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Arun Rajgopal, Stephen R Missler, Jeffery D Scholten
ETHNOPHARMACOLOGICAL RELEVANCE: The highly aromatic bark of Magnolia officinalis Rehder & EH Wilson, (magnolia bark) has been widely used in traditional Chinese medicine where it is known as Hou Po. Historically the bark of the tree has been used for treating variety of disorders the most common use of magnolia bark in traditional prescription has been to treat stress and anxiety disorders. Till date it is not clear regarding the fundamental cellular pathway it modulates. NRF2 signaling has emerged as the central pathway that protects cells from variety of stressors this led us to hypothesize that basis for magnolia bark's effects could be via activating NRF2 pathway...
October 6, 2016: Journal of Ethnopharmacology
Nobuaki Matsui, Haruka Akae, Nana Hirashima, Yuki Kido, Satoshi Tanabe, Mayumi Koseki, Yoshiyasu Fukuyama, Masaaki Akagi
Magnolol is the main constituent of Magnolia bark and has been reported to exhibit antidepressant effects in rodent models. Hippocampal neurogenesis and neurotrophins such as brain-derived neurotrophic factor are integrally involved in the action of conventional antidepressants. Here, we investigated the effects of magnolol on depressive behaviours, impaired hippocampal neurogenesis and neurotrophin-related signal transduction in an olfactory bulbectomy (OBX) mouse model of depression. Mice were submitted to OBX to induce depressive behaviour, which was evaluated in the tail suspension test...
August 11, 2016: Phytotherapy Research: PTR
Riccardo Bertin, Zheng Chen, Raffaella Marin, Maddalena Donati, Angela Feltrinelli, Monica Montopoli, Sabina Zambon, Enzo Manzato, Guglielmina Froldi
Studies indicate that oxidative modifications of endothelium and LDL play a preeminent role in atherogenesis; therefore, the preservation of the endothelial antioxidant capacity and the inhibition of LDL oxidation by use of plant-derived compounds are an appealing strategy against several vascular disorders. On this basis, baicalein, eupatorin, galangin, magnolol, myricetin, oleuropein, silibinin and bilobalide were studied against various oxidative conditions. The radical scavenging capacity was analysed using DPPH and ORAC assays...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tsuimin Tsai, Chen-Yu Kao, Chun-Liang Chou, Lu-Chun Liu, Tz-Chong Chou
Magnolol has shown inhibitory effects on NO production and TNF-alpha production in lipopolysaccharide (LPS)-activated macrophages and LPS-induced acute lung injury; however, the poor solubility of magnolol has hindered its clinical success. In this study, magnolol-loaded microparticles were prepared via single emulsion method from a polyketal polymer, termed PK3. The particle sizes of magnolol-loaded PK3 microparticle is 3.73 ± 0.41 μm, and was suitable for phagocytosis by macrophages and pulmonary drug delivery...
August 2016: Journal of Microencapsulation
Giovanna Pani, Alessandro Dessì, Roberto Dallocchio, Barbara Scherm, Emanuela Azara, Giovanna Delogu, Quirico Migheli
A model of the trichodiene synthase (TRI5) of the wheat fungal pathogen and type-B trichothecene producer Fusarium culmorum was developed based on homology modelling with the crystallized protein of F. sporotrichioides. Eight phenolic molecules, namely ferulic acid 1, apocynin 2, propyl gallate 3, eugenol 4, Me-dehydrozingerone 5, eugenol dimer 6, magnolol 7, and ellagic acid 8, were selected for their ability to inhibit trichothecene production and/or fungal vegetative growth in F. culmorum. The chemical structures of phenols were constructed and partially optimised based on Molecular Mechanics (MM) studies and energy minimisation by Density Functional Theory (DFT)...
2016: PloS One
Yuting Liu, Yunli Tong, Xia Yang, Fangyuan Li, Liang Zheng, Wenqin Liu, Jinjun Wu, Rilan Ou, Guiyu Zhang, Ming Hu, Zhongqiu Liu, Linlin Lu
Histone modifications play critical roles in the progression of non-small cell lung cancer (NSCLC), which accounts for almost 85% of all diagnosed lung cancers. Magnolol and polyphenol mixture (PM) derived from Magnolia officinalis exhibited remarkable antitumor activities in lung cancer. However, the epigenetic effects and molecular mechanisms of magnolol and PM in NSCLC have yet to be reported. In this study, the epigenetic effects of magnolol and PM in NSCLC were examined in vitro and in vivo. Results revealed that magnolol and PM significantly suppressed the expression levels and function of class I histone deacetylases (HDACs)...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Chen Mei, Sha-Sha He, Peng Yin, Lei Xu, Ya-Ran Shi, Xiao-Hong Yu, An Lyu, Feng-Hua Liu, Lin-Shu Jiang
OBJECTIVE: Heat stress (HS) is an important environmental stressor that adversely influences livestock during the summer. The aim of this study was to investigate whether magnolol protects against HS-induced intestinal epithelial cell injury. MATERIALS AND METHODS: An intestinal epithelial cell line (IEC-6) was subjected to HS at 42 °C, with and without magnolol pretreatment. Cell injury was detected by monitoring lactate dehydrogenase (LDH) release. MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay was used to assess cell proliferation and viability, including identifying effective concentrations of magnolol...
June 2016: Journal of Zhejiang University. Science. B
Chwan-Fwu Lin, Chi-Feng Hung, Ibrahim A Aljuffali, Yu-Ling Huang, Wei-Chun Liao, Jia-You Fang
PURPOSE: As a continuing effort to elucidate the impact of structure modification upon cutaneous absorption behavior, we attempted to assess the skin permeation of magnolol by methylation and acetylation. METHODS: Diacetylmagnolol and 2-O-acetyl-2'-O-methylmagnolol (AMM) were designed and synthesized in this study. The anti-inflammatory activity against stimulated neutrophils and keratinocytes was evaluated to check the bioactivity of the analogues. In vitro skin absorption was investigated using nude mouse and pig skin models at both equimolar and saturated doses...
September 2016: Pharmaceutical Research
Ke Fang, Xiao-Fen Yuan, Qiong Liao, Zhi-Yong Zhang, Guan-Hua Song, Qiang Guo, Xia Ren, Guo-Sheng Jiang
OBJECTIVE: To investigate the effect of magnolol on proliferation and apoptosis of HL-60 cells and its mechanism. METHODS: MTT assay was used to measure the proliferation of HL-60 cells after treatment with different concentration of magnolol (5, 10, 20, 40, 80 and 160 µg/ml). The morphological changes of HL-60 cells were examined by light microscopy, and DAPI staining was performed to observe the nuclear morphology of HL-60 cells. The early cell apoptosis was detected by flow cytometry with Annexin V-FITC/PI double-staining...
April 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Huiling Hu, Zhanguo Wang, Wan Hua, Yu You, Liang Zou
The stem of Magnoliae officinalis (MO) cortex is always preliminarily processed before being applied in traditional Chinese medicine. The definite bioavailability of honokiol (HO) and magnolol (MA) in processed MO (PMO) and the effect of chemical profiling change on the pharmacokinetics of HO and MA are always a greater challenge compared with those of MO. Compared with that of MO, the pharmacokinetic profiling of HO and MA in the PMO was significantly changed and the mean Tmax of HO and MA was increased by 31 and 50% (P < 0...
August 2016: Journal of Chromatographic Science
Yu-Chen Cheng, Dueng-Yuan Hueng, Hua-Yin Huang, Jang-Yi Chen, Ying Chen
Glioblastoma (GBM) is a malignant brain tumor associated with a high mortality rate. The aim of this study is to investigate the synergistic effects of honokiol (Hono) and magnolol (Mag), extracted from Magnolia officinalis, on cytotoxicity and inhibition of human GBM tumor progression in cellular and animal models. In comparison with Hono or Mag alone, co-treatment with Hono and Mag (Hono-Mag) decreased cyclin A, D1 and cyclin-dependent kinase 2, 4, 6 significantly, leading to cell cycle arrest in U87MG and LN229 human glioma cells...
May 17, 2016: Oncotarget
Toshihisa Onoda, Wei Li, Tatsunori Sasaki, Megumi Miyake, Koji Higai, Kazuo Koike
ETHNOPHARMACOLOGICAL RELEVANCE: Masiningan is a traditional medicine consisting of six crude drugs that have been used for treating constipation and diabetes mellitus in both Japan and China. Masiningan has been reported to have significant PTP1B inhibitory activity and to affect cells in the insulin-signaling pathway. The aim of the present study is to identify the PTP1B inhibitory compounds in Masiningan. MATERIALS AND METHODS: Bioactivity peaks were identified by analytical HPLC profiling and PTP1B inhibitory activity profiling of sub-fractions from Masiningan extract...
June 20, 2016: Journal of Ethnopharmacology
Mohamed Ali Seyed, Ibrahim Jantan, Syed Nasir Abbas Bukhari, Kavitha Vijayaraghavan
Cancer is a diverse class of diseases characterized by uncontrolled cell growth that constitutes the greatest cause of mortality and morbidity worldwide. Despite steady progress, the treatment modalities of cancer are still insufficient. Several new concepts have emerged for therapeutic intervention in malignant diseases with the goal of identifying specific targets and overcoming resistance against current cytotoxic therapies. Many studies have reported the remarkable and significant properties of dietary plant polyphenols such as curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, epigallocatechin gallate, and cucurbitacin as anticancer agents known for their pleiotropic effects on cancer, immune cells, and inflammation...
February 3, 2016: Journal of Agricultural and Food Chemistry
Jun Yi, Jian-Guo Wu, Jin-Yu Wu, Yan-Bin Wu
The high-performance liquid chromatography fingerprint method is a simple and reliable technique to evaluate the quality of leaves of Magnolia officinalis Wils. var. biloba Wils. We used the following bioactive phenolic constituents as reference compounds: rutin, afzelin, hyperoside, isoquercitrin, quercetin-3-O-α-l-rhamnoside, honokiol and magnolol. The conditions of an Agilent 1200 HPLC were: YMC-Pack-ODS-AQ column (250 × 4.6 mm id S-5 μm, 12 nm), mobile phase acetonitrile and 0.2% phosphoric acid in a gradient elute mode, flow rate 1...
February 2016: Journal of Separation Science
Valérian Bunel, Marie-Hélène Antoine, Caroline Stévigny, Joëlle Nortier, Pierre Duez
Aristolochic acids (AA) are nephrotoxic agents found in Aristolochia species whose consumption leads to the onset of a progressive tubulointerstitial fibrosis. This AA-nephropathy was first reported during the Belgian outbreak of the 1990's in which more than a hundred patients consumed slimming pills containing an Aristolochia species and Magnolia officinalis. The patients developed an end-stage kidney disease requiring dialysis or transplantation. Magnolol and honokiol are bioactive compounds from M. officinalis known for their potent antioxidant activity...
January 2016: Food and Chemical Toxicology
Xiangfeng Zhang, Han Huang, Huijuan Chang, Xiuhong Jin
Magnolol, a compound extracted from the Chinese medicinal herb Magnolia officinalis, has been proved to exert multiple pharmacological effects, including anti-oxidant and anti-inflammation activities. In this study, how it influenced bleomycin-induced lung fibrosis of rats was investigated. A single intratracheal instillation of bleomycin (5 mg/Kg, sacrificed 7 and 28 days post bleomycin instillation) caused body weight decrease and lung indices increase. Hodroxyproline content, myeloperoxidase (MPO) activity, tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) levels increased in the rat lung tissues after bleomycin administration, while superoxide dismutase (SOD) activity decreased in the rat lung tissues...
2015: International Journal of Clinical and Experimental Medicine
Guo-Ying Zuo, Xin-Juan Zhang, Jun Han, Yu-Qing Li, Gen-Chun Wang
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a problematic pathogen posing a serious therapeutic challenge in the clinic. It is often multidrug-resistant (MDR) to conventional classes of antibacterial agents and there is an urgent need to develop new agents or strategies for treatment. Magnolol (ML) and honokiol (HL) are two naturally occurring diallylbiphenols which have been reported to show inhibition of MRSA. In this study their synergistic effects with antibacterial agents were further evaluated via checkerboard and time-kill assays...
2015: BMC Complementary and Alternative Medicine
Xiaoqing Hu, Xianjin Sui, Yijing Wang, Wenshu Wang, Haibo Wu, Feiran Zhang, Yuna Tan, Feng Zhang
The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), together with three lignans, obovatol (4), honokiol (5) and magnolol (6). Their structures were elucidated on the basis of spectral analysis and by comparison with related literature data. Compounds 1, 4-6 showed a protective effect on UV inductive DNA damage in mice lymphocyte cells, while compound 1 indicated the smallest Olive Tail Moment 7...
July 2016: Natural Product Research
Hongmei Li, Jing Li, Wei Jin, Xing Guo, Nan Li, Tao Ma, Qiang Huo, ChengZhu Wu
OBJECTIVE: To improve the water solubility and biological activity of neoligans (magnolol and honokiol) and test the antitumor activity of the modified compounds. METHODS: The glycosylated products of magnolol and honokiol were obtained by enzymatic synthesis using a UDP-glycosyltransferase (YjiC) from Bacillus. The products were characterized by high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR) analysis...
November 2015: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Meng-Chuan Chen, Yen-Lin Chen, Chi-Feng Lee, Chih-Huang Hung, Tz-Chong Chou
Skeletal muscle atrophy, the most prominent phenotypic feature of cancer cachexia, is often observed in cancer patients undergoing chemotherapy. Magnolol (M) extracted from Magnolia officinalis exhibits several pharmacological effects including anti-inflammatory and anticancer activities. In this study, we investigated whether magnolol supplementation protects against the development of cachexia symptoms in bladder cancer-bearing mice undergoing chemotherapy. Combined treatment of magnolol with chemotherapeutic drugs, such as gemcitabine and cisplatin (TGCM) or gemcitabine (TGM), markedly attenuates the body weight loss and skeletal muscle atrophy compared with conventional chemotherapy (TGC)...
2015: PloS One
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