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https://www.readbyqxmd.com/read/28087552/screening-for-atrial-fibrillation-using-economical-and-accurate-technology-safety-a-pilot-study
#1
Mark Lown, Arthur Yue, George Lewith, Paul Little, Mike Moore
INTRODUCTION: Atrial fibrillation (AF) is a cause of stroke and a marker of atherosclerosis and of all patients with stroke, around 17% have AF. The screening and treatment of AF could prevent about 12% of all strokes. Several relatively low-cost devices with good accuracy now exist which can detect AF including WatchBP and AliveCor. However, they can only measure the ECG or pulse over short time periods. Inexpensive devices such as heart rate monitors, which are widely available, can measure heart rate for prolonged periods and may have potential in screening for AF...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28075337/implementation-of-point-of-care-diagnostics-in-rural-primary-healthcare-clinics-in-south-africa-perspectives-of-key-stakeholders
#2
Tivani P Mashamba-Thompson, Ngcwalisa A Jama, Benn Sartorius, Paul K Drain, Rowan M Thompson
INTRODUCTION: Key stakeholders' involvement is crucial to the sustainability of quality point-of-care (POC) diagnostics services in low-and-middle income countries. The aim of this study was to explore key stakeholder perceptions on the implementation of POC diagnostics in rural primary healthcare (PHC) clinics in South Africa. METHOD: We conducted a qualitative study encompassing in-depth interviews with multiple key stakeholders of POC diagnostic services for rural and resource-limited PHC clinics...
January 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28073760/better-diagnostic-signatures-from-rnaseq-data-through-use-of-auxiliary-co-data
#3
Putri W Novianti, Barbara C Snoek, Saskia M Wilting, Mark A van de Wiel
: Our aim is to improve omics based prediction and feature selection using multiple sources of auxiliary information: co-data. Adaptive group regularized ridge regression (GRridge) was proposed to achieve this by estimating additional group-based penalty parameters through an empirical Bayes method at a low computational cost. We illustrate the GRridge method and software on RNA sequencing data sets. The method boosts the performance of an ordinary ridge regression and outperforms other classifiers...
January 10, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28071605/carbon-nanotube-on-eraser-based-eco-friendly-fabrication-of-skin-like-large-area-matrix-of-flexible-strain-and-pressure-sensor
#4
Parikshit Sahatiya, Sushmee Badhulika
This paper reports a new type of electronic, recoverable skin-like pressure and strain sensor on flexible, bio-degradable pencil eraser substrate and has been fabricated by a solvent-free, low-cost and energy efficient process. Multi-walled carbon nanotube (MWCNTs) film as strain sensing element was patterned on pencil eraser by rolling pin and pre-compaction mechanical press which induces high interfacial bonding between the MWCNTs and eraser substrate which enables the sensor to achieve recoverability under ambient conditions...
January 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28070227/disposable-fluidic-actuators-for-miniature-in-vivo-surgical-robotics
#5
Abolfazl Pourghodrat, Carl A Nelson
Fusion of robotics and minimally invasive surgery (MIS) has created new opportunities to develop diagnostic and therapeutic tools. Surgical robotics is advancing from externally actuated systems to miniature in-vivo robotics. However, with miniaturization of electric-motor-driven surgical robots, there comes a trade-off between the size of the robot and its capability. Slow actuation, low load capacity, sterilization difficulties, leaking electricity and transferring produced heat to tissues, and high cost are among the key limitations of the use of electric motors in in-vivo applications...
March 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/28069883/comparison-of-phenotypic-methods-for-the-detection-of-penicillinase-in-staphylococcus-aureus-and-proposal-of-a-practical-diagnostic-approach
#6
Michael Hombach, Christoph Weissert, Maria Magdalena Senn, Reinhard Zbinden
OBJECTIVES: Disc diffusion is a cost-efficient, low-complexity, reliable method for detection of blaZ-mediated benzylpenicillin resistance in Staphylococcus aureus if the zone edge is inspected. EUCAST breakpoints cannot fully separate β-lactamase-positive from β-lactamase-negative strains, and EUCAST recommends the zone edge test. Literature on nitrocefin-based testing and the zone edge test is scarce with wide variations in reported assay performance. METHODS: This study compared two different nitrocefin-based commercial and in-house tests and the EUCAST-based zone edge test for penicillinase detection in S...
January 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28068607/micro-electromechanical-film-bulk-acoustic-sensor-for-plasma-and-whole-blood-coagulation-monitoring
#7
Da Chen, Shuren Song, Jilong Ma, Zhen Zhang, Peng Wang, Weihui Liu, Qiuquan Guo
Monitoring blood coagulation is an important issue in the surgeries and the treatment of cardiovascular diseases. In this work, we reported a novel strategy for the blood coagulation monitoring based on a micro-electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated under the shear mode with a frequency of 1.9GHz. According to the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics were measured with the sample consumption of only 1μl...
December 30, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28068279/identifying-predictors-of-central-sleep-apnea-cheyne-stokes-breathing-in-chronic-heart-failure-a-pathophysiological-approach
#8
Aneliya I Draganova, Kiril V Terziyski, Stefan S Kostianev
Chronic heart failure (CHF) is a major health problem associated with increased mortality, despite modern treatment options. Central sleep apnea (CSA)/Cheyne-Stokes breathing (CSB) is a common and yet largely under-diagnosed co-morbidity, adding significantly to the poor prognosis in CHF because of a number of acute and chronic effects, including intermittent hypoxia, sympathetic overactivation, disturbed sleep architecture and impaired physical tolerance. It is characterized by repetitive periods of crescendo-decrescendo ventilatory pattern, alternating with central apneas and hypopneas...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28067370/automated-3d-printed-unibody-immunoarray-for-chemiluminescence-detection-of-cancer-biomarker-proteins
#9
C K Tang, A Vaze, J F Rusling
A low cost three-dimensional (3D) printed clear plastic microfluidic device was fabricated for fast, low cost automated protein detection. The unibody device features three reagent reservoirs, an efficient 3D network for passive mixing, and an optically transparent detection chamber housing a glass capture antibody array for measuring chemiluminescence output with a CCD camera. Sandwich type assays were built onto the glass arrays using a multi-labeled detection antibody-polyHRP (HRP = horseradish peroxidase)...
January 9, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28067340/ultra-filtration-of-human-serum-for-improved-quantitative-analysis-of-low-molecular-weight-biomarkers-using-atr-ir-spectroscopy
#10
Franck Bonnier, Hélène Blasco, Clément Wasselet, Guillaume Brachet, Renaud Respaud, Luis Felipe C S Carvalho, Dominique Bertrand, Matthew J Baker, Hugh J Byrne, Igor Chourpa
Infrared spectroscopy is a reliable, rapid and cost effective characterisation technique, delivering a molecular finger print of the sample. It is expected that its sensitivity would enable detection of small chemical variations in biological samples associated with disease. ATR-IR is particularly suitable for liquid sample analysis and, although air drying is commonly performed before data collection, just a drop of human serum is enough for screening and early diagnosis. However, the dynamic range of constituent biochemical concentrations in the serum composition remains a limiting factor to the reliability of the technique...
January 9, 2017: Analyst
https://www.readbyqxmd.com/read/28063462/going-digital-a-narrative-overview-of-the-clinical-and-organisational-impacts-of-ehealth-technologies-in-hospital-practice
#11
Justin Keasberry, Ian A Scott, Clair Sullivan, Andrew Staib, Richard Ashby
Objective The aim of the present study was to determine the effects of hospital-based eHealth technologies on quality, safety and efficiency of care and clinical outcomes.Methods Systematic reviews and reviews of systematic reviews of eHealth technologies published in PubMed/Medline/Cochrane Library between January 2010 and October 2015 were evaluated. Reviews of implementation issues, non-hospital settings or remote care or patient-focused technologies were excluded from analysis. Methodological quality was assessed using a validated appraisal tool...
January 9, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28062210/hyperthermostable-binding-molecules-on-phage-assay-components-for-point-of-care-diagnostics-for-active-tuberculosis-infection
#12
Ning Zhao, John Spencer, Margaret A Schmitt, John D Fisk
Tuberculosis is the leading cause of death from infectious disease worldwide. The low sensitivity, extended processing time, and high expense of current diagnostics are major challenges to the detection and treatment of tuberculosis. Mycobacterium tuberculosis ornithine transcarbamylase (Mtb OTC, Rv1656) has been identified in the urine of patients with active TB infection and is a promising target for point-of-care diagnostics. Specific binding proteins with low nanomolar affinities for Mtb OTC were selected from a phage display library built upon a hyperthermostable Sso7d scaffold...
January 3, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28061421/low-cost-and-facile-fabrication-of-a-paper-based-capillary-electrophoresis-microdevice-for-pathogen-detection
#13
Jee Won Lee, Dohwan Lee, Yong Tae Kim, Eun Yeol Lee, Do Hyun Kim, Tae Seok Seo
This paper describes the development of a novel paper-based capillary electrophoresis (pCE) microdevice using mineral paper, which is durable, oil and tear resistant, and waterproof. The pCE device is inexpensive (~$1.6 per device for materials), simple to fabricate, lightweight, and disposable, so it is more adequate for point-of-care (POC) pathogen diagnostics than a conventional CE device made of glass, quartz, silicon or polymer. In addition, the entire fabrication process can be completed within 1h without using expensive clean room facilities and cumbersome photolithography procedures...
December 28, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28058085/microfluidic-cytometers-with-integrated-on-chip-optical-systems-for-red-blood-cell-and-platelet-counting
#14
Yingying Zhao, Qin Li, Xiaoming Hu, Yuhwa Lo
A microfluidic cytometer with integrated on-chip optical systems was designed for red blood cell (RBC) and platelet (PLT) counting. The design, fabrication, and characterization of the microfluidic cytometer with on-chip optical signal detection were described. With process using only a single mask, the device that integrates optical fibers and on-chip microlens with microfluidic channels on a polydimethylsiloxane layer by standard soft photolithography. This compact structure increased the sensitivity of the device and eliminated time-consuming free-space optical alignments...
November 2016: Biomicrofluidics
https://www.readbyqxmd.com/read/28056634/relating-cause-of-death-with-place-of-care-and-healthcare-costs-in-the-last-year-of-life-for-patients-who-died-from-cancer-chronic-obstructive-pulmonary-disease-heart-failure-and-dementia-a-descriptive-study-using-registry-data
#15
Annicka Gm van der Plas, Mariska G Oosterveld-Vlug, H Roeline W Pasman, Bregje D Onwuteaka-Philipsen
BACKGROUND: The four main diagnostic groups for palliative care provision are cancer, chronic obstructive pulmonary disease, heart failure and dementia. But comparisons of costs and care in the last year of life are mainly directed at cancer versus non-cancer or within cancer patients. AIM: Our aim is to compare the care and expenditures in their last year of life for Dutch patients with cancer, chronic obstructive pulmonary disease, heart failure or dementia. DESIGN: Data from insurance company Achmea (2009-2010) were linked to information on long-term care at home or in an institution, the National Hospital Registration and Causes of Death-Registry from Statistics Netherlands...
January 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28048484/we-fg-201-04-cloud-based-collaboration-for-radiotherapy-clinical-trials-research-and-training
#16
J Palta
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048374/we-fg-201-00-high-impact-technologies-for-low-resource-environments
#17
Laurence Edward Court
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047729/we-fg-201-01-patient-centric-technologies-for-diagnosis-of-breast-and-cervical-cancer
#18
N Ramanujam
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047079/we-fg-201-02-automated-treatment-planning-for-low-resource-settings
#19
L Court
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046948/su-f-j-159-influence-of-the-elevated-posterior-position-by-using-the-customized-vacuum-bag-on-the-abdominal-mr-image-quality-a-quantitative-phantom-study
#20
O Wong, J Yuan, M Law, A Ding, S Yu, K Cheung
PURPOSE: Signal-to-noise ratio(SNR) of MR abdominal imaging in diagnostic radiology is maximized by minimizing the coil-to-patient distance. However, for radiotherapy applications, customized vacuum-bag is needed for abdominal immobilization at the cost of the increasing distance to the posterior spine coil. This sub-optimized coil setting for RT applications may compromise image quality, such as SNR and homogeneity, thus potentially affect tissue delineation. In this study, we quantitatively evaluate the effect of the vertical position change on SNR and image quality change using an ACR MR phantom...
June 2016: Medical Physics
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