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https://www.readbyqxmd.com/read/29783139/inspection-of-baked-carbon-anodes-using-a-combination-of-multi-spectral-acousto-ultrasonic-techniques-and-principal-component-analysis
#1
Moez Ben Boubaker, Donald Picard, Carl Duchesne, Jayson Tessier, Houshang Alamdari, Mario Fafard
This paper reports on the application of an acousto-ultrasonic (AU) scheme for the inspection of industrial-size carbon anode blocks used in the production of primary aluminium by the Hall-Héroult process. A frequency-modulated wave is used to excite the anode blocks at multiple points. The collected attenuated AU signals are decomposed using the Discrete Wavelet Transform (DTW) after which vectors of features are calculated. Principal Component Analysis (PCA) is utilized to cluster the AU responses of the anodes...
May 17, 2018: Ultrasonics
https://www.readbyqxmd.com/read/29782315/tlr4-gene-expression-and-pro-inflammatory-cytokines-in-alzheimer-s-disease-and-in-response-to-hippocampal-deafferentation-in-rodents
#2
Justin Miron, Cynthia Picard, Josée Frappier, Doris Dea, Louise Théroux, Judes Poirier
One important aspect in Alzheimer's disease pathology is the presence of chronic inflammation. Considering its role as a key receptor in the microglial innate immune system, TLR4 was shown to regulate the binding and phagocytosis of amyloid plaques by microglia in several mouse models of amyloidosis, as well as the production of pro-inflammatory cytokines. To our knowledge, TLR4 and its association with cytokines have not been thoroughly examined in the brains of subjects affected with Alzheimer's disease. Using quantitative reverse transcription polymerase chain reaction (qRT-PCR) in postmortem human brains, we observed increased expression for the TLR4 and TNF genes (p = 0...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29782314/a-retrospective-belgian-multi-center-mri-biomarker-study-in-alzheimer-s-disease-remember
#3
Ellis Niemantsverdriet, Annemie Ribbens, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Roxanne Bladt, Lene Claes, Peter Paul De Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Jean-Claude Lemper, Eric Mormont, Gaëtane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Dirk Smeets, Hanne Struyfs, Evert Thiery, Jos Tournoy, Eric Triau, Anne-Marie Vanbinst, Jan Versijpt, Maria Bjerke, Sebastiaan Engelborghs
BACKGROUND: Magnetic resonance imaging (MRI) acquisition/processing techniques assess brain volumes to explore neurodegeneration in Alzheimer's disease (AD). OBJECTIVE: We examined the clinical utility of MSmetrix and investigated if automated MRI volumes could discriminate between groups covering the AD continuum and could be used as a predictor for clinical progression. METHODS: The Belgian Dementia Council initiated a retrospective, multi-center study and analyzed whole brain (WB), grey matter (GM), white matter (WM), cerebrospinal fluid (CSF), cortical GM (CGM) volumes, and WM hyperintensities (WMH) using MSmetrix in the AD continuum...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29777780/pierre-robin-sequence-a-comprehensive-narrative-review-of-the-literature-over-time
#4
Amerigo Giudice, Selene Barone, Kahina Belhous, Anne Morice, Véronique Soupre, Francesco Bennardo, Nathalie Boddaert, Marie-Paule Vazquez, Véronique Abadie, Arnaud Picard
Pierre Robin syndrome (PRS) is characterized of a triad of clinical signs: micrognathia, glossoptosis and obstruction of the upper airways frequently associated with palatal cleft. It is a heterogenic pathological entity and it can be found as isolated disease (nsPRS) or in association with other syndromes (sPRS), with more pronounced symptoms and systemic involvement. This review aims to summarize the principal features of PRS, analysing the different aspects of the disease. Epidemiological data highlight incidence, severity and mortality of PRS; pathophysiological mechanism reports the etiology and pathogenesis of the disease distinguishing between isolated and syndromic form...
May 16, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29777376/comprehensive-molecular-diagnosis-of-epstein-barr-virus-associated-lymphoproliferative-diseases-using-next-generation-sequencing
#5
Shintaro Ono, Manabu Nakayama, Hirokazu Kanegane, Akihiro Hoshino, Saeko Shimodera, Hirofumi Shibata, Hisanori Fujino, Takahiro Fujino, Yuta Yunomae, Tsubasa Okano, Motoi Yamashita, Takahiro Yasumi, Kazushi Izawa, Masatoshi Takagi, Kohsuke Imai, Kejian Zhang, Rebecca Marsh, Capucine Picard, Sylvain Latour, Osamu Ohara, Tomohiro Morio
Epstein-Barr virus (EBV) is associated with several life-threatening diseases, such as lymphoproliferative disease (LPD), particularly in immunocompromised hosts. Some categories of primary immunodeficiency diseases (PIDs) including X-linked lymphoproliferative syndrome (XLP), are characterized by susceptibility and vulnerability to EBV infection. The number of genetically defined PIDs is rapidly increasing, and clinical genetic testing plays an important role in establishing a definitive diagnosis. Whole-exome sequencing is performed for diagnosing rare genetic diseases, but is both expensive and time-consuming...
May 18, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29774333/optical-tweezing-using-tunable-optical-lattices-along-a-few-mode-silicon-waveguide
#6
C Pin, J-B Jager, M Tardif, E Picard, E Hadji, F de Fornel, B Cluzel
Fourteen years ago, optical lattices and holographic tweezers were considered as a revolution, allowing for trapping and manipulating multiple particles at the same time using laser light. Since then, near-field optical forces have aroused tremendous interest as they enable efficient trapping of a wide range of objects, from living cells to atoms, in integrated devices. Yet, handling at will multiple objects using a guided light beam remains a challenging task for current on-chip optical trapping techniques...
May 18, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29762444/efficacy-of-autologous-platelet-concentrates-as-adjuvant-therapy-to-surgical-excision-in-the-treatment-of-keloid-scars-refractory-to-conventional-treatments-a-pilot-prospective-study
#7
Barbara Hersant, Mounia SidAhmed-Mezi, Frédéric Picard, Oana Hermeziu, Anne-Marie Rodriguez, Khaled Ezzedine, Jean Paul Meningaud
BACKGROUND: After conventional treatments, keloid scars show varying degrees of recurrence. The aim of this study was to assess the efficacy and safety of platelet-rich plasma in the treatment of postoperative keloid scars refractory to conventional treatments. METHODS: This pilot prospective study was conducted in 17 patients with keloid scars who did not respond to 4 injections of cortisone or radiotherapy after extralesional resection of keloid. Platelet-rich plasma was injected intraoperatively and then 3 times with a 1-month interval...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29755766/percutaneous-irreversible-electroporation-with-systemic-treatment-for-locally-advanced-pancreatic-adenocarcinoma
#8
Edward Leen, John Picard, Justin Stebbing, Mark Abel, Tony Dhillon, Harpreet Wasan
Background: The prognosis for unresectable locally advanced pancreatic adenocarcinoma (LAPC) remains poor. There is increasing interest in modern ablative techniques to improve outcomes. We report on the potential value of integrating percutaneous irreversible electroporation (IRE) in patients undergoing systemic chemotherapy. Methods: Seventy-five patients with unresectable pancreatic carcinoma underwent percutaneous IRE after chemotherapy using computerised tomography guidance under general anaesthesia...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29751105/use-of-liquid-isoelectric-focusing-offgel-on-the-discovery-of-meat-tenderness-biomarkers
#9
Lorea R Beldarrain, Noelia Aldai, Brigitte Picard, Enrique Sentandreu, Jose L Navarro, Miguel A Sentandreu
Protein biomarkers of meat tenderness are known to be of primary importance for the prediction of meat quality, and hence, industry profitability. Proteome analysis was performed on meat from 8 Main Anjou beef cattle, previously classified as tender or tough meats by Warner Bratzler shear force measurements. Myofibrillar fraction of Longissimus thoracis muscle was separated by a novel fractionation approach based on liquid isoelectric focusing (OFFGEL) and further analyzed by SDS-PAGE and liquid chromatography coupled to tandem mass spectrometry...
May 8, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29746487/loss-of-malat1-does-not-modify-age-or-diet-induced-adipose-tissue-accretion-and-insulin-resistance-in-mice
#10
Sophie Carter, Stéphanie Miard, Louise Boivin, Sandrine Sallé-Lefort, Frédéric Picard
Several studies have suggested that signals emerging from white adipose tissue can contribute to the control of longevity. In turn, aging is associated with perturbed regulation and partitioning of fat depots and insulin resistance. However, the exact mechanisms involved in these relationships remain undetermined. Using RAP-PCR on adipose tissue of young and old male mice coupled with qPCR validation, we have uncovered the long non-coding RNA Malat1 as a gene robustly downregulated in visceral white adipose tissue (vWAT) during normal aging in male mice and men...
2018: PloS One
https://www.readbyqxmd.com/read/29744714/picard-marceau-md-phd-frcs-c-facs
#11
Philippe Topart
No abstract text is available yet for this article.
May 9, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29744467/3d-bioactive-composite-scaffolds-for-bone-tissue-engineering
#12
REVIEW
Gareth Turnbull, Jon Clarke, Frédéric Picard, Philip Riches, Luanluan Jia, Fengxuan Han, Bin Li, Wenmiao Shu
Bone is the second most commonly transplanted tissue worldwide, with over four million operations using bone grafts or bone substitute materials annually to treat bone defects. However, significant limitations affect current treatment options and clinical demand for bone grafts continues to rise due to conditions such as trauma, cancer, infection and arthritis. Developing bioactive three-dimensional (3D) scaffolds to support bone regeneration has therefore become a key area of focus within bone tissue engineering (BTE)...
September 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29741259/primary-red-cell-hydration-disorders-pathogenesis-and-diagnosis
#13
A Caulier, R Rapetti-Mauss, H Guizouarn, V Picard, L Garçon, C Badens
Hydration status is critical for erythrocyte survival and is mainly determined by intracellular cation content. Active pumps, passive transporters, and ion channels are the key components of volume homeostasis, whereas water passively fits ionic movements. Whenever cation content increases, erythrocyte swells, whereas it shrinks when cation content decreases. Thus, inappropriate cation leak causes erythrocyte hydration disorders, hemolytic anemia, and characteristic red cell shape abnormalities named stomatocytosis...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29738402/is-first-rib-fracture-a-culprit-or-a-sign-of-injury-severity-it-is-both
#14
Alexander Fokin, Joanna Wycech, Eric Picard, Russell Weisz, Ivan Puente
OBJECTIVES: First rib fractures (1 RFX) have been correlated with increased morbidity and mortality. Whether this is due to the fracture of the rib itself or due to an increased number of associated injuries remains debatable. DESIGN: Retrospective cohort study SETTING:: Level 1 trauma center PATIENTS:: 1089 patients with rib fractures divided into 3 groups: Group A (n=44) with isolated 1 RFX, Group B (n=116) with 1 RFX combined with other rib fractures, and Group C (n=929) with rib fractures without 1 RFX...
May 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29737978/corrigendum-collocated-observations-of-cloud-condensation-nuclei-particle-size-distributions-and-chemical-composition
#15
Julia Schmale, Silvia Henning, Bas Henzing, Helmi Keskinen, Karine Sellegri, Jurgita Ovadnevaite, Aikaterini Bougiatioti, Nikos Kalivitis, Iasonas Stavroulas, Anne Jefferson, Minsu Park, Patrick Schlag, Adam Kristensson, Yoko Iwamoto, Kirsty Pringle, Carly Reddington, Pasi Aalto, Mikko Äijälä, Urs Baltensperger, Jakub Bialek, Wolfram Birmili, Nicolas Bukowiecki, Mikael Ehn, Ann Mari Fjæraa, Markus Fiebig, Göran Frank, Roman Fröhlich, Arnoud Frumau, Masaki Furuya, Emanuel Hammer, Liine Heikkinen, Erik Herrmann, Rupert Holzinger, Hiroyuki Hyono, Maria Kanakidou, Astrid Kiendler-Scharr, Kento Kinouchi, Gerard Kos, Markku Kulmala, Nikolaos Mihalopoulos, Ghislain Motos, Athanasios Nenes, Colin O'Dowd, Mikhail Paramonov, Tuukka Petäjä, David Picard, Laurent Poulain, André Stephan Henry Prévôt, Jay Slowik, Andre Sonntag, Erik Swietlicki, Birgitta Svenningsson, Hiroshi Tsurumaru, Alfred Wiedensohler, Cerina Wittbom, John A Ogren, Atsushi Matsuki, Seong Soo Yum, Cathrine Lund Myhre, Ken Carslaw, Frank Stratmann, Martin Gysel
This corrects the article DOI: 10.1038/sdata.2017.3.
May 8, 2018: Scientific Data
https://www.readbyqxmd.com/read/29737243/subcutaneous-administration-of-paracetamol-good-local-tolerability-in-palliative-care-patients-an-observational-study
#16
Benoît F Leheup, Stéphanie Ducousso, Stéphane Picard, Raphaël Alluin, Christophe Goetz
BACKGROUND: The subcutaneous route is widely used in both palliative care and geriatrics. Numerous compounds are administered by this route, including paracetamol. However, there is no recommendation on which to base this latter practice and, in the absence of published evidence, nothing is known regarding its local tolerability in palliative care patients. AIM: The main objective of this study was to assess the local tolerability of paracetamol when administered subcutaneously for analgesic or antipyretic purposes in patients hospitalized in the palliative care unit...
May 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29726580/hla-drb3-4-5-mismatches-are-associated-with-increased-risk-of-acute-gvhd-in-10-10-matched-unrelated-donor-hematopoietic-cell-transplantation
#17
Stéphanie Ducreux, Valérie Dubois, Kahina Amokrane, Ibrahim Yakoub-Agha, Myriam Labalette, Mauricette Michallet, Marie-Thérèse Rubio, Anne Kennel, Edouard Forcade, Xavier Lafarge, Claude-Eric Bulabois, Dominique Masson, Etienne Daguindau, Anne Devys, Virginie Moalic, Erwann Quelvennec, Abdelali Boudifa, Christophe Picard, Peter Van Endert, Muriel de Matteis, Florent Delbos, Matthieu Filloux, Béatrice Pedron, Virginie Renac, Françoise Hau, Julie Bonneau, Anne Parissiadis, Marylise Fort, Anne Dormoy, Natacha Maillard, Isabelle Jollet, Patrice Chevallier, Anne Cesbron, Jacques-Olivier Bay, Fabienne Quainon, Federico Garnier, Gérard Socié, Pascale Loiseau, Raphaël Porcher, Régis Peffault de Latour
Matching for HLA-A, -B, -C, and -DRB1 loci (8/8 match) is currently the gold standard for unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at the HLA-DQB1 loci (10/10 match). However, there is increasing evidence that matching at HLA-DRB3/4/5 loci may help to lower transplant-related morbidity and mortality. We therefore investigated the impact of HLA-DRB3/4/5 mismatches on outcomes in 1975 patients who received a first 10/10 matched unrelated donor (MUD) HCT in France from 2000 to 2012 for a hematological malignancy...
May 4, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29722725/antegrade-enema-after-total-mesorectal-excision-for-rectal-cancer-the-last-chance-to-avoid-definitive-colostomy-for-refractory-low-anterior-resection-syndrome-and-fecal-incontinence
#18
Romain Didailler, Quentin Denost, Paula Loughlin, Edouard Chabrun, Julie Ricard, Flor Picard, Frank Zerbib, Eric Rullier
BACKGROUND: Total mesorectal excision and preoperative radiotherapy in mid and low rectal cancer allow us to achieve very good oncological results. However, major and refractory low anterior resection syndrome and fecal incontinence alter the quality of life of patients with a long expected life span. OBJECTIVE: We assessed the functional results of patients treated by antegrade enema for refractory low anterior resection syndrome and fecal incontinence after total mesorectal excision...
June 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29707796/calculating-particle-pair-potentials-from-fluid-state-pair-correlations-iterative-ornstein-zernike-inversion
#19
Marco Heinen
An iterative Monte Carlo inversion method for the calculation of particle pair potentials from given particle pair correlations is proposed in this article. The new method, which is best referred to as Iterative Ornstein-Zernike Inversion, represents a generalization and an improvement of the established Iterative Boltzmann Inversion technique (Reith, Pütz and Müller-Plathe, J. Comput. Chem. 2003, 24, 1624). Our modification of Iterative Boltzmann Inversion consists of replacing the potential of mean force as an approximant for the pair potential with another, generally more accurate approximant that is based on a trial bridge function in the Ornstein-Zernike integral equation formalism...
April 29, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29694124/scattering-amplitudes-from-intersection-theory
#20
Sebastian Mizera
We use Picard-Lefschetz theory to prove a new formula for intersection numbers of twisted cocycles associated with a given arrangement of hyperplanes. In a special case when this arrangement produces the moduli space of punctured Riemann spheres, intersection numbers become tree-level scattering amplitudes of quantum field theories in the Cachazo-He-Yuan formulation.
April 6, 2018: Physical Review Letters
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