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JOURNAL ARTICLE
Yaning Wang, Zihao Wang, Xiaopeng Guo, Yaning Cao, Hao Xing, Yuekun Wang, Bing Xing, Yu Wang, Yong Yao, Wenbin Ma
BACKGROUND: Immune checkpoint inhibitors (ICIs) are a promising immunotherapy approach, but glioblastoma clinical trials have not yielded satisfactory results. OBJECTIVE: To screen glioblastoma patients who may benefit from immunotherapy. METHODS: Eighty-one patients receiving anti-PD1/PD-L1 treatment from a large-scale clinical trial and 364 patients without immunotherapy from The Cancer Genome Atlas (TCGA) were included. Patients in the ICI-treated cohort were divided into responders and nonresponders according to overall survival (OS), and the most critical responder-relevant features were screened using random forest (RF)...
May 2024: Cancer Medicine
#22
JOURNAL ARTICLE
Francisco García-Córdova, Antonio Guerrero-González, Fernando Hidalgo-Castelo
This article presents a study on the neurobiological control of voluntary movements for anthropomorphic robotic systems. A corticospinal neural network model has been developed to control joint trajectories in multi-fingered robotic hands. The proposed neural network simulates cortical and spinal areas, as well as the connectivity between them, during the execution of voluntary movements similar to those performed by humans or monkeys. Furthermore, this neural connection allows for the interpretation of functional roles in the motor areas of the brain...
May 3, 2024: Sensors
#23
JOURNAL ARTICLE
Manob Jyoti Saikia, Arar Salim Alkhader
Concussions, a prevalent public health concern in the United States, often result from mild traumatic brain injuries (mTBI), notably in sports such as American football. There is limited exploration of smart-textile-based sensors for measuring the head impacts associated with concussions in sports and recreational activities. In this paper, we describe the development and construction of a smart textile impact sensor (STIS) and validate STIS functionality under high magnitude impacts. This STIS can be inserted into helmet cushioning to determine head impact force...
May 3, 2024: Sensors
#24
JOURNAL ARTICLE
Gaia Bonassi, Mingqi Zhao, Jessica Samogin, Dante Mantini, Roberta Marchese, Luciano Contrino, Paola Tognetti, Martina Putzolu, Alessandro Botta, Elisa Pelosin, Laura Avanzino
Walking encompasses a complex interplay of neuromuscular coordination and cognitive processes. Disruptions in gait can impact personal independence and quality of life, especially among the elderly and neurodegenerative patients. While traditional biomechanical analyses and neuroimaging techniques have contributed to understanding gait control, they often lack the temporal resolution needed for rapid neural dynamics. This study employs a mobile brain/body imaging (MoBI) platform with high-density electroencephalography (hd-EEG) to explore event-related desynchronization and synchronization (ERD/ERS) during overground walking...
April 30, 2024: Sensors
#25
JOURNAL ARTICLE
Tustanah Phukhachee, Suthathip Maneewongvatana, Chayapol Chaiyanan, Keiji Iramina, Boonserm Kaewkamnerdpong
Being motivated has positive influences on task performance. However, motivation could result from various motives that affect different parts of the brain. Analyzing the motivation effect from all affected areas requires a high number of EEG electrodes, resulting in high cost, inflexibility, and burden to users. In various real-world applications, only the motivation effect is required for performance evaluation regardless of the motive. Analyzing the relationships between the motivation-affected brain areas associated with the task's performance could limit the required electrodes...
April 30, 2024: Sensors
#26
REVIEW
Freiser Eceomo Cruz Mosquera, Santiago Lizcano Martinez, Yamil Liscano
In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed to examine the efficacy of psychobiotics-probiotics beneficial to mental health via the gut-brain axis-in adults with psychiatric and cognitive disorders. Out of the 51 studies involving 3353 patients where half received psychobiotics, there was a notably high measurement of effectiveness specifically in the treatment of depression symptoms. Most participants were older and female, with treatments commonly utilizing strains of Lactobacillus and Bifidobacteria over periods ranging from 4 to 24 weeks...
April 30, 2024: Nutrients
#27
JOURNAL ARTICLE
Marc Dörner, Katharina Seebach, Michael T Heneka, Inga Menze, Roland von Känel, Sebastian Euler, Frank Schreiber, Philipp Arndt, Katja Neumann, Annkatrin Hildebrand, Anna-Charlotte John, Anthony Tyndall, Johannes Kirchebner, Pawel Tacik, Robin Jansen, Alexander Grimm, Solveig Henneicke, Valentina Perosa, Sven G Meuth, Oliver Peters, Julian Hellmann-Regen, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Jan Ben Schulze, Sarah Lavinia Florence Schiebler, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy-Kluth, Michael Wagner, Ingo Frommann, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Melina Stark, Matthias Schmid, Ersin Ersözlü, Frederic Brosseron, Michael Ewers, Björn H Schott, Emrah Düzel, Gabriel Ziegler, Hendrik Mattern, Stefanie Schreiber, Jose Bernal
Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confirm them as an imaging biomarker. We investigated whether IFSHs were tied to Alzheimer's disease (AD) pathology and cognitive performance. We used data from 361 participants along the AD continuum, who were enrolled in the multicentre DELCODE study. The IFSHs were rated visually based on FLAIR magnetic resonance imaging...
April 30, 2024: Diagnostics
#28
JOURNAL ARTICLE
Radina Kirkova, Svetla Dineva, Elisa Stradiotto, Ivan Tanev, Alessandra Di Maria
A 77-year-old-man with arterial hypertension, diabetes mellitus type II presented at our clinic for a routine ophthalmological exam. He complained of intermittent double vision. The ophthalmic examination revealed paralysis of III (n. oculomotorius) and VI (n. abducens) cranial nerves with ptosis, deficit in elevation and abduction of the left eye. The patient underwent urgent MRI imaging of the brain/orbits and paranasal sinuses, and urgent neurological assessment. MRI revealed a volume-occupying process, starting from the posterior wall of the left maxillary sinus with perineural diffusion and involvement of the homolateral trigeminal nerve, intracranial spread in the medial cranial fossa and involvement of the cavernous, sphenoidal sinuses and the orbital apex on the left side...
April 29, 2024: Diagnostics
#29
JOURNAL ARTICLE
Haolin Zhan, Yulei Chen, Yinping Cui, Yunsong Zeng, Xiaozhen Feng, Chunhua Tan, Chengda Huang, Enping Lin, Yuqing Huang, Zhong Chen
Proton magnetic resonance spectroscopy (1 H MRS) presents a powerful tool for revealing molecular-level metabolite information, complementary to the anatomical insight delivered by magnetic resonance imaging (MRI), thus playing a significant role in in vivo/in vitro biological studies. However, its further applications are generally confined by spectral congestion caused by numerous biological metabolites contained within the limited proton frequency range. Herein, we propose a pure-shift-based 1 H localized MRS method as a proof of concept for high-resolution studies of biological samples...
April 25, 2024: International Journal of Molecular Sciences
#30
JOURNAL ARTICLE
Jood Dalbah, Shima A Mohammad Zadeh, Meeyoung Kim
Background : Sleep quality is known to affect automatic and executive brain functions such as gait control and cognitive processing. This study aimed to investigate the effect of dual tasks on gait spatiotemporal parameters among young adults with good and poor sleep quality. Methods : In total, 65 young adults with a mean age of 21.1 ± 2.5 were assessed for gait analysis during single-task and dual-task conditions. The participants' sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and gait was assessed using the BTS Gaitlab System...
April 27, 2024: Journal of Clinical Medicine
#31
JOURNAL ARTICLE
Akiko Yorita, Tomotaka Kawayama, Masayuki Inoue, Takashi Kinoshita, Hanako Oda, Yoshihisa Tokunaga, Takahisa Tateishi, Yoshihisa Shoji, Naohisa Uchimura, Toshi Abe, Tomoaki Hoshino, Takayuki Taniwaki
Background : Previous neuroimaging studies have identified brain regions related to respiratory motor control and perception. However, little is known about the resting-state functional connectivity (FC) associated with respiratory impairment. We aimed to determine the FC involved in mild respiratory impairment without altering transcutaneous oxygen saturation. Methods : We obtained resting-state functional magnetic resonance imaging data from 36 healthy volunteers during normal respiration and mild respiratory impairment induced by resistive load (effort breathing)...
April 26, 2024: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Giulia Cossu, Alberto Vandenbulcke, Sonia Zaccarini, John G Gaudet, Andreas F Hottinger, Nina Rimorini, Arnaud Potie, Valerie Beaud, Ursula Guerra-Lopez, Roy T Daniel, Chantal Berna, Mahmoud Messerer
BACKGROUND: Awake craniotomy (AC) is recommended for the resection of tumors in eloquent areas. It is traditionally performed under monitored anesthesia care (MAC), which relies on hypnotics and opioids. Hypnosis-assisted AC (HAAC) is an emerging technique that aims to provide psychological support while reducing the need for pharmacological sedation and analgesia. We aimed to compare the characteristics and outcomes of patients who underwent AC under HAAC or MAC. METHODS: We retrospectively analyzed the clinical, anesthetic, surgical, and neuropsychological data of patients who underwent awake surgical resection of eloquent brain tumors under HAAC or MAC...
May 5, 2024: Cancers
#33
JOURNAL ARTICLE
Gino Cioffi, Mustafa S Ascha, Kristin A Waite, Mantas Dmukauskas, Xiaoliang Wang, Trevor J Royce, Gregory S Calip, Timothy Waxweiler, Chad G Rusthoven, Brian D Kavanagh, Jill S Barnholtz-Sloan
Sex differences in cancer are well-established. However, less is known about sex differences in diagnosis of brain metastasis and outcomes among patients with advanced melanoma. Using a United States nationwide electronic health record-derived de-identified database, we evaluated patients diagnosed with advanced melanoma from 1 January 2011-30 July 2022 who received an oncologist-defined rule-based first line of therapy ( n = 7969, 33% female according to EHR, 35% w/documentation of brain metastases). The odds of documented brain metastasis diagnosis were calculated using multivariable logistic regression adjusted for age, practice type, diagnosis period (pre/post-2017), ECOG performance status, anatomic site of melanoma, group stage, documentation of non-brain metastases prior to first-line of treatment, and BRAF positive status...
May 3, 2024: Cancers
#34
JOURNAL ARTICLE
Zhi-Feng Shi, Kay Ka-Wai Li, Anthony Pak-Yin Liu, Nellie Yuk-Fei Chung, Sze-Ching Wong, Hong Chen, Peter Yat-Ming Woo, Danny Tat-Ming Chan, Ying Mao, Ho-Keung Ng
Pediatric brain tumors are often noted to be different from their adult counterparts in terms of molecular features. Primary CNS lymphomas (PCNSLs) are mostly found in elderly adults and are uncommon in children and teenagers. There has only been scanty information about the molecular features of PCNSLs at a young age. We examined PCNSLs in 34 young patients aged between 7 and 39 years for gene rearrangements of BCl2, BCL6, CCND1, IRF4, IGH, IGL, IGK, and MYC, homozygous deletions (HD) of CDKN2A, and HLA by FISH...
April 29, 2024: Cancers
#35
JOURNAL ARTICLE
Zhishuo Wei, Priyanka Srinivasan, Ritam Patel, Greg Bednarz, John C Flickinger, Constantinos G Hadjipanayis, Ajay Niranjan, L Dade Lunsford
BACKGROUND: The role of stereotactic radiosurgery (SRS) for patients with brain metastases from hepatopancreaticobiliary (HPB) cancers has yet to be established. The authors present a single-institution experience of patients with HPB cancers who underwent SRS when their cancer spread to the brain. METHODS: We surveyed our Gamma Knife SRS data base of 18,000 patients for the years 1987-2022. In total, 19 metastatic HPB cancer patients (13 male) with 76 brain metastases were identified...
April 25, 2024: Cancers
#36
JOURNAL ARTICLE
Julia Klingenschmid, Aleksandrs Krigers, Daniel Pinggera, Johannes Kerschbaumer, Nadine Pichler, Victoria Schoen, Matthias Demetz, Astrid E Grams, Claudius Thomé, Christian F Freyschlag
Metastases are the most frequent intracranial malignant tumors in adults. While Karnofsky Performance Status (KPS) and Clinical Frailty Scale (CFS) are known to have significant impact on overall survival (OS), temporal muscle thickness (TMT) has been postulated to be a promising new parameter to estimate prognosis. Patients who received a resection of one to three brain metastases in our institution were included. Temporal muscle thickness was measured in preoperative MRI scans according to a standardized protocol...
April 25, 2024: Cancers
#37
JOURNAL ARTICLE
Mathieu Boudreau, Agah Karakuzu, Julien Cohen-Adad, Ecem Bozkurt, Madeline Carr, Marco Castellaro, Luis Concha, Mariya Doneva, Seraina A Dual, Alex Ensworth, Alexandru Foias, Véronique Fortier, Refaat E Gabr, Guillaume Gilbert, Carri K Glide-Hurst, Matthew Grech-Sollars, Siyuan Hu, Oscar Jalnefjord, Jorge Jovicich, Kübra Keskin, Peter Koken, Anastasia Kolokotronis, Simran Kukran, Nam G Lee, Ives R Levesque, Bochao Li, Dan Ma, Burkhard Mädler, Nyasha G Maforo, Jamie Near, Erick Pasaye, Alonso Ramirez-Manzanares, Ben Statton, Christian Stehning, Stefano Tambalo, Ye Tian, Chenyang Wang, Kilian Weiss, Niloufar Zakariaei, Shuo Zhang, Ziwei Zhao, Nikola Stikov
PURPOSE: T1 mapping is a widely used quantitative MRI technique, but its tissue-specific values remain inconsistent across protocols, sites, and vendors. The ISMRM Reproducible Research and Quantitative MR study groups jointly launched a challenge to assess the reproducibility of a well-established inversion-recovery T1 mapping technique, using acquisition details from a seminal T1 mapping paper on a standardized phantom and in human brains. METHODS: The challenge used the acquisition protocol from Barral et al...
May 10, 2024: Magnetic Resonance in Medicine
#38
JOURNAL ARTICLE
Tingting Su, Haitao Shen, Mengyuan He, Shanshan Yang, Xue Gong, Ce Huang, Liuling Guo, Hao Wang, Shengyu Feng, Taotao Mi, Meili Zhao, Qing Liu, Fengjiao Huo, Jian-Kang Zhu, Jianbo Zhu, Hongbin Li, Hailiang Liu
BACKGROUND: Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative, anti-inflammatory, anticancer, neuroprotective and senescent cell-clearing activities. It has been shown to effectively alleviate neurodegenerative diseases and enhance cognitive functions in various models. The immune system has been implicated in the regulation of brain function and cognitive abilities. However, it remains unclear whether quercetin enhances cognitive functions by interacting with the immune system...
May 10, 2024: Immunity & Ageing: I & A
#39
JOURNAL ARTICLE
Dong Ah Lee, Ho-Joon Lee, Kang Min Park
PURPOSE: The objective of this research was to examine changes in the neural networks of both gray and white matter in individuals with obstructive sleep apnea (OSA) in comparison to those without the condition, employing a comprehensive multilayer network analysis. METHODS: Patients meeting the criteria for OSA were recruited through polysomnography, while a control group of healthy individuals matched for age and sex was also assembled. Utilizing T1-weighted imaging, a morphometric similarity network was crafted to represent gray matter, while diffusion tensor imaging provided structural connectivity for constructing a white matter network...
May 11, 2024: Sleep & Breathing
#40
JOURNAL ARTICLE
Xue Chen, Daqiang Xu, Xiaowen Gu, Zhisen Li, Yisha Zhang, Peng Wu, Zhou Huang, Jibin Zhang, Yonggang Li
OBJECTIVES: To evaluate the intracranial structures and brain parenchyma radiomics surrounding the occipital horn of the lateral ventricle in normal fetuses (NFs) and fetuses with ventriculomegaly (FVs), as well as to predict postnatally enlarged lateral ventricle alterations in FVs. METHODS: Between January 2014 and August 2023, 141 NFs and 101 FVs underwent 1.5 T balanced steady-state free precession (BSSFP), including 68 FVs with resolved lateral ventricles (FVM-resolved) and 33 FVs with stable lateral ventricles (FVM-stable)...
May 10, 2024: European Radiology
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