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https://www.readbyqxmd.com/read/29330775/a-peg-based-method-for-the-isolation-of-urinary-exosomes-and-its-application-in-renal-fibrosis-diagnostics-using-cargo-mir-29c-and-mir-21-analysis
#1
Chun-Yan Lv, Wei-Jun Ding, Yi-Li Wang, Zi-Yi Zhao, Jin-Hui Li, Yan Chen, Jiao Lv
PURPOSE: To assess a new and highly specific, but low-cost, easily performed and suitable for large-scale applications method for renal fibrosis (RF) diagnostics. METHODS: Thirty-five RF and twenty non-RF patients were enrolled in the study. An appropriate polyethylene glycol (PEG) was used to isolate urinary exosomes. The efficiency of isolation process was evaluated by the morphology and size observation, as well as the detection of specific markers (CD63, CD9)...
January 12, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29328522/cassava-flour-slurry-as-a-low-cost-alternative-to-commercially-available-gel-for-obstetrical-ultrasound-a-blinded-non-inferiority-trial-comparison-of-image-quality
#2
Aleha Aziz, Pe'er Dar, Francine Hughes, Clemencia Solorzano, Mundenga Mutendi Muller, Christian Salmon, Margaret Salmon, Nerys Benfield
OBJECTIVE: To evaluate the quality of ultrasound images obtained with cassava flour slurry (CFS) compared to conventional gel in order to determine objectively whether CFS could be a true low-cost alternative. DESIGN: Blinded non-inferiority trial. SETTING: Obstetrical ultrasound unit in an academic medical center. POPULATION OR SAMPLE: Women with a singleton pregnancy, undergoing anatomy ultrasounds. METHODS: Thirty pregnant women had standard biometry measures obtained with CFS and conventional gel...
January 12, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29326146/prior-authorization-requirements-for-proprotein-convertase-subtilisin-kexin-type-9-inhibitors-across-us-private-and-public-payers
#3
Jalpa A Doshi, Justin T Puckett, Michael S Parmacek, Daniel J Rader
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9is) are an innovative treatment option for patients with familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease who require further lowering of low-density lipoprotein cholesterol. However, the high costs of these agents have spurred payers to implement utilization management policies to ensure appropriate use. We examined prior authorization (PA) requirements for PCSK9is across private and public US payers...
January 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#4
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29321461/trends-in-paper-based-electrochemical-biosensors-from-design-to-application
#5
Vivian Bee Chin Lee, Noor Faizah Mohd-Naim, Eiichi Tamiya, Minhaz Uddin Ahmed
Electrochemical bio-sensing using paper-based detection systems is the main focus of this review. The different existing designs of 2-dimensional and 3-dimensional sensors, and fabrication techniques are discussed. This review highlights the effect of adopting different sensor designs, distinct fabrication techniques, as well as different modification methods, in order to produce reliable and reproducible reading. The use of various nanomaterials have been demonstrated in order to modify the surface of electrodes during fabrication to further enhance the signal for subsequent analysis...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29318878/ultrasensitive-enzyme-free-biosensor-by-coupling-cyclodextrin-functionalized-au-nanoparticles-and-high-performance-au-paper-electrode
#6
Xiaoxiao Zheng, Li Li, Kang Cui, Yan Zhang, Lina Zhang, Shenguang Ge, Jinghua Yu
Microfluidic paper-based analytical device (μPAD), originally developed for improving healthcare in developing countries, presents a simple yet powerful platform for performing low-cost and portable diagnostic devices. Here, we reported an enzyme-free μPAD for the detection of two tumor markers. Firstly, a porous structure of gold nanoparticles (AuNPs) modified paper working electrode (Au-PWE), with a feature of all-around conductivity and plenty of active sites favoring for the biological ligands attachment, was firstly fabricated as a sensor substrate...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29318413/evaluation-of-postoperative-fever-after-surgical-correction-of-neuromuscular-scoliosis-implication-on-management
#7
Mohamed Abdelhamid Ali Yousef, Scott Rosenfeld
BACKGROUND: Scoliosis is a common deformity in patients with neuromuscular disorders which usually necessitates surgical correction. Patients with neuromuscular scoliosis are characterized by increased incidence of associated medical co-morbidities and higher postoperative complication rate; therefore, these patients are often managed with a wide multidisciplinary care team. Postoperative fever is a frequent complication after surgery which is often routinely investigated using different workup tests to rule out infection...
January 9, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29317362/lumbar-dorsal-root-ganglion-block-as-a-prognostic-tool-prior-to-pulsed-radiofrequency-a-randomized-prospective-and-comparative-study-on-cost-effectiveness
#8
Cheng-Chia Lee, Ching-Jen Chen, Chien-Chen Chou, Hsin-Yi Wang, Wen-Yuh Chung, Giia-Sheun Peng, Ching-Po Lin
OBJECTIVES: In the study, we discuss the predictive value and cost-effectiveness of dorsal root ganglion (DRG) blocks prior to using dorsal root ganglion pulsed radiofrequency (DRG-PRF) in the treatment of low back pain. METHODS: The study comprised 60 patients with low back pain who were randomly assigned into two groups. Patients in Group 1 were screened using DRG block prior to DRG-PRF treatment for responders. Patients in Group 2 underwent DRG-PRF treatment without DRG block...
January 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29313472/diagnosis-of-trypanosoma-cruzi-infection-status-using-saliva-of-infected-subjects
#9
Nuria Cortes-Serra, Maria-Jesus Pinazo, Leonardo De la Torre, Melina Galizzi, Joaquim Gascon, Juan Manuel Bustamante
Chagas disease has the highest prevalence of any parasitic disease in the Americas, affecting 6-7 million people. Conventional diagnosis requires a well-equipped laboratory with experienced personnel. The development of new diagnostic tools that are easy to use and adapted to the reality of affected populations and health systems is still a significant challenge. The main objective of this study was to measure Trypanosoma cruzi infection status using saliva samples of infected subjects. Blood and saliva samples from 20 T...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29310974/sepsis-in-tropical-regions-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#10
Steven McGloughlin, Guy A Richards, Mohd Basri Mat Nor, Shirish Prayag, Tim Baker, Pravin Amin
Sepsis and septic shock in the tropics are caused by a wide array of organisms. These infections are encountered mainly in low and middle-income countries (LMIC) where a lack of infrastructure and medical facilities contribute to the high morbidity and mortality. Published sepsis guidelines are based on studies primarily performed in high income countries and as such recommendations may or may not be relevant to practice in the tropics. Failure to adhere to guidelines, particularly among non-intensive care specialists even in high-income countries, is an area of concern for sepsis management...
December 30, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29306269/sealone-safety-and-efficacy-of-coronary-computed-tomography-angiography-with-low-dose-in-patients-visiting-emergency-room-trial-study-protocol-for-a-randomized-controlled-trial
#11
Joonghee Kim, Joon-Won Kang, Kyuseok Kim, Sang Il Choi, Eun Ju Chun, Yeo Goon Kim, Won Young Kim, Dong Woo Seo, Jonghwan Shin, Huijai Lee, Kwang-Nam Jin, Soyeon Ahn, Seung Sik Hwang, Kwang Pyo Kim, Ru-Bi Jeong, Sang Ook Ha, Byungho Choi, Chang-Hwan Yoon, Jung-Won Suh, Hack-Lyoung Kim, Ju Kyoung Kim, Sujin Jang, Ji Seon Seo
OBJECTIVE: Chest pain is one of the most common complaints in the emergency department (ED). Cardiac computed tomography angiography (CCTA) is a frequently used tool for the early triage of patients with low- to intermediate-risk acute chest pain. We present a study protocol for a multicenter prospective randomized controlled clinical trial testing the hypothesis that a low-dose CCTA protocol using prospective electrocardiogram (ECG)-triggering and limited-scan range can provide sufficient diagnostic safety for early triage of patients with acute chest pain...
December 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29306118/diagnostic-accuracy-of-radiology-ct-x-ray-us-for-predicting-difficult-intubation-in-adults-a-meta-analysis
#12
REVIEW
Chao Ji, Qiang Ni, Wurong Chen
OBJECTIVE: The aim of this study was to evaluate the overall accuracy of radiological measurements in prediction of difficult airway and compare the diagnostic value between the radiological measurements and the modified Mallampati score through a meta-analysis of published studies. METHODS: A comprehensive electronic search of related literature was performed in PubMed, Embase, Cochrane Library and China National Knowledge Infrastructure. Meta-DiSc 1.4 and STATA 12...
January 3, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29304049/cost-and-affordability-of-non-communicable-disease-screening-diagnosis-and-treatment-in-kenya-patient-payments-in-the-private-and-public-sectors
#13
Sujha Subramanian, Robai Gakunga, Joseph Kibachio, Gladwell Gathecha, Patrick Edwards, Elijah Ogola, Gerald Yonga, Naftali Busakhala, Esther Munyoro, Jeremiah Chakaya, Nancy Ngugi, Nyawira Mwangi, Daniel Von Rege, Lili-Marie Wangari, David Wata, Robert Makori, Julius Mwangi, Walter Mwanda
INTRODUCTION: The prevalence of non-communicable diseases (NCDs) is rising in low- and middle-income countries, including Kenya, disproportionately to the rest of the world. Our objective was to quantify patient payments to obtain NCD screening, diagnosis, and treatment services in the public and private sector in Kenya and evaluate patients' ability to pay for the services. METHODS AND FINDINGS: We collected payment data on cardiovascular diseases, diabetes, breast and cervical cancer, and respiratory diseases from Kenyatta National Hospital, the main tertiary public hospital, and the Kibera South Health Center-a public outpatient facility, and private sector practitioners and hospitals...
2018: PloS One
https://www.readbyqxmd.com/read/29304039/establishing-ebola-virus-disease-evd-diagnostics-using-genexpert-technology-at-a-mobile-laboratory-in-liberia-impact-on-outbreak-response-case-management-and-laboratory-systems-strengthening
#14
Philomena Raftery, Orla Condell, Christine Wasunna, Jonathan Kpaka, Ruth Zwizwai, Mahmood Nuha, Mosoka Fallah, Maxwell Freeman, Victoria Harris, Mark Miller, April Baller, Moses Massaquoi, Victoria Katawera, John Saindon, Philip Bemah, Esther Hamblion, Evelyn Castle, Desmond Williams, Alex Gasasira, Tolbert Nyenswah
The 2014-16 Ebola Virus Disease (EVD) outbreak in West Africa highlighted the necessity for readily available, accurate and rapid diagnostics. The magnitude of the outbreak and the re-emergence of clusters of EVD cases following the declaration of interrupted transmission in Liberia, reinforced the need for sustained diagnostics to support surveillance and emergency preparedness. We describe implementation of the Xpert Ebola Assay, a rapid molecular diagnostic test run on the GeneXpert platform, at a mobile laboratory in Liberia and the subsequent impact on EVD outbreak response, case management and laboratory system strengthening...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29302798/cone-beam-ct-of-the-musculoskeletal-system-clinical-applications
#15
REVIEW
Magdalena Posadzy, Julie Desimpel, Filip Vanhoenacker
OBJECTIVES: The aim of this pictorial review is to illustrate the use of CBCT in a broad spectrum of musculoskeletal disorders and to compare its diagnostic merit with other imaging modalities, such as conventional radiography (CR), Multidetector Computed Tomography (MDCT) and Magnetic Resonance Imaging. BACKGROUND: Cone Beam Computed Tomography (CBCT) has been widely used for dental imaging for over two decades. DISCUSSION: Current CBCT equipment allows use for imaging of various musculoskeletal applications...
January 4, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29298013/low-cost-animal-disease-diagnostics-in-development
#16
(no author information available yet)
No abstract text is available yet for this article.
December 16, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29295635/real-world-utilization-of-molecular-diagnostic-testing-and-matched-drug-therapies-in-the-treatment-of-metastatic-cancers
#17
Anita Chawla, Miranda Peeples, Nanxin Li, Rachel Anhorn, Jason Ryan, James Signorovitch
AIMS: To assess the frequency of biopsies and molecular diagnostic testing (human DNA/RNA analysis), anti-cancer drug use (genomically-matched targeted therapy [GMTT], unmatched targeted therapy [UTT], endocrine therapy [ET], and chemotherapy [CT]), and medical service costs among adults with metastatic cancer. METHODS: Adults diagnosed with metastatic breast, non-small cell lung (NSCLC), colorectal, head and neck, ovarian, and uterine cancer (2010Q1-2015Q1) were identified in the OptumHealth Care Solutions claims database and followed from first metastatic diagnosis for ≥1 month and until end of data availability...
January 3, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29290893/ultrasound-curriculum-taught-by-first-year-medical-students-a-four-year-experience-in-tanzania
#18
Sean P Denny, William B Minteer, Reece T H Fenning, Sahil Aggarwal, Debora H Lee, Shella K Raja, Kaavya R Raman, Allison O Farfel, Priya A Patel, MarkLieber, Megan E Bernstein, Shadi Lahham, John C Fox
BACKGROUND: Diagnostic imaging is an integral aspect of care that is often insufficient, if not altogether absent, in rural and remote regions of low to middle income countries (LMICs) such as Tanzania. The introduction of ultrasound can significantly impact treatment in these countries due to its portability, low cost, safety, and usefulness in various medical assessments. This study reviews the implementation of a four-week ultrasound course administered annually from 2013-2016 in a healthcare professional school in Mwanza, Tanzania by first-year allopathic US medical students...
2018: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29290301/a-systematic-review-of-tests-for-the-detection-and-diagnosis-of-foot-lesions-causing-lameness-in-dairy-cows
#19
Kate J Dutton-Regester, Tamsin S Barnes, John D Wright, John I Alawneh, Ahmad R Rabiee
Foot lesions causing lameness in dairy cows are important economic and welfare issues. Prompt and correct detection and diagnosis are critical for improving economic and welfare outcomes. Few tests are currently available to aid the dairy farmer in the detection and diagnosis of foot lesions. The objectives of this systematic review were to identify those tests that have been investigated for the detection and diagnosis of foot lesions causing lameness in dairy cows, evaluate the methodological quality of the studies investigating the identified tests, compare the accuracy of the identified test, and determine which tests can be recommended for implementation on the farm based on accuracy and practicality for use by dairy farmers...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29289816/electrochemical-sensor-and-biosensor-platforms-based-on-advanced-nanomaterials-for-biological-and-biomedical-applications
#20
REVIEW
Govindhan Maduraiveeran, Manickam Sasidharan, Vellaichamy Ganesan
Introduction of novel functional nanomaterials and analytical technologies signify a foremost possibility for the advance of electrochemical sensor and biosensor platforms/devices for a broad series of applications including biological, biomedical, biotechnological, clinical and medical diagnostics, environmental and health monitoring, and food industries. The design of sensitive and selective electrochemical biological sensor platforms are accomplished conceivably by offering new surface modifications, microfabrication techniques, and diverse nanomaterials with unique properties for in vivo and in vitro medical analysis via relating a sensibly planned electrode/solution interface...
December 22, 2017: Biosensors & Bioelectronics
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