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https://www.readbyqxmd.com/read/29927696/pregnancy-as-a-window-to-racial-disparities-in-hypertension
#1
Claire E Margerison, Janet Catov, Claudia Holzman
BACKGROUND: The black-white disparity in hypertension (HTN) among U.S. women persists after accounting for known risk factors. Pregnancy complications may reveal increased risks for later HTN. We examined the contribution of HTN risk factors measured at both midlife and pregnancy to black-white disparities in midlife HTN. METHODS: Data came from a Michigan-based longitudinal study beginning in pregnancy. At 7-15 years postpregnancy (n = 615, mean age = 37), women were assessed for cardiovascular health, including blood pressure, and categorized as hypertensive (n = 126), prehypertensive (n = 149), and normotensive (n = 340)...
June 21, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29917228/title-reduced-blood-volume-decreases-cerebral-blood-flow-in-preterm-piglets
#2
Yvonne A Eiby, Nicole Y Shrimpton, Ian M R Wright, Eugenie R Lumbers, Paul B Colditz, Greg J Duncombe, Barbara E Lingwood
Preterm infants often have impaired cardiovascular function that may contribute to poor neurodevelopmental outcomes. The study aimed to determine the effects of reduced blood volume on cardiovascular function, including cerebral blood flow in preterm and term piglets. In preterm (97/115d) and term piglets, up to 10% of the estimated blood volume was removed. Removal of blood was ceased if MAP dropped below 20 mmHg. Heart rate, cardiac contractility and relaxation, cardiac output, mean arterial pressure (MAP), and cerebral blood flow were measured at baseline and again after blood volume reduction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29901012/prognosis-in-pregnant-females-with-systemic-lupus-erythematosus
#3
Enling Liu, Yuxiu Zhou
Objectives: This study aims to analyze the relationship between pregnancy and lupus, and explore the risk factors that adversely affect maternal and infant outcomes. Patients and methods: The pregnancy outcomes in 112 pregnant females (mean age 24.3±2.8 years; range 20 to 35 years) with systemic lupus erythematosus (SLE) were retrospectively analyzed. Pregnancy outcomes before and after pregnancy were compared, and the associations with lupus nephritis, positive anti-Ro/SSA antibody, positive La/SSB antibody, complement 3 and complement 4, high blood pressure, positive anti- cardiolipin (aCL) antibody, Raynaud's phenomenon, and lupus recurrence were evaluated...
December 2017: Archives of Rheumatology
https://www.readbyqxmd.com/read/29896975/maternal-mirna-146a-g-c-rs2910164-variation-hiv-aids-and-nitrogen-oxide-pollution-exposure-collectively-affects-foetal-growth
#4
P Naidoo, R N Naidoo, P Ramkaran, S Muttoo, K Asharam, A A Chuturgoon
OBJECTIVE: Nitrogen oxide (NOx) pollution and human immunodeficiency virus (HIV)/AIDS intensify inflammation during pregnancy and linked with adverse birth outcomes (ABOs). MicroRNA (miRNA)-146a plays a crucial role in regulating inflammation in the NF-κB pathway. The G/C rs2910164 dampens miRNA-146a activity and linked with inflammatory diseases. The present study investigated whether HIV/AIDS and NOx exposure throughout pregnancy further intensifies ABO in Black South African women genotyped for the rs2910164...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29895522/repeat-antenatal-betamethasone-and-cardiometabolic-outcomes
#5
Robert D Cartwright, Jane E Harding, Caroline A Crowther, Wayne S Cutfield, Malcolm R Battin, Stuart R Dalziel, Christopher J D McKinlay
BACKGROUND: Repeat dose(s) of antenatal betamethasone are recommended for women at <32 weeks with ongoing risk of preterm birth. However, there is concern that use of repeat dose(s) in fetal growth restriction (FGR) may increase the risk of later cardiometabolic disease. METHODS: We undertook secondary analysis of data from the Australasian Collaborative Trial of Repeat Doses of Corticosteroids Midchildhood Outcome Study to determine if FGR influences the effect of repeat betamethasone on growth and cardiometabolic function...
June 12, 2018: Pediatrics
https://www.readbyqxmd.com/read/29868521/measuring-near-infrared-spectroscopy-derived-cerebral-autoregulation-in-neonates-from-research-tool-toward-bedside-multimodal-monitoring
#6
REVIEW
Liesbeth Thewissen, Alexander Caicedo, Petra Lemmers, Frank Van Bel, Sabine Van Huffel, Gunnar Naulaers
Introduction: Cerebral autoregulation (CAR), the ability of the human body to maintain cerebral blood flow (CBF) in a wide range of perfusion pressures, can be calculated by describing the relation between arterial blood pressure (ABP) and cerebral oxygen saturation measured by near-infrared spectroscopy (NIRS). In literature, disturbed CAR is described in different patient groups, using multiple measurement techniques and mathematical models. Furthermore, it is unclear to what extent cerebral pathology and outcome can be explained by impaired CAR...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29848160/hypotension-in-small-preterms-what-does-it-mean
#7
Manuel R G Carrapato, Teresa Andrade, Teresa Caldeira
Small preterms often have low blood pressure readings in the first few days of life. However, what is hypotension in preterms? Should there be an aggressive approach to its management? What are the immediate and long-term side effects of powerful medications? Alternatively, could be accepted a low blood pressure instead? Our data show that, despite extremely low gestational age (ELGA) / extremely low birth weight (ELBW) neonates, almost half of these tiny babies have neither low mean arterial pressure (MAP) readings nor clinical signs of impaired perfusion...
May 30, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29843271/early-prediction-of-a-significant-patent-ductus-arteriosus-in-infants-32-weeks-gestational-age
#8
V Katheria, D M Poeltler, M Brown, K O Hassen, D Patel, W Rich, N N Finer, A C Katheria
BACKGROUND: The optimal thresholds for identification of preterm infants at greatest risk for adverse sequelae related to patent ductus arteriosus have not been well delineated. Our aim was to determine hemodynamic parameters in the first 24 hours using continuous non-invasive vital and structural measurements to predict which infants required PDA treatment in our institution. METHODS: Retrospective secondary analysis of data from infants born 23 to 32 weeks gestational age with cardiac output and stroke volume via electrical cardiometry, cerebral tissue oximetry measurements, mean arterial blood pressure (BP), heart rate, and oxygen saturation and functional echocardiography results at 12 hours of life were recorded when available (93 percent of subjects)...
May 23, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29804916/corrigendum-to-comparison-between-oscillometric-and-intra-arterial-blood-pressure-measurements-in-ill-preterm-and-full-term-neonates-journal-of-american-society-of-hypertension-january-2014-volume-8-issue-1-pages-36-44
#9
https://www.readbyqxmd.com/read/29793869/extreme-preterm-infant-rates-of-overweight-and-obesity-at-school-age-in-the-support-neuroimaging-and-neurodevelopmental-outcomes-cohort
#10
Betty R Vohr, Roy Heyne, Carla M Bann, Abhik Das, Rosemary D Higgins, Susan R Hintz
OBJECTIVE: To identify rates of overweight (body mass index [BMI] ≥85th percentile) and obesity (BMI ≥95th percentile) at 6-7 years of age and associated risk factors among extremely preterm infants born at <28 weeks of gestation. STUDY DESIGN: Anthropometrics, blood pressure, and active and sedentary activity levels were prospectively assessed. Three groups were compared, those with a BMI ≥85th percentile (overweight or obese for age, height, and sex) and ≥95th percentile (obese) vs <85th percentile...
May 21, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29792302/blood-pressure-patterns-and-subsequent-coronary-artery-calcification-in-women-who-delivered-preterm-births
#11
Janet M Catov, Gabrielle G Snyder, Abigail Fraser, Cora E Lewis, Kiang Liu, Andrew D Althouse, Marnie Bertolet, Erica P Gunderson
Women who delivered preterm infants have excess cardiovascular disease, but vascular pathways linking these conditions are not understood. We considered that higher blood pressure over 25 years among women with preterm delivery may be associated with coronary artery calcification (CAC). The CARDIA study (Coronary Artery Risk Development in Young Adults) enrolled 1049 black and white women with births between 1985 and 2010 (n=272 ever preterm [<37 weeks]; n=777 all term births [≥37 weeks]). Latent mixture modeling identified blood pressure trajectories across 20 years, and these were related to CAC at years 20 and 25...
May 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29783215/the-changes-of-some-bioregulators-and-gas-transmitters-in-patients-with-hypertonic-disease-under-the-influence-of-physical-loading
#12
Iryna S Dronyk, Ostap H Yavorsky, Olexandr Y Sklyarov
OBJECTIVE: Introduction: Nowadays arterial hypertension is supposed to be a pathogenetic factor of numerous cardiovascular diseases (CVD) and 18% cases of the preterm death. Due to the data of the American Heart Association in 77% of patients, who had stroke, the arterial pressure overexceeded 140/90 mm Hg. In Ukraine, according to the epidemiologic study more than 1/3 of the population have increased arterial pressure. One of the extremely important aspects of struggle with CVD is diagnosis and prevention of hypertonic disease...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29758543/magnesium-sulfate-versus-esomeprazole-impact-on-the-neonates-of-preeclamptic-rats
#13
Amani N Shafik, Mahmoud A Khattab, Ahmed H Osman
OBJECTIVE: Preeclampsia represents a major complication of pregnancy, associated with greater maternal and fetal complications. We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats. STUDY DESIGN: Preeclampsia was induced in pregnant rats with NG-nitro-l-arginine methyl ester (L-NAME) starting from day 10-till end of pregnancy...
June 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29756966/-may-pregestational-body-mass-index-be-related-to-mother-s-psychological-and-physical-condition-during-pregnancy
#14
Borja Romero-González, Rafael Arcangel Caparrós-González, Helen Strivens Vilchez, María Isabel Peralta-Ramírez
INTRODUCTION: pregestational Body Mass Index (BMI) affects mother's health during and after pregnancy and is related to negative outcomes such as low birth weight and preterm birth. Higher pregestational BMI may increase anxiety, stress and depression. OBJECTIVES: to assess potential differences on stress, psychopathological symptoms and physiological variables during pregnancy, among pregnant women with normal pregestational BMI rates and high pregestational BMI rates...
March 1, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29751781/full-normalization-of-severe-hypertension-after-parathryoidectomy-a-case-report-and-systematic-review
#15
Andreea Corina Sofronie, Isabelle Kooij, Claude Bursot, Giulia Santagati, Jean-Philippe Coindre, Giorgina Barbara Piccoli
BACKGROUND: Although the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a severely hypertensive dialysis patient, in which parathyroidectomy (PTX) corrected the metabolic imbalance and normalized blood pressure (BP), we tried to contextualize our observation with a systematic review of the recent literature on the effect of PTX on BP. CASE PRESENTATION: A dialysis patient, aged 19 years at the time of this report, with chronic kidney disease (CKD) from childhood; he was an early-preterm baby with very low birth weight (910 g), and is affected by a so-far unidentified familial nephropathy...
May 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29748248/bromodomain-protein-brd4-is-increased-in-human-placentas-from-women-with-early-onset-preeclampsia
#16
Stella Liong, Gillian Barker, Martha Lappas
Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exaggerated levels of pro-inflammatory cytokines, chemokines and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFLT1). Studies in non-gestational tissues have described the bromodomain (BRD) and extraterminal family of proteins, in particular BRD4 to play a critical role in propagating inflammation and is currently a therapeutic target for treating cancer, lung inflammation and asthma...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29734941/infective-endocarditis-due-to-burkholderia-cepacia-in-a-neonate-a-case-report
#17
Emir Yonas, Vito Damay, Raymond Pranata, Nuvi Nusarintowati
BACKGROUND: Burkholderia is a pathogen that is rarely seen in clinical cases. However, this organism is being found more commonly in hospitals. CASE PRESENTATION: A female Indonesian newborn was referred to our neonatal intensive care unit because of respiratory distress. The newborn had been delivered the previous night via cesarean section. A physical examination revealed intercostal retractions and weak cry. The newborn's gestational history was preterm, small for gestational age, and preterm premature ruptured membrane for 14 hours...
May 8, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29726010/lower-versus-higher-oxygen-concentrations-titrated-to-target-oxygen-saturations-during-resuscitation-of-preterm-infants-at-birth
#18
REVIEW
Kei Lui, Lisa J Jones, Jann P Foster, Peter G Davis, See Kwee Ching, Ju Lee Oei, David A Osborn
BACKGROUND: Initial resuscitation with air is well tolerated by most infants born at term. However, the optimal fractional inspired oxygen concentration (FiO2 - proportion of the breathed air that is oxygen) targeted to oxygen saturation (SpO2 - an estimate of the amount of oxygen in the blood) for infants born preterm is unclear. OBJECTIVES: To determine whether lower or higher initial oxygen concentrations, when titrated according to oxygen saturation targets during the resuscitation of preterm infants at birth, lead to improved short- and long-term mortality and morbidity...
May 4, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29723927/cardiovascular-impact-of-intravenous-caffeine-in-preterm-infants
#19
Jacqueline Huvanandana, Cindy Thamrin, Alistair L McEwan, Murray Hinder, Mark B Tracy
AIM: To evaluate the acute effect of intravenous caffeine on heart rate and blood pressure variability in preterm infants. METHODS: We extracted and compared linear and non-linear features of heart rate and blood pressure variability at two timepoints: prior to and in the two hours following a loading dose of 10 mg/kg caffeine base. RESULTS: We studied 31 preterm infants with arterial blood pressure data and 25 with electrocardiogram data, and compared extracted features prior to and following caffeine administration...
May 3, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29717098/effect-of-transcutaneous-electrode-temperature-on-accuracy-and-precision-of-carbon-dioxide-and-oxygen-measurements-in-the-preterm-infants
#20
Jessica F Jakubowicz, Shasha Bai, David N Matlock, Michelle L Jones, Zhuopei Hu, Betty Proffitt, Sherry E Courtney
BACKGROUND: High electrode temperature during transcutaneous monitoring is associated with skin burns in extremely premature infants. We evaluated the accuracy and precision of CO2 and O2 measurements using lower transcutaneous electrode temperatures below 42°C. METHODS: We enrolled 20 neonates. Two transcutaneous monitors were placed simultaneously on each neonate, with one electrode maintained at 42°C and the other randomized to temperatures of 38, 39, 40, 41, and 42°C...
May 1, 2018: Respiratory Care
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