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Iron overload MRI

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https://www.readbyqxmd.com/read/27778040/modern-american-scurvy-experience-with-vitamin-c-deficiency-at-a-large-children-s-hospital
#1
Farahnaz Golriz, Lane F Donnelly, Sridevi Devaraj, Raj Krishnamurthy
BACKGROUND: Until recently scurvy has been viewed in developed countries as a disease of the past. More recently there have been reports of case series of children with scurvy who have had a delayed diagnosis after an extensive diagnostic workup that included imaging. Most of these children have had underlying neurologic conditions such as autism. OBJECTIVE: To review the medical records of children diagnosed with vitamin C (ascorbic acid) deficiency based on serum ascorbic acid levels at a large pediatric health care system, to determine imaging findings and utility of imaging in management, and to identify at-risk pediatric populations...
October 24, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27752732/can-multi-slice-or-navigator-gated-r2-mri-replace-single-slice-breath-hold-acquisition-for-hepatic-iron-quantification
#2
Ralf B Loeffler, M Beth McCarville, Anne W Wagstaff, Matthew P Smeltzer, Axel J Krafft, Ruitian Song, Jane S Hankins, Claudia M Hillenbrand
BACKGROUND: Liver R2* values calculated from multi-gradient echo (mGRE) magnetic resonance images (MRI) are strongly correlated with hepatic iron concentration (HIC) as shown in several independently derived biopsy calibration studies. These calibrations were established for axial single-slice breath-hold imaging at the location of the portal vein. Scanning in multi-slice mode makes the exam more efficient, since whole-liver coverage can be achieved with two breath-holds and the optimal slice can be selected afterward...
October 17, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27752513/longitudinal-profile-of-iron-accumulation-in-good-grade-subarachnoid-hemorrhage
#3
Christoph Scherfler, Alois Josef Schiefecker, Margarete Delazer, Ronny Beer, Thomas Bodner, Georg Spinka, Mario Kofler, Bettina Pfausler, Christian Kremser, Michael Schocke, Thomas Benke, Elke R Gizewski, Erich Schmutzhard, Raimund Helbok
OBJECTIVE: MRI parameters of iron concentration (R2*, transverse relaxation rate), microstructural integrity (mean diffusivity and fractional anisotropy), as well as gray and white matter volumes were analyzed in patients with subarachnoid hemorrhage (SAH) and uncomplicated clinical course to detect the evolution of brain tissue changes 3 weeks and 12 months after ictus. METHODS: MRI scans of 14 SAH patients (aneurysm of the anterior communicating artery, n = 5; no aneurysm n = 9) were compared with 14 age-matched healthy control subjects...
October 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/27730342/myocardial-and-liver-iron-overload-assessed-using-t2-magnetic-resonance-imaging-with-an-excel-spreadsheet-for-post-processing-in-tunisian-thalassemia-major-patients
#4
Monia Ouederni, Monia Ben Khaled, Fethi Mellouli, Elhem Ben Fraj, Nawel Dhouib, Ismehen Ben Yakoub, Selem Abbes, Nejla Mnif, Mohamed Bejaoui
Thalassemia is a common genetic disorder in Tunisia. Early iron concentration assessment is a crucial and challenging issue. Most of annual deaths due to iron overload occurred in underdeveloped regions of the world. Limited access to liver and heart MRI monitoring might partially explain these poor prognostic results. Standard software programs are not available in Tunisia. This study is the first to evaluate iron overload in heart and liver using the MRI T2* with excel spreadsheet for post processing. Association of this MRI tool results to serum ferritin level, and echocardiography was also investigated...
October 12, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27685251/metabolic-and-hepatic-effects-of-bloodletting-in-dysmetabolic-iron-overload-syndrome-a-randomized-controlled-study-in-274-patients
#5
Fabrice Lainé, Marc Ruivard, Véronique Loustaud-Ratti, Fabrice Bonnet, Paul Calès, Edouard Bardou-Jacquet, Sylvie Sacher-Huvelin, Xavier Causse, Christine Beusnel, Alain Renault, Eric Bellissant, Yves Deugnier
: Dysmetabolic iron overload syndrome (DIOS) is a common cause of hyperferritinemia, accounting for a mild increase of iron stores in insulin-resistant subjects. Iron removal could improve insulin sensitivity. We performed a prospective, randomized, controlled trial (NCT01015525) in nondiabetic DIOS patients with hepatic iron >50 μmol/g at magnetic resonance imaging to compare the metabolic and hepatic outcomes of 1-year maintenance of serum ferritin levels <50 μg/L by bloodletting associated with lifestyle and diet advice (LFDA) to those of LFDA only...
September 29, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27684730/labile-plasma-iron-more-practical-and-more-sensitive-to-iron-overload-in-myelodysplastic-syndromes
#6
Shucheng Gu, Yanjun Xv, Chengming Fei, Chao Xiao, Juan Guo, Youshan Zhao, Feng Xv, Xiao Li, Chunkang Chang
OBJECTIVES: In order to gain an insight into labile plasma iron (LPI) in iron metabolism microenvironment in MDS. METHODS: We performed ELISA, quantitative real-time polymerase chain reaction, flow cytometry, MRI T2* assays to test LPI, iron biochemical parameters, and liver iron concentration (LIC) among 22 MDS patients. RESULTS: LPI has a statistical difference (P < 0.001 by analysis of variance (ANOVA)), which decreased gradually, among three groups, while no difference was found in adjusted serum ferritin (ASF) (P = 0...
August 11, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27650324/comparison-of-tissue-elastography-with-magnetic-resonance-imaging-t2-and-serum-ferritin-quantification-in-detecting-liver-iron-overload-in-patients-with-thalassemia-major
#7
Nirav Pipaliya, Dattatray Solanke, Pathik Parikh, Meghraj Ingle, Ratna Sharma, Sujata Sharma, Prabha Sawant
BACKGROUND & AIMS: We investigated whether tissue elastography (TE) can be used as an alternative to magnetic resonance imaging (MRI) T2* analysis to determine the degree of iron overload in patients with thalassemia major. METHODS: We conducted a prospective study of 154 patients (99 male; mean age, 12 ± 3.6 years) with thalassemia major requiring chronic blood transfusion and on iron chelator therapy. The study was performed at a tertiary hospital in India from January 2015 through June 2015...
September 17, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27617076/detection-of-early-right-ventricular-dysfunction-in-young-patients-with-thalassemia-major-using-tissue-doppler-imaging
#8
Helen Bornaun, Reyhan Dedeoglu, Kazim Oztarhan, Savas Dedeoglu, Erkan Erfidan, Muge Gundogdu, Gonul Aydogan, Dicle Cengiz
BACKGROUND: Myocardial iron overload is the most common cause of mortality in patients with thalassemia major (TM), also known as beta-thalassemia. T2* cardiovascular magnetic resonance imaging (MRI) is the best way of monitoring cardiac iron, and new echocardiographic techniques can be used to assess cardiac function. OBJECTIVES: The aim of this study was to assess the systolic and diastolic right ventricular (RV) function of patients with TM using tissue Doppler imaging (TDI) and to determine whether this echocardiographic technique is an adequate diagnostic tool for the screening and detection of subclinical cardiac dysfunction...
June 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/27614069/a-free-software-for-the-calculation-of-t2-values-for-iron-overload-assessment
#9
Juliano Lara Fernandes, Luciana Andrea Barozi Fioravante, Monica P Verissimo, Sandra R Loggetto
BACKGROUND: Iron overload assessment with magnetic resonance imaging (MRI) using T2* has become a key diagnostic method in the management of many diseases. Quantitative analysis of the MRI images with a cost-effective tool has been a limitation to increased use of the method. PURPOSE: To provide a free software solution for this purpose comparing the results with a commercial solution. MATERIAL AND METHODS: The free tool was developed as a standalone program to be directly downloaded and ran in a common personal computer platform without the need of a dedicated workstation...
September 10, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27595699/correlation-between-liver-iron-concentration-determined-by-magnetic-resonance-imaging-and-serum-ferritin-in-adolescents-with-thalassaemia-disease
#10
Ampaiwan Chuansumrit, Jiraporn Laothamathat, Nongnuch Sirachainan, Witaya Sungkarat, Pakawan Wongwerawattanakoon, Patrapop Kumkrua
BACKGROUND: MRI imaging is an alternative to serum ferritin for assessing iron overload in patients with thalassaemia disease. AIMS: To correlate liver iron concentration (LIC) determined by MRI and clinical and biochemical parameters. METHODS: An MRI study using cardiovascular magnetic resonance (CMR) tools to determine cardiac and liver iron was undertaken in adolescents with thalassaemia disease. RESULTS: Eighty-nine patients (48 males) with thalassaemia disease were enrolled...
August 2016: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/27583305/increased-mitochondrial-dna-deletions-and-copy-number-in-transfusion-dependent-thalassemia
#11
Ashutosh Lal, Esteban Gomez, Cassandra Calloway
BACKGROUND: Iron overload is the primary cause of morbidity in transfusion-dependent thalassemia. Increase in iron causes mitochondrial dysfunction under experimental conditions, but the occurrence and significance of mitochondrial damage is not understood in patients with thalassemia. METHODS: Mitochondrial DNA (mtDNA) to nuclear DNA copy number (Mt/N) and frequency of the common 4977-bp mitochondrial deletion (ΔmtDNA(4977)) were quantified using a quantitative PCR assay on whole blood samples from 38 subjects with thalassemia who were receiving regular transfusions...
August 4, 2016: JCI Insight
https://www.readbyqxmd.com/read/27576370/one-year-results-from-a-prospective-randomized-trial-comparing-phlebotomy-with-deferasirox-for-the-treatment-of-iron-overload-in-pediatric-patients-with-thalassemia-major-following-curative-stem-cell-transplantation
#12
Adlette Inati, Mario Kahale, Nada Sbeiti, Maria Domenica Cappellini, Ali T Taher, Suzanne Koussa, Therese A Nasr, Khaled M Musallam, Hussein A Abbas, John B Porter
BACKGROUND: Iron overload is well documented in patients with β-thalassemia major, and patients who have undergone hematopoietic stem cell transplantation (HSCT) remain at risk as a result of pre- and immediate post-HSCT transfusions. PROCEDURE: This is a prospective, randomized, 1-year clinical trial that compares the efficacy and safety of the once-daily oral iron chelator deferasirox versus phlebotomy for the treatment of iron overload in children with β-thalassemia major following HSCT...
August 31, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27548334/longitudinal-mri-and-ferritin-monitoring-of-iron-overload-in-chronically-transfused-and-chelated-children-with-sickle-cell-anemia-and-thalassemia-major
#13
Mélodie Aubart, Phalla Ou, Caroline Elie, Carla Canniffe, Shelby Kutty, Vincent Delos, Christine Graffigne, Mariane de Montalembert, Valentine Brousse
Iron overload is an ineluctable complication in chronically transfused children warranting accurate assessment to avoid related morbidity. We investigated longitudinally the relationships between ferritin levels and hepatic and cardiac T2* magnetic resonance imaging (MRI) in a cohort of chronically transfused children receiving chelation therapy. Thirty children with sickle cell anemia (SCA) and 7 with thalassemia major (TM) chelated similarly by deferasirox were analyzed. Sex ratio, age, median duration of transfusion programs (5 y; range, 2 to 14 y), median transfusion iron intake 0...
October 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27509836/mri-based-quantitative-susceptibility-mapping-qsm-and-r2-mapping-of-liver-iron-overload-comparison-with-squid-based-biomagnetic-liver-susceptometry
#14
Samir D Sharma, Roland Fischer, Bjoern P Schoennagel, Peter Nielsen, Hendrik Kooijman, Jin Yamamura, Gerhard Adam, Peter Bannas, Diego Hernando, Scott B Reeder
PURPOSE: We aimed to determine the agreement between quantitative susceptibility mapping (QSM)-based biomagnetic liver susceptometry (BLS) and confounder-corrected R2* mapping with superconducting quantum interference device (SQUID)-based biomagnetic liver susceptometry in patients with liver iron overload. METHODS: Data were acquired from two healthy controls and 22 patients undergoing MRI and SQUID-BLS as part of routine monitoring for iron overload. Magnetic resonance imaging was performed on a 3T system using a three-dimensional multi-echo gradient-echo acquisition...
August 11, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27507431/assessing-cardiac-and-liver-iron-overload-in-chronically-transfused-patients-with-sickle-cell-disease
#15
Sherif M Badawy, Robert I Liem, Cynthia K Rigsby, Richard J Labotka, R Andrew DeFreitas, Alexis A Thompson
Transfusional iron overload represents a substantial challenge in the management of patients with sickle cell disease (SCD) who receive chronic or episodic red blood cell transfusions. Iron-induced cardiomyopathy is a leading cause of death in other chronically transfused populations but rarely seen in SCD. Study objectives were to: (i) examine the extent of myocardial and hepatic siderosis using magnetic resonance imaging (MRI) in chronically transfused SCD patients, and (ii) evaluate the relationship between long-term (over the 5 years prior to enrolment) mean serum ferritin (MSF), spot-ferritin values and liver iron content (LIC) measured using MRI and liver biopsy...
November 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27440164/soluble-hemojuvelin-in-transfused-and-untransfused-thalassaemic-subjects
#16
Elisa Ferro, Angela Di Pietro, Giuseppa Visalli, Basilia Piraino, Carmelo Salpietro, Maria Angela La Rosa
OBJECTIVE: The hemojuvelin-bone morphogenetic protein axis is the principal iron-dependent mechanism of hepcidin regulation. The determination of soluble hemojuvelin (sHJV) levels could allow for a better understanding of the pathophysiological mechanisms of hepcidin regulation in thalassaemia. METHOD: We have assessed sHJV in 45 transfused and 15 untransfused thalassaemic patients in comparison with 15 healthy subjects, evaluating its relationships with some parameters of iron overload, anaemia and erythropoiesis...
July 21, 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/27431019/comparison-of-clinical-mri-liver-iron-content-measurements-using-signal-intensity-ratios-r-2-and-r-2
#17
Jurgen H Runge, Erik M Akkerman, Marian A Troelstra, Aart J Nederveen, Ulrich Beuers, Jaap Stoker
PURPOSE: To compare three types of MRI liver iron content (LIC) measurement performed in daily clinical routine in a single center over a 6-year period. METHODS: Patients undergoing LIC MRI-scans (1.5T) at our center between January 1, 2008 and December 31, 2013 were retrospectively included. LIC was measured routinely with signal intensity ratio (SIR) and MR-relaxometry (R 2 and R 2*) methods. Three observers placed regions-of-interest. The success rate was the number of correctly acquired scans over the total number of scans...
July 18, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27405703/quantification-of-liver-fat-in-the-presence-of-iron-overload
#18
Debra E Horng, Diego Hernando, Scott B Reeder
PURPOSE: To evaluate the accuracy of R2* models (1/T2 * = R2*) for chemical shift-encoded magnetic resonance imaging (CSE-MRI)-based proton density fat-fraction (PDFF) quantification in patients with fatty liver and iron overload, using MR spectroscopy (MRS) as the reference standard. MATERIALS AND METHODS: Two Monte Carlo simulations were implemented to compare the root-mean-squared-error (RMSE) performance of single-R2* and dual-R2* correction in a theoretical liver environment with high iron...
July 13, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27377500/evaluation-of-carotid-artery-dynamics-correlation-with-cardiac-hepatic-iron-in-%C3%AE-thalassaemia-patients
#19
Rashid H Merchant, Someshwar Chate, Javed Ahmed, Noor Ahmad, Alka Karnik, Bhavin Jankaria
BACKGROUND & OBJECTIVES: Early atherosclerosis and vascular complication have been described in thalassaemia patients. There is lack of data or guidelines regarding monitoring of vascular health in thalassaemia. This study was conducted to compare carotid artery structural and functional indices such as carotid artery intima-media thickness (CIMT), stiffness index (SI) and Young's elastic modulus (YEM) in β-thalassemia patients with age and sex matched controls, and to correlate these parameters with serum ferritin, cardiac iron, and hepatic iron...
April 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27240936/influence-of-the-analysis-technique-on-estimating-hepatic-iron-content-using-mri
#20
El-Sayed H Ibrahim, Ayman M Khalifa, Ahmed K Eldaly
PURPOSE: To investigate the effect of the analysis technique on estimating hepatic iron content using MRI. MATERIALS AND METHODS: We evaluated the influences of single-exponential (EXP), bi-exponential (BEXP), and exponential-plus-constant (CEXP) models; and pixel-wise (MAP), average (AVG), and median (MED) signal calculation methods on T2* measurement using numerical simulations, calibrated phantoms, and nine patients scanned on 3 Tesla MRI, based on regression, correlation, and t-test statistical analysis...
December 2016: Journal of Magnetic Resonance Imaging: JMRI
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