Eric Y Helm, Tomas Zelenka, Valeriu B Cismasiu, Shamima Islam, Leonardo Silvane, Beatrice Zitti, Tim D Holmes, Theodore T Drashansky, Alexander J Kwiatkowski, Christine Tao, Joseph Dean, Alyssa N Obermayer, Xianghong Chen, Benjamin G Keselowsky, Weizhou Zhang, Zhiguang Huo, Liang Zhou, Brian S Sheridan, Jose R Conejo-Garcia, Timothy I Shaw, Yenan T Bryceson, Dorina Avram
The networks of transcription factors (TFs) that control intestinal-resident memory CD8+ T (TRM ) cells, including multipotency and effector programs, are poorly understood. In this work, we investigated the role of the TF Bcl11b in TRM cells during infection with Listeria monocytogenes using mice with post-activation, conditional deletion of Bcl11b in CD8+ T cells. Conditional deletion of Bcl11b resulted in increased numbers of intestinal TRM cells and their precursors as well as decreased splenic effector and circulating memory cells and precursors...
April 28, 2023: Science Immunology