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https://www.readbyqxmd.com/read/28214703/polyester-fabric-sheet-layers-functionalized-with-graphene-oxide-for-sensitive-isolation-of-circulating-tumor-cells
#1
Jiyoon Bu, Young Jun Kim, Yoon-Tae Kang, Tae Hee Lee, Jeongsuk Kim, Young-Ho Cho, Sae-Won Han
The metastasis of cancer is strongly associated with the spread of circulating tumor cells (CTCs). Based on the microfluidic devices, which offer rapid recovery of CTCs, a number of studies have demonstrated the potential of CTCs as a diagnostic tool. However, not only the insufficient specificity and sensitivity derived from the rarity and heterogeneity of CTCs, but also the high-cost fabrication processes limit the use of CTC-based medical devices in commercial. Here, we present a low-cost fabric sheet layers for CTC isolation, which are composed of polyester monofilament yarns...
February 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28212519/early-calibration-of-the-hpa-axis-by-maternal-psychopathology
#2
Heidemarie Laurent
Given the central role of stress-responsive neurophysiology in mental and physical health, it is important to understand how particular patterns of stress responsivity may become entrained by the early caregiving environment. In this study we investigated links between maternal depression and anxiety symptom profiles and within-infant development of hypothalamic-pituitary-adrenal (HPA) axis responses from 6 to 18 months of life. Associations with infant cognitive and social-emotional development were also tested to gauge the adjustment implications of HPA response trajectories...
February 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28205108/water-assisted-colonoscopy
#3
REVIEW
Sergio Cadoni, Felix W Leung
The current review will attempt to describe the important lessons learned from published randomized controlled trials (RCT) comparing water immersion (WI) or water exchange (WE) techniques with gas insufflation colonoscopy. Air insufflation (AI) to distend the colon to permit visualization and passage through the lumen was developed for diagnostic colonoscopy. When screening colonoscopy was adopted, the same AI method was used. Interval cancers, diagnosed within 3 to 5 years after an index screening colonoscopy, appeared to be linked to low adenoma detection rate (ADR)...
February 15, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28202796/evaluation-of-genotypic-and-phenotypic-protease-virulence-tests-for-dichelobacter-nodosus-infection-in-sheep
#4
Andrew S McPherson, Om P Dhungyel, Richard J Whittington
Dichelobacter nodosus is a fastidious, strictly anaerobic bacterium, an obligate parasite of the ruminant hoof and the essential causative agent of virulent ovine footrot. The clinical disease results from a complex interplay between pathogen, environment and host. Sheep flocks diagnosed with virulent but not benign footrot in Australia may be quarantined and required to undergo a compulsory eradication program, with costs met by the farmer. Virulence of D. nodosus is at least partially dependent on elaboration of a protease coded by aprV2 and manifest as elastase activity...
February 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28201922/diagnosis-of-osteoporosis-in-rural-arctic-greenland-a-clinical-case-using-plain-chest-radiography-for-secondary-prevention-and-consideration-of-tools-for-primary-prevention-in-remote-areas
#5
Inuuteq Fleischer, Louise K Schæbel, Nadja Albertsen, Vibeke N Sørensen, Stig Andersen
CONTEXT: Osteoporosis is a frequent disease in many populations. The hallmark is fragility fractures, which are harbingers of future fractures, disability, mortality and cost on society. The occurrence increases with age, low vitamin D level and smoking. Smoking rates are high, vitamin D is low and life expectancy is rising steeply in Greenland, as is the need for focus on osteoporosis. We report a case that uses a simple and readily available tool to diagnose osteoporosis at the hospital in Sisimiut, a town of 5000 inhabitants on the west coast of Greenland...
January 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28195650/cell-tube-block-a-new-technique-to-produce-cell-blocks-from-fluid-cytology-samples
#6
Ricardo Marcos, Marta Santos, Carla Marrinhas, Mario Caniatti
BACKGROUND: Cell blocks are widely used in human cytopathology. Several techniques have been proposed to convert fluid specimens into solid material, which after embedding in paraffin can be used for histochemistry, immunohistochemistry, or molecular testing. In contrast, only in the last few years, have cell blocks begun to be used in the veterinary field. OBJECTIVES: The purpose of the study was to present the production and features of cell tube blocks (CTB) with veterinary liquid samples...
February 13, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28194719/the-impact-of-ptsd-on-functioning-in-patients-seeking-treatment-for-chronic-pain-and-validation-of-the-posttraumatic-diagnostic-scale
#7
Sophia Åkerblom, Sean Perrin, Marcelo Rivano Fischer, Lance M McCracken
PURPOSE: The purpose of this study was to assess the psychometric properties of a Swedish version of the Posttraumatic Diagnostic Scale (PDS); to investigate the prevalence of traumatic experiences, trauma types, and posttraumatic stress disorder (PTSD) in a sample of patients seeking treatment for chronic pain; and to examine how indices of pain-related functioning vary with a history of traumatic exposure and PTSD diagnostic status. METHOD: Participants were 463 consecutive patients with chronic pain referred for assessment at the Pain Rehabilitation Unit at Skåne University Hospital...
February 13, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28193012/metal-organic-framework-nanomaterials-as-novel-signal-probes-for-electron-transfer-mediated-ultrasensitive-electrochemical-immunoassay
#8
Ting-Zhi Liu, Rong Hu, Xi Zhang, Kun-Lei Zhang, Yi Liu, Xiao-Bing Zhang, Ru-Yan Bai, Delei Li, Yun-Hui Yang
A novel and simple electrochemical immunoassay for C-reactive protein was developed using metal-organic frameworks (Au-MOFs) as signal unit. In this study, we found MOFs could be used as signal probe. And this new class of signal probe differs from traditional probe. The signal of the copper ions (Cu(2+)) from MOFs could be directly detected without acid dissolution and preconcentration, which would greatly simplify the detection steps and reduce the detection time. Moreover, MOFs contain large amounts of Cu(2+) ions, providing high electrochemical signals...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192992/protein-adsorbed-magnetic-nanoparticle-mediated-assay-for-rapid-detection-of-bacterial-antibiotic-resistance
#9
Taku A Cowger, Yaping Yang, David E Rink, Trever Todd, Hongmin Chen, Ye Shen, Yajun Yan, Jin Xie
Antibiotic susceptibility tests have been used for years as a crucial diagnostic tool against antibiotic-resistant bacteria. However, due to a lack of biomarkers specific to resistant types, these approaches are often time-consuming, inaccurate, and inflexible in drug selections. Here, we present a novel susceptibility test method named protein-adsorbed nanoparticle-mediated matrix-assisted laser desorption-ionization mass spectrometry, or PANMS. Briefly, we adsorb five different proteins (β-casein, α-lactalbumin, human serum albumin, fibrinogen, and avidin) onto the surface of Fe3O4...
February 17, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28192523/bead-based-immunoassay-allows-sub-picogram-detection-of-histidine-rich-protein-2-from-plasmodium-falciparum-and-estimates-reliability-of-malaria-rapid-diagnostic-tests
#10
Eric Rogier, Mateusz Plucinski, Naomi Lucchi, Kimberly Mace, Michelle Chang, Jean Frantz Lemoine, Baltazar Candrinho, James Colborn, Rafael Dimbu, Filomeno Fortes, Venkatachalam Udhayakumar, John Barnwell
Detection of histidine-rich protein 2 (HRP2) from the malaria parasite Plasmodium falciparum provides evidence for active or recent infection, and is utilized for both diagnostic and surveillance purposes, but current laboratory immunoassays for HRP2 are hindered by low sensitivities and high costs. Here we present a new HRP2 immunoassay based on antigen capture through a bead-based system capable of detecting HRP2 at sub-picogram levels. The assay is highly specific and cost-effective, allowing fast processing and screening of large numbers of samples...
2017: PloS One
https://www.readbyqxmd.com/read/28187298/piezoelectric-immunochip-coated-with-thin-films-of-bacterial-cellulose-nanocrystals-for-dengue-detection
#11
Cleverton Luiz Pirich, Rilton Alves de Freitas, Roberto Manuel Torresi, Guilherme Fadel Picheth, Maria Rita Sierakowski
Low-cost piezoelectric devices, such as simple frequency monitoring quartz crystal microbalance (QCM) devices, have good clinical utility as fast diagnostic tools for the detection of several diseases. However, unspecific antigen recognition, poor molecular probe adsorption and the need for sample dilution are still common drawbacks that hinder their use in routine diagnosis. In this work, piezoelectric sensors were previously coated with thin films of bacterial cellulose nanocrystals (CN) to provide a more sensitive and adapted interface for the attachment of monoclonal immunoglobulin G (IgGNS1) and to favor specific detection of non-structural protein 1 (NS1) of dengue fever...
February 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28185691/thoracic-ultrasound-technique-applications-and-interpretation
#12
REVIEW
Suraj H Rambhia, Catherine A D'Agostino, Ali Noor, Robert Villani, Jason J Naidich, John S Pellerito
Thoracic ultrasound is used at the bedside in emergency and critical care settings. Advantages of ultrasound include rapid real-time, low-cost, diagnostic information that can direct patient care without the use of ionizing radiation. We describe methods on how to perform lung ultrasound, with the intent to educate the radiologist who might otherwise be relatively unfamiliar with thoracic sonography. We describe and depict the normal sonographic appearance of lung anatomy. We also show the sonographic appearance of a wide range of lung and pleural pathologies such as pneumonia, pneumothorax, as well as lung and pleural masses...
December 15, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28179612/ad-hoc-vs-non-ad-hoc-percutaneous-coronary-intervention-strategies-in-patients-with-stable-coronary-artery-disease
#13
Toshiaki Toyota, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Koh Ono, Satoshi Shizuta, Takao Kato, Naritatsu Saito, Yutaka Furukawa, Yoshihisa Nakagawa, Minoru Horie, Takeshi Kimura
BACKGROUND: Few studies have evaluated the prevalence and clinical outcomes of ad hoc percutaneous coronary intervention (PCI), performing diagnostic coronary angiography and PCI in the same session, in stable coronary artery disease (CAD) patients.Methods and Results:From the CREDO-Kyoto PCI/CABG registry cohort-2, 6,943 patients were analyzed as having stable CAD and undergoing first PCI. Ad hoc PCI and non-ad hoc PCI were performed in 1,722 (24.8%) and 5,221 (75.1%) patients, respectively...
February 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28177611/optomagnetic-detection-of-microrna-based-on-duplex-specific-nuclease-assisted-target-recycling-and-multilayer-core-satellite-magnetic-superstructures
#14
Bo Tian, Jing Ma, Zhen Qiu, Teresa Zardán Gómez de la Torre, Marco Donolato, Mikkel Fougt Hansen, Peter Svedlindh, Mattias Strömberg
Superstructural assembly of magnetic nanoparticles enables approaches to biosensing by combining specially tailored properties of superstructures and the particular advantages associated with a magnetic or optomagnetic read-out such as low background signal, easy manipulation, cost-efficiency, and potential for bioresponsive multiplexing. Herein, we demonstrate a sensitive and rapid miRNA detection method based on optomagnetic read-out, duplex-specific nuclease (DSN)-assisted target recycling, and the use of multilayer core-satellite magnetic superstructures...
February 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28176181/transthoracic-contrast-echocardiography-using-vitamin-b6-and-sodium-bicarbonate-as-contrast-agents-for-the-diagnosis-of-patent-foramen-ovale
#15
Jiang-Chun He, Jian-Yong Zheng, Xin Li, Ye Yang, Bo-Yang Zhang, Yu Chen, Xian-Feng Li, Ying-Ming Liu, Yi Cao, Li Zhao, Tian-Chang Li
To evaluate the utility of transthoracic contrast echocardiography (cTTE) using vitamin B6 and sodium bicarbonate as contrast agents for diagnosing right-to-left shunt (RLS) caused by patent foramen ovale (PFO) compared to that of transesophageal echocardiography (TEE). We investigated 125 patients admitted to our neurology department with unexplained cerebral infarction and migraine. All patients underwent cTTE using vitamin B6 and sodium bicarbonate as contrast agents, after which they underwent transthoracic echocardiography...
February 7, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28170133/optimal-strategies-for-the-diagnosis-of-community-onset-diarrhea-in-solid-organ-transplant-recipients-less-is-more
#16
Sonya A Trinh, Ignacio A Echenique, Sudhir Penugonda, Michael P Angarone
BACKGROUND: Diarrhea, a common complication after solid organ transplant (SOT), is associated with allograft failure and death. No evidence-based guidelines exist for the evaluation of diarrhea in SOT recipients. We performed a cost-analysis to derive a testing algorithm for the diagnosis of community-onset diarrhea that minimizes costs without compromising diagnostic yields. DESIGN: A cost-analysis was performed on a retrospective cohort of 422 SOT admissions for community-onset diarrhea over an 18-month period...
February 7, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28167769/multifunctional-inexpensive-and-reusable-nanoparticle-printed-biochip-for-cell-manipulation-and-diagnosis
#17
Rahim Esfandyarpour, Matthew J DiDonato, Yuxin Yang, Naside Gozde Durmus, James S Harris, Ronald W Davis
Isolation and characterization of rare cells and molecules from a heterogeneous population is of critical importance in diagnosis of common lethal diseases such as malaria, tuberculosis, HIV, and cancer. For the developing world, point-of-care (POC) diagnostics design must account for limited funds, modest public health infrastructure, and low power availability. To address these challenges, here we integrate microfluidics, electronics, and inkjet printing to build an ultra-low-cost, rapid, and miniaturized lab-on-a-chip (LOC) platform...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28166451/serology-in-finfish-for-diagnosis-surveillance-and-research-a-systematic-review
#18
Diana Jaramillo, Edmund J Peeler, Emilie Laurin, Ian A Gardner, Richard J Whittington
Historically, serological tests for finfish diseases have been underused when compared with their use in terrestrial animal health. For years the nonspecific immune response in fish was judged to make serology unreliable and inferior to the direct measurement of agent analytes. We conducted a systematic review of peer-reviewed publications that reported on the development, validation, or application of serological tests for finfish diseases. A total of 168 articles met the screening criteria; most of them were focused on salmonid pathogens (e...
March 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28166394/exosome-separation-using-microfluidic-systems-size-based-immunoaffinity-based-and-dynamic-methodologies
#19
REVIEW
Fang Yang, Xiangzhi Liao, Yuan Tian, Guiying Li
Exosomes, nanovesicles secreted by most types of cells, exist in virtually all bodily fluids. Their rich nucleic acid and protein content make them potentially valuable biomarkers for noninvasive molecular diagnostics. They also show promise, after further development, to serve as a drug delivery system. Unfortunately, existing exosome separation technologies, such as ultracentrifugation and methods incorporating magnetic beads, are time-consuming, laborious and separate only exosomes of low purity. Thus, a more effective separation method is highly desirable...
February 6, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28162099/cost-effectiveness-of-active-case-finding-of-household-contacts-of-pulmonary-tuberculosis-patients-in-a-low-hiv-tuberculosis-endemic-urban-area-of-lima-peru
#20
L Shah, M Rojas, O Mori, C Zamudio, J S Kaufman, L Otero, E Gotuzzo, C Seas, T F Brewer
We compared the cost-effectiveness (CE) of an active case-finding (ACF) programme for household contacts of tuberculosis (TB) cases enrolled in first-line treatment to routine passive case-finding (PCF) within an established national TB programme in Peru. Decision analysis was used to model detection of TB in household contacts through: (1) self-report of symptomatic cases for evaluation (PCF), (2) a provider-initiated ACF programme, (3) addition of an Xpert MTB/RIF diagnostic test for a single sputum sample from household contacts, and (4) all strategies combined...
February 6, 2017: Epidemiology and Infection
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