Marissa A Lithopoulos, Xavier Toussay, Shumei Zhong, Liqun Xu, Shamimunisa B Mustafa, Julie Ouellette, Moises Freitas-Andrade, Cesar C Comin, Hayam A Bassam, Adam N Baker, Yiren Sun, Michael Wakem, Alvaro G Moreira, Cynthia L Blanco, Arul Vadivel, Catherine Tsilfidis, Steven R Seidner, Ruth S Slack, Diane C Lagace, Jing Wang, Baptiste Lacoste, Bernard Thébaud
Preterm birth is the leading cause of death in children under 5 years of age. Premature infants who receive life-saving oxygen therapy often develop bronchopulmonary dysplasia (BPD), a chronic lung disease. Infants with BPD are at a high risk of abnormal neurodevelopment, including motor and cognitive difficulties. While neural progenitor cells (NPCs) are crucial for proper brain development, it is unclear whether they play a role in BPD-associated neurodevelopmental deficits. Here, we showed that hyperoxia-induced experimental BPD in newborn mice led to life-long impairments in cerebrovascular structure and function, as well as impairments in NPC self-renewal and neurogenesis...
September 22, 2022: Journal of Clinical Investigation