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etoposide with cisplatin mCRPC

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https://www.readbyqxmd.com/read/29063171/-neuroendocrine-prostate-cancer
#1
S Tritschler, R Erdelkamp, C Stief, M Hentrich
Neuroendocrine prostate cancer (NEPC) mostly occurs as a treatment-emergent adaptive response under the pressure of intensive androgen deprivation treatment (t-NEPC). Approximately 30-40% of patients with metastatic castration-resistant prostate cancer (mCRPC) also have neuroendocrine involvement. In contrast primary small cell prostate cancer is very rare (<1%). A t‑NEPC should be clinically suspected in patients who have particularly aggressive mCRPC but a disproportionately low prostate-specific antigen (PSA) level and elevated neuroendocrine tumor markers, such as chromogranin A and neuron-specific enolase...
November 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/26807222/carboplatin-etoposide-combination-chemotherapy-in-metastatic-castration-resistant-prostate-cancer-a-retrospective-study
#2
Matthieu Caubet, Erion Dobi, Astrid Pozet, Hamadi Almotlak, Philippe Montcuquet, Tristan Maurina, Guillaume Mouillet, Thierry N'guyen, Ulrich Stein, Antoine Thiery-Vuillemin, Frederic Fiteni
The combination of cisplatin or carboplatin and etoposide is the standard treatment for certain poorly differentiated neuroendocrine cancers, such as small-cell lung cancer. The aim of this study was to assess the efficacy and tolerability of the carboplatin-etoposide regimen in metastatic castration-resistant prostate cancer (mCRPC). A total of 27 patients treated by carboplatin [area under the curve (AUC)=5] and etoposide (100 mg/m(2) intravenous infusion on days 1-3 or 75 mg orally/day for 10 days) for mCRPC were included for analysis...
November 2015: Molecular and Clinical Oncology
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