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https://www.readbyqxmd.com/read/28223503/mitochondrial-energy-deficiency-leads-to-hyperproliferation-of-skeletal-muscle-mitochondria-and-enhanced-insulin-sensitivity
#1
Ryan M Morrow, Martin Picard, Olga Derbeneva, Jeremy Leipzig, Meagan J McManus, Gilles Gouspillou, Sébastien Barbat-Artigas, Carlos Dos Santos, Russell T Hepple, Deborah G Murdock, Douglas C Wallace
Diabetes is associated with impaired glucose metabolism in the presence of excess insulin. Glucose and fatty acids provide reducing equivalents to mitochondria to generate energy, and studies have reported mitochondrial dysfunction in type II diabetes patients. If mitochondrial dysfunction can cause diabetes, then we hypothesized that increased mitochondrial metabolism should render animals resistant to diabetes. This was confirmed in mice in which the heart-muscle-brain adenine nucleotide translocator isoform 1 (ANT1) was inactivated...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28221109/potentially-zoonotic-bartonella-in-bats-from-france-and-spain
#2
Matthew J Stuckey, Henri-Jean Boulouis, Florence Cliquet, Evelyne Picard-Meyer, Alexandre Servat, Nidia Aréchiga-Ceballos, Juan E Echevarría, Bruno B Chomel
We detected Bartonella in 11 of 109 insectivorous bats from France and 1 of 26 bats from Spain. These genetic variants are closely related to bat-associated Bartonella described in Finland and the United Kingdom and to B. mayotimonensis, the agent of a human endocarditis case in the United States.
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28215958/characteristics-of-defenestrating-craniofacial-injuries-in-pediatric-patients
#3
Aline Joly, Virginie Pineau, Juliette Montmayeur, Philippe Meyer, Kahina Belhous, Nathalie Boddaert, Arnaud Picard, Natacha Kadlub
No abstract text is available yet for this article.
February 13, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28187060/risk-factors-in-children-older-than-5-years-with-pneumococcal-meningitis-data-from-a-national-network
#4
Fanny Hénaff, Corinne Levy, Robert Cohen, Capucine Picard, Emmanuelle Varon, Christèle Gras Le Guen, Elise Launay
INTRODUCTION: The occurrence of meningitis in children > 5 years old may be associated with specific predisposing factors that can be anatomic, such as cerebrospinal fluid (CSF) fistula or breach, or related to genetic susceptibility or N inborn or acquired immunologic defect. This study aimed to assess the anatomical and immunologic risk factors in children > 5 years old with pneumococcal meningitis and prospectively enrolled in the French national meningitis network. METHODS: We analyzed all data for children 5 to 15 years old with a diagnosis of pneumococcal meningitis between 2001 and 2013...
December 13, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28176812/quantification-of-detergents-complexed-with-membrane-proteins
#5
Vincent Chaptal, Frédéric Delolme, Arnaud Kilburg, Sandrine Magnard, Cédric Montigny, Martin Picard, Charlène Prier, Luca Monticelli, Olivier Bornert, Morgane Agez, Stéphanie Ravaud, Cédric Orelle, Renaud Wagner, Anass Jawhari, Isabelle Broutin, Eva Pebay-Peyroula, Jean-Michel Jault, H Ronald Kaback, Marc le Maire, Pierre Falson
Most membrane proteins studies require the use of detergents, but because of the lack of a general, accurate and rapid method to quantify them, many uncertainties remain that hamper proper functional and structural data analyses. To solve this problem, we propose a method based on matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) that allows quantification of pure or mixed detergents in complex with membrane proteins. We validated the method with a wide variety of detergents and membrane proteins...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28173065/p779-cd-patients-in-deep-remission-harbor-a-high-dysbiosis-index-similar-to-active-cd-at-diagnosis-yet-both-are-higher-in-comparison-to-healthy-controls
#6
Y Haberman, T Klein, A Di Segni, S Neuman, N Levhar, M Bubis, O Picard, M BenShoshan, S Farage Barhom, E Glick Saar, K Cesarkas, A Lahad, D Shouval, B Weiss, R Eliakim, S Ben-Horin, U Kopylov
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172535/p181-home-smart-phone-based-measurement-of-fecal-calprotectin-by-ibd-patients-correlation-with-laboratory-assay-and-applicability-as-patient-friendly-monitoring-tool
#7
B Ungar, A Lahat, L Selinger, N Levhar, S Neuman, U Kopylov, M Yavzori, E Fudim, M Bubis, O Picard, R Eliakim, S Ben-Horin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28168964/surgical-versus-medical-therapy-for-prosthetic-valve-endocarditis-a%C3%A2-meta-analysis-of-32-studies
#8
REVIEW
Christos G Mihos, Romain Capoulade, Evin Yucel, Michael H Picard, Orlando Santana
Prosthetic valve endocarditis (PVE) is associated with significant morbidity, and the optimal treatment strategy has not been clearly defined. A systematic review and meta-analysis of 32 studies comparing valve reoperation and medical therapy was performed; it included 2,636 patients, with a mean follow-up of 22 months. A valve reoperation was associated with a lower risk of 30-day mortality, greater survival at follow-up, and a similar rate of PVE recurrence. Prospective studies are warranted to confirm these findings and to clarify clinical decision-making regarding the timing and necessity of a valve reoperation, as opposed to treatment with medical therapy alone...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28164017/alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy-in-a-patient-with-a-chronic-total-occlusion-of-the-right-coronary-artery-beware-of-collateral-damage
#9
Quentin de Hemptinne, Fabien Picard, Philippe L L'Allier
Alcohol septal ablation (ASA) is an effective semi-invasive alternative to surgical myectomy in selected patients for the management of severely symptomatic and drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). One contraindication of this procedure is the presence of collateral flow originating from the target septal perforator to a remote myocardial territory. In such circumstances, ethanol injection could cause remote non-target myocardial necrosis in the collateralized territory. Percutaneous revascularization of the collateralized vessel prior to ASA might cope with this contraindication by restoring normal antegrade flow in the occluded artery...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28160376/fractional-flow-reserve-and-resting-indices-for-coronary-physiologic-assessment-practical-guide-tips-and-tricks
#10
Fabien Picard, Michele Pighi, Hung Q Ly
Physiologic assessment using fractional flow reserve (FFR) to guide percutaneous coronary interventions (PCI) has been demonstrated to improve clinical outcomes, compared to angiography-guided PCI. Recently, resting indices such as resting Pd/Pa, "instantaneous wave-free ratio", and contrast medium induced FFR have been evaluated for the assessment of the functional consequences of coronary lesions. Herein, we review and discuss the use of FFR and other indices for the functional assessment of coronary lesions...
February 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28160051/characterization-and-identification-of-eight-designer-benzodiazepine-metabolites-by-incubation-with-human-liver-microsomes-and-analysis-by-a-triple-quadrupole-mass-spectrometer
#11
Souleiman El Balkhi, Maxime Chaslot, Nicolas Picard, Sylvain Dulaurent, Martine Delage, Olivier Mathieu, Franck Saint-Marcoux
Designer benzodiazepines (DBZDs) have become of particular importance in the past few years. The metabolite monitoring of DBZD in biological fluids could be of great interest in clinical and forensic toxicology. However, DBZD metabolites are not known or not commercially available. The identification of some DBZD metabolites has been mostly explored by self-administration studies or by in vitro studies followed by high-resolution mass spectrometry. The question arose whether a unit resolution instrument could be efficient enough to allow the identification of DBZD metabolites...
February 4, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28153355/traitements-personnalis%C3%A3-s-gr%C3%A3-ce-%C3%A3-la-pharmacog%C3%A3-n%C3%A3-tique%C3%A2-niveaux-de-preuve-et-de-recommandations-du-r%C3%A3-seau-national-de-pharmacog%C3%A3-n%C3%A3-tique-rnpgx
#12
Nicolas Picard, Jean-Christophe Boyer, Marie-Christine Etienne-Grimaldi, Chantal Barin-Le Guellec, Fabienne Thomas, Marie-Anne Loriot
No abstract text is available yet for this article.
January 3, 2017: Thérapie
https://www.readbyqxmd.com/read/28151489/molecular-diagnosis-of-pik3ca-related-overgrowth-spectrum-pros-in-162-patients-and-recommendations-for-genetic-testing
#13
Paul Kuentz, Judith St-Onge, Yannis Duffourd, Jean-Benoît Courcet, Virginie Carmignac, Thibaud Jouan, Arthur Sorlin, Claire Abasq-Thomas, Juliette Albuisson, Jeanne Amiel, Daniel Amram, Stéphanie Arpin, Tania Attie-Bitach, Nadia Bahi-Buisson, Sébastien Barbarot, Geneviève Baujat, Didier Bessis, Olivia Boccara, Maryse Bonnière, Odile Boute, Anne-Claire Bursztejn, Christine Chiaverini, Valérie Cormier-Daire, Christine Coubes, Bruno Delobel, Patrick Edery, Salima El Chehadeh, Christine Francannet, David Geneviève, Alice Goldenberg, Damien Haye, Bertrand Isidor, Marie-Line Jacquemont, Philippe Khau Van Kien, Didier Lacombe, Ludovic Martin, Jelena Martinovic, Annabel Maruani, Michèle Mathieu-Dramard, Juliette Mazereeuw-Hautier, Caroline Michot, Cyril Mignot, Juliette Miquel, Fanny Morice-Picard, Florence Petit, Alice Phan, Massimiliano Rossi, Renaud Touraine, Alain Verloes, Marie Vincent, Catherine Vincent-Delorme, Sandra Whalen, Marjolaine Willems, Nathalie Marle, Daphné Lehalle, Julien Thevenon, Christel Thauvin-Robinet, Smaïl Hadj-Rabia, Laurence Faivre, Pierre Vabres, Jean-Baptiste Rivière
PURPOSE: Postzygotic activating mutations of PIK3CA cause a wide range of mosaic disorders collectively referred to as PIK3CA-related overgrowth spectrum (PROS). We describe the diagnostic yield and characteristics of PIK3CA sequencing in PROS. METHODS: We performed ultradeep next-generation sequencing (NGS) of PIK3CA in various tissues from 162 patients referred to our clinical laboratory and assessed diagnostic yield by phenotype and tissue tested. RESULTS: We identified disease-causing mutations in 66...
February 2, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28147230/multimodal-and-polymorphic-interactions-between-anillin-and-actin-their-implications-for-cytokinesis
#14
Silvana Jananji, Cristina Risi, Indeewari K S Lindamulage, Louis-Philippe Picard, Robert Van Sciver, Guillaume Laflamme, Abe Albaghjati, Gilles R X Hickson, Benjamin H Kwok, Vitold E Galkin
Cytokinesis of animal cells requires the assembly of a contractile ring, which promotes daughter cell splitting. Anillin is a conserved scaffold protein involved in organizing the structural components of the contractile ring including filamentous actin (F-actin), myosin, and septins and in forming the subsequent midbody ring. Like other metazoan homologs, Drosophila anillin contains a conserved domain that can bind and bundle F-actin, but the importance and molecular details of its interaction with F-actin remain unclear...
January 29, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28144854/emergency-echocardiography-second-edition-aleksandar-n-neskovic-frank-a-flachskampf-michael-h-picard-252-pages-2016-crc-press-taylor-francis-group-isbn-9781482243857
#15
Vincent Lecluyse
No abstract text is available yet for this article.
January 31, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28134930/xist-dependent-imprinted-x-inactivation-and-the-early-developmental-consequences-of-its-failure
#16
Maud Borensztein, Laurène Syx, Katia Ancelin, Patricia Diabangouaya, Christel Picard, Tao Liu, Jun-Bin Liang, Ivaylo Vassilev, Rafael Galupa, Nicolas Servant, Emmanuel Barillot, Azim Surani, Chong-Jian Chen, Edith Heard
The long noncoding RNA Xist is expressed from only the paternal X chromosome in mouse preimplantation female embryos and mediates transcriptional silencing of that chromosome. In females, absence of Xist leads to postimplantation lethality. Here, through single-cell RNA sequencing of early preimplantation mouse embryos, we found that the initiation of imprinted X-chromosome inactivation absolutely requires Xist. Lack of paternal Xist leads to genome-wide transcriptional misregulation in the early blastocyst and to failure to activate the extraembryonic pathway that is essential for postimplantation development...
January 30, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28130074/loss-of-ucp2-impairs-cold-induced-non-shivering-thermogenesis-by-promoting-a-shift-toward-glucose-utilization-in-brown-adipose-tissue
#17
Alexandre Caron, Sébastien M Labbé, Sophie Carter, Marie-Claude Roy, Roger Lecomte, Daniel Ricquier, Frédéric Picard, Denis Richard
Uncoupling protein 2 (UCP2) was discovered in 1997 and classified as an uncoupling protein largely based on its homology of sequence with UCP1. Since its discovery, the uncoupling function of UCP2 has been questioned and there is yet no consensus on the true function of this protein. UCP2 was first proposed to be a reactive oxygen species (ROS) regulator and an insulin secretion modulator. More recently, it was demonstrated as a regulator of the mitochondrial fatty acid oxidation, which prompted us to investigate its role in the metabolic and thermogenic functions of brown adipose tissue...
March 2017: Biochimie
https://www.readbyqxmd.com/read/28124061/microfluidic-coagulation-assay-for-monitoring-anticoagulant-therapy-in-acute-stroke-patients
#18
Annemarie Bluecher, Sascha Meyer Dos Santos, Nerea Ferreirós, Sandra Labocha, Isabel Maria Rodrigues Meyer Dos Santos, Bettina Picard-Willems, Sebastian Harder, Oliver C Singer
Reliable detection of anticoagulation status in patients treated with non-vitamin K antagonist oral anticoagulants (NOACs) is challenging but of importance especially in the emergency setting. This study evaluated the potential of a whole-blood clotting time assay based on Surface Acoustic Waves (SAW-CT) in stroke-patients. The SAW-technology was used for quick and homogenous recalcification of whole blood inducing a surface-activated clotting reaction quantified and visualised by real-time fluorescence microscopy with automatic imaging processing...
January 26, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28117096/%C3%A3-ditorial
#19
EDITORIAL
Laurent Becquemont, Nicolas Picard, Céline Verstuyft
No abstract text is available yet for this article.
January 3, 2017: Thérapie
https://www.readbyqxmd.com/read/28110056/current-knowledge-and-management-of-hypersensitivity-reactions-to-monoclonal-antibodies
#20
Matthieu Picard, Violeta Régnier Galvão
Hypersensitivity reactions (HSRs) to monoclonal antibodies (mAbs) are increasingly frequent as this class of therapeutic agents is rapidly expanding. Immediate and nonimmediate HSRs have been reported with mAbs. Immediate HSRs can be explained by 3 main mechanisms: cytokine release syndrome, IgE-mediated, and IgG-mediated reactions. Importantly, IgE-mediated reactions can occur on first exposure due to preformed specific IgEs, as shown for cetuximab. Almost all patients with an immediate HSR can be safely re-exposed either through desensitization or challenge depending on the severity and mechanism of the initial reaction...
January 18, 2017: Journal of Allergy and Clinical Immunology in Practice
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