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https://www.readbyqxmd.com/read/27902900/sensitivity-and-specificity-estimation-for-the-clinical-diagnosis-of-highly-pathogenic-avian-influenza-in-the-egyptian-participatory-disease-surveillance-program
#1
C Verdugo, I El Masry, Y Makonnen, H Hannah, F Unger, M Soliman, S Galal, J Lubroth, D Grace
Many developing countries lack sufficient resources to conduct animal disease surveillance. In recent years, participatory epidemiology has been used to increase the cover and decrease the costs of surveillance. However, few diagnostic performance assessments have been carried out on participatory methods. The objective of the present study was to estimate the diagnostic performance of practitioners working for the Community-Based Animal Health and Outreach (CAHO) program, which is a participatory disease surveillance system for the detection of highly pathogenic avian influenza outbreaks in Egypt...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902755/the-utility-of-malaria-rapid-diagnostic-tests-as-a-tool-in-enhanced-surveillance-for-malaria-elimination-in-vanuatu
#2
Wesley Donald, Cielo Pasay, Jean-Olivier Guintran, Harry Iata, Karen Anderson, Johnny Nausien, Karryn J Gresty, Norman C Waters, Lasse S Vestergaard, George Taleo, Qin Cheng
BACKGROUND: As part of efforts to eliminate malaria, Vanuatu has piloted the implementation of enhanced malaria surveillance and response strategies since 2011. This involves passive case detection (PCD) in health facilities, proactive case detection (Pro-ACD) and reactive case detection (Re-ACD) in communities using malaria rapid diagnostic tests (RDTs). While RDTs improve case management, their utility for detection of malaria infections in ACDs in this setting is unclear. METHODS: The utility of malaria RDTs as diagnostic tools was evaluated in PCD, in five rounds of Pro-ACDs and five rounds of Re-ACDs conducted in Tafea and Torba Provinces between 2011 and 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27897197/on-site-rapid-diagnosis-of-intracranial-hematoma-using-portable-multi-slice-microwave-imaging-system
#3
Ahmed Toaha Mobashsher, A M Abbosh
Rapid, on-the-spot diagnostic and monitoring systems are vital for the survival of patients with intracranial hematoma, as their conditions drastically deteriorate with time. To address the limited accessibility, high costs and static structure of currently used MRI and CT scanners, a portable non-invasive multi-slice microwave imaging system is presented for accurate 3D localization of hematoma inside human head. This diagnostic system provides fast data acquisition and imaging compared to the existing systems by means of a compact array of low-profile, unidirectional antennas with wideband operation...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895817/current-noninvasive-tests-for-colorectal-cancer-screening-an-overview-of-colorectal-cancer-screening-tests
#4
REVIEW
Le-Le Song, Yue-Min Li
Colorectal cancer (CRC) has become the third most common cancer in the world. Screening has been shown to be an effective way to identify early CRC and precancerous lesions, and to reduce its morbidity and mortality. Several types of noninvasive tests have been developed for CRC screening, including the fecal occult blood test (FOBT), the fecal immunochemical test (FIT), the fecal-based DNA test and the blood-based DNA test (the SEPT9 assay). FIT has replaced FOBT and become the major screening test due to high sensitivity, specificity and low costs...
November 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27894433/the-role-of-minimally-invasive-surgery-in-pediatric-trauma
#5
REVIEW
Erik G Pearson, Matthew S Clifton
Minimally invasive surgery (MIS) in the management of blunt and penetrating pediatric trauma has evolved in the past 30 years. Laparoscopy and thoracoscopy possess high levels of diagnostic accuracy with low associated missed injury rates. Currently available data advocate limiting the use of MIS to blunt or penetrating injuries in the hemodynamically stable child. In the pediatric trauma population, MIS offers both diagnostic and therapeutic potential, as well as reduced postoperative pain, a decreased rate of postoperative complications, shortened hospital stay, and potentially reduced cost...
February 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27893534/clinical-predictors-of-positive-postoperative-blood-cultures
#6
Libby R Copeland-Halperin, Joshua Stodghill, Erica Emery, Amber W Trickey, Jonathan Dort
OBJECTIVE: To define clinical features of surgical patients in whom postoperative blood cultures are likely to identify pathogens. BACKGROUND: Bacteremia is a worrisome postoperative complication and blood cultures (BCx) are routinely used for evaluation of postoperative bacteremia, but are costly and not always diagnostic. Better methods are needed to select patients in whom BCx identify pathogens. METHODS: We reviewed records of patients ≥18 years old with BCx drawn ≤10 days after surgery in 2013 seeking independent predictors of positive cultures by simple and multiple logistic regression models with statistical significance at α = 0...
November 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27888859/treatment-adherence-is-always-worse-than-we-think-an-unresolved-problem-in-inflammatory-bowel-disease
#7
Fernando Gomollón
New diagnostic and treatment tools are the "stars" of scientific meetings but other aspects may have an even greater impact on patients' lives. Several new studies presented at DDW (Digestive Disease Week) 2016 demonstrated that: a) treatment adherence continues to be suboptimal even in the most advanced health systems; b) lack of adherence correlates with low treatment effectiveness, with higher levels of intestinal damage and higher costs; and c) the factor most consistently associated with poor adherence is age (the younger the patient, the poorer the adherence)...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27888023/integrated-process-for-the-purification-and-immobilization-of-the-envelope-protein-domain-iii-of-dengue-virus-type-2-expressed-in-rachiplusia-nu-larvae-and-its-potential-application-in-a-diagnostic-assay
#8
María Emilia Smith, Alexandra Marisa Targovnik, Julieta Cerezo, María Alejandra Morales, María Victoria Miranda, Julián Rodríguez Talou
Dengue incidence has grown dramatically in the last years, with about 40% of the world population at risk of infection. Recently, a vaccine developed by Sanofi Pasteur has been registered, but only in a few countries. Moreover, specific antiviral drugs are not available. Thus, an efficient and accurate diagnosis is important for disease management. To develop a low-cost immunoassay for dengue diagnosis, in the present study we expressed the envelope protein domain III of dengue virus type 2 in Rachiplusia nu larvae by infection with a recombinant baculovirus...
November 22, 2016: Protein Expression and Purification
https://www.readbyqxmd.com/read/27886789/electrophysiology-in-the-developing-world-challenges-and-opportunities
#9
REVIEW
Michael Bestawros
As a subset of the growing epidemic of cardiovascular morbidity and mortality in low-income and middle-income countries (LMICs), the significant burdens of heart rhythm disorders also increase. Effective diagnostic and treatment modalities exist, but financial resources and expertise are limited. Cost-effective strategies exist to address most of these limitations, but many surmountable barriers need to be overcome to introduce and improve electrophysiologic care in LMICs. In this article, current and potential solutions are offered for the diagnostic and therapeutic challenges of managing bradyarrhythmias and tachyarrhythmias...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27886604/a-low-cost-and-palm-size-analyzer-for-rapid-and-sensitive-protein-detection-by-ac-electrokinetics-capacitive-sensing
#10
Xiaozhu Liu, Cheng Cheng, Jayne Wu, Shigetoshi Eda, Yongcai Guo
Specific detection of protein biomarkers has a wide range of applications in areas such as medical science, diagnostics, and pharmacology. Quantitative detection of protein biomarkers in biological media, such as serum, is critically important in detecting disease or physiological malfunction, or tracking disease progression. Among various detection methods, electrical detection is particularly well suited for point-of-care (POC) specific protein detection, being of low cost, light weight and small form factor...
November 11, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27885040/development-and-application-of-a-fluorescence-protein-microarray-for-detecting-serum-alpha-fetoprotein-in-patients-with-hepatocellular-carcinoma
#11
Aiying Zhang, Chengzeng Yin, Zhenshun Wang, Yonghong Zhang, Yuanshun Zhao, Ang Li, Huanqin Sun, Dongdong Lin, Ning Li
OBJECTIVE: To develop a simple, effective, time-saving and low-cost fluorescence protein microarray method for detecting serum alpha-fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC). METHOD: Non-contact piezoelectric print techniques were applied to fluorescence protein microarray to reduce the cost of prey antibody. Serum samples from patients with HCC and healthy control subjects were collected and evaluated for the presence of AFP using a novel fluorescence protein microarray...
November 24, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27882544/prospective-evaluation-of-the-ages-and-stages-questionnaire-3rd-edition-in-very-low-birthweight-infants
#12
Pratibha K Agarwal, Luming Shi, Lourdes M Daniel, Phey Hong Yang, Poh Choo Khoo, Bin Huey Quek, Qishi Zheng, Victor S Rajadurai
AIM: To evaluate the predictive and concurrent diagnostic agreement of the Ages and Stages Questionnaire 3rd Edition (ASQ-3) with the Bayley Scales of Infant and Toddler Development 3rd Edition (Bayley-III) in infants born preterm and very-low-birthweight (PT/VLBW; ≤1250g). METHOD: We evaluated 141 PT/VLBW infants (68 males, 73 females) born at the KK Women's and Children's Hospital between January 2010 and December 2011, to determine predictive and concurrent diagnostic agreement between the ASQ-3 at 9, 12, 18, and 24 months corrected age and Bayley-III at 24 months...
November 24, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27875528/effectiveness-of-seasonal-malaria-chemoprevention-in-children-under-ten-years-of-age-in-senegal-a-stepped-wedge-cluster-randomised-trial
#13
Badara Cissé, El Hadj Ba, Cheikh Sokhna, Jean Louis NDiaye, Jules F Gomis, Yankhoba Dial, Catherine Pitt, Mouhamed NDiaye, Matthew Cairns, Ernest Faye, Magatte NDiaye, Aminata Lo, Roger Tine, Sylvain Faye, Babacar Faye, Ousmane Sy, Lansana Konate, Ekoue Kouevijdin, Clare Flach, Ousmane Faye, Jean-Francois Trape, Colin Sutherland, Fatou Ba Fall, Pape M Thior, Oumar K Faye, Brian Greenwood, Oumar Gaye, Paul Milligan
BACKGROUND: Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), given each month during the transmission season, is recommended for children living in areas of the Sahel where malaria transmission is highly seasonal. The recommendation for SMC is currently limited to children under five years of age, but, in many areas of seasonal transmission, the burden in older children may justify extending this age limit. This study was done to determine the effectiveness of SMC in Senegalese children up to ten years of age...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27869388/-cost-effectiveness-of-diagnostic-strategies-of-severe-bacterial-infection-in-infants-with-fever-without-a-source
#14
Jefferson Antonio Buendía, Juana Patricia Sánchez-Villamil, Gabriela Urman
Serious bacterial infections in infants under 2-years-of-age with fever without a source remains, despite advances in vaccination, a matter of concern for both physicians and parents. Having cost-effectiveness information is relevant to guide decision making in clinical practice in this scenario. Objective: To determine the cost-effectiveness of four different strategies of screening in Argentina for serious bacterial infection in children presenting with fever without a source. Materials and methods: We designed a decision tree to model a hypothetical cohort of 10,000 children with fever without a source...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27867079/variability-in-diagnostic-error-rates-of-ten-mri-centers-performing-lumbar-spine-mri-exams-on-the-same-patient-within-a-three-week-period
#15
Richard Herzog, Daniel R Elgort, Adam E Flanders, Peter J Moley
BACKGROUND CONTEXT: In today's healthcare climate, Magnetic Resonance Imaging (MRI) is often perceived as a commodity - a service where there are no meaningful differences in quality and thus an area in which patients can be advised to select a provider based on price and convenience alone. If this prevailing view is correct, then a patient should expect to receive the same radiological diagnosis regardless of which imaging center he or she visits or which radiologist reviews the examination...
November 17, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27865485/comparison-of-the-effectiveness-of-stress-echocardiography-versus-myocardial-perfusion-imaging-in-patients-presenting-to-the-emergency-department-with-low-risk-chest-pain
#16
Rhian Davies, Guodong Liu, Christopher Sciamanna, William R Davidson, Douglas L Leslie, Andrew J Foy
The aim of this study was to compare clinically relevant cardiovascular outcomes and downstream resource utilization associated with stress echocardiography (SE) and myocardial perfusion imaging (MPI) in emergency department patients with low-risk chest pain. This was a retrospective analysis of health insurance claims data for a national sample of privately insured patients over the period January 1 to December 31, 2011. Subjects were selected who presented to the emergency department with a primary or secondary diagnosis of chest pain and underwent either SE or MPI...
October 18, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27864448/evaluation-of-a-rapid-antigen-test-for-detection-of-streptococcus-pneumoniae-in-cerebrospinal-fluid
#17
Angel Boulos, Derek Fairley, James McKenna, Peter Coyle
Detection of Streptococcus pneumoniae antigen in cerebrospinal fluid (CSF) using lateral flow immunochromatography tests (ICTs) is an effective, rapid and low-cost method to diagnose pneumococcal meningitis. This study evaluated the diagnostic accuracy of the Uni-Gold ICT to detect pneumococcal antigen in CSF specimens, compared with gold standard bacteriology and quantitative real-time PCR (qPCR) testing. CSF specimens (n=69) from patients with suspected bacterial meningitis were included in the study. 13/69 (19%) were positive and 56/69 (81%) were negative for pneumococcus by the gold standard tests...
November 18, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27864340/microfluidic-tissue-mesodissection-in-molecular-cancer-diagnostics
#18
Christine Surrette, David Shoudy, Alex Corwin, Wei Gao, Maria I Zavodszky, Stanislav L Karsten, Todd Miller, Michael J Gerdes, Nichole Wood, John R Nelson, Chris M Puleo
We present a mesodissection platform that retains the advantages of laser-based dissection instrumentation with the speed and ease of manual dissection. Tissue dissection in clinical laboratories is often performed by manually scraping a physician-selected region from standard glass slide mounts. In this manner, costs associated with dissection remain low, but spatial resolution is compromised. In contrast, laser microdissection methods maintain spatial resolution that matches the requirements for analysis of important tissue heterogeneity but remains costly and labor intensive...
November 18, 2016: Journal of Laboratory Automation
https://www.readbyqxmd.com/read/27864098/screening-for-mucopolysaccharidoses-in-the-turkish-population-analytical-and-clinical-performance-of-an-age-range-specific-dye-based-urinary-glycosaminoglycan-assay
#19
Khaled El Moustafa, Serap Sivri, Sevilay Karahan, Turgay Coşkun, Filiz Akbıyık, İncilay Lay
Comprehensive analytical and diagnostic performance of urinary quantitative GAG analysis with dimethylmethylene blue (DMB) and the age-specific reference ranges were determined in Turkish population, which has a high incidence of MPSs. Precision, linearity, recovery and accuracy/trueness, limits, stability, and effect of interferents were tested according to CLSI guideline. Clinical performance was evaluated with ROC analyses including 45 MPS patients. Intra-day and inter-day precisions were <5% and <11% (CV), respectively...
November 15, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27863016/appropriateness-and-diagnostic-yield-of-inpatient-pediatric-echocardiograms
#20
Sean M Lang, Elijah Bolin, Joshua A Daily, Xinyu Tang, R Thomas Collins
OBJECTIVE: Multiple reports have shown echocardiograms for certain indications are neither cost-effective nor of high diagnostic yield. Given the ease with which tests can be obtained at a tertiary academic children's hospital, our aims were to: (1) determine the diagnostic yield of inpatient studies by in-hospital location; (2) evaluate inpatient echocardiograms to determine indications and level of appropriateness; and (3) evaluate the frequency of cardiology involvement prior to those echocardiograms...
November 8, 2016: Congenital Heart Disease
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