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https://www.readbyqxmd.com/read/29151031/significant-association-between-low-mitochondrial-dna-content-in-peripheral-blood-leukocytes-and-ischemic-stroke
#1
Li-Ming Lien, Hung-Yi Chiou, Hsu-Ling Yeh, Shang-Yen Chiu, Jiann-Shing Jeng, Huey-Juan Lin, Chaur-Jong Hu, Fang-I Hsieh, Yau-Huei Wei
BACKGROUND: Cumulative evidence has shown that low mitochondrial DNA (mtDNA) content is related to elevated oxidative stress and atherosclerosis, which play important roles in ischemic stroke. The objective of this study was to explore the association between mtDNA content in peripheral blood leukocytes and ischemic stroke. METHODS AND RESULTS: A total of 350 patients with first-ever ischemic stroke and 350 healthy controls were recruited in this case-control study...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29150664/histological-evidence-for-a-dynamic-dental-battery-in-hadrosaurid-dinosaurs
#2
Katherine Bramble, Aaron R H LeBlanc, Denis O Lamoureux, Mateusz Wosik, Philip J Currie
The first histological study of an entire hadrosaurid dental battery provides a comprehensive look at tooth movement within this complex structure. Previous studies have focused on isolated teeth, or in-situ batteries, but this is the first study to examine an entire dental battery of any dinosaur. The absence of direct tooth-to-tooth contact across the entire battery and a unique arrangement of the dental tissues in hadrosaurids led us to compare their teeth with the ever-growing incisors of mammals. The similarity in the distributions of tissues along the incisor, coupled with continuous eruption, make for helpful comparisons to hadrosaurid teeth...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150490/gut-roundtable-meeting-paper-selected-recent-advances-in-hepatocellular-carcinoma
#3
REVIEW
Alexander Gerbes, Fabien Zoulim, Herbert Tilg, Jean-François Dufour, Jordi Bruix, Valérie Paradis, Riad Salem, Markus Peck-Radosavljevic, Peter R Galle, Tim F Greten, Jean-Charles Nault, Matias A Avila
Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the rise, HCC represents an ever increasing challenge. While there is still no curative treatment for most patients numerous novel drugs have been proposed, but most ultimately failed in phase III trials. This manuscript targets therapeutic advances and most burning issues. Expert key point summaries and urgent research agenda are provided regarding risk factors, including microbiota, need for prognostic and predictive biomarkers and the equivocal role of liver biopsy...
November 17, 2017: Gut
https://www.readbyqxmd.com/read/29150473/patient-level-and-practice-level-factors-associated-with-consultation-duration-a-cross-sectional-analysis-of-over-one-million-consultations-in-english-primary-care
#4
Sarah Stevens, Clare Bankhead, Toqir Mukhtar, Rafael Perera-Salazar, Tim A Holt, Chris Salisbury, F D Richard Hobbs
OBJECTIVES: Consultation duration has previously been shown to be associated with patient, practitioner and practice characteristics. However, previous studies were conducted outside the UK, considered only small numbers of general practitioner (GP) consultations or focused primarily on practitioner-level characteristics. We aimed to determine the patient-level and practice-level factors associated with duration of GP and nurse consultations in UK primary care. DESIGN AND SETTING: Cross-sectional data were obtained from English general practices contributing to the Clinical Practice Research Datalink (CPRD) linked to data on patient deprivation and practice staffing, rurality and Quality and Outcomes Framework (QOF) achievement...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29150357/caregiver-burden-of-parents-of-young-children-with-cystic-fibrosis
#5
C Fitzgerald, S George, R Somerville, B Linnane, P Fitzpatrick
BACKGROUND: There is a paucity of research examining the impact of informal caregiving on parents of young children with cystic fibrosis (CF). The aim of this study was to examine caregiver burden and identify risk factors associated with high caregiver burden in mothers and fathers of young children with CF. METHODS: This was a cross-sectional study of parents of young children with CF. A total of 213 families were invited to complete the CarerQoL questionnaire, a validated tool composed of two parts: (i) the CarerQol-7D which describes the care situation in terms of the negative and positive effects of caregiving and (ii) the visual analogue scale (VAS) which measures happiness on a scale from 0 to 10 (0=completely unhappy and 10=completely happy)...
November 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29149887/prostate-cancer-in-firefighting-and-police-work-a-systematic-review-and-meta-analysis-of-epidemiologic-studies
#6
REVIEW
Jeavana Sritharan, Manisha Pahwa, Paul A Demers, Shelley A Harris, Donald C Cole, Marie-Elise Parent
OBJECTIVES: We conducted a systematic review and meta-analysis to evaluate potential associations between firefighting and police occupations, and prostate cancer incidence and mortality. METHODS: Original epidemiological studies published from 1980 to 2017 were identified through PubMed and Web of Science. Studies were included if they contained specific job titles for ever/never firefighting and police work and associated prostate cancer risk estimates with 95% confidence intervals (CI)...
November 17, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29149738/associations-of-urinary-polycyclic-aromatic-hydrocarbon-metabolites-with-fractional-exhaled-nitric-oxide-and-exhaled-carbon-monoxide-a-cross-sectional-study
#7
Yun Zhou, Yuewei Liu, Huizhen Sun, Jixuan Ma, Lili Xiao, Limin Cao, Wei Li, Bin Wang, Jing Yuan, Weihong Chen
Exposure to Polycyclic aromatic hydrocarbons (PAHs) has been associated with inflammatory responses. Fractional exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) are both important inflammatory mediators especially in airways. However, few studies have investigated associations of PAH exposures with FeNO or eCO. Therefore, we aimed to quantify the associations of urinary PAH metabolites with FeNO and eCO levels, and investigate their potential effect modifiers by linear mixed models among 4133 participants from the Wuhan-Zhuhai cohort in China...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149272/use-of-paracetamol-ibuprofen-or-aspirin-in-pregnancy-and-risk-of-cerebral-palsy-in-the-child
#8
Tanja Gram Petersen, Zeyan Liew, Anne-Marie Nybo Andersen, Guro L Andersen, Per Kragh Andersen, Torben Martinussen, Jørn Olsen, Cristina Rebordosa, Mette Christophersen Tollånes, Peter Uldall, Allen J Wilcox, Katrine Strandberg-Larsen
Background: It has been debated whether mild analgesics, mainly paracetamol, adversely affect aspects of neurodevelopment. We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child. Method: We included 185 617 mother-child pairs from the Danish National Birth Cohort and the Norwegian Mother and Child Cohort Study. We created harmonized definitions of analgesic use in pregnancy, as well as indications for analgesic use and other potential confounders...
November 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29148424/effect-of-the-metabolic-syndrome-on-organ-damage-and-mortality-in-patients-with-systemic-lupus-erythematosus-a-longitudinal-analysis
#9
Chi Chiu Mok, Sau Mei Tse, Kar Li Chan, Ling Yin Ho
OBJECTIVES: To study the effect of the metabolic syndrome (MetS) on organ damage and mortality in patients with SLE. METHODS: Consecutive patients who fulfilled ≥4 ACR criteria for SLE were assessed for the MetS in October 2010. The MetS was defined by the updated joint consensus criteria, using the Asian criteria for central obesity. Longitudinal data on organ damage and mortality were retrieved. The association between MetS and new damage and mortality was studied by logistic regression...
October 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148421/a-validation-study-of-the-simple-psoriatic-arthritis-screening-sipas-questionnaire-to-screen-psoriasis-patients-for-psoriatic-arthritis
#10
Fausto Salaffi, Marco Di Carlo, Michele Maria Luchetti, Eleonora Di Donato, Anna Campanati, Devis Benfaremo, Massimiliano Nicolini, Marina Carotti, Alfredo Giacchetti, Giulia Ganzetti, Leonardo Bugatti, Armando Gabrielli, Anna Maria Offidani
OBJECTIVES: To validate in a multicentric cohort of patients a self-administered PsA screening tool, called Simple Psoriatic Arthritis Screening (SiPAS) questionnaire, to screen psoriasis patients for signs and symptoms of PsA. METHODS: The SiPAS questionnaire was validated in a multicentric Italian cohort of psoriasis patients referred to two rheumatological centres. RESULTS: A total of 202 psoriasis patients were screened with SiPAS in the validation study...
November 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148298/understanding-patient-requirements-for-technology-systems-that-support-pain-management-in-palliative-care-services-a-qualitative-study
#11
Matthew J Allsop, Sally Taylor, Michael I Bennett, Bridgette M Bewick
Approaches to pain management using electronic systems are being developed for use in palliative care. This article explores palliative care patients' perspectives on managing and talking about pain, the role of technology in their lives and how technology could support pain management. Face-to-face interviews were used to understand patient needs and concerns to inform how electronic systems are developed. A total of 13 interviews took place with a convenience sample of community-based patients with advanced cancer receiving palliative care through a hospice...
November 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/29147629/trial-watch-immune-checkpoint-blockers-for-cancer-therapy
#12
REVIEW
Claire Vanpouille-Box, Claire Lhuillier, Lucillia Bezu, Fernando Aranda, Takahiro Yamazaki, Oliver Kepp, Jitka Fucikova, Radek Spisek, Sandra Demaria, Silvia C Formenti, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi
Immune checkpoint blockers (ICBs) are literally revolutionizing the clinical management of an ever more diversified panel of oncological indications. Although considerable attention persists around the inhibition of cytotoxic T lymphocyte-associated protein 4 (CTLA4) and programmed cell death 1 (PDCD1, best known as PD-1) signaling, several other co-inhibitory T-cell receptors are being evaluated as potential targets for the development of novel ICBs. Moreover, substantial efforts are being devoted to the identification of biomarkers that reliably predict the likelihood of each patient to obtain clinical benefits from ICBs in the absence of severe toxicity...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29147433/does-obesity-related-hemodilution-of-carcinoembryonic-antigen-exist-in-non-small-cell-lung-cancer-patients
#13
Masaki Tomita, Takanori Ayabe, Kunihide Nakamura
Background: Previous investigations reported inverse relationship between prostate-specific antigen concentration and body mass index (BMI). These results have been explained by a hemodilution effect among obese men. However, the hemodilution of serum carcinoembryonic antigen (CEA) concentration in obese patients with non-small cell lung cancer (NSCLC) has not been ever reported. Methods: Consecutive 381 NSCLC patients were enrolled. A body surface area (BSA)-based and a hematocrit (HCT)-based equations were applied for plasma volume (PV) estimation...
April 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29147170/clinical-assessment-of-warfarin-therapy-in-patients-with-maintenance-dialysis-clinical-efficacy-risks-and-development-of-calciphylaxis
#14
Hajime Hasegawa
Recent years, multiple studies regarding clinical efficacy and risks of Warfarin therapy in dialysis patients have been reported, and not a few reports conclude that clinical advantage of Warfarin is questionable in dialysis patients. Conversely, its hemorrhagic risk might be a little more serious in dialysis patients comparing to non-dialysis patients. Basically, it is assumed that long-term administration of Warfarin accelerates the development of vascular athelosclerosis because of the abolished anti-calcification effect of Gla-protein activation by decreased vitamin K activity...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29146970/origin-of-the-unusually-strong-and-selective-binding-of-vanadium-by-polyamidoximes-in-seawater
#15
Alexander S Ivanov, Christina J Leggett, Bernard F Parker, Zhicheng Zhang, John Arnold, Sheng Dai, Carter W Abney, Vyacheslav S Bryantsev, Linfeng Rao
Amidoxime-functionalized polymeric adsorbents are the current state-of-the-art materials for collecting uranium (U) from seawater. However, marine tests show that vanadium (V) is preferentially extracted over U and many other cations. Herein, we report a complementary and comprehensive investigation integrating ab initio simulations with thermochemical titrations and XAFS spectroscopy to understand the unusually strong and selective binding of V by polyamidoximes. While the open-chain amidoxime functionalities do not bind V, the cyclic imide-dioxime group of the adsorbent forms a peculiar non-oxido V(5+) complex, exhibiting the highest stability constant value ever observed for the V(5+) species...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146568/health-seeking-influence-reflected-by-online-health-related-messages-received-on-social-media-cross-sectional-survey
#16
Rahila Iftikhar, Bahaa Abaalkhail
BACKGROUND: Major social networking platforms, such as Facebook, WhatsApp, and Twitter, have become popular means through which people share health-related information, irrespective of whether messages disseminated through these channels are authentic. OBJECTIVE: This study aims to describe the demographic characteristics of patients that may demonstrate their attitudes toward medical information shared on social media networks. Second, we address how information found through social media affects the way people deal with their health...
November 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29146383/not-just-antibiotics-is-cancer-chemotherapy-driving-antimicrobial-resistance
#17
REVIEW
Lito E Papanicolas, David L Gordon, Steve L Wesselingh, Geraint B Rogers
The global spread of antibiotic-resistant pathogens threatens to increase the mortality of cancer patients significantly. We propose that chemotherapy contributes to the emergence of antibiotic-resistant bacteria within the gut and, in combination with antibiotics, drives pathogen overgrowth and translocation into the bloodstream. In our model, these processes are mediated by the effects of chemotherapy on bacterial mutagenesis and horizontal gene transfer, the disruption of commensal gut microbiology, and alterations to host physiology...
November 13, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/29146193/detection-of-relationships-among-multi-modal-brain-imaging-meta-features-via-information-flow
#18
Robyn L Miller, Victor M Vergara, Vince D Calhoun
BACKGROUND: Neuroscientists and clinical researchers are awash in data from an ever-growing number of imaging and other bio-behavioral modalities. This flow of brain imaging data, taken under resting and various task conditions, combines with available cognitive measures, behavioral information, genetic data plus other potentially salient biomedical and environmental information to create a rich but diffuse data landscape. The conditions being studied with brain imaging data are often extremely complex and it is common for researchers to employ more than one imaging, behavioral or biological data modality (e...
November 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29146155/a-comparison-of-childbirth-costs-for-adolescents-and-adults-from-2001-to-2010
#19
Smadar Ronen, Jinhyung Lee, Parin Patel, Pooja Patel
PURPOSE: Although teenage birth rates in America have fallen to a historic low of 26.2 births per 1,000 teenagers, the U.S. remains behind the rest of the industrialized world. Adolescent pregnancy is relatively well discussed in today's literature, with ever more detailed estimates constantly emerging to quantify the cost of children born to America's teenagers. This study, however, describes the financial cost of childbirth in the U.S. with a specific focus on understanding the impact of adolescent childbirth in comparison to that of adult women and of annual childbirth as a whole...
November 13, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29146119/an-updated-meta-analysis-of-pioglitazone-exposure-and-bladder-cancer-and-comparison-to-the-drug-s-effect-on-cardiovascular-disease-and-non-alcoholic-steatohepatitis
#20
Mayer B Davidson, Deyu Pan
AIM: We performed a meta-analysis of epidemiological studies evaluating exposure to pioglitazone and the risk for bladder cancer and compared these results to the drug's effects on cardiovascular disease (CVD) and non-alcoholic steatohepatitis (NASH). METHODS: Pubmed and Embase were searched for cohort and case control studies for all years through 2016. RESULTS: Data from 17 papers were analyzed. In cohort studies, 822 of 357,888 pioglitazone-exposed patients (0...
November 13, 2017: Diabetes Research and Clinical Practice
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