Cinthia C S Menezes da Silveira, Diandra A Luz, Carla C S da Silva, Rui D S Prediger, Manoela D Martins, Marco A T Martins, Enéas A Fontes-Júnior, Cristiane S F Maia
Propolis consists of a honeybee product, with a complex mix of substances that have been widely used in traditional medicine. Among several compounds present in propolis, caffeic acid phenethyl ester (CAPE), and pinocembrin emerge as two principal bioactive compounds, with benefits in a variety of body systems. In addition to its well-explored pharmacological properties, neuropharmacological activities have been poorly discussed. In an unprecedented way, the present review addresses the current finding on the promising therapeutic purposes of propolis, focusing on CAPE and pinocembrin, highlighting its use on neurological disturbance, as cerebral ischemia, neuroinflammation, convulsion, and cognitive impairment, as well as psychiatric disorders, such as anxiety and depression...
November 11, 2020: Medicinal Research Reviews