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https://www.readbyqxmd.com/read/29458204/a-review-of-implantable-biosensors-for-closed-loop-glucose-control-and-other-drug-delivery-applications
#1
Kee Scholten, Ellis Meng
Closed-loop drug delivery promises autonomous control of pharmacotherapy through the continuous monitoring of biomarker levels. For decades, researchers have strived for portable closed-loop systems, capable of treating ambulatory patients with chronic conditions such as diabetes mellitus. After years of development, the first of these systems have left the laboratory and entered commercial use. This long-awaited advance reflects recent development of chronically stable implantable biosensors, able to accurately measure biomarker levels in vivo...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29457144/functional-near-infrared-spectroscopy-enabling-routine-functional-brain-imaging
#2
Meryem A Yücel, Juliette J Selb, Theodore J Huppert, Maria Angela Franceschini, David A Boas
Functional Near-Infrared Spectroscopy (fNIRS) maps human brain function by measuring and imaging local changes in hemoglobin concentrations in the brain that arise from the modulation of cerebral blood flow and oxygen metabolism by neural activity. Since its advent over 20 years ago, researchers have exploited and continuously advanced the ability of near infrared light to penetrate through the scalp and skull in order to non-invasively monitor changes in cerebral hemoglobin concentrations that reflect brain activity...
December 2017: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29456420/timely-news-for-the-multidisciplinary-care-team
#3
Max Bingham
Welcome to Diabetes Spectrum 's first installment of Diabetes is Primary, a round-up of the latest diabetes developments for health care providers. In this issue, we take a look at radical weight loss for diabetes remission, Hong Kong's diabetes risk assessment and management program, personalized A1C targets, and diabetes diagnoses. The American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) panel gives its verdict on continuous glucose monitoring (CGM) devices, and we learn how Medicare will soon pay for a diabetes prevention program...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29455306/dentinal-tubule-sealing-effects-of-532-nm-diode-pumped-solid-state-laser-gallic-acid-fe-3-complex-and-three-commercial-dentin-desensitizers
#4
Soram Oh, Yu Gu, Hiran Perinpanayagam, Yeon-Jee Yoo, Yoon Lee, Ryun Kyung Kim, Seok Woo Chang, Jongho Lee, Qiang Zhu, Kee Yeon Kum
The purpose of this study was to compare dentinal tubule sealing effects of a 532-nm diode-pumped solid-state (DPSS) laser, gallic acid/Fe3+ complex, and three commercially available dentin desensitizers. Human premolars (n = 44) extracted for orthodontics had standardized cervical cavities prepared, etched (37% phosphoric acid) and randomly assigned to either a control (n = 4), or one of five treatment groups (n = 8/group). Desensitizing treatments were either a 532-nm DPSS laser, gallic acid/Fe3+ complex, oxalate-based Super Seal™ (SS), DIO™ Enamel Coating Pen Pro Tooth (Dio), or adhesive-type Hybrid Coat™ (HC)...
February 17, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29451021/the-uva-padova-type-1-diabetes-simulator-goes-from-single-meal-to-single-day
#5
Roberto Visentin, Enrique Campos-Náñez, Michele Schiavon, Dayu Lv, Martina Vettoretti, Marc Breton, Boris P Kovatchev, Chiara Dalla Man, Claudio Cobelli
BACKGROUND: A new version of the UVA/Padova Type 1 Diabetes (T1D) Simulator is presented which provides a more realistic testing scenario. The upgrades to the previous simulator, which was accepted by the Food and Drug Administration in 2013, are described. METHOD: Intraday variability of insulin sensitivity (S I ) has been modeled, based on clinical T1D data, accounting for both intra- and intersubject variability of daily S I . Thus, time-varying distributions of both subject's basal insulin infusion and insulin-to-carbohydrate ratio were calculated and made available to the user...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29446646/accuracy-of-flash-glucose-monitoring-and-continuous-glucose-monitoring-technologies-implications-for-clinical-practice
#6
Ramzi A Ajjan, Michael H Cummings, Peter Jennings, Lalantha Leelarathna, Gerry Rayman, Emma G Wilmot
Continuous glucose monitoring and flash glucose monitoring technologies measure glucose in the interstitial fluid and are increasingly used in diabetes care. Their accuracy, key to effective glycaemic management, is usually measured using the mean absolute relative difference of the interstitial fluid sensor compared to reference blood glucose readings. However, mean absolute relative difference is not standardised and has limitations. This review aims to provide a consensus opinion on assessing accuracy of interstitial fluid glucose sensing technologies...
February 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29444169/monitoring-chest-compression-quality-during-cardiopulmonary-resuscitation-proof-of-concept-of-a-single-accelerometer-based-feedback-algorithm
#7
Digna María González-Otero, Jesus María Ruiz, Sofía Ruiz de Gauna, Jose Julio Gutiérrez, Mohamud Daya, James Knox Russell, Izaskun Azcarate, Mikel Leturiondo
BACKGROUND: The use of real-time feedback systems to guide rescuers during cardiopulmonary resuscitation (CPR) significantly contributes to improve adherence to published resuscitation guidelines. Recently, we designed a novel method for computing depth and rate of chest compressions relying solely on the spectral analysis of chest acceleration. That method was extensively tested in a simulated manikin scenario. The purpose of this study is to report the results of this method as tested in human out-of-hospital cardiac arrest (OHCA) cases...
2018: PloS One
https://www.readbyqxmd.com/read/29428144/when-is-device-detected-atrial-fibrillation-actionable
#8
REVIEW
Jeremiah Wasserlauf, Rod S Passman
Device-detected atrial high-rate episodes (AHREs) are frequently encountered in patients with no history of atrial fibrillation (AF) and represent a challenge for clinicians because patients with device-only documented AF have not been included in clinical trials of anticoagulants and other AF therapies. For patients with known history of AF, wireless continuous rhythm monitoring and rapidly acting oral anticoagulants offer the possibility of tailored anticoagulation in response to AHREs, with studies ongoing to evaluate the safety of this approach...
March 2018: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29425167/-i-was-relieved-to-know-that-my-baby-was-safe-women-s-attitudes-and-perceptions-on-using-a-new-electronic-fetal-heart-rate-monitor-during-labor-in-tanzania
#9
Sara Rivenes Lafontan, Johanne Sundby, Hege L Ersdal, Muzdalifat Abeid, Hussein L Kidanto, Columba K Mbekenga
To increase labor monitoring and prevent neonatal morbidity and mortality, a new wireless, strap-on electronic fetal heart rate monitor called Moyo was introduced in Tanzania in 2016. As part of the ongoing evaluation of the introduction of the monitor, the aim of this study was to explore the attitudes and perceptions of women who had worn the monitor continuously during their most recent delivery and perceptions about how it affected care. This knowledge is important to identify barriers towards adaptation in order to introduce new technology more effectively...
February 9, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29417956/ilid-low-power-sensing-of-fatigue-and-drowsiness-measures-on-a-computational-eyeglass
#10
Soha Rostaminia, Addison Mayberry, Deepak Ganesan, Benjamin Marlin, Jeremy Gummeson
The ability to monitor eye closures and blink patterns has long been known to enable accurate assessment of fatigue and drowsiness in individuals. Many measures of the eye are known to be correlated with fatigue including coarse-grained measures like the rate of blinks as well as fine-grained measures like the duration of blinks and the extent of eye closures. Despite a plethora of research validating these measures, we lack wearable devices that can continually and reliably monitor them in the natural environment...
June 2017: Proc ACM Interact Mob Wearable Ubiquitous Technol
https://www.readbyqxmd.com/read/29416471/a-successful-anesthetic-approach-in-a-patient-with-schwartz-jampel-syndrome
#11
Fernando Calado de Oliveira Camacho, Tânia Marina Lopes Amaral, Joana Irene de Barros Mourão
Schwartz-Jampel syndrome (SJS) is a rare genetic condition that is characterized by several musculoskeletal abnormalities, such as myotonia, joint contractures, and facial dysmorphisms. Patients with this syndrome can present an anesthetic challenge, due to an increased risk of developing malignant hyperthermia (MH) and the possibility of encountering a difficult airway. Several precautions must be taken when general anesthesia is required, such as the avoidance of potential triggers for MH, continuous core temperature, and end-tidal CO2 monitoring, assuring that dantrolene is readily available...
January 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29412837/glucose-lowering-therapies-in-type-2-diabetes-opportunities-and-challenges-for-peptides
#12
REVIEW
Clifford J Bailey
This overview considers the opportunities and challenges that face the use of gluco-regulatory peptides to treat type 2 diabetes. New insulin analogues and formulations are being developed with pharmacokinetic properties to speed-up or prolong transfer from a subcutaneous injection site to the target tissues, or to selectively favour effects on the liver. Alternative routes of insulin administration continue to attract attention, and advances in the integration of glucose monitoring with insulin pump devices are improving miniaturised 'closed loop' artificial pancreas systems...
February 2018: Peptides
https://www.readbyqxmd.com/read/29411300/the-sound-of-air-point-of-care-lung-ultrasound-in-perioperative-medicine
#13
REVIEW
Alberto Goffi, Richelle Kruisselbrink, Giovanni Volpicelli
PURPOSE: Lung ultrasound (LUS) has emerged as an effective and accurate goal-directed diagnostic tool that can be applied in real time for the bedside assessment of patients with respiratory symptoms and signs. Lung ultrasound has definite and easily recognized findings and has been shown to outperform physical examination and chest radiography for the diagnosis and monitoring of many pulmonary and pleural conditions. In this article, we review the principles of LUS image acquisition and interpretation, summarizing key terms and sonographic findings...
February 6, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29409776/the-validation-of-simplified-eeg-derived-from-the-bispectral-index-monitor-in-post-cardiac-arrest-patients
#14
Jolien Haesen, Ward Eertmans, Cornelia Genbrugge, Ingrid Meex, Jelle Demeestere, Margot Vander Laenen, Willem Boer, Dieter Mesotten, Jo Dens, Frank Jans, Ludovic Ernon, Cathy De Deyne
AIMS: We aimed to validate retrospectively the accuracy of simplified electroencephalography (EEG) monitoring derived from the bispectral index (BIS) monitor in post-cardiac arrest (CA) patients. METHODS: Successfully resuscitated CA patients were transferred to the Catherization Lab followed by percutaneous coronary intervention when indicated. On arrival at the coronary care unit, bilateral BIS monitoring was started and continued up to 72 h. Raw simplified EEG tracings were extracted from the BIS monitor at a time point coinciding with the registration of standard EEG monitoring...
February 1, 2018: Resuscitation
https://www.readbyqxmd.com/read/29403196/biomedical-waste-management-in-india-critical-appraisal
#15
REVIEW
Priya Datta, Gursimran Kaur Mohi, Jagdish Chander
The safe and sustainable management of biomedical waste (BMW) is social and legal responsibility of all people supporting and financing health-care activities. Effective BMW management (BMWM) is mandatory for healthy humans and cleaner environment. This article reviews the recent 2016 BMWM rules, practical problems for its effective implementation, the major drawback of conventional techniques, and the latest eco-friendly methods for BMW disposal. The new rules are meant to improve the segregation, transportation, and disposal methods, to decrease environmental pollution so as to change the dynamic of BMW disposal and treatment in India...
January 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29403158/hybrid-online-sensor-error-detection-and-functional-redundancy-for-systems-with-time-varying-parameters
#16
Jianyuan Feng, Kamuran Turksoy, Sediqeh Samadi, Iman Hajizadeh, Elizabeth Littlejohn, Ali Cinar
Supervision and control systems rely on signals from sensors to receive information to monitor the operation of a system and adjust manipulated variables to achieve the control objective. However, sensor performance is often limited by their working conditions and sensors may also be subjected to interference by other devices. Many different types of sensor errors such as outliers, missing values, drifts and corruption with noise may occur during process operation. A hybrid online sensor error detection and functional redundancy system is developed to detect errors in online signals, and replace erroneous or missing values detected with model-based estimates...
December 2017: Journal of Process Control
https://www.readbyqxmd.com/read/29401340/prevalence-of-use-and-perceptions-of-electronic-smoking-devices-in-a-us-army-infantry-division
#17
Joseph Chin, Michael B Lustik, Matthew Pflipsen
Introduction: The increasing interest in electronic smoking devices (ESDs) among consumers shows promise for ESDs as a less harmful alternative for smoking and possibly for smoking cessation. Limited data on prevalence of ESD use in the military are available and data on perceptions of ESD use have not yet been published within an active duty, military-specific population. The primary outcome of this study was to define the prevalence of ESD use in a US Army division. Methods: We surveyed 1,288 military service members (response rate 95%, n = 1,225) from the 25th Infantry Division, Schofield Barracks, HI, in late 2015, on smoking habits, ESD usage, and perceptions surrounding ESDs...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29393063/development-of-real-time-abdominal-compression-force-monitoring-and-visual-biofeedback-system
#18
Tae-Ho Kim, Siyong Kim, Dong-Su Kim, Seong-Hee Kang, Min-Seok Cho, Kyeong-Hyun Kim, Dong-Seok Shin, Tae-Suk Suh
In this study, we developed and evaluated a system that could monitor abdominal compression force (ACF) in real time and provide a surrogating signal, even under abdominal compression. The system could also provide visual-biofeedback (VBF). The real-time ACF monitoring system developed consists of an abdominal compression device, an ACF monitoring unit and a control system including an in-house ACF management program. We anticipated that ACF variation information caused by respiratory abdominal motion could be used as a respiratory surrogate signal...
February 2, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29389853/prolonged-corrosion-stability-of-a-microchip-sensor-implant-during-in-vivo-exposure
#19
Paul Glogener, Michael Krause, Jens Katzer, Markus A Schubert, Mario Birkholz, Olaf Bellmann, Claudia Kröger-Koch, Harald M Hammon, Cornelia C Metges, Christine Welsch, Roman Ruff, Klaus P Hoffmann
A microelectronic biosensor was subjected to in vivo exposure by implanting it in the vicinity of m. trapezii (Trapezius muscle) from cattle. The implant is intended for the continuous monitoring of glucose levels, and the study aimed at evaluating the biostability of exposed semiconductor surfaces. The sensor chip was a microelectromechanical system (MEMS) prepared using 0.25 µm complementary metal-oxide-semiconductor CMOS/BiCMOS technology. Sensing is based on the principle of affinity viscometry with a sensoric assay, which is separated by a semipermeable membrane from the tissue...
February 1, 2018: Biosensors
https://www.readbyqxmd.com/read/29386668/expert-panel-consensus-recommendations-for-home-blood-pressure-monitoring-in-asia-the-hope-asia-network
#20
Sungha Park, Peera Buranakitjaroen, Chen-Huan Chen, Yook-Chin Chia, Romeo Divinagracia, Satoshi Hoshide, Jinho Shin, Saulat Siddique, Jorge Sison, Arieska Ann Soenarta, Guru Prasad Sogunuru, Jam Chin Tay, Yuda Turana, Ji-Guang Wang, Yuqing Zhang, Kazuomi Kario
Hypertension is the leading cause of mortality throughout Asia. Home blood pressure monitoring has the potential to improve hypertension control and is a useful adjunct to conventional office blood pressure measurements due to its diagnostic accuracy and prognostic value in predicting cardiovascular outcomes. At present, there are no region-specific guidelines addressing the use of home blood pressure monitoring in Asia. Therefore, an expert panel was convened to address the use of home blood pressure monitoring and develop key recommendations to help guide clinical practice throughout the Asia region...
January 31, 2018: Journal of Human Hypertension
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