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https://www.readbyqxmd.com/read/28719855/high-fat-diet-and-aging-interact-to-produce-neuroinflammation-and-impair-hippocampal-and-amygdalar-dependent-memory
#1
Sarah J Spencer, Heather D'Angelo, Alita Soch, Linda R Watkins, Steven F Maier, Ruth M Barrientos
More Americans are consuming diets higher in saturated fats and refined sugars than ever before, and based on increasing obesity rates, this is a growing trend among older adults as well. While high saturated fat diet (HFD) consumption has been shown to sensitize the inflammatory response to a subsequent immune challenge in young adult rats, the inflammatory effect of HFD in the already-vulnerable aging brain has not yet been assessed. Here, we explored whether short-term (3 days) consumption of HFD would serve as a neuroinflammatory trigger in aging animals, leading to cognitive deficits...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28719854/clinically-silent-alzheimer-s-and-vascular-pathologies-influence-brain-networks-supporting-executive-function-in-healthy-older-adults
#2
Brian T Gold, Christopher A Brown, Jonathan G Hakun, Leslie M Shaw, John Q Trojanowski, Charles D Smith
Aging is associated with declines in executive function. We examined how executive functional brain systems are influenced by clinically silent Alzheimer's disease (AD) pathology and cerebral white-matter hyperintensities (WMHs). Twenty-nine younger adults and 34 cognitively normal older adults completed a working memory paradigm while functional magnetic resonance imaging was performed. Older adults further underwent lumbar cerebrospinal fluid draw for the assessment of AD pathology and FLAIR imaging for the assessment of WMHs...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28719807/evaluation-of-a-novel-radiotracer-for-positron-emission-tomography-imaging-of-reactive-oxygen-species-in-the-central-nervous-system
#3
Alan A Wilson, Oleg Sadovski, José N Nobrega, Roger J Raymond, Francis R Bambico, Mina G Nashed, Armando Garcia, Peter M Bloomfield, Sylvain Houle, Romina Mizrahi, Junchao Tong
INTRODUCTION: Few, if any, radiotracers are available for the in vivo imaging of reactive oxygen species (ROS) in the central nervous system. ROS play a critical role in normal cell processes such as signaling and homeostasis but overproduction of ROS is implicated in several disorders. We describe here the radiosynthesis and initial ex vivo and in vivo evaluation of [(11)C]hydromethidine ([(11)C]HM) as a radiotracer to image ROS using positron emission tomography (PET). METHODS: [(11)C]HM and its deuterated isotopologue [(11)C](4) were produced using [(11)C]methyl triflate in a one-pot, two-step reaction and purified by high performance liquid chromatography...
June 1, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28719572/neuroimaging-correlates-of-post-stroke-aphasia-rehabilitation-in-a-pilot-randomized-trial-of-constraint-induced-aphasia-therapy
#4
Rodolphe Nenert, Jane B Allendorfer, Amber M Martin, Christi Banks, Angel Ball, Jennifer Vannest, Aimee R Dietz, Jerzy P Szaflarski
BACKGROUND Recovery from post-stroke aphasia is a long and complex process with an uncertain outcome. Various interventions have been proposed to augment the recovery, including constraint-induced aphasia therapy (CIAT). CIAT has been applied to patients suffering from post-stroke aphasia in several unblinded studies to show mild-to-moderate linguistic gains. The aim of the present study was to evaluate the neuroimaging correlates of CIAT in patients with chronic aphasia related to left middle cerebral artery stroke...
July 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28719507/the-relationship-between-chronic-pain-and-neurocognitive-function-a-systematic-review
#5
Diana M Higgins, Aaron M Martin, Dewleen G Baker, Jennifer J Vasterling, Victoria Risbrough
OBJECTIVE: Understanding the relationship between chronic pain and neurocognition has important implications for the assessment and treatment of pain. This paper provides an overview of the current literature examining the neurocognition-chronic pain relationship and suggests future avenues of research, along with a discussion of clinical implications of the literature findings. Consideration of potential moderators and mediators of this relationship, as well as a brief discussion of the importance of future research in special populations at particular risk for these problems, are also a focus of this paper...
July 17, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28719087/mri-guided-stereotactic-neurosurgical-procedures-in-a-diagnostic-mri-suite-background-and-safe-practice-recommendations
#6
Paul S Larson, Jon T Willie, Sudhakar Vadivelu, Hooman Azmi-Ghadimi, Amy Nichols, Loretta Litz Fauerbach, Helen Boehm Johnson, Denise Graham
The development of navigation technology facilitating MRI-guided stereotactic neurosurgery has enabled neurosurgeons to perform a variety of procedures ranging from deep brain stimulation to laser ablation entirely within an intraoperative or diagnostic MRI suite while having real-time visualization of brain anatomy. Prior to this technology, some of these procedures required multisite workflow patterns that presented significant risk to the patient during transport. For those facilities with access to this technology, safe practice guidelines exist only for procedures performed within an intraoperative MRI...
July 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28719076/multimodal-image-analysis-of-clinical-influences-on-preterm-brain-development
#7
Gareth Ball, Paul Aljabar, Phumza Nongena, Nigel Kennea, Nuria Gonzalez-Cinca, Shona Falconer, Andrew T M Chew, Nicholas Harper, Julia Wurie, Mary A Rutherford, Serena J Counsell, A David Edwards
Objective Premature birth is associated with numerous complex abnormalities of white and grey matter and a high incidence of long-term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents. Methods In a prospective cohort of 449 infants (226 male), we performed a multi-variate and data-driven analysis combining multiple imaging modalities...
July 18, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28718955/an-electrochemiluminescent-method-for-glutamate-measurement-in-small-microdialysate-samples-in-asphyxiated-young-rats
#8
Jorge Ortega-Ibarra, Silvia López-Pérez, Alberto Morales-Villagrán
Glutamate (Glu) quantification has been performed by a combination of intracerebral microdialysis through which the samples are obtained and analyzed by high performance liquid chromatography (HPLC); its measurement requires a large expenditure of time (15-30 min per sample) and special training. Therefore, an alternative method is presented here, based on the electrochemiluminescence produced by the use of an enzymatic reactor, containing glutamate-oxidase, mixed and incubated with microdialysate from dorsal striatum (DS) and prefrontal cortex (PFC) of young rats asphyxiated during the neonatal period, under a global asphyxia model in order to test this method...
July 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28718779/a-review-and-experimental-study-on-application-of-classifiers-and-evolutionary-algorithms-in-eeg-based-brain-machine-interface-systems
#9
Farajollah Tahernezhad-Javazm, Vahid Azimirad, Maryam Shoaran
OBJECTIVE: Considering the importance and the near future development of noninvasive Brain-Machine Interface (BMI) systems, this paper presents a comprehensive theoretical-experimental survey on the classification and evolutionary methods for BMI-based systems in which EEG signals are used. APPROACH: The paper is divided into two main parts. In the first part a wide range of different types of the base and combinatorial classifiers including boosting and bagging classifiers and also evolutionary algorithms are reviewed and investigated...
July 18, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28718512/overweight-is-associated-with-lower-resting-state-functional-connectivity-in-females-after-eliminating-genetic-effects-a-twin-study
#10
Stieneke Doornweerd, Eelco van Duinkerken, Eco J de Geus, Parniane Arbab-Zadeh, Dick J Veltman, Richard G IJzerman
Obesity is related to altered functional connectivity of resting state brain networks that are involved in reward and motivation. It is unknown to what extent these associations reflect genetic confounding and whether the obesity-related connectivity changes are associated with differences in dietary intake. In this study, resting state functional MRI was performed after an overnight fast in 16 female monozygotic twin pairs (aged 48.8 ± 9.8 years) with a mean BMI discordance of 3.96 ± 2.1 kg/m(2) (range 0...
July 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28718301/web-addiction-in-the-brain-cortical-oscillations-autonomic-activity-and-behavioral-measures
#11
Michela Balconi, Salvatore Campanella, Roberta Finocchiaro
Background and aims Internet addiction (IA) was recently defined as a disorder tagging both the impulse control and the reward systems. Specifically, inhibitory deficits and reward bias were considered highly relevant in IA. This research aims to examine the electrophysiological correlates and autonomic activity [skin conductance response (SCR) and heart rate] in two groups of young subjects (N = 25), with high or low IA profile [tested by the Internet Addiction Test (IAT)], with specific reference to gambling behavior...
July 18, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28718187/brain-natriuretic-propeptide-as-an-early-marker-of-bronchopulmonary-dysplasia-or-death-in-the-preterm-newborn
#12
Alicia Montaner, Raquel Pinillos, Zenaida Galve, Hector Boix, Carmen Ruiz de la Cuesta, Lorenzo Jimenez, Pilar Samper, Segundo Rite
Aim To investigate whether increased brain natriuretic propeptide (NT-proBNP) levels at 48 to 72 h of life are associated with the development of bronchopulmonary dysplasia (BPD) or death in premature neonates. Methods A retrospective study was performed in neonates born before 32 weeks' gestation or with birth weight below 1500 grams, in whom NT-proBNP determination and echocardiography were performed at 48 to 72 h of life. Associations between NT-proBNP levels and the combined outcome BPD or death were analyzed using multivariate logistic regression analysis...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28717971/subnetwork-mining-on-functional-connectivity-network-for-classification-of-minimal-hepatic-encephalopathy
#13
Daoqiang Zhang, Liyang Tu, Long-Jiang Zhang, Biao Jie, Guang-Ming Lu
Hepatic encephalopathy (HE), as a complication of cirrhosis, is a serious brain disease, which may lead to death. Accurate diagnosis of HE and its intermediate stage, i.e., minimal HE (MHE), is very important for possibly early diagnosis and treatment. Brain connectivity network, as a simple representation of brain interaction, has been widely used for the brain disease (e.g., HE and MHE) analysis. However, those studies mainly focus on finding disease-related abnormal connectivity between brain regions, although a large number of studies have indicated that some brain diseases are usually related to local structure of brain connectivity network (i...
July 17, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28717885/risk-of-severe-acute-liver-injury-among-patients-with-brain-cancer-treated-with-temozolomide-a-nested-case-control-study-using-the-healthcore-integrated-research-database
#14
Vibha C A Desai, Scott C Quinlan, Anne C Deitz, Jinghua He, Crystal N Holick, Stephan Lanes
Temozolomide (TMZ) is used to treat adult patients with glioblastoma multiforme (GBM). Cases of hepatotoxicity have been reported among patients using TMZ. The objective of the study was to assess the relation, if any, between exposure to TMZ and serious acute liver injury (SALI). We used the HealthCore Integrated Research Database to perform a case-control study nested within a retrospective cohort of adult patients aged 18-100 years with at least two diagnoses of brain cancer anytime between 2006 and 2014...
July 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28717668/different-renal-phenotypes-in-related-adult-males-with-fabry-disease-with-the-same-classic-genotype
#15
Renzo Mignani, Mariarita Moschella, Giovanna Cenacchi, Ilaria Donati, Marta Flachi, Daniela Grimaldi, Davide Cerretani, Paola De Giovanni, Marcello Montevecchi, Angelo Rigotti, Alessandro Ravasio
BACKGROUND: Fabry disease related patients with classical mutation usually exhibit similar severe phenotype especially concerning renal manifestation. METHODS: A dry blood spot screening (DBS) and the DNA analysis has been performed in a 48-year-old man (Patient 1) because of paresthesia. RESULTS: The DBS revealed absent leukocyte α-Gal A enzyme activity while DNA analysis identified the I354K mutation. Serum creatinine and e-GFR were in normal range and also albuminuria and proteinuria were absent...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28717667/haploinsufficiency-of-bcl11a-associated-with-cerebellar-abnormalities-in-2p15p16-1-deletion-syndrome
#16
Hiroko Shimbo, Takayuki Yokoi, Noriko Aida, Seiji Mizuno, Hiroshi Suzumura, Junichi Nagai, Kazumi Ida, Yumi Enomoto, Chihiro Hatano, Kenji Kurosawa
BACKGROUND: Chromosome 2p15p16.1 deletion syndrome is a rare genetic disorder characterized by intellectual disability (ID), neurodevelopmental delay, language delay, growth retardation, microcephaly, structural brain abnormalities, and dysmorphic features. More than 30 patients with 2p15p16.1 microdeletion syndrome have been reported in the literature. METHODS: Molecular analysis was performed using microarray-based comparative genomic hybridization (array CGH)...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28717571/visible-spectrum-extended-focus-optical-coherence-microscopy-for-label-free-sub-cellular-tomography
#17
Paul J Marchand, Arno Bouwens, Daniel Szlag, David Nguyen, Adrien Descloux, Miguel Sison, Séverine Coquoz, Jérôme Extermann, Theo Lasser
We present a novel extended-focus optical coherence microscope (OCM) attaining 0.7 μm axial and 0.4 μm lateral resolution maintained over a depth of 40 μm, while preserving the advantages of Fourier domain OCM. Our system uses an ultra-broad spectrum from a supercontinuum laser source. As the spectrum spans from near-infrared to visible wavelengths (240 nm in bandwidth), we call the system visOCM. The combination of such a broad spectrum with a high-NA objective creates an almost isotropic 3D submicron resolution...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28717517/knowledge-mapping-visualization-analysis-of-the-military-health-and-medicine-papers-published-in-the-web-of-science-over-the-past-10%C3%A2-years
#18
Xuan-Ming Zhang, Xuan Zhang, Xu Luo, Hai-Tao Guo, Li-Qun Zhang, Ji-Wei Guo
BACKGROUND: Military medicine is a research field that seeks to solve the medical problems that occur in modern war conditions based on public medicine theory. METHODS: We explore the main research topics of military health and medical research in the web of science™ core collection (WoSCC) from 2007 to 2016, and the goal of this work is to serve as a reference for orientation and development in military health and medicine. Based on CiteSpace III, a reference co-citation analysis is performed for 7921 papers published in the WoSCC from 2007 to 2016...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28717427/comparison-of-the-effects-of-low-dose-interferon-and-high-dose-interferon-on-reduction-of-the-number-and-size-of-plaques-in-patients-with-multiple-sclerosis-a-historical-cohort
#19
Payam Khomand, Ghobad Moradi, Behrooz Ahsan, Setareh Abtahi
Background: This study was performed to compare the effects of low dose interferon beta-1 (IFN-β-1) (CinnoVex, 30 mcg) and high dose IFN-β-1 (REBIF, 44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (MRI) in patients with multiple sclerosis (MS). Methods: This historical cohort study, which was performed in 2014 in Sanandaj (western part of Iran). 43 MS patients in two groups were investigated. The first group, which included 19 patients, was treated using high dose IFN (44 mcg) and the second group, which was consisted of 24 patients, was treated using low dose IFN (30 mcg)...
January 5, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28717226/safe-brain-tumor-resection-does-not-depend-on-surgery-alone-role-of-hemodynamics
#20
Stefanie Bette, Benedikt Wiestler, Felicitas Wiedenmann, Johannes Kaesmacher, Martin Bretschneider, Melanie Barz, Thomas Huber, Yu-Mi Ryang, Eberhard Kochs, Claus Zimmer, Bernhard Meyer, Tobias Boeckh-Behrens, Jan S Kirschke, Jens Gempt
Aim of this study was to determine if perioperative hemodynamics have an impact on perioperative infarct volume and patients' prognosis. 201 cases with surgery for a newly diagnosed or recurrent glioblastoma were retrospectively analyzed. Clinical data and perioperative hemodynamic parameters, blood tests and time of surgery were recorded. Postoperative infarct volume was quantitatively assessed by semiautomatic segmentation. Mean diastolic blood pressure (dBP) during surgery (rho -0.239, 95% CI -0.11 - -0...
July 17, 2017: Scientific Reports
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