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https://www.readbyqxmd.com/read/28641172/the-impact-of-speed-and-time-on-gait-dynamics
#1
Kathleen S Thomas, Daniel M Russell, Bonnie L Van Lunen, Sheri R Colberg, Steven Morrison
To determine the effects of speed on gait previous studies have examined young adults walking at different speeds; however, the small number of strides may have influenced the results. The aim of this study was to investigate the immediate and long-term impact of continuous slow walking on the mean, variability and structure of stride-to-stride measures. Fourteen young adults walked at a constant pace on a treadmill at three speeds (preferred walking speed (PWS), 90% and 80% PWS) for 30 min each. Spatiotemporal gait parameters were computed over six successive 5-min intervals...
June 19, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28640998/oximes-and-hydrazones-in-bioconjugation-mechanism-and-catalysis
#2
Dominik K Kölmel, Eric T Kool
The formation of oximes and hydrazones is employed in numerous scientific fields as a simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as diverse as polymer chemistry, biomaterials and hydrogels, dynamic combinatorial chemistry, organic synthesis, and chemical biology. Here we outline chemical developments in this field, with special focus on the past ∼10 years of developments. Recent strategies for installing reactive carbonyl groups and α-nucleophiles into biomolecules are described...
June 22, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28632427/speed-of-processing-and-executive-functions-in-adults-with-phenylketonuria-quick-in-finding-the-word-but-not-the-ladybird
#3
Cristina Romani, Anita MacDonald, Sara De Felice, Liana Palermo
A reduction in processing speed is widely reported in phenylketonuria (PKU), possibly due to white matter pathology. We investigated possible deficits and their relationships with executive functions in a sample of 37 early-treated adults with PKU (AwPKUs). AwPKUs were not characterized by a generalized speed deficit, but instead their performance could be explained by two more specific impairments: (a) a deficit in the allocation of visuo-spatial attention that reduced speed in visual search tasks, in some reading conditions and visuo-motor coordination tasks; and (b) a more conservative decision mechanism that slowed down returning an answer across domains...
June 20, 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/28617009/-the-feasibility-of-implementing-cognitive-remediation-for-work-in-community-based-psychiatric-rehabilitation-programs-correction-to-mcgurk-et-al-2017
#4
(no author information available yet)
Reports an error in "The feasibility of implementing cognitive remediation for work in community based psychiatric rehabilitation programs" by Susan R. McGurk, Kim T. Mueser, Melanie A. Watkins, Carline M. Dalton and Heather Deutsch (Psychiatric Rehabilitation Journal, 2017[Mar], Vol 40[1], 79-86). In the article, the author order was incorrect due to a printer error. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2017-13255-004.) Objective: Adding cognitive remediation to vocational rehabilitation services improves cognitive and work functioning in people with serious mental illness, but despite interest, the uptake of cognitive programs into community services has been slow...
June 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28613315/bulk-advection-and-interfacial-flows-in-the-binary-coalescence-of-surfactant-laden-and-surfactant-free-drops
#5
Emilia Nowak, Zhihua Xie, Nina M Kovalchuk, Omar K Matar, Mark J H Simmons
This work focuses on the study of bulk flows accompanying the coalescence of two aqueous drops, one containing surfactant and the other surfactant-free, in silicone oils of various viscosities. It is observed that the surfactant-free drop intrudes into the surfactant-laden drop in the form of a penetrating jet whose speed increases and average radius decreases with increasing outer phase viscosity. Mixing patterns within the coalescing drops are due to the force imbalance caused by capillary pressure difference and surfactant-induced Marangoni stresses...
June 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/28611613/simultaneous-processing-of-noun-cue-and-to-be-produced-verb-in-verb-generation-task-electromagnetic-evidence
#6
Anna V Butorina, Anna A Pavlova, Anastasia Y Nikolaeva, Andrey O Prokofyev, Denis P Bondarev, Tatiana A Stroganova
A long-standing but implicit assumption is that words strongly associated with a presented cue are automatically activated in the memory through rapid spread of activation within brain semantic networks. The current study was aimed to provide direct evidence of such rapid access to words' semantic representations and to investigate its neural sources using magnetoencephalography (MEG) and distributed source localization technique. Thirty-three neurotypical subjects underwent the MEG recording during verb generation task, which was to produce verbs related to the presented noun cues...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28600563/multivariate-classification-of-echellograms-a-new-perspective-in-laser-induced-breakdown-spectroscopy-analysis
#7
Pavel Pořízka, Jakub Klus, Jan Mašek, Martin Rajnoha, David Prochazka, Pavlína Modlitbová, Jan Novotný, Radim Burget, Karel Novotný, Jozef Kaiser
In this work, we proposed a new data acquisition approach that significantly improves the repetition rates of Laser-Induced Breakdown Spectroscopy (LIBS) experiments, where high-end echelle spectrometers and intensified detectors are commonly used. The moderate repetition rates of recent LIBS systems are caused by the utilization of intensified detectors and their slow full frame (i.e. echellogram) readout speeds with consequent necessity for echellogram-to-1D spectrum conversion (intensity vs. wavelength)...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28598673/entangled-dynamics-in-macroscopic-quantum-tunneling-of-bose-einstein-condensates
#8
Diego A Alcala, Joseph A Glick, Lincoln D Carr
Tunneling of a quasibound state is a nonsmooth process in the entangled many-body case. Using time-evolving block decimation, we show that repulsive (attractive) interactions speed up (slow down) tunneling. While the escape time scales exponentially with small interactions, the maximization time of the von Neumann entanglement entropy between the remaining quasibound and escaped atoms scales quadratically. Stronger interactions require higher-order corrections. Entanglement entropy is maximized when about half the atoms have escaped...
May 26, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28598417/age-related-delay-in-visual-and-auditory-evoked-responses-is-mediated-by-white-and-grey-matter-differences
#9
D Price, L K Tyler, R Neto Henriques, K L Campbell, N Williams, M S Treder, J R Taylor, R N A Henson
Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalographic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time...
June 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28598292/effects-of-primary-and-recurrent-sacral-chordoma-on-the-motor-and-nociceptive-function-of-hindlimbs-in-rats-an-orthotopic-spine-model
#10
Rachel Sarabia-Estrada, Alejandro Ruiz-Valls, Sagar R Shah, A Karim Ahmed, Alvaro A Ordonez, Fausto J Rodriguez, Hugo Guerrero-Cazares, Ismael Jimenez-Estrada, Esteban Velarde, Betty Tyler, Yuxin Li, Neil A Phillips, C Rory Goodwin, Rory J Petteys, Sanjay K Jain, Gary L Gallia, Ziya L Gokaslan, Alfredo Quinones-Hinojosa, Daniel M Sciubba
OBJECTIVE Chordoma is a slow-growing, locally aggressive cancer that is minimally responsive to conventional chemotherapy and radiotherapy and has high local recurrence rates after resection. Currently, there are no rodent models of spinal chordoma. In the present study, the authors sought to develop and characterize an orthotopic model of human chordoma in an immunocompromised rat. METHODS Thirty-four immunocompromised rats were randomly allocated to 4 study groups; 22 of the 34 rats were engrafted in the lumbar spine with human chordoma...
June 9, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28596532/high-throughput-analysis-of-in-vitro-lfp-electrophysiological-signals-a-validated-workflow-software-package
#11
P Tsakanikas, C Sigalas, P Rigas, I Skaliora
Synchronized brain activity in the form of alternating epochs of massive persistent network activity and periods of generalized neural silence, has been extensively studied as a fundamental form of circuit dynamics, important for many cognitive functions including short-term memory, memory consolidation, or attentional modulation. A key element in such studies is the accurate determination of the timing and duration of those network events. The local field potential (LFP) is a particularly attractive method for recording network activity, because it allows for long and stable recordings from multiple sites, allowing researchers to estimate the functional connectivity of local networks...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28595806/conversion-of-biowastes-to-biomaterial-an-innovative-waste-management-approach
#12
M Bobby Kannan, Karly Ronan
The study suggests that biowastes (eggshells and urine) can be potentially used as precursors to produce hydroxyapatite (HAp) biomaterial in a simple chemical process. A batch reactor was used in this work to produce HAp powder from eggshells and synthetic urine (SU). Fine powder of calcined eggshells was dissolved in water to produce aqueous calcium hydroxide. The solution was then mixed with concentrated SU in stoichiometric amounts corresponding to HAp (Ca/P molar ratio∼1.67). The initial pH of the solution was alkaline (pH∼8...
June 5, 2017: Waste Management
https://www.readbyqxmd.com/read/28592365/assisted-baseline-subtraction-in-complex-chromatograms-using-the-beads-algorithm
#13
J A Navarro-Huerta, J R Torres-Lapasió, S López-Ureña, M C García-Alvarez-Coque
The data processing step of complex signals in high-performance liquid chromatography may constitute a bottleneck to obtain significant information from chromatograms. Data pre-processing should be preferably done with little (or no) user supervision, for a maximal benefit and highest speed. In this work, a tool for the configuration of a state-of-the-art baseline subtraction algorithm, called BEADS (Baseline Estimation And Denoising using Sparsity) is developed and verified. A quality criterion based on the measurement of the autocorrelation level was designed to select the most suitable working parameters to obtain the best baseline...
May 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28585160/relative-speed-of-processing-determines-color-word-contingency-learning
#14
Noah D Forrin, Colin M MacLeod
In three experiments, we tested a relative-speed-of-processing account of color-word contingency learning, a phenomenon in which color identification responses to high-contingency stimuli (words that appear most often in particular colors) are faster than those to low-contingency stimuli. Experiment 1 showed equally large contingency-learning effects whether responding was to the colors or to the words, likely due to slow responding to both dimensions because of the unfamiliar mapping required by the key press responses...
June 5, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28582582/codon-usage-regulates-protein-structure-and-function-by-affecting-translation-elongation-speed-in-drosophila-cells
#15
Fangzhou Zhao, Chien-Hung Yu, Yi Liu
Codon usage biases are found in all eukaryotic and prokaryotic genomes and have been proposed to regulate different aspects of translation process. Codon optimality has been shown to regulate translation elongation speed in fungal systems, but its effect on translation elongation speed in animal systems is not clear. In this study, we used a Drosophila cell-free translation system to directly compare the velocity of mRNA translation elongation. Our results demonstrate that optimal synonymous codons speed up translation elongation while non-optimal codons slow down translation...
June 5, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28577861/diagnostic-preparedness-for-infectious-disease-outbreaks
#16
Mark D Perkins, Christopher Dye, Manica Balasegaram, Christian Bréchot, Jean-Vivien Mombouli, John-Arne Røttingen, Marcel Tanner, Catharina C Boehme
Diagnostics are crucial in mitigating the effect of disease outbreaks. Because diagnostic development and validation are time consuming, they should be carried out in anticipation of epidemics rather than in response to them. The diagnostic response to the 2014-15 Ebola epidemic, although ultimately effective, was slow and expensive. If a focused mechanism had existed with the technical and financial resources to drive its development ahead of the outbreak, point-of-care Ebola tests supporting a less costly and more mobile response could have been available early on in the diagnosis process...
May 31, 2017: Lancet
https://www.readbyqxmd.com/read/28576935/inflammatory-pain-reduces-c-fibre-activity-dependent-slowing-in-a-sex-dependent-manner-amplifying-nociceptive-input-to-the-spinal-cord
#17
Allen C Dickie, Barry McCormick, Veny Lukito, Kirsten L Wilson, Carole Torsney
C fibres display activity-dependent slowing (ADS), whereby repetitive stimulation (≥1Hz) results in a progressive slowing of action potential conduction velocity, which manifests as a progressive increase in response latency. However, the impact of ADS upon spinal pain processing has not been explored nor whether ADS is altered in inflammatory pain conditions. To investigate, compound action potentials were made, from dorsal roots isolated from rats with or without complete Freund's adjuvant (CFA) hindpaw inflammation, in response to electrical stimulus trains...
June 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28575024/efficient-method-for-site-directed-mutagenesis-in-large-plasmids-without-subcloning
#18
Louay K Hallak, Kelly Berger, Rita Kaspar, Anna R Kwilas, Federica Montanaro, Mark E Peeples
Commonly used methods for site-directed DNA mutagenesis require copying the entire target plasmid. These methods allow relatively easy modification of DNA sequences in small plasmids but become less efficient and faithful for large plasmids, necessitating full sequence verification. Introduction of mutations in larger plasmids requires subcloning, a slow and labor-intensive process, especially for multiple mutations. We have developed an efficient DNA mutagenesis technique, UnRestricted Mutagenesis and Cloning (URMAC) that replaces subcloning steps with quick biochemical reactions...
2017: PloS One
https://www.readbyqxmd.com/read/28533945/the-role-of-speed-in-adhd-related-working-memory-deficits-a-time-based-resource-sharing-and-diffusion-model-account
#19
Alexander Weigard, Cynthia Huang-Pollock
Several recent commentaries suggest that, for psychological science to move beyond "homuncular" explanations for cognitive control, it is critically important to examine the role of basic and computationally well-defined processes (e.g. cognitive processing speed). Correlational evidence has previously linked slow speed to working memory (WM) deficits in ADHD, but the directionality of this relationship has not been investigated experimentally and the mechanisms through which speed may influence WM are unclear...
March 2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28529478/slow-and-fast-responses-two-mechanisms-of-trial-outcome-processing-revealed-by-eeg-oscillations
#20
Nikita A Novikov, Yulia M Nurislamova, Natalia A Zhozhikashvili, Evgenii E Kalenkovich, Anna A Lapina, Boris V Chernyshev
Cognitive control includes maintenance of task-specific processes related to attention, and non-specific regulation of motor threshold. Depending upon the nature of the behavioral tasks, these mechanisms may predispose to different kinds of errors, with either increased or decreased response time (RT) of erroneous responses relative to correct responses. Specifically, slow responses are related to attentional lapses and decision uncertainty, these conditions tending to delay RTs of both erroneous and correct responses...
2017: Frontiers in Human Neuroscience
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