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https://www.readbyqxmd.com/read/28322895/baicalin-benefits-the-anti-hbv-therapy-via-inhibiting-hbv-viral-rnas
#1
Hai Huang, Wei Zhou, Haiyan Zhu, Pei Zhou, Xunlong Shi
BACKGROUND: Although current antiviral treatments (nucleoside analogs, NAs) for chronic hepatitis B virus (HBV) infection are effective in suppressing HBV-DNA replication, their clinical outcomes can be compromised by the increasing drug resistance and the inefficiency in promoting HBsAg/HBeAg seroconversion. OBJECTIVES: In this study, we will explore possible effects and mechanism of a natural product baicalin (BA) with the anti-HBV efficacy of entecavir (ETV), a first-line anti-HBV drug, in HBV-DNA, HBsAg/HBeAg seroconversion and drug-resistance...
March 18, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28319184/streptococcus-suis-sortase-a-is-ca2-independent-and-is-inhibited-by-acteoside-isoquercitrin-and-baicalin
#2
Fuguang Chen, Fang Xie, Baoling Yang, Chengcheng Wang, Siguo Liu, Yueling Zhang
Sortase A (SrtA) has long been recognized as an ideal drug target for therapeutic agents against Gram-positive pathogens. However, the SrtA of Streptococcus suis (Ss-SrtA), an important zoonotic agent, has not been studied. In this study, the enzymatic properties of Ss-SrtA were investigated, and inhibition of Ss-SrtA by natural products was evaluated. Ss-SrtA was expressed and purified. The purified recombinant Ss-SrtA had maximal activity at pH 6.0-7.5, 45°C, and showed a Km of 6.7 μM for the hydrolysis of substrate abz-LPATG-dnp...
2017: PloS One
https://www.readbyqxmd.com/read/28306207/development-and-validation-of-a-uhplc-ms-ms-method-for-the-simultaneous-determination-of-five-bioactive-flavonoids-in-rat-plasma-and-comparative-pharmacokinetic-study-after-oral-administration-of-xiaochaihu-tang-and-three-compatibilities
#3
Yunhai Bo, Lijuan Wang, Xiao Wu, Longshan Zhao, Jingyu Yang, Zhili Xiong, Chunfu Wu
An accurate, rapid and reliable ultra high performance liquid chromatography with tandem mass spectrometry method was developed and validated for the simultaneous determination of baicalin, wogonoside, baicalein, wogonin and oroxylinA in rat plasma. Then, the stability of baicalin and baicalein in the preparation of plasma sample was systematically investigated. The Waters BEH C18 column was used with a gradient mobile phase system of acetonitrile and water containing 0.1% formic acid. The analytes were detected in the multiple reaction monitoring mode with positive electrospray ionization...
March 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28299800/the-formation-of-a-host-guest-inclusion-complex-system-between-%C3%AE-cyclodextrin-and-baicalin-and-its-dissolution-characteristics
#4
Jing Li, Qihua Jiang, Ping Deng, Qian Chen, Mingan Yu, Jingchuan Shang, Wei Li
OBJECTIVES: Baicalin (BCL) has potential therapeutic benefits, but its clinical outcomes are restricted mainly because of low water solubility. This study sought to improve the water solubility of BCL by the formation of inclusion complex with β-cyclodextrin (β-CD). METHODS: The inclusion complex was studied by solubility test, differential scanning calorimeter (DSC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), (1) H Nuclear magnetic resonance ((1) HNMR) and scanning electron microscopy (SEM)...
March 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28288320/therapeutic-potentials-of-baicalin-and-its-aglycone-baicalein-against-inflammatory-disorders
#5
REVIEW
Biswanath Dinda, Subhajit Dinda, Saikat DasSharma, Rajarshi Banik, Ankita Chakraborty, Manikarna Dinda
The flavonoids, baicalin (5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-O-d-β-glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants, Scutellaria baicalensis Georgi and Oroxylum indicum (L.) Kurz in abundant quantities. The antioxidant and anti-inflammatory effects of these flavonoids have been demonstrated in various disease models, including diabetes, cardiovascular diseases, inflammatory bowel diseases, gout and rheumatoid arthritis, asthma, neurodegenerative-, liver- and kidney diseases, encephalomyelitis, and carcinogenesis...
March 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28284428/distribution-patterns-of-the-contents-of-five-biologically-activate-ingredients-in-the-root-of-scutellaria-baicalensis
#6
Rong-Xiu Liu, Guo-Hu Song, Pei-Gen Wu, Xue-Wen Zhang, Hui-Juan Hu, Jia Liu, Xiao-Su Miao, Zhi-Yan Hou, Wen-Quan Wang, Sheng-Li Wei
As an important herbaceous plant, Scutellaria baicalensis Georgi (Chinese skullcap) is geographically widespread and commonly used throughout the world. In the Chinese medicine market, S. baicalensis has been divided into two primary types, "Ku Qin" (WXR) and "Tiao Qin" (TST). Moreover, TST is also divided into different grades according to the diameter of roots. To explore the distribution patterns of the contents of five biologically activate ingredients (FBAI), we used six-year-old cultivated S. baicalensis and analyzed its growth characteristics as well as the quality difference among different types and diameters in roots...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28260397/comparative-pharmacokinetics-of-chlorogenic-acid-in-beagles-after-oral-administrations-of-single-compound-the-extracts-of-lonicera-japanica-and-the-mixture-of-chlorogenic-acid-baicalin-and-forsythia-suspense
#7
COMPARATIVE STUDY
Rong Liu, Ke Lai, Yu Xiao, Jing Ren
CONTEXT: Chlorogenic acid (ChA) is the major compound in Shuang-Huang-Lian (SHL), which is mainly composed of ChA, baicalin, and Forsythia suspense Thunb Vahl. OBJECTIVE: The effects of co-existing compounds in SHL and Lonicera japanica Thunb on the absorption of ChA was investigated. MATERIALS AND METHODS: According to 3 × 3 Latin-square test, ChA alone, the extracts of Lonicera japanica, or the mixture of ChA, baicalin and Forsythia suspense (ChA effective doses is 60 mg/kg) was separately given to six beagles for seven days...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28260014/baicalin-ameliorates-renal-fibrosis-via-inhibition-of-transforming-growth-factor-%C3%AE-1-production-and-downstream-signal-transduction
#8
Long Zheng, Chao Zhang, Long Li, Chao Hu, Mushuang Hu, Niyazi Sidikejiang, Xuanchuan Wang, Miao Lin, Ruiming Rong
Previous studies have demonstrated the potential antifibrotic effects of baicalin in vitro, via examination of 21 compounds isolated from plants. However, its biological activity and underlying mechanisms of action in vivo remain to be elucidated. The present study aimed to evaluate the effect of baicalin on renal fibrosis in vivo, and the potential signaling pathways involved. A unilateral ureteral obstruction (UUO)‑induced renal fibrosis model was established using Sprague‑Dawley rats. Baicalin was administrated intraperitoneally every 2 days for 10 days...
February 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28252551/effect-of-baicalin-on-oxygen-glucose-deprivation-induced-endothelial-cell-damage
#9
Si Luo, Shi Li, Lei Zhu, Shu-Huan Fang, Jun-Li Chen, Qing-Qing Xu, Hong-Ying Li, Na-Chuan Luo, Cong Yang, Dan Luo, Lin Li, Xiao-Hui Ma, Rong Zhang, Hong Wang, Yun-Bo Chen, Qi Wang
Baicalin, a plant-derived flavonoid, has been reported to exert neuroprotective effects on ischemia-like or excitotoxic injury. To confirm this function and explore the possible mechanism, we investigated the protective effect of baicalin on an in-vitro model of ischemia (oxygen-glucose deprivation-treated endothelial cell). In the present study, we found that baicalin (100 μM) inhibited cell death, reduced cell membrane damage, and maintained the integrity of the nucleus. Flow cytometric analysis and Hoechst 33258/propidium iodide double staining results showed that the necroptosis ratio decreased with baicalin treatment...
March 1, 2017: Neuroreport
https://www.readbyqxmd.com/read/28245362/comparative-research-on-stability-of-baicalin-and-baicalein-administrated-in-monomer-and-total-flavonoid-fraction-form-of-radix-scutellariae-in-biological-fluids-in-vitro
#10
COMPARATIVE STUDY
Zhiqiang Feng, Jie Zhou, Xueying Shang, Guojun Kuang, Jian Han, Liping Lu, Lei Zhang
CONTEXT: Baicalin (BL) and baicalein (B) as the major flavonoids of Scutellaria baicalensis Georgi (Lamiaceae) have been investigated intensively, and shown to possess a multitude of pharmacological activities. OBJECTIVE: This study systematically evaluates the stability of BL and B in monomer and total flavonoid fraction (FSR) form in vitro, and further studies whether the protective measures are effective to make B and BL stable enough to meet the requirement of quantitative analysis in various biological samples...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28236406/lc-ms-ms-analysis-and-pharmacokinetic-study-on-five-bioactive-constituents-of-tanreqing-injection-in-rats
#11
Feng Zhang, Liang Sun, Shou-Hong Gao, Wan-Sheng Chen, Yi-Feng Chai
Tanreqing injection (TRQ), a well-known traditional Chinese medicine formula, is commonly used to treat respiratory diseases. In the present study, a rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determinate the plasma contents of 5 major constituents of TRQ, including chlorogenic acid (CHA), caffeic acid (CFA), baicalin (BA), ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in rats after intravenous administration of TRQ...
October 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28216440/protective-effect-of-hwangryunhaedok-tang-water-extract-against-chronic-obstructive-pulmonary-disease-induced-by-cigarette-smoke-and-lipopolysaccharide-in-a-mouse-model
#12
Na-Rae Shin, Je-Won Ko, Sung-Hyeuk Park, Young-Kwon Cho, Sei-Ryang Oh, Kyung-Seob Ahn, Jung-Min Ryu, Jong-Choon Kim, Chang-Seob Seo, In-Sik Shin
ETHNOPHARMACOLOGICAL RELEVANCE: Hwangryunhaedok-tang is an oriental herbal formula treated to cure inflammation and gastric disorders in China, Japan, and Korea. We explored the protective effects of Hwangryunhaedok-tang water extract (HRWE) against airway pathophysiological changes caused by cigarette smoke (CS) and lipopolysaccharide (LPS) in a mouse. MATERIALS AND METHODS: We performed quantitative analyses of five marker components, namely geniposide, baicalin, coptisine, plamatine, and berberine, using high-performance liquid chromatography...
February 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28214892/baicalin-attenuates-cardiac-dysfunction-and-myocardial-remodeling-in-a-chronic-pressure-overload-mice-model
#13
Yanqing Zhang, Pingping Liao, Meng'en Zhu, Wei Li, Dan Hu, Siming Guan, Long Chen
BACKGROUND/AIMS: Baicalin has been shown to be effective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial ischaemic injury. However, whether baicalin plays a role in cardiac hypertrophy remains unknown. Here we investigated the protective effects of baicalin on cardiac hypertrophy induced by pressure overload and explored the potential mechanisms involved. METHODS: C57BL/6J-mice were treated with baicalin or vehicle following transverse aortic constriction or Sham surgery for up to 8 weeks, and at different time points, cardiac function and heart size measurement and histological and biochemical examination were performed...
February 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28205294/simultaneous-determination-of-the-bioactive-components-in-rat-plasma-by-uplc-ms-ms-and-application-in-pharmacokinetic-studies-after-oral-administration-of-radix-scutellariae-extract
#14
Jin-Hua Tao, Jun Xu, Shu Jiang, Yong Ling, Dong-Geng Wang
A highly sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for simultaneous quantification of the four main bioactive compounds, i.e. baicalin, baicalein, wogonoside and wogonin, in rat plasma after oral administration of Radix Scutellariae extract. Clarithromycin was used as an internal standard (IS). Plasma samples were processed by protein precipitation with methanol. The separation was performed on an Acquity BEH C18 column (100 × 2...
February 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28184027/baicalin-promotes-the-bacteriostatic-activity-of-lysozyme-on-s-aureus-in-mammary-glands-and-neutrophilic-granulocytes-in-mice
#15
Xuejiao Gao, Mengyao Guo, Zecai Zhang, Peng Shen, Zhengtao Yang, Naisheng Zhang
Staphylococcus aureus causes mastitis as a result of community-acquired or nosocomial infections. Lysozyme (LYSO) is an enzyme that is upregulated in many organisms during the innate immune response against infection by bacterial pathogens. Baicalin is a bioactive flavonoid that can bind to enzymes, often to potentiate their effect. Here we tested the effects of baicalin on the activity of LYSO using the S. aureus mastitis mouse model and neutrophilic granulocyte model of S. aureus infection. In our experiments, S...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28182699/bifunctional-effects-of-o-methylated-flavones-from-scutellaria-baicalensis-georgi-on-melanocytes-inhibition-of-melanin-production-and-intracellular-melanosome-transport
#16
Michiko Kudo, Kumiko Kobayashi-Nakamura, Kentaro Tsuji-Naito
The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect on melanogenesis; (2) wogonin and its glycoside are the active components of S. baicalensis; and (3) O-methylated flavones from S. baicalensis, such as wogonin, inhibit intracellular melanosome transport...
2017: PloS One
https://www.readbyqxmd.com/read/28158928/baicalin-positively-regulates-osteoclast-function-by-activating-mapk-mitf-signalling
#17
Li Lu, Li Rao, Huanhuan Jia, Jun Chen, Xingyan Lu, Guozhu Yang, Qingnan Li, Kenneth Ka Ho Lee, Li Yang
Activation of osteoblasts in bone formation and osteoclasts in bone resorption is important during the bone fracture healing process. There has been a long interest in identifying and developing a natural therapy for bone fracture healing. In this study, we investigated the regulation of osteoclast differentiation by baicalin, which is a natural molecule extracted from Eucommiaulmoides (small tree native to China). It was determined that baicalin enhanced osteoclast maturation and bone resorption activity in a dose-dependent manner...
February 3, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28135651/baicalin-and-chrysin-mixture-imparts-cyto-protection-against-methylglyoxal-induced-cytotoxicity-and-diabetic-tubular-injury-by-modulating-rage-oxidative-stress-and-inflammation
#18
Jyotsna Singh, Bhushan P Chaudhari, Poonam Kakkar
Protective effect of mixture of flavonoids baicalin and chrysin (BCH) was studied against methylglyoxal (MG, a precursor of AGEs) induced cytotoxicity in NRK 52E kidney epithelial cells. Flow cytometry and microscopic analysis showed increased ROS generation, compromised antioxidant status, depolarization of mitochondria and apoptosis in MG stressed cells which were significantly transformed (p≤0.01) during BCH co-treatment. In vivo studies in streptozotocin induced diabetic rats increased protein levels of iNOS, protein kinase C (PKC) and decreased IκB which was modulated by oral BCH treatment (75mg baicalin and 10mg chrysin/kg b...
March 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28123992/sodium-dithionite-enhanced-quality-of-radix-scutellariae-through-modification-of-secondary-metabolism
#19
Guo Huimin, Fu Xiaoying, Du Hongwei, Cong Wei, Meng Xiangcai
INTRODUCTION: The quality of radix scutellariae is particularly associated with environmental stresses, but detailed mechanisms remained unclear. Plant under unfavorable situation generates redundant reactive oxygen species (ROS), and ROS can modify the secondary metabolism. The varied quality of radix scutellariae could be explained by ROS. MATERIALS AND METHODS: .004, 0.4, and 40 μmol/L of sodium dithionite (Na2S2O4), a material producing ROS, were applied to Scutellaria baicalensis to mimic unfavorable situation...
October 2016: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28123719/the-pharmacokinetics-of-tiangou-antihypertensive-capsule-in-rat-in-vivo
#20
Ji-Zheng Song, Ling-Jun Li, Li Ji, Li Shun, Yan Rui
The aim of the study was to examine the effect of complex prescription on the pharmacokinetics of baicalin, rhynochophylline and gastrodin in Tiangou antihypertensive capsule. After administration, rat plasma was collected at different time-points. High-performance liquid chromatography was used to determine the content of baicalin, rhynochophylline and gastrodin in plasma. Two peaks occurred in the baicalin concentration-time curve. No significant difference was found for the peak concentration time (tmax) and area under concentration-time curve (AUC) of baicalin between the complex prescription and baicalin groups...
January 2017: Biomedical Reports
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