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https://www.readbyqxmd.com/read/27923724/strain-specific-impact-of-the-high-pathogenicity-island-on-virulence-in-extra-intestinal-pathogenic-escherichia-coli
#1
Mounira Smati, Giuseppe Magistro, Sandrine Adiba, Andreas Wieser, Bertrand Picard, Sören Schubert, Erick Denamur
In order to clarify the role of the high-pathogenicity island (HPI) in the experimental virulence of Escherichia coli, we constructed different deletion mutants of the entire HPI and of three individual genes (irp2, fyuA and ybtA), encoding for three main functions within the HPI. Those mutants were constructed for three phylogroup B2 strains (536-STc127, CFT073-STc73, and NU14-STc95), representative of the main B2 subgroups causing extra-intestinal infections. Transcriptional profiles obtained for the selected HPI genes irp2, fyuA and ybtA revealed similar patterns for all strains, both under selective iron-deplete conditions and in intracellular bacterial communities in vitro, with a high expression of irp2...
November 22, 2016: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/27918928/effect-of-a-grazing-period-prior-to-finishing-on-a-high-concentrate-diet-on-meat-quality-from-bulls-and-steers
#2
L Moran, M G O'Sullivan, J P Kerry, B Picard, M McGee, E G O'Riordan, A P Moloney
Bulls and steers (n=60) were assigned to a pre-finishing grazing period and subsequently finished on concentrates or offered concentrates without grazing until slaughter (19months). Colour and pH of longissimus thoracis were measured (48h post-slaughter), and samples collected for proximate composition, collagen, sarcomere length, muscle fibre and enzymatic profile analysis. Steaks for texture, cook loss and sensory were aged (14days). Castration increased intramuscular fat content, cook loss and myosin isoforms IIa and I proportions, and decreased IIx proportion (P<0...
November 29, 2016: Meat Science
https://www.readbyqxmd.com/read/27910438/a-micro-nano-rheometer-for-the-mechanics-of-soft-matter-at-interfaces
#3
Léo Garcia, Chloé Barraud, Cyril Picard, Jérôme Giraud, Elisabeth Charlaix, Benjamin Cross
We present a nano-rheometer based on the dynamic drainage flow between a sphere and a plane from bulk regime to highly confined regime. The instrument gives absolute measurements of the viscosity of simple liquids in both regimes. For complex fluids, the measurements involve the viscosity and the elastic modulus. The device operates on distances ranging over four orders of magnitude from 1 nm to 10 μm, bridging rheological properties from the macroscopic to the molecular scale. This allows to measure an hydrodynamic or visco-elastic boundary condition and to explore the causes of the boundary condition at the microscopic level...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27906653/longer-left-ventricular-electric-delay-reduces-mitral-regurgitation-after-cardiac-resynchronization-therapy-mechanistic-insights-from-the-smart-av-study-smartdelay-determined-av-optimization-a-comparison-to-other-av-delay-methods-used-in-cardiac-resynchronization
#4
Neal A Chatterjee, Michael R Gold, Alan D Waggoner, Michael H Picard, Kenneth M Stein, Yinghong Yu, Timothy E Meyer, Nicholas Wold, Kenneth A Ellenbogen, Jagmeet P Singh
BACKGROUND: Mitral regurgitation (MR) is associated with worse survival in those undergoing cardiac resynchronization therapy (CRT). Left ventricular (LV) lead position in CRT may ameliorate mechanisms of MR. We examine the association between a longer LV electric delay (QLV) at the LV stimulation site and MR reduction after CRT. METHODS AND RESULTS: QLV was assessed retrospectively in 426 patients enrolled in the SMART-AV study (SmartDelay Determined AV Optimization: A Comparison to Other AV Delay Methods Used in CRT)...
November 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27906110/failed-upregulation-of-tfam-protein-and-mitochondrial-dna-in-oxidatively-deficient-fibers-of-chronic-obstructive-pulmonary-disease-locomotor-muscle
#5
Yana Konokhova, Sally Spendiff, R Thomas Jagoe, Sudhakar Aare, Sophia Kapchinsky, Norah J MacMillan, Paul Rozakis, Martin Picard, Mylène Aubertin-Leheudre, Charlotte H Pion, Jean Bourbeau, Russell T Hepple, Tanja Taivassalo
BACKGROUND: Low mitochondrial content and oxidative capacity are well-established features of locomotor muscle dysfunction, a prevalent and debilitating systemic occurrence in patients with chronic obstructive pulmonary disease (COPD). Although the exact cause is not firmly established, physical inactivity and oxidative stress are among the proposed underlying mechanisms. Here, we assess the impact of COPD pathophysiology on mitochondrial DNA (mtDNA) integrity, biogenesis, and cellular oxidative capacity in locomotor muscle of COPD patients and healthy controls...
February 18, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27902786/southern-elephant-seals-replenish-their-lipid-reserves-at-different-rates-according-to-foraging-habitat
#6
Gaëtan Richard, Samantha L Cox, Baptiste Picard, Jade Vacquié-Garcia, Christophe Guinet
Assessing energy gain and expenditure in free ranging marine predators is difficult. However, such measurements are critical if we are to understand how variation in foraging efficiency, and in turn individual body condition, is impacted by environmentally driven changes in prey abundance and/or accessibility. To investigate the influence of oceanographic habitat type on foraging efficiency, ten post-breeding female southern elephant seals Mirounga leonina (SES) were equipped and tracked with bio-loggers to give continuous information of prey catch attempts, body density and body activity...
2016: PloS One
https://www.readbyqxmd.com/read/27899089/familial-forms-of-disorders-of-sex-development-may-be-common-if-infertility-is-considered-a-comorbidity
#7
Raja Brauner, Flavia Picard-Dieval, Henri Lottmann, Sébastien Rouget, Joelle Bignon-Topalovic, Anu Bashamboo, Ken McElreavey
BACKGROUND: Families with 46,XY Disorders of Sex Development (DSD) have been reported, but they are considered to be exceptionally rare, with the exception of the familial forms of disorders affecting androgen synthesis or action. The families of some patients with anorchia may include individuals with 46,XY gonadal dysgenesis. We therefore analysed a large series of patients with 46,XY DSD or anorchia for the occurrence in their family of one of these phenotypes and/or ovarian insufficiency and/or infertility and/or cryptorchidism...
November 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27881907/retinal-safety-of-intravitreal-rtpa-in-healthy-rats-and-under-excitotoxic-conditions
#8
Alejandra Daruich, Jérôme Parcq, Kimberley Delaunay, Marie-Christine Naud, Quentin Le Rouzic, Emilie Picard, Patricia Crisanti, Denis Vivien, Marianne Berdugo, Francine Behar-Cohen
PURPOSE: Intravitreal recombinant tissue plasminogen activator (rtPA) is used off-label for the surgical management of submacular hemorrhage, a severe complication of neovascular age-related macular degeneration. rtPA is approved for coronary and cerebral thrombolysis. However, in ischemic stroke rtPA is known to increase excitotoxic neural cell death by interacting with the N-methyl-D-aspartate (NMDA) receptor. We therefore investigated the retinal toxicity of rtPA in healthy rats and in a model of NMDA-induced retinal excitotoxicity...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27879130/newton-s-method-for-nonlinear-stochastic-wave-equations-driven-by-one-dimensional-brownian-motion
#9
Henryk Leszczynski, Monika Wrzosek
We consider nonlinear stochastic wave equations driven by one-dimensional white noise with respect to time. The existence of solutions is proved by means of Picard iterations. Next we apply Newton's method. Moreover, a second-order convergence in a probabilistic sense is demonstrated.
February 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/27876562/early-multiple-coronary-micro-aneurysms-after-bioresorbable-vascular-scaffold-implantation
#10
Fabien Picard, Philippe L L'allier, Jean-François Tanguay
Bioresorbable vascular scaffold (BVS) is a novel technology designed to overcome the long-term limitations of permanent metallic stent implantation in percutaneous coronary intervention. However, little is known about the development of coronary aneurysms after the use of BVSs, and additional experience is needed to establish the entire spectrum of complications related to the use of these emerging materials. We hereby report an unusual case of early multiple coronary artery micro aneurysms formation after BVS implantation...
September 13, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27871937/elevated-levels-of-alpha-synuclein-blunt-cellular-signal-transduction-downstream-of-gq-protein-coupled-receptors
#11
Mattia Volta, Alexandros A Lavdas, Julia Obergasteiger, Christa Überbacher, Anne Picard, Peter P Pramstaller, Andrew A Hicks, Corrado Corti
Alpha-synuclein is central to Parkinson's disease pathogenesis and pathology, however its precise functions are still unclear. It has been shown to bind both PLCβ1 and MAPKs, but how this property influences the downstream signaling of Gq protein-coupled receptors has not been elucidated. Here we show that recombinant expression of alpha-synuclein in human neuroblastoma cells enhances cellular levels of PLCβ1 but blunts its signaling pathway, preventing the agonist-dependent rise of cytoplasmic Ca(2+). In addition, overexpressing alpha-synuclein abolishes the activation of ERK1/2 upon agonist stimulation, indicating an upstream action in the signal transduction pathway...
November 18, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27867134/residual-anxiety-after-high-fidelity-simulation-in-anaesthesiology-an-observational-prospective-pilot-study
#12
Jean-Noël Evain, Lana Zoric, Laurent Mattatia, Olivier Picard, Jacques Ripart, Philippe Cuvillon
BACKGROUND: High fidelity simulation (HFS) in anaesthesiology intentionally provides stress on students, but anxiety may be detrimental if it goes on through debriefing. The primary goal of this study was to estimate the proportion of students with significant anxiety remaining after debriefing (Residual Anxiety: RA). Secondary goals were to evaluate the instructors' ability to estimate students' RA and to identify potential risk factors for high RA. SUBJECTS AND METHODS: Following IRB approval and informed consent, data from a cohort of subjects were prospectively collected by an independent expert...
November 17, 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27863068/scaffold-free-tissue-engineering-of-functional-corneal-stromal-tissue
#13
Fatima N Syed-Picard, Yiqin Du, Andrew J Hertsenberg, Rachelle Palchesko, Martha L Funderburgh, Adam W Feinberg, James L Funderburgh
Blinding corneal scarring is predominately treated with allogeneic graft tissue, however, there is a worldwide shortage of donor tissue leaving millions in need of therapy. Human corneal stromal stem cells (CSSC) have been shown produce corneal tissue when cultured on nanofiber scaffolding, but this tissue cannot be readily separated from the scaffold. In this study, scaffold-free tissue engineering methods were used to generate biomimetic corneal stromal tissue constructs that can be transplanted in vivo without introducing the additional variables associated with exogenous scaffolding...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27863026/design-and-synthesis-of-selurampanel-a-novel-orally-active-and-competitive-ampa-receptor-antagonist
#14
David Orain, Engin Tasdelen, Samuel Haessig, Manuel Koller, Anne Picard, Celine Dubois, Kurt Lingenhoehl, Sandrine Desrayaud, Phillip Floersheim, David Carcache, Stephan Urwyler, Joerg Kallen, Henri Mattes
A series of potent quinazolinedione sulfonamide antagonists of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor were designed and synthesized. The structure-activity relationships (SAR) and in vivo activity of the series were investigated. In particular, compound 1 S (selurampanel; N-[7-isopropyl-6-(2-methylpyrazol-3-yl)-2,4-dioxo-1H-quinazolin-3-yl]methanesulfonamide) has shown excellent oral potency against maximal electroshock seizure (MES)-induced generalized tonic-clonic seizures in rodents as well as significant activity in patients suffering from various forms of epilepsy...
November 15, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27862102/addition-of-an-immunomodulator-can-reverse-antibody-formation-and-loss-of-response-in-patients-treated-with-adalimumab
#15
B Ungar, U Kopylov, T Engel, M Yavzori, E Fudim, O Picard, A Lang, N Williet, S Paul, Y Chowers, A Bar-Gil Shitrit, R Eliakim, S Ben-Horin, X Roblin
BACKGROUND: Anti-adalimumab antibodies (AAA) are associated with loss of clinical response (LOR). Addition of an immunomodulator has been shown to reverse immunogenicity and regain response with infliximab monotherapy. Similar data on adalimumab are lacking. AIM: To study the impact of immunomodulator addition on the emergence of AAA and LOR among adalimumab therapy patients. METHODS: The databases of three tertiary medical centres were reviewed to identify patients who developed AAA during adalimumab monotherapy with resultant LOR, and received an immunomodulator as a salvage combination therapy...
November 16, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27862069/mutations-in-the-ercc2-xpd-gene-associated-with-severe-fetal-ichthyosis-and-dysmorphic-features
#16
Marguerite Miguet, Julien Thevenon, Vincent Laugel, Mathilde Lefebvre, Aurélie Bourchany, Jean-Baptiste Rivière, Yannis Duffourd, Elise Schaefer, Maria Cristina Antal, Rosalie Abida, Anne-Sophie Weingertner, Valérie Kremer, Pierre Vabres, Fanny Morice-Picard, Marie Gonzales, Dan Lipsker, Sylvie Fraitag, Jean-Louis Mandel, Jamel Chelly, Hélène Dollfus, Laurence Faivre, Christel Thauvin-Robinet, Nadège Calmels, Salima El Chehadeh
No abstract text is available yet for this article.
November 9, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27861235/prolonged-viral-suppression-over-a-12-year-follow-up-of-hiv-infected-patients-the-persistent-impact-of-adherence-at-4-months-after-initiation-of-combined-antiretroviral-therapy-in-the-anrs-co8-aproco-copilote-cohort
#17
Camelia Protopopescu, Maria Patrizia Carrieri, François Raffi, Odile Picard, Lucile Hardel, Lionel Piroth, Corinne Jadand, Janine Pierret, Bruno Spire, Catherine Leport
The effect of early adherence on long-term viral suppression was assessed among 1,281 HIV-patients starting a protease inhibitor-containing regimen in 1997-1999, followed up to 12 years. Association between 4-months adherence (three-level score) and prolonged viral suppression (PVS) was evaluated using a multivariate mixed logistic model in 891 eligible patients. High 4-months adherence (OR [95% CI]: 3.72 [1.98 to 6.98]) was associated with long-term PVS, irrespective of maintenance adherence. This unexpected long-term virological impact of early adherence reinforces the message that, when starting antiretrovirals, all means should be mobilized to ensure optimum early adherence to achieve prolonged antiretroviral success...
November 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27860182/from-tricuspid-to-double-orifice-morphology-percutaneous-tricuspid-regurgitation-repair-with-the-mitraclip-device-in-congenitally-corrected-transposition-of-great-arteries
#18
Fabien Picard, Victor-Xavier Tadros, Anita W Asgar
Edge to edge transcatheter mitral valve repair with MitraClip (Abbott Vascular, Menlo Park, CA) is increasing for high-risk surgical patients with significant mitral regurgitation. Patients with congenitally corrected transposition of the great arteries (CCTGA) presenting with tricuspid valve regurgitation of a systemic right ventricle may represent particularly challenging candidates for MitraClip given their anatomy. We report the case of a 67-year-old gentleman with CCTGA and severe tricuspid regurgitation who was referred for MitraClip implantation after heart team consensus...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27858053/-on-water-reaction-of-deactivated-anilines-with-4-methoxy-3-buten-2-one-an-effective-butynone-surrogate
#19
Meriam Jebari, Karine Pasturaud, Baptiste Picard, Jacques Maddaluno, Farhat Rezgui, Isabelle Chataigner, Julien Legros
Poorly nucleophilic aromatic amines (nitroanilines, chloroanilines, etc.) react readily and selectively with trans-4-methoxy-3-buten-2-one, a convenient, effective and inexpensive surrogate for 3-butyn-2-one, to afford (Z)-enaminones. The efficiency of the reaction mostly lies in the use of water as a solvent, which enhances the reaction rate by a 45 to 200-fold factor with regard to other media.
November 18, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27855950/-polymorphism-in-hla-and-kir-genes-and-the-impact-on-hematopoietic-stem-cell-transplantation-outcomes-and-unrelated-donor-selection-guidelines-from-the-francophone-society-of-bone-marrow-transplantation-and-cellular-therapy-sfgm-tc
#20
Valérie Dubois, Anne Brignier, Vincent Elsermans, Katia Gagne, Anne Kennel, Béatrice Pedron, Christophe Picard, Aurélie Ravinet, Pauline Varlet, Anne Cesbron, Florent Delbos, Ibrahim Yakoub-Agha, Pascale Loiseau
In an attempt to harmonize clinical practices among French hematopoietic stem cell transplantation centers, the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) held its sixth annual workshop series in September 2015 in Lille. This event brought together practitioners from across the country with the purpose of offering careful analysis of published studies on clinical practice issues that remain to be disputed. This article addresses the impact of HLA and KIR gene polymorphism on the outcome of the transplantation in order to optimize unrelated donor selection...
November 2016: Bulletin du Cancer
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