keyword
MENU ▼
Read by QxMD icon Read
search

baicalin

keyword
https://www.readbyqxmd.com/read/29763944/baicalin-ameliorates-imiquimod-induced-psoriasis-like-inflammation-in-mice
#1
Chien-Hui Hung, Chien-Neng Wang, Huei-Hsuan Cheng, Jiunn-Wang Liao, Yi-Ting Chen, Ya-Wen Chao, Jia Liang Jiang, Chen-Chen Lee
Baicalin is the main flavonoid from the roots of an important medicinal plant, Scutellaria baicalensis , which shows a variety biological activities. Psoriasis is a chronic immune-mediated inflammatory disease that affects the skin. The unmet need of psoriasis is that many patients do not respond adequately to available clinical treatment. In this study, we found that baicalin showed inhibited dermal inflammation in a murine model of psoriasis via topical application of imiquimod. After a 5-day topical imiquimod application, baicalin or the control vehicle cream was to applied to the lesions of BALB/c mice for a further 4 days...
May 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29757958/hydroxypropyl-%C3%AE-cyclodextrin-for-delivery-of-baicalin-via-inclusion-complexation-by-supercritical-fluid-encapsulation
#2
Ying Li, Zhen-Dan He, Qian-En Zheng, Chengshen Hu, Wing-Fu Lai
Over the years, various methods have been developed to enhance the solubility of insoluble drugs; however, most of these methods are time-consuming and labor intensive or involve the use of toxic materials. A method that can safely and effectively enhance the solubility of insoluble drugs is lacking. This study adopted baicalin as an insoluble drug model, and used hydroxypropyl-β-cyclodextrin for the delivery of baicalin via the inclusion complexation by supercritical fluid encapsulation. Different parameters for the complex preparation as well as the physicochemical properties of the complex have been investigated...
May 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29757435/antiviral-effect-of-baicalin-phospholipid-complex-against-duck-hepatitis-a-virus-type-1
#3
Y Chen, Y Yang, F Wang, X Yang, F Yao, K Ming, W Yuan, L Zeng, J Liu
Duck hepatitis A virus type 1 (DHAV-1) is one of the main pathogens of ducklings and causes a high mortality rate. Baicalin (BA) has potent antiviral effect, but the solubility is very poor. In order to increase the absorption, solubility, and pharmacological activity, the phospholipid complex was used to modify BA in present study. Therefore, BA phospholipid complex (BAPC) was prepared. The anti-DHAV-1 abilities of BA and BAPC in vitro was evaluated by cell counting kit-8 and reverse transcription quantitative PCR...
May 11, 2018: Poultry Science
https://www.readbyqxmd.com/read/29751706/-comparison-of-three-different-thermophilic-beta-glucosidases-for-baicalin-transformation
#4
Tao Wu, Shan-Shan Zhang, Jian-Jun Pei, Wei Xiao, Zhen-Zhong Wang, Lin-Guo Zhao
Three different beta-glycosidase sequences of Ttebgl3, Tpebgl1 and Tpengl3 from Thermotoga thermarum DSM 5069 and Thermotoga petrophila RKU-1 were analyzed. Also, the influence of temperature, pH, concentration of DMSO, metal ions and kinetic constant on catalytic conversion of baicalin had been compared. The results indicated that the optimal pH and optimum temperature for transformation of baicalin was 4.5 85 °C, 5.0 80 °C and 5.5 80 °C, respectively. The family GH3 beta-glycosidase Ttebgl3 and Tpebgl3 had the better DMSO tolerance...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29732005/baicalein-and-baicalin-inhibit-colon-cancer-using-two-distinct-fashions-of-apoptosis-and-senescence
#5
Jie Dou, Zhou Wang, Leon Ma, Bo Peng, Ke Mao, Chengqin Li, Mengqi Su, Changlin Zhou, Guangyong Peng
Baicalein and baicalin are active components of the Scutellaria baicalensis Georgi and both have broad anti-tumor activity. However, how and whether baicalein and baicalin inhibit colon cancer is unclear. Here we demonstrate that baicalein and baicalin can significantly inhibit human colon cancer cell growth and proliferation. Furthermore, both can induce cell cycle arrest, and suppress cancer cell colony formation and migration. The suppressive effects are mechanistically due to the induction of colon cancer cell apoptosis and senescence mediated by baicalein and baicalin, respectively...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29702580/baicalin-inhibits-haemophilus-parasuis-induced-high-mobility-group-box-1-release-during-inflammation
#6
Shulin Fu, Huashan Liu, Xiao Chen, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Ling Guo, Yongqing Hou, Chien-An Andy Hu
Haemophilus parasuis ( H. parasuis ) can cause Glässer’s disease in pigs. However, the molecular mechanism of the inflammation response induced by H. parasuis remains unclear. The high-mobility group box 1 (HMGB1) protein is related to the pathogenesis of various infectious pathogens, but little is known about whether H. parasuis can induce the release of HMGB1 in piglet peripheral blood monocytes. Baicalin displays important anti-inflammatory and anti-microbial activities. In the present study, we investigated whether H...
April 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29681974/baicalin-downregulates-rlrs-signaling-pathway-to-control-influenza-a-virus-infection-and-improve-the-prognosis
#7
Peng Pang, Ke Zheng, Sizhi Wu, Huachong Xu, Li Deng, Yucong Shi, Xiaoyin Chen
The objective of this study is to investigate the effects of baicalin on controlling the pulmonary infection and improving the prognosis in influenza A virus (IAV) infection. PCR and western blot were used to measure the changes of some key factors in RLRs signaling pathway. MSD electrochemiluminescence was used to measure the expression of pulmonary inflammatory cytokines including IFN- γ , TNF- α , IL-1 β , IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, and KC/GRO. Flow cytometry was used to detect the proportion of Th1, Th2, Th17, and Treg...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29675572/baicalin-modulates-appl2-glucocorticoid-receptor-signaling-cascade-promotes-neurogenesis-and-attenuates-emotional-and-olfactory-dysfunctions-in-chronic-corticosterone-induced-depression
#8
Chong Gao, Qiaohui Du, Wenting Li, Ruixia Deng, Qi Wang, Aimin Xu, Jiangang Shen
Olfactory dysfunction is often accompanied with anxiety- and depressive-like behaviors in depressive patients. Impaired neurogenesis in hippocampus and subventricular zone (SVZ)-olfactory bulb (OB) contribute to anxiety- and depressive-like behaviors and olfactory dysfunctions. However, the underlying mechanisms of olfactory dysfunction remain unclear. Our previous study indicates that adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), could affect the activity and sensitivity of glucocorticoid receptor (GR) and mediate impaired hippocampal neurogenesis, which contribute the development of depression...
April 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29672961/baicalin-is-a-substrate-of-oatp2b1-and-oatp1b3
#9
Bernadett Kalapos-Kovács, Viktória Juhász, Csilla Temesszentandrási-Ambrus, Balázs Magda, Pál T Szabó, István Antal, Imre Klebovich, Péter Krajcsi
No abstract text is available yet for this article.
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29671127/quantitative-analysis-of-the-anti-inflammatory-activity-of-orengedokuto-ii-berberine-is-responsible-for-the-inhibition-of-no-production
#10
Naohiro Oshima, Tomofumi Shimizu, Yuji Narukawa, Noriyasu Hada, Fumiyuki Kiuchi
Orengedokuto is a Kampo formula that has been used for removing "heat" and "poison" to treat inflammation, hypertension, gastrointestinal disorders, and liver and cerebrovascular diseases. We report here our analysis of the anti-inflammatory effect of the component crude drugs of orengedokuto and their constituents using the inhibition of nitric oxide (NO) production in the murine macrophage-like cell line J774.1. An initial comparison of NO production inhibitory activities of the extracts of the component crude drugs and their combinations revealed that the activity could be attributed to Phellodendron Bark and Coptis Rhizome...
April 18, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29669327/effects-of-baicalin-on-diabetic-cardiac-autonomic-neuropathy-mediated-by-the-p2y12-receptor-in-rat-stellate-ganglia
#11
Xuan Sheng, Jiayue Wang, Jingjing Guo, Yurong Xu, Huaide Jiang, Chaoran Zheng, Zixi Xu, Yuanruohan Zhang, Hongyu Che, Shangdong Liang, Gaochun Zhu, Guilin Li
BACKGROUND/AIMS: Chronic diabetic hyperglycemia can damage various of organ systems and cause serious complications. Although diabetic cardiac autonomic neuropathy (DCAN) is the primary cause of death in diabetic patients, its pathogenesis remains to be fully elucidated. Baicalin is a flavonoid extracted from Scutellaria baicalensis root and has antibacterial, diuretic, anti-inflammatory, anti- metamorphotic, and antispasmodic effects. Our study explored the effects of baicalin on enhancing sympathoexcitatory response induced by DCAN via the P2Y12 receptor...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29656117/baicalin-modulates-the-treg-teff-balance-to-alleviate-uveitis-by-activating-the-aryl-hydrocarbon-receptor
#12
Wenjie Zhu, Xiaoqing Chen, Jianfeng Yu, Yichen Xiao, Yingqi Li, Shangtao Wan, Wenru Su, Dan Liang
Autoimmune uveitis is a sight-threatening ocular inflammatory disorder. Immunological inflammation is regarded as the key to pathogenesis in autoimmune uveitis. Baicalin, the major bioactive component of Scutellaria baicalensis, possesses immunomodulatory properties. However, the role of baicalin in uveitis and its underlying mechanisms remain unclear. In the current study, we found that baicalin treatment obviously inhibited the intraocular inflammatory process in mice with experimental autoimmune uveitis, along with clear declines in infiltrated inflammatory cells and inflammatory cytokine transcription in the retina and draining lymph nodes...
April 12, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29615909/systems-pharmacology-based-strategy-for-q-markers-discovery-of-huangqin-decoction-to-attenuate-intestinal-damage
#13
Xiao-Min Dai, Dong-Ni Cui, Jing Wang, Wei Zhang, Zun-Jian Zhang, Feng-Guo Xu
The quality control research of traditional Chinese medicine (TCM) is lagged far behind the space of progress in modernization and globalization. Thus the concept of quality marker (Q-marker) was proposed recently to guide the quality investigations of TCM. However, how to discover and validate the Q-marker is still a challenge. In this paper, a system pharmacology based strategy was proposed to discover Q-marker of HuangQin decoction (HQD) to attenuate Intestinal Damage. Using this strategy, nine measurable compounds including paeoniflorin, baicalin, scutellarein, liquiritigenin, norwogonin, baicalein, glycyrrhizic acid, wogonin, and oroxylin A were screened out as potential markers...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29610452/baicalin-inhibits-human-cervical-cancer-cells-by-suppressing-protein-kinase-c-signal-transducer-and-activator-of-transcription-pkc-stat3-signaling-pathway
#14
Qianqian Wang, Haiou Xu, Xiaofeng Zhao
BACKGROUND Like other human cancers, the malignancy of cervical cancer is also characterized by abilities of proliferation, migration, and invasion. Protein kinase C-zeta (PKCζ) has been highly correlated with several human cancers. Baicalin was proven to regulate PKC. This study aimed to investigate the anti-cancer effect and involved molecular mechanisms of baicalin on human cervical cancer. MATERIAL AND METHODS Baicalin at various concentrations was used to treat 2 human cervical cancer cell lines HeLa and SiHa...
April 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29600641/-advance-in-studies-on-pharmacokinetics-of-baicalin
#15
REVIEW
Hong-Chao Zhou, Rui Du, Hui Wang, Fan-Li Zeng, Kun Shi, Jian-Ming Li, Ying Zong
Scutellariae baicalensis is one of the most important traditional Chinese medicinal herbs, mainly distributed in Shandong and Hebei provinces. It has significant pharmacological effects such as antimicrobial activity, anti-inflammatory and antioxidation. Baicalin is one of its main effective components. However, baicalin's low bioavailability has restricted its clinical application. In recent decades, extensive studies have been carried out on the metabolism of baicalin in vivo at home and abroad. In order to provide scientific references for baicalin's further studies, this paper would not only review the advances in pharmacokinetics research of baicalin and Chinese herbal preparations containing baicalin, but also make a summary on research status of baicalin...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29595191/targeting-rns-caveolin-1-mmp-signaling-cascades-to-protect-against-cerebral-ischemia-reperfusion-injuries-potential-application-for-drug-discovery
#16
REVIEW
Han-Sen Chen, Xi Chen, Wen-Ting Li, Jian-Gang Shen
Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-reperfusion injury. RNS activate multiple signaling pathways and participate in different cellular events in cerebral ischemia-reperfusion injury. Recent studies have indicated that caveolin-1 and matrix metalloproteinase (MMP) are important signaling molecules in the pathological process of ischemic brain injury. During cerebral ischemia-reperfusion, the production of nitric oxide (NO) and peroxynitrite (ONOO- ), two representative RNS, down-regulates the expression of caveolin-1 (Cav-1) and, in turn, further activates nitric oxide synthase (NOS) to promote RNS generation...
March 29, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29577854/flavonoids-and-its-neuroprotective-effects-on-brain-ischemia-and-neurodegenerative-diseases
#17
Manish Putteeraj, Wei Ling Lim, Seong Lin Teoh, Mohamad Fairuz Yahaya
Brain ischemia is among the leading cause of death with majority of the cases are associated with ischemic strokes. It can occur in two form of either focal or global ischemia. Neurodegenerative disorder such as Alzheimer and Parkinson diseases is also on the rise worldwide. These disorders have common similarities; i.e. they all affecting the central nervous system with debilitating effect to the patient. In this review, we look into the promising role of flavonoids, a natural bioactive compound found abundant in vegetables, fruits and traditional herbs...
March 26, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29572682/the-inhibitory-effect-of-sodium-baicalin-on-oseltamivir-resistant-influenza-a-virus-via-reduction-of-neuraminidase-activity
#18
Jing Jin, Yuanjin Chen, Dechuan Wang, Lingman Ma, Min Guo, Changlin Zhou, Jie Dou
Baicalin was identified as a neuraminidase (NA) inhibitor displaying anti-influenza A virus (IAV) activity. However, its poor solubility in saline has limited its use in the clinic. We generated sodium baicalin and showed that it exhibited greatly increased solubility in saline. Its efficacy against oseltamivir-resistant mutant A/FM/1/47-H275Y (H1N1-H275Y) was evaluated in vitro and in vivo. Results showed that 10 μM of sodium baicalin inhibited A/FM/1/47 (H1N1), A/Beijing/32/92 (H3N2) and H1N1-H275Y in MDCK cells in a dose-dependent manner, with inhibitory rates of 83...
March 23, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29554655/baicalin-augments-hyperthermia-induced-apoptosis-in-u937-cells-and-modulates-the-mapk-pathway-via-ros-generation
#19
Shahbaz Ahmad Zakki, Zheng-Guo Cui, Lu Sun, Qian-Wen Feng, Meng-Ling Li, Hidekuni Inadera
BACKGROUND/AIMS: Hyperthermia is a widely used therapeutic tool for cancer therapy and a well-known inducer of apoptosis. Although the flavonoid compound baicalin (BCN) is a potent anticancer agent for several human carcinomas, it is less potent in the human U937 myelomonocytic leukemia cell line. To explore any enhancing effects of BCN on hyperthermia-induced apoptosis, this study investigated the combined effects and apoptotic mechanisms of hyperthermia and BCN in U937 cells. METHODS: U937 cells were heat treated at 44ºC for 12 min with or without pre-treatment with BCN (10-50 µM) and then incubated for 6 h at 37 ºC with 5% CO2 and 95% air...
March 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29552845/-exogenous-h%C3%A2-o%C3%A2-regulated-secondary-metabolism-of-scutellaria-baicalensis-and-enhanced-drug-quality
#20
Xiao-Ying Fu, Hui-Min Guo, Wei Cong, Xiang-Cai Meng
The increasing demand of Chinese materia medica could not be supplied by wild resource, and the cultivated medicinal materials become popular, which led to decreased quality of many medicinal materials due to the difference of the circumstance between the wild and the cultivated. How to improve quality becomes key points of Chinese medicine resource. The leaves of Scutellaria baicalensis were sprayed with H₂O₂, the activities of superoxide dismutase (SOD) and catalase (CAT) changed little, but there had been a marked decrease of peroxidase (POD) and ascorbic oxidase (APX), which showed that the antioxidase system declined...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
keyword
keyword
85205
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"