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https://www.readbyqxmd.com/read/28817239/novel-dissection-of-the-central-nervous-system-to-bridge-gross-anatomy-and-neuroscience-for-an-integrated-medical-curriculum
#1
Rebecca J Hlavac, Rachel Klaus, Kourtney Betts, Shilo M Smith, Maureen E Stabio
Medical schools in the United States continue to undergo curricular change, reorganization, and reformation as more schools transition to an integrated curriculum. Anatomy educators must find novel approaches to teach in a way that will bridge multiple disciplines. The cadaveric extraction of the central nervous system (CNS) provides an opportunity to bridge gross anatomy, neuroanatomy, and clinical neurology. In this dissection, the brain, brainstem, spinal cord, cauda equina, optic nerve/tract, and eyes are removed in one piece so that the entire CNS and its gateway to the periphery through the spinal roots can be appreciated...
August 17, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28817229/performance-equivalency-between-computer-based-and-traditional-pen-and-paper-assessment-a-case-study-in-clinical-anatomy
#2
Bruno Guimarães, José Ribeiro, Bernardo Cruz, André Ferreira, Hélio Alves, Ricardo Cruz-Correia, Maria Dulce Madeira, Maria Amélia Ferreira
The time, material, and staff-consuming nature of anatomy's traditional pen-and-paper assessment system, the increase in the number of students enrolling in medical schools and the ever-escalating workload of academic staff have made the use of computer-based assessment (CBA) an attractive proposition. To understand the impact of such shift in the assessment method, an experimental study evaluating its effect on students' performance was designed. Additionally, students' opinions toward CBA were gathered. Second-year medical students attending a Clinical Anatomy course were randomized by clusters in two groups...
August 17, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28816518/balancing-between-prejudice-and-fact-for-gaming-disorder-does-the-existence-of-alcohol-use-disorder-stigmatize-healthy-drinkers-or-impede-scientific-research
#3
Seung-Yup Lee, Hyekyung Choo, Hae Kook Lee
The inclusion of Gaming Disorder (GD) criteria in the 11th Revision of the International Classification of Diseases (ICD-11) beta draft was recently criticized, and an argument was made for its removal to "avoid a waste of public resources." However, these misleading statements are believed to be based on under estimation of this ever-growing problem. Such claims may endanger public health and the psychosocial well-being of affected individuals. Thus, the seriousness of the problem was briefly emphasized in our response paper...
August 17, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28816103/assessment-of-work-related-accidents-associated-with-waste-handling-in-belo-horizonte-brazil
#4
Marcos Pg Mol, Amanda F Pereira, Dirceu B Greco, Sandy Cairncross, Leo Heller
As more urban solid waste is generated, managing it becomes ever more challenging and the potential impacts on the environment and human health also become greater. Handling waste - including collection, treatment and final disposal - entails risks of work accidents. This article assesses the perception of waste management workers regarding work-related accidents in domestic and health service contexts in Belo Horizonte, Brazil. These perceptions are compared with national data from the Ministry of Social Security on accidents involving workers in solid waste management...
August 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28815890/a-semi-synthetic-glycoconjugate-vaccine-candidate-for-carbapenem-resistant-klebsiella-pneumoniae
#5
Peter H Seeberger, Claney L Pereira, Naeem Khan, Guozhi Xiao, Elizabeth Diago-Navarro, Katrin Reppe, Bastian Opitz, Bettina C Fries, Martin Witzenrath
Hospital acquired infections are an increasingly serious health concern. Infections caused by carpabenem-resistant Klebsiella pneumoniae (CR-Kp) are especially problematic, with a 50% average survival rate. CR-Kp are isolated from patients with ever greater frequency: 7% within the EU but 62% in Greece. At a time when antibiotics are becoming less effective, no vaccines to protect from this severe bacterial infection exist. Here, we describe the convergent [3+3] synthesis of the hexasaccharide repeating unit from its capsular polysaccharide and related sequences...
August 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28815633/the-gas-that-fuels-the-engine-individuals-motivations-for-medicalisation
#6
Ann V Bell
It is well established that the drivers of medicalisation have shifted alongside changes in the institution of medicine. The process of medicalisation is no longer incited by macro processes of institutional prestige or control; rather, individual patients/consumers are pushing the process forward. The present study complicates this neat transition and examines the relationship between structure and agency using the case of assisted reproductive technology (ART), specifically the medicalisation of lesbian reproduction in the US...
August 16, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28815524/endoplasmic-reticulum-plasma-membrane-contacts-regulate-cellular-excitability
#7
Eamonn J Dickson
Cells that have intrinsic electrical excitability utilize changes in membrane potential to communicate with neighboring cells and initiate cellular cascades. Excitable cells like neurons and myocytes have evolved highly specialized subcellular architectures to translate these electrical signals into cellular events. One such structural specialization is sarco-/endoplasmic reticulum-plasma membrane contact sites. These membrane contact sites are positioned by specific membrane-membrane tethering proteins and contain an ever-expanding list of additional proteins that organize information transfer across the junctional space (~ 15-25 nm distance) to shape membrane identity and control cellular excitability...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28815519/over-six-decades-of-discovery-and-characterization-of-the-architecture-at-mitochondria-associated-membranes-mams
#8
Maria Sol Herrera-Cruz, Thomas Simmen
The discovery of proteins regulating ER-mitochondria tethering including phosphofurin acidic cluster sorting protein 2 (PACS-2) and mitofusin-2 has pushed contact sites between the endoplasmic reticulum (ER) and mitochondria into the spotlight of cell biology. While the field is developing rapidly and controversies have come and gone multiple times during its history, it is sometimes overlooked that significant research has been done decades ago with the original discovery of these structures in the 1950s and the first characterization of their function (and coining of the term mitochondria-associated membrane, MAM) in 1990...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28815476/long-term-safety-and-effectiveness-of-adalimumab-for-moderate-to-severe-psoriasis-results-from-7-year-interim-analysis-of-the-esprit-registry
#9
Alan Menter, Diamant Thaçi, Jashin J Wu, William Abramovits, Francisco Kerdel, Dilek Arikan, Dianlin Guo, Arijit Ganguli, Mareike Bereswill, Anne Camez, Wendell C Valdecantos
INTRODUCTION: ESPRIT (NCT00799877) is an ongoing 10-year international prospective observational registry evaluating the long-term safety and effectiveness of originator adalimumab in routine clinical practice for adult patients with chronic plaque psoriasis. Herein, we report the long-term safety, effectiveness, and patient-reported outcomes (PROs) following adalimumab treatment over the first 7 years of the ESPRIT registry. METHODS: All treatment-emergent (All-TE) adverse events (AE) since the initial (first ever) dose of adalimumab were assessed...
August 16, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28815465/non-injection-drug-use-and-injection-initiation-assistance-among-people-who-inject-drugs-in-tijuana-mexico
#10
Amen Ben Hamida, Claudia Rafful, Sonia Jain, Shelly Sun, Patricia Gonzalez-Zuniga, Gudelia Rangel, Steffanie A Strathdee, Dan Werb
Although most people who inject drugs (PWID) report receiving assistance during injection initiation events, little research has focused on risk factors among PWID for providing injection initiation assistance. We therefore sought to determine the influence of non-injection drug use among PWID on their risk to initiate others. We used generalized estimating equation (GEE) models on longitudinal data among a prospective cohort of PWID in Tijuana, Mexico (Proyecto El Cuete IV), while controlling for potential confounders...
August 16, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28815360/epidemiology-in-germany-general-development-and-personal-experience
#11
Heinz-Erich Wichmann
Did you ever hear about epidemiology in Germany? Starting from an epidemiological desert the discipline has grown remarkably, especially during the last 10-15 years: research institutes have been established, research funding has improved, multiple curriculae in Epidemiology and Public Health are offered. This increase has been quite steep, and now the epidemiological infrastructure is much better. Several medium-sized and even big population cohorts are ongoing, and the number and quality of publications from German epidemiologists has reached a respectable level...
August 16, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28815019/therapeutic-potential-of-systemic-brain-rejuvenation-strategies-for-neurodegenerative-disease
#12
REVIEW
Alana M Horowitz, Saul A Villeda
Neurodegenerative diseases are a devastating group of conditions that cause progressive loss of neuronal integrity, affecting cognitive and motor functioning in an ever-increasing number of older individuals. Attempts to slow neurodegenerative disease advancement have met with little success in the clinic; however, a new therapeutic approach may stem from classic interventions, such as caloric restriction, exercise, and parabiosis. For decades, researchers have reported that these systemic-level manipulations can promote major functional changes that extend organismal lifespan and healthspan...
2017: F1000Research
https://www.readbyqxmd.com/read/28814858/spotlight-on-glycopyrronium-formoterol-fumarate-inhalation-aerosol-in-the-management-of-copd-design-development-and-place-in-therapy
#13
REVIEW
Santosh Dhungana, Gerard J Criner
Long-acting bronchodilators are the mainstay of the treatment of COPD. With the advent of several combination inhalers with long-acting antimuscarinic agents (LAMAs) and long-acting beta agonists (LABAs), the choice of therapy in the treatment of COPD has been ever expanding. With the focus of COPD management shifting from FEV1-based treatment escalation to symptoms and risk-based treatment, we are seeing a paradigm shift in COPD treatment with early introduction of LAMA-LABA combination as a single inhaler...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28814811/the-3-d-structure-of-the-somma-vesuvius-volcanic-complex-italy-inferred-from-new-and-historic-gravimetric-data
#14
Niklas Linde, Tullio Ricci, Ludovic Baron, Alexis Shakas, Giovanna Berrino
Existing 3-D density models of the Somma-Vesuvius volcanic complex (SVVC), Italy, largely disagree. Despite the scientific and socioeconomic importance of Vesuvius, there is no reliable 3-D density model of the SVVC. A considerable uncertainty prevails concerning the presence (or absence) of a dense body underlying the Vesuvius crater (1944 eruption) that is implied from extensive seismic investigations. We have acquired relative gravity measurements at 297 stations, including measurements in difficult-to-access areas (e...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814803/the-bhlh-transcription-factor-cgbhlh001-is-a-potential-interaction-partner-of-cdpk-in-halophyte-chenopodium-glaucum
#15
Juan Wang, Gang Cheng, Cui Wang, Zhuanzhuan He, Xinxin Lan, Shiyue Zhang, Haiyan Lan
Plants have evolved different abilities to adapt to the ever-fluctuating environments for sessility. Calcium-dependent protein kinase (CDPK) is believed to play a pivotal role in abiotic stress signaling. So far, study on the specific substrates that CDPK recognized in response to adversity is limited. In the present study, we revealed a potential interaction between CDPK and a bHLH transcription factor under salt stress in Chenopodium glaucum. First, we identified a CgCDPK, which was up-regulated under salt and drought stress; then by Y2H screening, CgCDPK was detected to be involved in interaction with a bHLH TF (named as CgbHLH001), which also positively respond to salt and drought stress...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814701/-byoin-in-modern-japan-focusing-on-the-terminological-introduction-of-hospital-and-the-complex-formation-of-its-concept
#16
Youngsoo Kim
This paper aims to clarify when the term of Byoin (hospital) was introduced and how its concept was developed in modern Japan. The word "Byoin" was introduced in Japan in 1787 for the first time, but it had not been in use until early 1860s. Instead, various medical institutions performing the functions of modern medical facilities, such as Yojosho (A place for preserving health), Shijuku (private school), called by traditional names as ever. Japanese intellectuals already adopted the word Byoin and the concept of western hospital in early 1860s when their national delegates were dispatched to Europe to revise the treaties forged with western powers...
April 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28814593/unique-case-of-herniated-small-bowel-infarction-within-a-colonic-stomal-prolapse
#17
Robert Lloyd Miller, Derek Yeung, Simon McCluney, Oliver J Warren
The number of permanent colostomies carried out in the United Kingdom is approximately 6400 per year1. Stomal prolapse is a known complication of colostomy formation. We presented the first case of small bowel herniation into a healthy stomal prolapse with subsequent ischaemia of the herniated bowel in a 102-year-old patient. This rare sequela of a relatively common stomal complication highlights an important consideration when faced with a large prolapse presenting acutely. It also raises an important discussion point for the management of our ever-ageing patient population...
August 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28814428/mortality-in-idiopathic-inflammatory-myopathy-results-from-a-swedish-nationwide-population-based-cohort-study
#18
Gerd Cecilie Dobloug, John Svensson, Ingrid E Lundberg, Marie Holmqvist
Patients with idiopathic inflammatory myopathies (IIMs) suffer an increased burden of comorbidities, but data on mortality in recently diagnosed IIM are conflicting. Also, little is known when, if ever, in relation to IIM diagnosis, mortality is increased. METHODS: A population-based IIM cohort of patients diagnosed between 2002 and 2011 and general population comparators were identified using healthcare registers. They were linked to the cause of death register for follow-up. RESULTS: 224 (31%) of the 716 patients with IIM and 870 (12%) of the 7100 general population died during follow-up...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28814315/incidental-detection-of-two-adult-gravid-filarial-worms-in-breast-a-case-report
#19
Santosh Tummidi, Kanchan Kothari, Roshni Patil, Shruti S Singhal, Pooja Keshan
BACKGROUND: Microfilaria is a major public health problem in tropical and subtropical countries and is an endemic problem in India. Wuchereria bancrofti is the commonest filarial infection. In some lesions, microfilariae and adult filarial worm have been incidentally detected in fine-needle aspirates. CASE PRESENTATION: A 35 year old hindu female presented with lump in upper outer quadrant of left breast. Fine needle aspiration revealed two adult gravid female filarial worms...
August 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28814301/incidence-of-cancer-among-licenced-commercial-pilots-flying-north-atlantic-routes
#20
Eva Maria Gudmundsdottir, Jon Hrafnkelsson, Vilhjalmur Rafnsson
BACKGROUND: To evaluate cancer incidence among licenced commercial pilots in association with cosmic radiation. METHODS: Cohort study where ionizing radiation dose of cosmic radiation was estimated from airline data and software program and cancer incidence was obtained by record linkage with nation-wide cancer registry. All licenced commercial male airline pilots were followed from 1955 to 2015, ever or never employed at airline with international routes. Standardized incidence ratios were calculated and relative risk by Poisson regression, to examine exposure-response relation...
August 16, 2017: Environmental Health: a Global Access Science Source
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