify patients age 66 to 99 years diagnosed with prostate, bladder, esophageal, pancreatic, lung, liver, kidney, colorectal, breast, or ovarian cancer from 2007 to 2012. We attributed each patient to one or more phases of care (ie, initial, continuing, and end of life) according to time from diagnosis until death or end of study interval...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29426941/microfluidic-channel-optimization-to-improve-hydrodynamic-dissociation-of-cell-aggregates-and-tissue
#2
Xiaolong Qiu, Jen-Huang Huang, Trisha M Westerhof, Jeremy A Lombardo, Katrina M Henrikson, Marissa Pennell, Pedram P Pourfard, Edward L Nelson, Pulak Nath, Jered B Haun
Maximizing the speed and efficiency at which single cells can be liberated from tissues would dramatically advance cell-based diagnostics and therapies. Conventional methods involve numerous manual processing steps and long enzymatic digestion times, yet are still inefficient. In previous work, we developed a microfluidic device with a network of branching channels to improve the dissociation of cell aggregates into single cells. However, this device was not tested on tissue specimens, and further development was limited by high cost and low feature resolution...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29409743/tolerance-induction-in-hla-disparate-living-donor-kidney-transplantation-by-facilitating-cell-enriched-donor-stem-cell-infusion-the-importance-of-durable-chimerism
#3
REVIEW
Joseph R Leventhal, Suzanne T Ildstad
Successful solid organ transplantation currently requires the life-long use of medications to suppress the immune system in order to prevent transplant rejection. Drug-based immunosuppression significantly increases the risk of infection and cancer, as well as being very costly. Development of new therapies to minimize or eliminate entirely the need for anti-rejection drugs is of great interest to the transplant community. Therapeutic cell transfer for the control of the human immune system represents a compelling approach to reduce or eliminate the need for anti-rejection drugs...
February 2, 2018: Human Immunology
https://www.readbyqxmd.com/read/29397279/cost-of-tobacco-related-cancer-hospitalizations-in-the-u-s-2014
#4
Eric W Tai, Gery P Guy, C Brooke Steele, S Jane Henley, Michael S Gallaway, Lisa C Richardson
INTRODUCTION: Smoking has been causally linked to 12 tobacco-related cancers: oral cavity and pharynx, esophagus, stomach, colon and rectum, liver, pancreas, larynx, lung, cervix, bladder, kidney, and acute myeloid leukemia. Tobacco-related cancers-related morbidity and mortality have been well described, but little is known about the prevalence of tobacco-related cancer hospitalizations and associated costs. This study estimates the annual number of tobacco-related cancer hospitalizations and their associated direct medical costs in the U...
January 31, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29394358/treatment-outcomes-of-multidrug-resistant-tuberculosis-in-taiwan-tackling-loss-to-follow-up
#5
Ming-Chih Yu, Chen-Yuan Chiang, Jen-Jyh Lee, Shun-Tien Chien, Chou-Jui Lin, Shih-Wei Lee, Chih-Bin Lin, Wen-Ta Yang, Ying-Hsun Wu, Yi-Wen Huang
Background: The proportion of treatment success among multidrug-resistant tuberculosis (MDR-TB) patients enrolled between 1992 and 1996 was 51.2%, and that among patients enrolled between 2000 and April 2007 was 61%. To address the challenge of MDR-TB, the Taiwan MDR-TB Consortium (TMTC) was established in May 2007. To assess the performance of the TMTC, we analyzed the data of patients enrolled in its first 5 years. Methods: Comprehensive care was provided at no cost to patients, who were usually hospitalized for one month initially...
January 31, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29304049/cost-and-affordability-of-non-communicable-disease-screening-diagnosis-and-treatment-in-kenya-patient-payments-in-the-private-and-public-sectors
#6
Sujha Subramanian, Robai Gakunga, Joseph Kibachio, Gladwell Gathecha, Patrick Edwards, Elijah Ogola, Gerald Yonga, Naftali Busakhala, Esther Munyoro, Jeremiah Chakaya, Nancy Ngugi, Nyawira Mwangi, Daniel Von Rege, Lili-Marie Wangari, David Wata, Robert Makori, Julius Mwangi, Walter Mwanda
INTRODUCTION: The prevalence of non-communicable diseases (NCDs) is rising in low- and middle-income countries, including Kenya, disproportionately to the rest of the world. Our objective was to quantify patient payments to obtain NCD screening, diagnosis, and treatment services in the public and private sector in Kenya and evaluate patients' ability to pay for the services. METHODS AND FINDINGS: We collected payment data on cardiovascular diseases, diabetes, breast and cervical cancer, and respiratory diseases from Kenyatta National Hospital, the main tertiary public hospital, and the Kibera South Health Center-a public outpatient facility, and private sector practitioners and hospitals...
2018: PloS One
https://www.readbyqxmd.com/read/29238222/the-burden-of-selected-cancers-in-the-us-health-behaviors-and-health-care-resource-utilization
#7
Laura Iadeluca, Jack Mardekian, Pratibha Chander, Markay Hopps, Geoffrey T Makinson
Objective: To characterize the disease burden among survivors of those cancers having the highest incidence in the US. Methods: Adult (≥18 years) survivors of the 11 most frequently diagnosed cancers were identified from publically available data sources, including the Surveillance Epidemiology and End Results 9 1973-2012, National Health Interview Survey 2013, and the Medical Expenditure Panel Survey 2011. Chi-square tests and one-way analyses of variance were utilized to assess differences between cancer survivors and non-cancer controls in behavioral characteristics, symptoms and functions, preventative screenings, and health care costs...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29234938/impact-of-incisional-hernia-development-following-abdominal-operations-on-total-healthcare-cost
#8
Vamsi V Alli, Jianying Zhang, Dana A Telem
BACKGROUND: Introduction of the category III CPT code (0437T) for prophylactic mesh augmentation (PMA) highlights efforts to reduce incisional hernia (IH). PMA's value in the context of value-based care requires understanding both the cost of IH development and the savings from prevention. We hypothesized large healthcare costs with IH development. Appreciating which subsets of patients are at highest risk for IH, and the subsets who have the costliest care is essential in targeting interventions for hernia prevention...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29207219/-donor-and-recipient-selection-in-living-donor-kidney-transplantation-eligibility
#9
REVIEW
Marilena Gregorini, Eleonora Francesca Pattonieri, Gianluca Fasoli, Mauro Valente, Edoardo La Porta, Michele Canevari, Fulvia Erasmi, Teresa Rampino
This review is intended to be a guide for the physician to evaluate and prepare a donor / recipient couple for living kidney transplantation. Although it is intended to be exhaustive, it will not be able to respond at all possible and different cases, but it may apply at most of them. Renal transplantation is considered the choice treatment for patients with chronic renal failure and if the kidney transplant is performed pre-emptive it is associated with better organ and patient survival. The main aim of the program is to evaluate the risks of donor and recipient and to ensure the donor safety and well-being...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29205995/volume-and-health-outcomes-evidence-from-systematic-reviews-and-from-evaluation-of-italian-hospital-data
#10
Laura Amato, Danilo Fusco, Anna Acampora, Katia Bontempi, Alessandro Cesare Rosa, Paola Colais, Fabio Cruciani, Mariangela D'Ovidio, Francesca Mataloni, Silvia Minozzi, Zuzana Mitrova, Luigi Pinnarelli, Rosella Saulle, Salvatore Soldati, Chiara Sorge, Simona Vecchi, Martina Ventura, Marina Davoli
BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29145841/rehabilitation-for-cancer-patients-at-black-lion-hospital-addis-ababa-ethiopia-a-cross-sectional-study
#11
Teshager Worku, Zuriash Mengistu, Agumasie Semahegn, Gezahegn Tesfaye
BACKGROUND: In Ethiopia, there were greater than 2000 adult and 200 pediatric cancer patients annually in 2010, but the estimated number of cancer patients were increasing. Oncologic rehabilitation treatment may result in improved physical and mental impairment. There is a paucity of information about rehabilitation service utilization among cancer patients in Ethiopia. Hence, the purpose of this study was to assess the rehabilitation service for cancer patient and associated factors at Black Lion hospital, Addis Ababa, Ethiopia...
November 16, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29097278/hamda-hybrid-approach-for-mirna-disease-association-prediction
#12
Xing Chen, Ya-Wei Niu, Guang-Hui Wang, Gui-Ying Yan
For decades, enormous experimental researches have collectively indicated that microRNA (miRNA) could play indispensable roles in many critical biological processes and thus also the pathogenesis of human complex diseases. Whereas the resource and time cost required in traditional biology experiments are expensive, more and more attentions have been paid to the development of effective and feasible computational methods for predicting potential associations between disease and miRNA. In this study, we developed a computational model of Hybrid Approach for MiRNA-Disease Association prediction (HAMDA), which involved the hybrid graph-based recommendation algorithm, to reveal novel miRNA-disease associations by integrating experimentally verified miRNA-disease associations, disease semantic similarity, miRNA functional similarity, and Gaussian interaction profile kernel similarity into a recommendation algorithm...
October 30, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28993132/screen-failure-rates-in-contemporary-randomized-clinical-phase-ii-iii-therapeutic-trials-in-genitourinary-malignancies
#13
Sarah E Wong, Scott A North, Christopher J Sweeney, Martin R Stockler, Srikala S Sridhar
BACKGROUND: Screen failures, defined as individuals who undergo screening but are not enrolled in a clinical trial, incur significant costs without contributing valuable data to the study. Despite these costs, there are few published data about the rate or reasons for screen failures in advanced genitourinary cancer clinical trials. MATERIALS AND METHODS: We reviewed 50 phase II and III trials in advanced genitourinary cancers conducted between 1999 and 2016. RESULTS: Of the 50 trials, only 48% (24 of 50) published screen failure rates: 68% (13 of 19) of those in prostate cancer, 33% (6 of 18) in kidney cancer, and 58% (5 of 13) in bladder cancer...
September 8, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28917949/linear-association-between-number-of-modifiable-risk-factors-and-multiple-chronic-conditions-results-from-the-behavioral-risk-factor-surveillance-system
#14
Mary L Adams, Joseph Grandpre, David L Katz, Douglas Shenson
Multiple (≥2) chronic conditions (MCCs) are responsible for a large fraction of healthcare costs. Our aim was to examine possible associations between MCCs and composite measures of behavioral risk factors (RFs). Data were publicly available 2013 Behavioral Risk Factor Surveillance System and included 483,865 non-institutionalized US adults ages ≥18years. Chronic conditions included asthma, arthritis, chronic obstructive pulmonary disease, cognitive impairment, heart disease, stroke, cancer, and kidney disease...
December 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28890005/-ablative-therapy-in-kidney-cancer-oncological-functional-perioperative-outcomes-and-cost
#15
P Mouracade, T Tricard, A Gangi, X Cathelineau, H Lang
INTRODUCTION: The incidence of kidney cancer has increased significantly over the past few decades presumably due to the increased use of imaging. The aim of this article is to describe contemporary outcomes of ablative therapy and to compare them to other therapeutic options in terms of oncological, functional, perioperative outcomes and cost. MATERIAL AND METHODS: We searched MEDLINE(®), Embase(®), using (MeSH) words; from January 2005 through May 2017, and we looked for all the studies...
September 7, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28886426/synthesis-characterization-and-evaluation-cytotoxic-activity-of-silver-nanoparticles-synthesized-by-chinese-herbal-cornus-officinalis-via-environment-friendly-approach
#16
Yangqing He, Xing Li, Ju Wang, Qian Yang, Binghua Yao, Yingjuan Zhao, Aiming Zhao, Wenxing Sun, Qian Zhang
Cornus officinalis has been widely used as a precious herb and as the tonic food to improve kidney function in China. Its fruits have been used in many traditional Chinese medicine prescriptions to treat kidney diseases, diabetes, cancer and shock. In this study, a new eco-friendly approach for green synthesis of silver nanoparticles (AgNPs) by using the fruits of Cornus officinalis aqueous extract as a reducing and stabilizing agent. The so-synthesized AgNPs showed quasi-spherical in shape with uniform dispersal and an average mean size of 11...
September 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28880839/differences-between-younger-and-older-us-adults-with-multiple-chronic-conditions
#17
Mary L Adams
INTRODUCTION: Adults with multiple (≥2) chronic conditions (MCCs) account for a large portion of US health care costs. Despite the increase in MCC rates with age, most people with MCCs are working age. The study objective was to compare adults with MCCs who were younger than 65 years with those aged 65 years or older on selected measures to better understand the differences between groups and inform interventions that could lower health care costs. METHODS: Data from respondents to the 2015 Behavioral Risk Factor Surveillance System data (N = 201,711) were used to compare adults aged 65 or older with MCCs with those younger than 65 with MCCs in unadjusted and adjusted analyses on chronic conditions, quality of life measures, disability status, access to health care, and modifiable risk factors...
September 7, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28877856/geriatric-cancer-trends-in-the-middle-east-findings-from-lebanese-cancer-projections-until-2025
#18
Fady G H Haddad, Joseph Kattan, Hampig R Kourie, Elie El Rassy, Tarek Assi, Salim M Adib
OBJECTIVE: By 2020, 70% of all cancers will occur in patients aged 65years and older, causing an increase in related morbidity, mortality, and cost. This study projects cancer trends in the elderly population in Lebanon, a country experiencing accelerating aging trends. Findings will guide future policy decisions regarding geriatric oncology in Lebanon and the surrounding Arab world. MATERIALS AND METHODS: Cancer incidence rates were derived for men and women 65years and above, divided into three age groups: 65-69years, 70-74years, and 75years and above...
September 4, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28869173/-ablative-therapy-in-kidney-cancer-indications
#19
T Tricard, G Tsoumakidou, V Lindner, J Garnon, G Albrand, X Cathelineau, A Gangi, H Lang
BACKGROUND: Ablative therapies (AT) in kidney cancer are rising. It's important to evaluate the situation of this therapy. The aim of this study is to identify the best indications for AT treatment for kidney cancer. METHODS: Review of literature using Medline and Embase databases. Study were selected based on scientific relevance. Clinical keys centered on the best requirements to indicate ablative therapies. RESULTS: AT is indicated according to specific tumor and patients criteria...
August 30, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28847047/-deaths-and-life-expectancy-losses-attributable-to-diet-high-in-sodium-in-china
#20
S W Liu, Y Cai, X Y Zeng, P Yin, J L Qi, Y N Liu, J M Liu, Z P Zhao, M Zhang, L M Wang, L J Wang, M Xue, M G Zhou
Objective: To quantitatively estimate the deaths and life expectancy losses attributable to diet high in sodium in China, and examine the gains and shifts under different control scenarios of sodium consumption. Methods: Based on data from the cause-of-death through the National Mortality Surveillance System, and 24 hours urinary sodium values from Global Burden of Disease study on Chinese's estimates, population attributable fractions with the framework of comparative risk assessment were used to analyze the deaths and life expectancy losses due to diet high in sodium...
August 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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