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Iron overload MRI

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https://www.readbyqxmd.com/read/29770484/inter-method-reproducibility-of-biexponential-r-2-mr-relaxometry-for-estimation-of-liver-iron-concentration
#1
Ali Pirasteh, Qing Yuan, Diego Hernando, Scott B Reeder, Ivan Pedrosa, Takeshi Yokoo
PURPOSE: To assess the reproducibility of biexponential R2 -relaxometry MRI for estimation of liver iron concentration (LIC) between proprietary and nonproprietary analysis methods. METHODS: This single-center retrospective study, approved by investigational review board and compliant with the Health Insurance Portability and Accountability Act, included 40 liver MRI exams in 38 subjects with suspected or known iron overload. From spin-echo images of the liver, acquired at 5 different echo times (TE = 6-18 ms), biexponential R2 maps were calculated using 1 proprietary (FerriScan, Resonance Health Ltd...
May 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29769185/unusual-case-of-iron-overload-with-cancer-mimicking-abdominal-splenosis
#2
Giacomo Marchi, Giacomo Avesani, Alberto Zamò, Domenico Girelli
A 48-year-old man, former alcohol abuser and drug addicted, was referred to our tertiary referral centre for iron disorders because of marked hyperferritinaemia. His clinical history revealed chronic hepatitis C, ß-thalassaemia trait and post-traumatic splenectomy at age of 22. MRI-estimated liver iron content was markedly elevated, while first-line genetic test for haemochromatosis was negative. Alpha-fetoprotein was increased but liver ultrasonography did not reveal focal liver lesions. Multiphasic contrast-enhanced CT confirmed this result but showed two abdominal masses (diameter of 9 cm and 7 cm, respectively) among bowel loops, strongly suspicious for cancer...
May 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29718694/feasibility-and-agreement-of-stiffness-measurements-using-gradient-echo-and-spin-echo-mr-elastography-sequences-in-unselected-patients-undergoing-liver-mri
#3
Guilherme M Cunha, Kevin J Glaser, Anke Bergman, Rodrigo P Luz, Eduardo Figueiredo, Flavia Paiva Proença Lobo Lopes
OBJECTIVE: To evaluate the agreement of three MRE sequences in patients undergoing liver MRI for clinical care. METHODS: A cross-sectional retrospective study was performed with 223 patients referred for liver MRI, including 12 patients with liver iron overload. Data obtained with Spin-Echo (SE) and Gradient-Echo (GRE) MRE sequences were compared. Multiple linear regression adjusted for the presence of liver fat was also performed to assess the correlation between fat infiltration and stiffness measurements results...
May 2, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29675354/quantification-of-liver-iron-concentration-using-the-apparent-susceptibility-of-hepatic-vessels
#4
Saifeng Liu, Chaoyue Wang, Xiaoqi Zhang, Panli Zuo, Jiani Hu, E Mark Haacke, Hongyan Ni
Background: The quantification of liver iron concentration (LIC) is important for the monitoring of the body iron level in patients with iron overload. Conventionally, LIC is quantified through R2 or R2* mapping using MRI. In this paper, we demonstrate an alternative approach for LIC quantification through measuring the apparent susceptibility of hepatic vessels using quantitative susceptibility mapping (QSM). Methods: QSM was performed in the liver region with the iterative susceptibility weighted imaging and mapping (iSWIM) algorithm, using the geometry of the vessels extracted from magnitude images as constraints...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29663858/assessment-of-liver-and-cardiac-iron-overload-using-mri-in-patients-with-chronic-anemias-in-latin-american-countries-results-from-asimila-study
#5
Rodolfo Cancado, Nora P Watman, Clarisse Lobo, Zulay Chona, Fernando Manzur, Fabiola Traina, Miriam Park, Guillermo Drelichman, Juan Pablo Zarate, Luis Marfil
OBJECTIVES: A multicenter, noninterventional, observational study was conducted in the Latin American countries including Argentina, Brazil, Colombia, Mexico, and Venezuela to assess the prevalence of liver and cardiac iron overload using magnetic resonance imaging (MRI) in patients with chronic anemias except thalassemia. METHODS: Patients aged >10 years with transfusion-dependent anemias, except thalassemia, either with <20 units of red blood cell (RBC) transfusions with serum ferritin (SF) levels >2000 ng/mL or with ≥20 units of RBC transfusions regardless of SF level in their lifetime, were enrolled...
April 17, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29663188/magnetic-resonance-imaging-during-management-of-patients-with-transfusion-dependent-thalassemia-a-single-center-experience
#6
Zeynep Karakas, Yasin Yilmaz, Zuhal Bayramoglu, Serap Karaman, Selime Aydogdu, Ayse Ozkan Karagenc, Deniz Tugcu, Memduh Dursun
BACKGROUND: Cardiac and hepatic magnetic resonance imaging evaluation during treatment can tailor physicians' chelation therapy titrations. AIM: The aim of the study was to assess the relationship of cardiac and hepatic T2* values with chelation therapy in patients with transfusion-dependent thalassemia (TDT). METHODS: A total of 106 patients with TDT who were followed up in Istanbul Medical Faculty Thalassemia Center were evaluated for the study...
April 16, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29628397/enhanced-labile-plasma-iron-and-outcome-in-acute-myeloid-leukaemia-and-myelodysplastic-syndrome-after-allogeneic-haemopoietic-cell-transplantation-allive-a-prospective-multicentre-observational-trial
#7
Martin Wermke, Julia Eckoldt, Katharina S Götze, Stefan A Klein, Gesine Bug, Liesbeth C de Wreede, Michael Kramer, Friedrich Stölzel, Malte von Bonin, Johannes Schetelig, Michael Laniado, Verena Plodeck, Wolf-Karsten Hofmann, Gerhard Ehninger, Martin Bornhäuser, Dominik Wolf, Igor Theurl, Uwe Platzbecker
BACKGROUND: The effect of systemic iron overload on outcomes after allogeneic haemopoietic cell transplantation (HCT) has been a matter of substantial debate. We aimed to investigate the predictive value of both stored (MRI-derived liver iron content) and biologically active iron (enhanced labile plasma iron; eLPI) on post-transplantation outcomes in patients with acute myeloid leukaemia or myelodysplastic syndrome undergoing allogenic HCT. METHODS: The prospective, multicentre, observational, ALLogeneic Iron inVEstigators (ALLIVE) trial recruited patients at five centres in Germany...
April 5, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29575047/assessment-of-mr-based-r2-and-quantitative-susceptibility-mapping-for-the-quantification-of-liver-iron-concentration-in-a-mouse-model-at-7t
#8
Gregory Simchick, Zhi Liu, Tamas Nagy, May Xiong, Qun Zhao
PURPOSE: To assess the feasibility of quantifying liver iron concentration (LIC) using R2* and quantitative susceptibility mapping (QSM) at a high field strength of 7 Tesla (T). METHODS: Five different concentrations of Fe-dextran were injected into 12 mice to produce various degrees of liver iron overload. After mice were sacrificed, blood and liver samples were harvested. Ferritin enzyme-linked immunosorbent assay (ELISA) and inductively coupled plasma mass spectrometry were performed to quantify serum ferritin concentration and LIC...
March 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29569468/relationship-between-uric-acid-levels-and-cardiometabolic-findings-in-a-large-cohort-of-%C3%AE-thalassemia-major-patients
#9
Cristina Vassalle, Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Anna Spasiano, Calogera Gerardi, Angelo Zuccarelli, Tommaso Casini, Riccardo Righi, Massimiliano Missere, Vincenzo Positano, Rudina Ndreu, Alessia Pepe
AIM: to evaluate the relationship between uric acid (UA), hepatic and cardiac iron overload (T2*-MRI), ferritin, endocrinological diseases and cardiac complications in a large thalassemia major (TM) cohort. METHODS:  A total of 369 TM patients (187 men; 33 ± 6 years) were retrospectively studied, from the myocardial iron overload in thalassemia (MIOT) electronic databank. RESULTS: Multiple regression model identified male sex (p < 0...
March 23, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29566449/quantitative-susceptibility-mapping-qsm-minimizes-interference-from-cellular-pathology-in-r2-estimation-of-liver-iron-concentration
#10
Jianqi Li, Huimin Lin, Tian Liu, Zhuwei Zhang, Martin R Prince, Kelly Gillen, Xu Yan, Qi Song, Ting Hua, Xiance Zhao, Miao Zhang, Yu Zhao, Gaiying Li, Guangyu Tang, Guang Yang, Gary M Brittenham, Yi Wang
BACKGROUND: A challenge for R2 and R2* methods in measuring liver iron concentration (LIC) is that fibrosis, fat, and other hepatic cellular pathology contribute to R2 and R2* and interfere with LIC estimation. PURPOSE: To examine the interfering effects of fibrosis, fat, and other lesions on R2* LIC estimation and to use quantitative susceptibility mapping (QSM) to reduce these distortions. STUDY TYPE: Prospective. PHANTOMS, SUBJECTS: Water phantoms with various concentrations of gadolinium (Gd), collagen (Cl, modeling fibrosis), and fat; nine healthy controls with no known hepatic disease, nine patients with known or suspected hepatic iron overload, and nine patients with focal liver lesions...
March 22, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29561522/diffusion-weighted-imaging-shows-a-false-negative-finding-for-bone-marrow-involvement-on-18f-fdg-pet-mri-in-a-patient-with-malignant-lymphoma-after-blood-transfusion
#11
Feibi Zeng, Munenobu Nogami, Taiichiro Shirai, Yoh Zen, Takamichi Murakami
Iron overload is a major complication in blood transfusion procedures. This report presents a case of malignant lymphoma, in which the findings of bone marrow involvement were discordant between F-FDG PET imaging studies and MRI with diffusion-weighted imaging studies. In this case, the PET imaging studies were positive for malignant lymphoma, whereas the MRI studies were negative. Iron deposition in the reticuloendothelial system due to posttransfusion iron overload was considered to be the cause of the decrease in signal intensity on diffusion-weighted imaging, resulting in a false-negative finding on MRI...
March 20, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29493312/hepatocellular-carcinoma-in-a-%C3%AE-thalassemia-intermedia-patient-yet-another-case-in-the-expanding-epidemic
#12
Hassan M Moukhadder, Joseph E Roumi, Rayan Bou-Fakhredin, Ali T Taher
The incidence of hepatocellular carcinoma (HCC) in patients with thalassemia is increasing, the two well recognized HCC risk factors in thalassemia being iron overload and chronic hepatitis C. The carcinogenicity of iron is related to its induction of oxidative damage, whereas chronic hepatitis leads to necroinflammation that can accelerate progression to HCC. We hereby report the case of a non transfused, hepatitis C-negative, β-thalassemia intermedia (β-TI) patient from our practice who had evidence of significant iron overload, suggesting the importance of increased iron burden as a HCC risk factor in this patient population...
January 2018: Hemoglobin
https://www.readbyqxmd.com/read/29470640/quantitative-susceptibility-mapping-in-combination-with-water-fat-separation-for-simultaneous-liver-iron-and-fat-fraction-quantification
#13
Huimin Lin, Hongjiang Wei, Naying He, Caixia Fu, Shu Cheng, Jun Shen, Baisong Wang, Xu Yan, Chunlei Liu, Fuhua Yan
PURPOSES: To evaluate the feasibility of simultaneous quantification of liver iron concentration (LIC) and fat fraction (FF) using water-fat separation and quantitative susceptibility mapping (QSM). METHODS: Forty-five patients suspected of liver iron overload (LIO) were included. A volumetric interpolated breath-hold examination sequence for QSM and FF, a fat-saturated gradient echo sequence for R2 * , a spin echo sequence for LIC measurements and MRS analyses for FF (FF-MRS) were performed...
February 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29470624/measuring-liver-t2-and-cardiac-t2-in-a-single-acquisition
#14
Suraj D Serai, Andrew T Trout, Robert J Fleck, Charles T Quinn, Jonathan R Dillman
PURPOSE: The purpose of this study is determine if both liver T2* and cardiac T2* can be measured on a single breath-hold acquisition. MATERIALS AND METHODS: For this IRB-approved retrospective study, 137 patients with dedicated Cardiac MRI and Liver MRI examinations obtained sequentially on 1.5T scanners and on the same day were included for analysis. Both the cardiac and liver MRI examinations utilized GRE sequences for quantification of tissue iron. Specifically, T2* was measured using an 8-echo, multi-echo gradient echo single breath-hold sequence...
February 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29467999/the-correlation-of-cardiac-and-hepatic-hemosiderosis-as-measured-by-t2-mri-technique-with-ferritin-levels-and-hemochromatosis-gene-mutations-in-iranian-patients-with-beta-thalassemia-major
#15
Mohammad Soleiman Soltanpour, Kambiz Davari
Objectives: Organ-specific hemosiderosis and iron overload complications are more serious and more frequent in some patients with beta thalassemia major (BTM) compared with others. We investigated whether coinheritance of HFE H63D or C282Y gene mutations in patients with BTM contributes to the phenotypic variation of iron overload complications and assessed the correlation of cardiac and hepatic hemosiderosis with plasma ferritin levels. Methods: We studied 60 patients with BTM with a mean age of 17...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29458732/mri-for-iron-overload-in-thalassemia
#16
REVIEW
Juliano Lara Fernandes
MRI is a key tool in the current management of patients with thalassemia. Given its capability of assessing iron overload in different organs noninvasively and without contrast, it has significant advantages over other metrics, including serum ferritin. Liver iron concentration can be measured either with relaxometry methods T2*/T2 or signal intensity ratio techniques. Myocardial iron can be assessed in the same examination through T2* imaging. In this review, we focus on showing how MRI evaluates iron in both organs and the clinical applications as well as practical approaches to using this tool by clinicians taking care of patients with thalassemia...
April 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29458731/iron-chelation-therapy-as-a-modality-of-management
#17
REVIEW
Yesim Aydinok
Introduction of MRI techniques for identifying and monitoring tissue iron overload and the current understanding of iron homeostasis in transfusion-dependent (TDT) and non-transfusion-dependent thalassemia have allowed for a more robust administration of iron chelation therapies. The development of safe and efficient oral iron chelators and the insights gained from large-scale prospective studies using these agents have improved iron overload management. A significant reduction in iron toxicity-induced morbidity and mortality and improvements in quality of life were observed in TDT...
April 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29427184/polyneuropathy-and-myopathy-in-beta-thalassemia-major-patients
#18
P Nemtsas, M Arnaoutoglou, V Perifanis, E Koutsouraki, G Spanos, N Arnaoutoglou, P Chalkia, D Pantelidou, A Orologas
The thalassemias are the most common single gene disorder in the world. Nowadays, the average life expectancy of patients in developed countries has increased significantly, while, there was an increase of complications. We aimed to investigate peripheral neuropathy and myopathy in this patient group using a neurophysiological study. We performed nerve conduction studies and electromyography of upper and lower extremities on 36 beta-thalassemia major (β-thal) patients. The electrophysiological findings were correlated with demographic data and laboratory parameters of the disease...
May 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29399871/the-correlation-between-cardiac-magnetic-resonance-t2-and-left-ventricular-global-longitudinal-strain-in-people-with-%C3%AE-thalassemia
#19
Mozhgan Parsaee, Nehzat Akiash, Azita Azarkeivan, Zahra Alizadeh Sani, Ahmad Amin, Mahboubeh Pazoki, Niloufar Samiei, Mohammad Ali Jalili, Mohammad Hassan Adel, Nahid Rezaian
BACKGROUND: Heart failure is the biggest cause of mortality and morbidity in people with thalassemia, and iron deposition in cardiac tissue impairs cardiovascular function. Therefore, early detection of cardiac involvement is important to improve the prognosis in these individuals. METHOD: Two- and three-dimensional echocardiography was performed to evaluate left ventricular ejection fraction (LVEF), left ventricular volumes and diameters, and global longitudinal strain (GLS) in 130 individuals with β-thalassemia using the speckle tracking method...
April 2018: Echocardiography
https://www.readbyqxmd.com/read/29384977/improvement-of-chronic-hepatitis-b-by-iron-chelation-therapy-in-a-patient-with-iron-overload-a-case-report
#20
Dong-Mei Zou, Dong-Dong Rong, Hong Zhao, Li Su, Wan-Ling Sun
RATIONALE: This report describes seroconversion of hepatitis B surface antigen (HBsAg) in a patient with marked iron overload caused by chronic hepatitis B (CHB) after receiving iron chelation therapy and discusses the role of iron chelation therapy in CHB. PATIENT CONCERNS: Increased serum ferritin level for 2 months. DIAGNOSIS: Secondary iron overload and CHB. INTERVENTION: To relieve iron load of the body, the patient underwent regular phlebotomy therapy and deferoxamine (DFO) therapy...
December 2017: Medicine (Baltimore)
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