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https://www.readbyqxmd.com/read/28941404/development-of-a-simple-multi-residue-determination-method-of-80-veterinary-drugs-in-oplegnathus-punctatus-by-liquid-chromatography-coupled-to-quadrupole-orbitrap-mass-spectrometry
#1
Fei Zhao, Xin Gao, Zhixu Tang, Xin Luo, Miaomiao Wu, Jiachao Xu, Xiaoting Fu
A simple, rapid and sensitive multi-residue analytical method was developed and validated for 80 veterinary drugs in Oplegnathus punctatus using ultrahigh performance liquid chromatography-Orbitrap high resolution mass spectrometry (LC-HRMS). The analytes belong to 12 different families include benzimidazoles, β-lactams, lincosamides, macrolides, nitromidazoles, quinolones, sulfonamides and trimethoprim, tetracyclines, triphenylmethane dyes, amphenicols, nonsteroidal estrogens and steroid hormones. The sample preparation was optimized base on QuEChERS (quick, easy, cheap, effective, rugged and safe) procedure...
September 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28938573/iatc-mhyb-a-hybrid-multi-label-classifier-for-predicting-the-classification-of-anatomical-therapeutic-chemicals
#2
Xiang Cheng, Shu-Guang Zhao, Xuan Xiao, Kuo-Chen Chou
Recommended by the World Health Organization (WHO), drug compounds have been classified into 14 main ATC (Anatomical Therapeutic Chemical) classes according to their therapeutic and chemical characteristics. Given an uncharacterized compound, can we develop a computational method to fast identify which ATC class or classes it belongs to? The information thus obtained will timely help adjusting our focus and selection, significantly speeding up the drug development process. But this problem is by no means an easy one since some drug compounds may belong to two or more than two ATC classes...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937989/limited-synapse-overproduction-can-speed-development-but-sometimes-with-long-term-energy-and-discrimination-penalties
#3
Harang Ju, Costa M Colbert, William B Levy
Neural circuit development requires that synapses be formed between appropriate neurons. In addition, for a hierarchical network, successful development involves a sequencing of developmental events. It has been suggested that one mechanism that helps speed up development of proper connections is an early overproduction of synapses. Using a computational model of synapse development, such as adaptive synaptogenesis, it is possible to study such overproduction and its role in speeding up development; it is also possible to study other outcomes of synapse overproduction that are seemingly new to the literature...
September 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28937981/cognitive-function-in-patients-with-stable-coronary-heart-disease-related-cerebrovascular-and-cardiovascular-responses
#4
Mathieu Gayda, Vincent Gremeaux, Louis Bherer, Martin Juneau, Joffrey Drigny, Olivier Dupuy, Gabriel Lapierre, Véronique Labelle, Annik Fortier, Anil Nigam
Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy, asymptomatic individuals. We sought to assess cognitive function in a stable coronary heart disease (CHD) sample and its relationship to cerebral oxygenation-perfusion, cardiac hemodynamic responses, and [Formula: see text] peak compared to age-matched and young healthy control subjects. Twenty-two young healthy controls (YHC), 20 age-matched old healthy controls (OHC) and 25 patients with stable CHD were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28937644/american-sign-language-alphabet-recognition-using-a-neuromorphic-sensor-and-an-artificial-neural-network
#5
Miguel Rivera-Acosta, Susana Ortega-Cisneros, Jorge Rivera, Federico Sandoval-Ibarra
This paper reports the design and analysis of an American Sign Language (ASL) alphabet translation system implemented in hardware using a Field-Programmable Gate Array. The system process consists of three stages, the first being the communication with the neuromorphic camera (also called Dynamic Vision Sensor, DVS) sensor using the Universal Serial Bus protocol. The feature extraction of the events generated by the DVS is the second part of the process, consisting of a presentation of the digital image processing algorithms developed in software, which aim to reduce redundant information and prepare the data for the third stage...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937638/effects-of-processing-parameters-on-surface-roughness-of-additive-manufactured-ti-6al-4v-via-electron-beam-melting
#6
Pan Wang, Wai Jack Sin, Mui Ling Sharon Nai, Jun Wei
As one of the powder bed fusion additive manufacturing technologies, electron beam melting (EBM) is gaining more and more attention due to its near-net-shape production capacity with low residual stress and good mechanical properties. These characteristics also allow EBM built parts to be used as produced without post-processing. However, the as-built rough surface introduces a detrimental influence on the mechanical properties of metallic alloys. Thereafter, understanding the effects of processing parameters on the part's surface roughness, in turn, becomes critical...
September 22, 2017: Materials
https://www.readbyqxmd.com/read/28937205/electrospun-p-type-nickel-oxide-semiconducting-nanowires-for-low-voltage-field-effect-transistors
#7
Ao Liu, You Meng, Huihui Zhu, Yong-Young Noh, Guoxia Liu, Fukai Shan
One-dimensional metal-oxide nanowires are regarded as important building blocks in nanoscale electronics due to their unique mechanical and electrical properties. In this work, p-type nickel oxide nanowires (NiO NWs) were fabricated by combining sol-gel and electrospinning processes. The polyvinylpyrrolidone (PVP) with 1,300,000 molecular weight was used as the polymer matrix to increase the viscosity of NiO precursor solution. The formation and properties of the as-spun NiO/PVP composite NWs before/after calcination treatment were investigated using various techniques...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28936707/immunoglobulin-genotypes-and-cognitive-functions-in-schizophrenia
#8
Janardan P Pandey, Aryan M Namboodiri, Paul J Nietert, Reiji Yoshimura, Hikaru Hori
Exposure to neurotropic viruses, such as herpes simplex virus type 1 and human cytomegalovirus, has been reported to be associated with cognitive impairment in schizophrenia. These viruses have evolved highly sophisticated strategies for decreasing the efficacy of the host immune response and interfering with viral clearance. Particular immunoglobulin GM (γ marker) genotypes modulate these viral immunoevasion strategies, influence antibody responsiveness to viral proteins, and are also associated with susceptibility to schizophrenia, providing an excellent rationale for determining their possible involvement in the cognitive functions in this highly heritable neurodevelopmental disorder...
September 22, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28935710/neural-specific-deletion-of-the-focal-adhesion-adaptor-protein-paxillin-slows-migration-speed-and-delays-cortical-layer-formation
#9
Mamunur Rashid, Judson Belmont, David Carpenter, Christopher E Turner, Eric C Olson
Paxillin and Hic-5 are homologous focal adhesion adaptor proteins that coordinate cytoskeletal rearrangements in response to integrin-signaling, but their role(s) in cortical development are unknown. Here, we find that Hic-5 deficient mice are postnatal viable with normal cortical layering. Mice with a neural-specific deletion of paxillin are also postnatal viable, but show evidence of a cortical neuron migration delay that is evident pre and perinatally, but is not detected at postnatal day 35 (P35). This phenotype is not modified by Hic-5 deficiency (double knockout)...
September 21, 2017: Development
https://www.readbyqxmd.com/read/28935224/the-test-retest-reliability-of-three-computerized-neurocognitive-tests-used-in-the-assessment-of-sport-concussion
#10
Jacob E Resch, Mathew Schneider, C Munro Cullum
Computerized neurocognitive tests (CNTs) are widely used at all competitive levels of sport to assess sport concussion (SC). Whereas there are multiple CNTs available, little is known about how some of the most popular platforms compare. The purpose of this study was to investigate the test-retest reliability of the Automated Neuropsychological Assessment Metrics (ANAM), Concussion Vital Signs (CVS) and the Immediate Postconcussion and Cognitive Testing battery (ImPACT) using clinically relevant time points in healthy college-age participants...
September 18, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28935210/office-based-procedures-for-the-diagnosis-and-treatment-of-laryngeal-pathology
#11
REVIEW
David J Wellenstein, Henrieke W Schutte, Robert P Takes, Jimmie Honings, Henri A M Marres, James A Burns, Guido B van den Broek
INTRODUCTION: Since the development of distal chip endoscopes with a working channel, diagnostic and therapeutic possibilities in the outpatient clinic in the management of laryngeal pathology have increased. Which of these office-based procedures are currently available, and their clinical indications and possible advantages, remains unclear. MATERIAL AND METHODS: Review of literature on office-based procedures in laryngology and head and neck oncology. RESULTS: Flexible endoscopic biopsy (FEB), vocal cord injection, and laser surgery are well-established office-based procedures that can be performed under topical anesthesia...
September 18, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28934947/-1-h-nmr-spectroscopy-based-metabolomics-analysis-for-the-diagnosis-of-symptomatic-e-coli-associated-urinary-tract-infection-uti
#12
Milena Lussu, Tania Camboni, Cristina Piras, Corrado Serra, Francesco Del Carratore, Julian Griffin, Luigi Atzori, Aldo Manzin
BACKGROUND: Urinary tract infection (UTI) is one of the most common diagnoses in girls and women, and to a lesser extent in boys and men younger than 50 years. Escherichia coli, followed by Klebsiella spp. and Proteus spp., cause 75-90% of all infections. Infection of the urinary tract is identified by growth of a significant number of a single species in the urine, in the presence of symptoms. Urinary culture is an accurate diagnostic method but takes several hours or days to be carried out...
September 21, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28934192/metabolomics-and-cognition-in-african-american-adults-in-midlife-the-atherosclerosis-risk-in-communities-study
#13
J Bressler, B Yu, T H Mosley, D S Knopman, R F Gottesman, A Alonso, A R Sharrett, L M Wruck, E Boerwinkle
Clinical studies have shown alterations in metabolic profiles when patients with mild cognitive impairment and Alzheimer's disease dementia were compared to cognitively normal subjects. Associations between 204 serum metabolites measured at baseline (1987-1989) and cognitive change were investigated in 1035 middle-aged community-dwelling African American participants in the biracial Atherosclerosis Risk in Communities (ARIC) Study. Cognition was evaluated using the Delayed Word Recall Test (DWRT; verbal memory), the Digit Symbol Substitution Test (DSST; processing speed) and the Word Fluency Test (WFT; verbal fluency) at visits 2 (1990-1992) and 4 (1996-1998)...
July 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28934108/markers-of-microbial-translocation-and-immune-activation-predict-cognitive-processing-speed-in-heavy-drinking-men-living-with-hiv
#14
Mollie A Monnig, Christopher W Kahler, Patricia A Cioe, Peter M Monti, Kenneth H Mayer, David W Pantalone, Ronald A Cohen, Bharat Ramratnam
HIV infection and alcohol use disorder are associated with deficits in neurocognitive function. Emerging evidence points to pro-inflammatory perturbations of the gut-brain axis as potentially contributing to neurocognitive impairment in the context of HIV and chronic heavy alcohol use. This study examined whether plasma markers of microbial translocation (LPS) from the gastrointestinal tract and related immune activation (sCD14, EndoCAb) were associated with neurocognition in 21 men living with HIV who were virally suppressed on antiretroviral therapy...
September 21, 2017: Microorganisms
https://www.readbyqxmd.com/read/28933261/pharmacological-treatment-of-cognitive-symptoms-in-major-depressive-disorder
#15
Zihang Pan, Radu C Grovu, Danielle S Cha, Nicole E Carmona, Mehala Subramaniapillai, Margarita Shekotikhina, Carola Rong, Yena Lee, Roger S McIntyre
: Background: Cognitive dysfunction is a core transdiagnostic domain of Major Depressive Disorder (MDD) and is a principal determinant of functional recovery. However, it has been insufficiently targeted within the current therapeutic framework for MDD. OBJECTIVE: To highlight these unmet cognitive needs in MDD. METHODS: An article search was conducted using PubMed from inception to November 2016: Major Depressive Disorder (and/or variant) was cross-referenced with the following terms: antidepressants, augmentation, cognition, cognitive deficits, cognitive dysfunction, functional outcomes, mechanism of action, and treatment...
September 18, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28933075/-key-technologies-in-synthetic-biology-of-natural-products
#16
Xue-Jun Kuang, Li-Qiu Zou, Ying Li, Chao Sun, Shi-Lin Chen
Natural products with complex and diverse structures are the major sources of new drugs. The biosynthesis of natural products is considered to be one of the best ways to solve the problems of complex and scarce natural products. DNA assembly technology and genome editing technology are two key technologies in the emerging interdisciplinary field of synthetic biology. A number of novel DNA assembly methods developed in the last few years have paved the way for the engineering of high molecular weight DNA molecules, including whole genomes, hence, it can realize the reconstruction of the metabolic pathways and speed up optimization process...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28932777/dataset-on-the-associations-between-sleep-quality-duration-and-cognitive-performance-in-cognitively-healthy-older-adults
#17
A Tsapanou, Y Gu, D M O'Shea, M Yannakoulia, M H Kosmidis, E Dardiotis, G Hadjigeorgiou, P Sakka, Y Stern, N Scarmeas
In the present data, we provide the details of the cross-sectional study examining the associations between sleep quality/sleep duration and cognitive performance. Data are from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A total of 1484 older adults (65 y.o. or older) took part in the study. Sleep measurements were drawn from the sleep scale of the Medical Outcomes Study (MOS). Cognition was used as a z-score drawn by different tests. The domains examined were: executive function, visuo-spatial ability, language, attention- speed of processing, as well as the composite z-score of all the cognitive domains (including memory)...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28932174/internet-based-computer-technology-on-radiotherapy
#18
REVIEW
James C L Chow
Recent rapid development of Internet-based computer technologies has made possible many novel applications in radiation dose delivery. However, translational speed of applying these new technologies in radiotherapy could hardly catch up due to the complex commissioning process and quality assurance protocol. Implementing novel Internet-based technology in radiotherapy requires corresponding design of algorithm and infrastructure of the application, set up of related clinical policies, purchase and development of software and hardware, computer programming and debugging, and national to international collaboration...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28931957/the-k%C3%A3-htai-data-set-25-years-of-lysimetric-snow-pillow-and-meteorological-measurements
#19
P Krajči, R Kirnbauer, J Parajka, J Schöber, G Blöschl
Snow measurements at the Kühtai station in Tirol, Austria, (1920 m.a.s.l.) are described. The data set includes snow water equivalent from a 10 m(2) snow pillow, snow melt outflow from a 10 m(2) snow lysimeter placed at the same location as the pillow, meteorological data (precipitation, incoming shortwave radiation, reflected shortwave radiation, air temperature, relative air humidity, and wind speed), and other data (snow depths, snow temperatures at seven heights) from the period October 1990 to May 2015...
June 2017: Water Resources Research
https://www.readbyqxmd.com/read/28931620/effects-of-physical-activity-on-poststroke-cognitive-function-a-meta-analysis-of-randomized-controlled-trials
#20
Lauren E Oberlin, Aashna M Waiwood, Toby B Cumming, Anna L Marsland, Julie Bernhardt, Kirk I Erickson
BACKGROUND AND PURPOSE: Despite the social, health, and economic burdens associated with cognitive impairment poststroke, there is considerable uncertainty about the types of interventions that might preserve or restore cognitive abilities. The objective of this systematic review and meta-analysis was to evaluate the effects of physical activity (PA) training on cognitive function poststroke and identify intervention and sample characteristics that may moderate treatment effects. METHODS: Randomized controlled trials examining the association between structured PA training and cognitive performance poststroke were identified using electronic databases EMBASE and MEDLINE...
September 20, 2017: Stroke; a Journal of Cerebral Circulation
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