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https://www.readbyqxmd.com/read/29352322/qportal-a-platform-for-data-driven-biomedical-research
#1
Christopher Mohr, Andreas Friedrich, David Wojnar, Erhan Kenar, Aydin Can Polatkan, Marius Cosmin Codrea, Stefan Czemmel, Oliver Kohlbacher, Sven Nahnsen
Modern biomedical research aims at drawing biological conclusions from large, highly complex biological datasets. It has become common practice to make extensive use of high-throughput technologies that produce big amounts of heterogeneous data. In addition to the ever-improving accuracy, methods are getting faster and cheaper, resulting in a steadily increasing need for scalable data management and easily accessible means of analysis. We present qPortal, a platform providing users with an intuitive way to manage and analyze quantitative biological data...
2018: PloS One
https://www.readbyqxmd.com/read/29352052/estrogen-receptor-positive-breast-cancer-exploiting-signaling-pathways-implicated-in-endocrine-resistance
#2
REVIEW
Adam M Brufsky, Maura N Dickler
Advancements in molecular profiling and endocrine therapy (ET) have led to more focused clinical attention on precision medicine. These advances have expanded our understanding of breast cancer (BC) pathogenesis and hold promising implications for the future of therapy. The estrogen receptor-α is a predominant endocrine regulatory protein in the breast and in estrogen-induced BC. Successful targeting of proteins and genes within estrogen receptor (ER) nuclear and nonnuclear pathways remains a clinical goal...
January 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29351636/effectiveness-of-respiratory-syncytial-virus-immunoprophylaxis-on-bronchiolitis-hospitalizations-among-high-risk-infants
#3
Pingsheng Wu, Gabriel J Escobar, Tebeb Gebretsadik, Kecia N Carroll, Sherian X Li, Eileen M Walsh, Edward F Mitchel, Chantel Sloan, William D Dupont, Chang Yu, Jeffrey R Horner, Tina V Hartert
We sought to determine the real-world effectiveness of respiratory syncytial virus (RSV) immunoprophylaxis in a population-based cohort to inform policy. The study population included infants born 1996-2008 and enrolled in Kaiser Permanente Northern California. During the RSV season (November-March), RSV immunoprophylaxis administration and the following 30 days were defined as RSV immunoprophylaxis protected period(s), and all other days as unprotected period(s). Bronchiolitis hospitalizations were determined using the International Classification of Diseases Ninth Revision codes during RSV season...
January 17, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29351572/differential-susceptibility-in-ambient-particle-related-first-ever-stroke-onset-risk-findings-from-a-national-case-crossover-study
#4
Tianjia Guan, Tao Xue, Yuanli Liu, Yixuan Zheng, Siyuan Fan, Kebin He, Qiang Zhang
Different populations may respond differently to ambient fine particulate (PM2.5) exposure; however, less is known about the distribution of susceptible individuals among the entire population. We conducted a time-stratified case-crossover design to assess associations between stroke risk and PM2.5. During 2013-2015, 1,356 first-ever stroke onset events were derived from a large representative sample, the China National Stroke Screening Survey (CNSSS) database; daily PM2.5 averages with a spatial resolution of 0...
January 17, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29351497/screen-targeting-lung-and-prostate-cancer-oncogene-identifies-novel-inhibitors-of-rgs17-and-problematic-chemical-substructures
#5
Christopher R Bodle, Josephine H Schamp, Joseph B O'Brien, Michael P Hayes, Meng Wu, Jonathan A Doorn, David L Roman
Regulator of G protein signaling (RGS) proteins temporally regulate heterotrimeric G protein signaling cascades elicited by G protein-coupled receptor activation and thus are essential for cell homeostasis. The dysregulation of RGS protein expression has been linked to several pathologies, spurring discovery efforts to identify small-molecule inhibitors of these proteins. Presented here are the results of a high-throughput screening (HTS) campaign targeting RGS17, an RGS protein reported to be inappropriately upregulated in several cancers...
January 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29351249/utilizing-dietary-micronutrient-ratios-in-nutritional-research-may-be-more-informative-than-focusing-on-single-nutrients
#6
Owen J Kelly, Jennifer C Gilman, Jasminka Z Ilich
The 2015 US dietary guidelines advise the importance of good dietary patterns for health, which includes all nutrients. Micronutrients are rarely, if ever, consumed separately, they are not tissue specific in their actions and at the molecular level they are multitaskers. Metabolism functions within a seemingly random cellular milieu however ratios are important, for example, the ratio of adenosine triphosphate to adenosine monophosphate, or oxidized to reduced glutathione. Health status is determined by simple ratios, such as the waist hip ratio, or ratio of fat mass to lean mass...
January 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29350805/is-this-primip-a-nullip-the-daily-abuse-of-language-in-obstetrics
#7
Geoffrey Hughes
A decade ago Opara and Zaidi1 detailed the poor understanding of the word parity in this journal, detailing different definitions, but preferring "the number of pregnancies at or above 24 weeks gestation, regardless of outcome". The reader is therefore left to wonder if an undelivered woman at 30 weeks in her first ever pregnancy (therefore having attained viability) has a parity of zero or one. They also describe the confusion regarding surrounding a twin birth; 79% of the surveyed obstetricians and midwives incorrectly assigned that single parous event to a parity of two...
January 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29350571/intimate-partner-violence-perpetration-corresponds-to-a-dorsal-ventral-gradient-in-medial-pfc-reactivity-to-interpersonal-provocation
#8
David S Chester, C Nathan DeWall
Intimate partner violence (IPV) perpetration is often preceded by perceived interpersonal provocations such as slights, insults, and rejections. Yet the neural mechanisms that link provocation to IPV remain unclear. In the context of interactions with strangers, the medial prefrontal cortex (MPFC) has been repeatedly shown to respond to provocation, with more dorsal activation associated with more aggressive reactions and more ventral activation associated with less aggressive reactions. We used functional brain imaging to test whether this dorsal-ventral MPFC reactivity gradient would also correlate with greater aggression towards an unexamined target: intimate partners...
January 19, 2018: Social Neuroscience
https://www.readbyqxmd.com/read/29350112/a-comparison-of-hiv-risk-behaviors-between-young-black-cisgender-men-who-have-sex-with-men-and-young-black-transgender-women-who-have-sex-with-men
#9
Richard A Crosby, Laura F Salazar, Brandon Hill, Leandro Mena
This study compared sexually transmitted infection (STI)-associated risks between young Black cisgender men who have sex with men (YBMSM) and young Black transwomen who have sex with men (YBTWSM). Comparisons pertained to: (1) prevalence of infections; (2) sexual risk; (3) partner-related risks; and (4) socioeconomic marginalization. YBMSM (n = 577) and YBTWSM (n = 32) were recruited from an STI clinic in the USA. Volunteers completed a computer-assisted self-interview and medical records were abstracted for STI/HIV information...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29349942/ancient-soil-transmitted-parasite-eggs-detected-from-the-sixth-century-three-kingdom-period-silla-tomb
#10
Min Seo, Chang Seok Oh, Jong Ha Hong, Jong Yil Chai, Jin Og Ju, Dong Hoon Shin
The parasitic infection patterns of the Joseon period have begun to be revealed in a series of paleoparasitological studies. However, parasitism prevailing during or before the Three Kingdom period is still relatively unexplored. In the present study, we therefore conducted parasitological examinations of soil and organic-material sediments precipitated upon human hipbone and sacrum discovered inside an ancient Mokgwakmyo tomb dating to the Silla Dynasty (57 BCE-660 CE). Within the samples, we discovered ancient Ascaris lumbricoides (eggs per gram [EPG], 46...
February 5, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349758/is-dcis-overrated
#11
Joshua Feinberg, Rachel Wetstone, Dana Greenstein, Patrick Borgen
Ductal carcinoma in situ (DCIS), the noninvasive form of breast cancer (BC), comprises just over 20% of breast cancer cases diagnosed each year in the USA. Most patients are treated with local excision of the disease followed by whole breast radiation therapy. Total mastectomy is not an uncommon approach, and total mastectomy with a contralateral risk-reducing mastectomy has been on the rise in the past decade. In estrogen receptor-positive disease, patients are often offered endocrine ablative therapy with a selective estrogen receptor modulator or an aromatase inhibitor as both treatment and prevention...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29349282/does-non-standard-work-mean-non-standard-health-exploring-links-between-non-standard-work-schedules-health-behavior-and-well-being
#12
Megan R Winkler, Susan Mason, Melissa N Laska, Mary J Christoph, Dianne Neumark-Sztainer
The last century has seen dramatic shifts in population work circumstances, leading to an increasing normalization of non-standard work schedules (NSWSs), defined as non-daytime, irregular hours. An ever-growing body of evidence links NSWSs to a host of non-communicable chronic conditions; yet, these associations primarily concentrate on the physiologic mechanisms created by circadian disruption and insufficient sleep. While important, not all NSWSs create such chronobiologic disruption, and other aspects of working time and synchronization could be important to the relationships between work schedules and chronic disease...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29349278/machine-learning-approaches-to-the-social-determinants-of-health-in-the-health-and-retirement-study
#13
Benjamin Seligman, Shripad Tuljapurkar, David Rehkopf
Background: Social and economic factors are important predictors of health and of recognized importance for health systems. However, machine learning, used elsewhere in the biomedical literature, has not been extensively applied to study relationships between society and health. We investigate how machine learning may add to our understanding of social determinants of health using data from the Health and Retirement Study. Methods: A linear regression of age and gender, and a parsimonious theory-based regression additionally incorporating income, wealth, and education, were used to predict systolic blood pressure, body mass index, waist circumference, and telomere length...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29349207/gender-career-divide-and-women-s-disadvantage-in-depressive-symptoms-and-physical-limitations-in-france
#14
Emmanuelle Cambois, Clémentine Garrouste, Ariane Pailhé
This study investigated the relationship between women's disadvantage in mental health and physical functioning and gender differences in career backgrounds. Sexual division of labor persists and key career characteristics are overrepresented in women: low-skilled first job, downward occupational trajectory, interruptions. These interrelated characteristics are usually linked to poor health. Their overrepresentation in women may be related to the female-male health gap; however, it may not if overrepresentation transposed into substantially weaker associations with poor health outcomes...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29349106/the-wildland-urban-interface-raster-dataset-of-catalonia
#15
Fermín J Alcasena, Cody R Evers, Cristina Vega-Garcia
We provide the wildland urban interface (WUI) map of the autonomous community of Catalonia (Northeastern Spain). The map encompasses an area of some 3.21 million ha and is presented as a 150-m resolution raster dataset. Individual housing location, structure density and vegetation cover data were used to spatially assess in detail the interface, intermix and dispersed rural WUI communities with a geographical information system. Most WUI areas concentrate in the coastal belt where suburban sprawl has occurred nearby or within unmanaged forests...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29349057/ectopic-preauricular-sinus-in-a-facial-cleft-and-microtia-patient
#16
Jae Yeon Park, Seil Lee, Hyo Joong Kim, Sung Gyun Jung
Preauricular sinus is a congenital malformation that is very commonly encountered among the general population and it has especially high prevalence among Asians when compared to other ethnic groups. It can often go unnoticed or easily overlooked by the patient or even by doctors because most of them are asymptomatic and is most of the time only a tiny pit that can be trivial in terms of aesthetics. We report a very rare and unique case that has no precedence what so ever; hence no reported case in the literature: an ectopic preauricular sinus in a facial cleft and microsomia patient...
December 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29348905/bridging-the-divide-preclinical-research-discrepancies-between-triple-negative-breast-cancer-cell-lines-and-patient-tumors
#17
REVIEW
Andrew Sulaiman, Lisheng Wang
Triple-negative breast cancer (TNBC) is the most refractory subtype of breast cancer and disproportionately accounts for the majority of breast cancer related deaths. Effective treatment of this disease remains an unmet medical need. Over the past several decades, TNBC cell lines have been used as the foundation for drug development and disease modeling. However, ever-mounting research demonstrates striking differences between cell lines and clinical TNBC tumors, disconnecting bench research and actual clinical responses...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348652/intensification-of-ice-nucleation-observed-in-ocean-ship-emissions
#18
E S Thomson, D Weber, H G Bingemer, J Tuomi, M Ebert, J B C Pettersson
Shipping contributes primary and secondary emission products to the atmospheric aerosol burden that have implications for climate, clouds, and air quality from regional to global scales. In this study we exam the potential impact of ship emissions with regards to ice nucleating particles. Particles that nucleate ice are known to directly affect precipitation and cloud microphysical properties. We have collected and analyzed particles for their ice nucleating capacity from a shipping channel outside a large Scandinavia port...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348647/the-contribution-of-predators-and-scavengers-to-human-well-being
#19
REVIEW
Christopher J O'Bryan, Alexander R Braczkowski, Hawthorne L Beyer, Neil H Carter, James E M Watson, Eve McDonald-Madden
Predators and scavengers are frequently persecuted for their negative effects on property, livestock and human life. Research has shown that these species play important regulatory roles in intact ecosystems including regulating herbivore and mesopredator populations that in turn affect floral, soil and hydrological systems. Yet predators and scavengers receive surprisingly little recognition for their benefits to humans in the landscapes they share. We review these benefits, highlighting the most recent studies that have documented their positive effects across a range of environments...
January 18, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29347869/social-support-networks-and-quality-of-life-of-rural-men-in-a-context-of-marriage-squeeze-in-china
#20
Sasa Wang, Xueyan Yang, Isabelle Attané
A significant number of rural Chinese men are facing difficulties in finding a spouse and may fail to ever marry due to a relative scarcity of women in the adult population. Research has indicated that marriage squeeze is a stressful event which is harmful to men's quality of life, and also weakens their social support networks. Using data collected in rural Chaohu city, Anhui, China, this study explores the effects of social support networks on quality of life of rural men who experience a marriage squeeze...
January 1, 2018: American Journal of Men's Health
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