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https://www.readbyqxmd.com/read/28156678/patterns-of-symptom-control-and-palliative-care-focused-original-research-articles-in-major-radiation-oncology-journals
#1
Tracy A Balboni, Edward Chow
: 216 Background: National oncology and palliative care organizations recommend greater incorporation of palliative care in clinical care and research in advanced cancer to improve care quality. In radiation oncology, palliative oncology care represents approximately 30-40% of treatment courses. Given the frequency of palliative care in radiation oncology and recommendations for greater research at this intersection, we sought to determine the prevalence and patterns of publication of symptom control and palliative care focused original research articles in two prominent radiation oncology journals from 2004-2015...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28123244/are-self-expandable-metal-stents-superior-to-plastic-stents-in-palliating-malignant-distal-biliary-strictures-a-meta-analysis-and-systematic-review
#2
Harsha Moole, Amy Jaeger, Micheal Cashman, Fritz H Volmar, Sonu Dhillon, Mathew L Bechtold, Srinivas R Puli
BACKGROUND: Palliation for inoperable malignant distal biliary strictures can be achieved with self-expandable metal stents (SEMS) and plastic stents (PS). This is a meta-analysis to compare PS and SEMS. The aim of the study is to compare clinical outcomes in patients with SEMS and PS. METHODS: Study selection criteria were studied using SEMS and PS for palliation in patients with malignant distal biliary stricture. For data collection and extraction, articles were searched in Ovid journals, Medline, Cochrane database, and Pubmed...
January 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28118323/chemotherapy-vs-tamoxifen-in-platinum-resistant-ovarian-cancer-a-phase-iii-randomised-multicentre-trial-ovaresist
#3
Kristina Lindemann, Emma Gibbs, Elisabeth Åvall-Lundqvist, Rene dePont Christensen, Kathrine Woie, Marten Kalling, Annika Auranen, Seija Grenman, Thomas Hoegberg, Per Rosenberg, Tone Skeie-Jensen, Elisabet Hjerpe, Anne Dørum, Val Gebski, Gunnar Kristensen
BACKGROUND: Chemotherapy in platinum-resistant ovarian cancer (PROC) aims for palliation and prolonging of progression-free survival (PFS). This study compares Health-related Quality of Life (HRQoL) and efficacy between single-agent chemotherapy and tamoxifen in PROC. METHODS: Patients with PROC were randomised (2 : 1) to chemotherapy (weekly paclitaxel 80 mg m(-2) or four weekly pegylated liposomal doxorubicin 40 mg m(-2)) or tamoxifen 40 mg daily...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28095397/a-randomised-phase-ii-trial-and-feasibility-study-of-palliative-chemotherapy-in-frail-or-elderly-patients-with-advanced-gastroesophageal-cancer-321go
#4
P S Hall, S R Lord, M Collinson, H Marshall, M Jones, C Lowe, H Howard, D Swinson, G Velikova, A Anthoney, R Roy, J Dent, S Cheeseman, K Last, M T Seymour
BACKGROUND: Elderly patients are commonly under-represented in cancer clinical trials. The 321GO was undertaken in preparation for a definitive phase three trial assessing different chemotherapy regimens in a frail and/or elderly population with advanced gastroesophageal (GO) cancer. METHODS: Patients with advanced GO cancer considered unfit for conventional dose chemotherapy were randomly assigned in a 1 : 1 : 1 ratio to: epirubicin, oxaliplatin and capecitabine (EOX); oxaliplatin and capecitabine (OX); and capecitabine alone (X) (all 80% of full dose and unblinded)...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28056635/palliative-care-research-state-of-play-and-journal-direction
#5
Catherine Walshe
No abstract text is available yet for this article.
January 2017: Palliative Medicine
https://www.readbyqxmd.com/read/27989871/state-of-research-on-palliative-care-in-heart-failure-as-evidenced-by-published-literature-conference-proceedings-and-nih-funding
#6
Kira Xie, Laura Gelfman, Jay R Horton, Nathan E Goldstein
BACKGROUND: Heart failure (HF) is the most common diagnosis in hospitalized patients older than 65 years of age. Although these patients often need specialist-directed palliative care, <10% ever receive these services. This may be due to a lack of evidence examining the benefits of palliative care for these patients. To understand the current state of research on the interface of palliative care and HF, we examined trends in publications, presentations at national meetings, and National Institutes of Health (NIH) funding...
February 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27984556/a-population-based-study-of-care-at-the-end-of-life-among-people-with-hiv-in-ontario-from-2010-to-2013
#7
Claire E Kendall, Mathieu Chalifoux, Doug Manuel, Robert Reinhard, Gregory Robinson, Jean Bacon, Sean B Rourke, Ron Rosenes, Peter Tanuseputro
BACKGROUND: Aging and increasing comorbidity is changing the end-of-life experience of people living with HIV (PLHIV) in the developed world. We quantified, at a population level, the receipt of health care services and associated costs across a comprehensive set of sectors among decedents with and without HIV. METHODS: We conducted a retrospective population-level observational study of all decedents in Ontario and their receipt of health care services, captured through linked health administrative databases, between April 1, 2010 and March 31, 2013...
December 7, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27924357/caring-at-home-until-death-enabled-determination
#8
Carole A Robinson, Joan L Bottorff, Erin McFee, Laura J Bissell, Gillian Fyles
PURPOSE: The importance of family caregivers in providing palliative care at home and in supporting a home death is well supported. Gaining a better understanding of what enables palliative family caregivers to continue caring at home for their family members until death is critical to providing direction for more effective support. The purpose of the study was to describe the experiences of bereaved family caregivers whose terminally ill family members with advanced cancer were successful in achieving a desired home death...
December 6, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27899400/study-protocol-a-phase-iii-randomised-double-blind-parallel-arm-stratified-block-randomised-placebo-controlled-trial-investigating-the-clinical-effect-and-cost-effectiveness-of-sertraline-for-the-palliative-relief-of-breathlessness-in-people-with-chronic-breathlessness
#9
Gareth J Watts, Katherine Clark, Meera Agar, Patricia M Davidson, Christine McDonald, Lawrence T Lam, Dimitar Sajkov, Nicola McCaffrey, Matthew Doogue, Amy P Abernethy, David C Currow
INTRODUCTION: Breathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27897391/a-systematic-review-on-the-role-of-vitamins-minerals-proteins-and-other-supplements-for-the-treatment-of-cachexia-in-cancer-a-european-palliative-care-research-centre-cachexia-project
#10
REVIEW
Mochamat, Henning Cuhls, Milka Marinova, Stein Kaasa, Christiane Stieber, Rupert Conrad, Lukas Radbruch, Martin Mücke
We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov, and a selection of cancer journals have been searched up until 15 April 2016. The systematic literature research yielded 4214 publications with 21 of these included in the final evaluation. Regarding minerals, our search identified only one study examining the use of magnesium with no effect on weight loss...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27872935/the-social-transformation-of-singapore-medicine-through-55-years-of-the-smj
#11
Ee Heok Kua, Jade Phek Hui Kua
The Singapore Medical Journal (SMJ) has in the past 55 years reflected the phenomenal socioeconomic progress of Singapore. Publications in the pre-independent years were mainly on diseases like cholera, diphtheria, leprosy, tetanus and worm infestation. In the new millennium, the research papers included molecular genetics, health economics, obesity, Internet medicine, cancer, cosmetic surgery and palliative medicine. The annual SMA Lecture published in the SMJ provides an ethical compass for doctors to remind them of primum non nocere...
November 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27849407/the-oxford-textbook-of-palliative-medicine-5th-edition
#12
Roger Woodruff
EDITOR'S NOTE The journal is delighted to begin a collaboration with the International Association for Hospice and Palliative Care (IAHPC) in publication of book reviews relevant to symptom control in advanced disease. These reviews are adapted from the work of Roger Woodruff, MD, FRACP, FAChPM, an internationally recognized oncologist and palliative care specialist physician from Australia. Dr. Woodruff's reviews appear concurrently or did so previously in the IAHPC Newsletter, which is accessible through the IAHPC Web site: http://hospicecare...
December 2016: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/27805799/early-detection-of-critical-illness-outside-the-intensive-care-unit-clarifying-treatment-plans-and-honoring-goals-of-care-using-a-supportive-care-team
#13
Russ Granich, Zoe Sutton, Yan S Kim, Megan Anderson, Helen Wood, John E Scharf, Arona Ragins, Gabriel J Escobar
Given the high mortality experienced by patients who deteriorate outside the intensive care unit, issues related to patient preferences around escalation of care are common. However, the literature on early warning systems (EWSs) provides limited information on how respecting patient preferences can be incorporated into clinical workflows. In this report, we describe how we developed workflows for integrating supportive care with an automated EWS in the context of a 2-hospital pilot. We used the Institute for Healthcare Improvement's Plan-Do-Study-Act approach to achieve consensus with clinicians and administrators...
November 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/27802455/downregulation-of-egfr-in-hypoxic-diffusion-limited-areas-of-squamous-cell-carcinomas-of-the-head-and-neck
#14
Arnulf Mayer, Sebastian Zahnreich, Jürgen Brieger, Peter Vaupel, Heinz Schmidberger
BACKGROUND: The receptor for the epidermal growth factor (EGFR) is widely considered to be one of the central drivers of oncogenesis in squamous cell carcinomas of the head and neck region (HNSCC). Inhibition of EGFR using monoclonal antibodies is established both in the curative and the palliative setting in this disease. HNSCCs are known to contain abundant hypoxic tissue areas and hypoxia has been shown to be involved in the (down)regulation of EGFR membrane expression. METHODS: A novel method for multiplex immunofluorescence and single-cell segmentation (via DAPI-stained nuclei) was established, to study the expression of EGFR, the endogenous hypoxia marker CA IX, and intratumoural diffusion distances from microvessels (using CD34 staining) in 58 human HNSCCs and 9 normal/cancer adjacent tissues...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27798020/optimum-a-protocol-for-a-multicentre-randomised-controlled-trial-comparing-out-patient-talc-slurry-via-indwelling-pleural-catheter-for-malignant-pleural-effusion-vs-usual-inpatient-management
#15
P Sivakumar, A Douiri, A West, D Rao, G Warwick, T Chen, L Ahmed
INTRODUCTION: The development of malignant pleural effusion (MPE) results in disabling breathlessness, pain and reduced physical capability with treatment a palliative strategy. Ambulatory management of MPE has the potential to improve quality of life (QoL). The OPTIMUM trial is designed to determine whether full outpatient management of MPE with an indwelling pleural catheter (IPC) and pleurodesis improves QoL compared with traditional inpatient care with a chest drain and talc pleurodesis...
October 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27798016/supporting-the-provision-of-palliative-care-in-the-home-environment-a-proof-of-concept-single-arm-trial-of-a-palliative-carers-education-package-precept
#16
Liz Forbat, Erna Haraldsdottir, Marsha Lewis, Ken Hepburn
INTRODUCTION: Practical educational interventions for palliative carers are needed. Current supports frequently rely on carers travelling to a central venue to receive education. A substantial gap therefore exists around determining how high-quality relevant information can be delivered nationally, with limited cost implications, using educational methods that are acceptable to carers in palliative care. This study seeks to design and assess feasibility and acceptability of a distance-learning approach to educating carers...
October 25, 2016: BMJ Open
https://www.readbyqxmd.com/read/27736846/genotypes-of-cyp2c8-and-fgd4-and-their-association-with-peripheral-neuropathy-or-early-dose-reduction-in-paclitaxel-treated-breast-cancer-patients
#17
Siu W Lam, Charlotte N Frederiks, Tahar van der Straaten, Aafke H Honkoop, Henk-Jan Guchelaar, Epie Boven
BACKGROUND: The purpose of this study was to evaluate single-nucleotide polymorphisms (SNPs) in genes encoding key metabolising enzymes or involved in pharmacodynamics for possible associations with paclitaxel-induced peripheral neuropathy. METHODS: The study population consists of 188 women from the multicenter, randomised, phase II ATX trial (BOOG2006-06; EudraCT number 2006-006058-83) that received paclitaxel and bevacizumab without or with capecitabine as first-line palliative therapy of HER2-negative metastatic breast cancer...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27648439/endoscopic-versus-percutaneous-biliary-drainage-in-palliation-of-advanced-malignant-hilar-obstruction-a-meta-analysis-and-systematic-review
#18
REVIEW
Harsha Moole, Sirish Dharmapuri, Abhiram Duvvuri, Sowmya Dharmapuri, Raghuveer Boddireddy, Vishnu Moole, Prathyusha Yedama, Naveen Bondalapati, Achuta Uppu, Charan Yerasi
Background. Palliation in advanced unresectable hilar malignancies can be achieved by endoscopic (EBD) or percutaneous transhepatic biliary drainage (PTBD). It is unclear if one approach is superior to the other in this group of patients. Aims. Compare clinical outcomes of EBD versus PTBD. Methods. (i) Study Selection Criterion. Studies using PTBD and EBD for palliation of advanced unresectable hilar malignancies. (ii) Data Collection and Extraction. Articles were searched in Medline, PubMed, and Ovid journals...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27641713/rural-residents-perspectives-on-the-rural-good-death-a-scoping-review
#19
Suzanne Rainsford, Roderick D MacLeod, Nicholas J Glasgow, Donna M Wilson, Christine B Phillips, Robert B Wiles
The 'good death' is one objective of palliative care, with many 'good death' viewpoints and research findings reflecting the urban voice. Rural areas are distinct and need special consideration. This scoping review identified and charted current research knowledge on the 'good' rural death through the perspectives of rural residents, including rural patients with a life-limiting illness, to identify evidence and gaps in the literature for future studies. A comprehensive literature search of English language articles (no date filter applied) was conducted in 2016 (2 January to 14 February) using five library databases...
September 19, 2016: Health & Social Care in the Community
https://www.readbyqxmd.com/read/27619829/protocol-for-a-systematic-review-of-preference-based-instruments-for-measuring-care-related-outcomes-and-their-suitability-for-the-palliative-care-setting
#20
Nikki McCaffrey, Hareth Al-Janabi, David Currow, Renske Hoefman, Julie Ratcliffe
INTRODUCTION: Despite informal caregivers' integral role in supporting people affected by disease or disability, economic evaluations often ignore the costs and benefits experienced by this group, especially in the palliative setting. The purpose of this systematic review is to identify preference-based instruments for measuring care-related outcomes and provide guidance on the selection of instrument in palliative care economic evaluations. METHODS AND ANALYSIS: A comprehensive search of the literature will be conducted from database inception (ASSIA; CINAHL; Cochrane library including DARE, NHS EED, HTA; Econlit; Embase; PsychINFO; PubMed)...
September 12, 2016: BMJ Open
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