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https://www.readbyqxmd.com/read/29443748/ultrasound-combined-with-fine-needle-aspiration-cytology-for-the-assessment-of-axillary-lymph-nodes-in-patients-with-early-stage-breast-cancer
#1
Fan Zhang, Jing Zhang, Qing-Xin Meng, Xin Zhang
This study aimed to explore the clinical usefulness of ultrasound-guided fine needle aspiration cytology (USG-FNAC) for the evaluation of axillary lymph nodes in patients with early stage breast cancer (BC) among the Chinese Han female population.Around 124 patients with early stage BC were included in this retrospective study. All patients underwent USG-FNAC (group A). Patients with proven metastasis also underwent axillary lymph node dissection (ALND) (group B). In addition, sentinel lymph node biopsy (SLNB) was performed 2 to 5 hours prior to the surgery...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29403164/to-evaluate-the-applicability-of-parameters-of-cytological-grading-systems-on-aspirates-of-breast-carcinoma
#2
Priyanshu Srivastava, Binay Kumar, Usha Joshi, Mehar Bano
Background: Fine-needle aspiration cytology (FNAC) is still an important first line diagnostic procedure in developing countries. FNAC of breast lesions is quite specific and sensitive investigation and the results are comparable to histopathology. Aim: To evaluate applicability of parameters of different cytological grading (CG) systems, for aspirates of breast cancers, and its correlation with histopathology grading parameters. Materials and Methods: A cross-sectional observational study was carried out on 30 female patients with ductal carcinoma breast, diagnosed on FNAC and subsequently confirmed histopathologically...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29402252/pre-operative-and-intra-operative-detection-of-axillary-lymph-node-metastases-in-108-patients-with-invasive-lobular-breast-cancer-undergoing-mastectomy
#3
Jerica Novak, Nikola Besic, Radan Dzodic, Barbara Gazic, Andrej Vogrin
BACKGROUND: Despite the recent changes in the treatment of the axilla in selected breast cancer patient, positive sentinel lymph node (SLN) in patients undergoing mastectomy still necessitates axillary lymph node dissection (ALND). In invasive lobular carcinoma (ILC), pre-operative detection of the lymph node metastasis may be demanding due to its unique morphology. The aim of this study was to examine the benefit of preoperative axillary ultrasound (AUS), ultrasound-guided fine-needle aspiration biopsy (US-FNAB), and intra-operative imprint cytology (IIC), in order to avoid two-stage axillary surgery in patients with ILC undergoing mastectomy...
February 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29394739/-tumor-displacement-resulting-from-core-needle-biopsy-of-breast-cancer-a-case-report
#4
Akiko Igawa, Takashi Nishi, Akimasa Nishimura, Satoko Morohashi, Kenichi Hakamada
Tumor cell displacement is occasionally observed in surgical specimens after core needle biopsy. We report a case involving a 58-year-old woman in whom a microlobulated mass was detected on mammography, after which she underwent an ultrasonography- guided core needle biopsy. Thirty-six days later, a new low-echoic lesion was detected on ultrasonography, located from the original mass to the subcutaneous insertion site of the needle biopsy. Fifty days after the biopsy, breast-conserving surgery was performed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29385322/sox10-keratin-dual-color-immunohistochemistry-an-effective-first-line-test-for-the-workup-of-epithelioid-malignant-neoplasms-in-fna-and-small-biopsy-specimens
#5
Jeffrey K Mito, James R Conner, Jason L Hornick, Edmund S Cibas, Xiaohua Qian
BACKGROUND: The characterization of poorly differentiated neoplasms in fine-needle aspiration (FNA) and small biopsy specimens usually requires immunohistochemistry (IHC) with a panel of markers. Because of an increasing need to preserve limited diagnostic material for tumor genotyping and a mounting demand for cost containment, the authors investigated the usefulness of dual-color IHC with antibodies directed against broad-spectrum keratins and SOX10, a neuroectodermal transcription factor consistently expressed in melanoma, in the workup of epithelioid malignant neoplasms...
January 31, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29347887/cryo-assisted-resection-en-bloc-and-cryoablation-in-situ-of-primary-breast-cancer-coupled-with-intraoperative-ultrasound-guided-tracer-injection-a-preliminary-clinical-study
#6
Nikolai N Korpan, Kecheng Xu, Philipp Schwarzinger, Masashi Watanabe, Gerhard Breitenecker, Le Pivert Patrick
The aim of the study was to perform cryosurgery on a primary breast tumor, coupled with simultaneous peritumoral and intratumoral tracer injection of a blue dye, to evaluate lymphatic mapping. We explored the ability of our strategy to prevent tumor cells, but not that of injected tracers, to migrate to the lymphovascular drainage during conventional resection of frozen breast malignancies. Seventeen patients aged 51 (14) years (mean [standard deviation]), presenting primary breast cancer with stage I to IV, were randomly selected and treated in The Rudolfinerhaus Private Clinic in Vienna, Austria, and included in this preliminary clinical study...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29317042/optimizing-success-and-avoiding-mishaps-in-the-most-difficult-image-guided-breast-biopsies
#7
Sughra Raza, Sona A Chikarmane, Eva C Gombos, Dianne Georgian-Smith, Elisabeth P Frost
Breast cancer is an increasing challenge in developed and limited resource areas of the world. Early detection of breast cancer offers the best chance for optimal care and best outcomes. A critical step in early detection is to obtain efficient and accurate tissue diagnoses. Although image-guided core needle breast biopsies are usually straightforward for experienced breast imagers, there are some not uncommon scenarios that present particular challenges. In this review article we will discuss these difficult situations and offer our tried and true methods to ensure safe and successful biopsies, while using stereotactic, ultrasound, and MRI guidance...
February 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29302488/oncoplastic-breast-conserving-surgery-with-tailored-needle-guided-excision
#8
Fernando Hernanz, Mónica González-Noriega, Sonia Sánchez, Lucia Paz, Pedro Muñoz, Sandra Hermana
Background: Breast conserving surgery (BCS) administered with oncoplastic approach (OBCS), when it is required, is currently the gold standard for the treatment of early breast cancer. Wire-guided localization (WL) is the most popular technique used to help surgeon in breast cancer excision. Currently, a universal and undeniable goal is to minimize the rate of positive margins and re-excision operation after BCS improving cosmetic outcome and decreasing health care costs. This study is aimed to report our experience combining OBCS and tailored WL as surgical approach for early breast cancers...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29298305/response-monitoring-of-breast-cancer-patients-receiving-neoadjuvant-chemotherapy-using-quantitative-ultrasound-texture-and-molecular-features
#9
Lakshmanan Sannachi, Mehrdad Gangeh, Hadi Tadayyon, Ali Sadeghi-Naini, Sonal Gandhi, Frances C Wright, Elzbieta Slodkowska, Belinda Curpen, William Tran, Gregory J Czarnota
BACKGROUND: Pathological response of breast cancer to chemotherapy is a prognostic indicator for long-term disease free and overall survival. Responses of locally advanced breast cancer in the neoadjuvant chemotherapy (NAC) settings are often variable, and the prediction of response is imperfect. The purpose of this study was to detect primary tumor responses early after the start of neoadjuvant chemotherapy using quantitative ultrasound (QUS), textural analysis and molecular features in patients with locally advanced breast cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29208778/comparison-of-the-ultrasound-guided-tru-cut-biopsy-with-postoperative-histopathology-results-in-patients-with-breast-mass
#10
Mehmet Emin Gunes
AIM: We aimed to compare the tru-cut biopsy and postoperative pathology results of breast lesions with suspicion of malignancy. Furthermore we aimed to determine the efficacy, specificity and sensitivity of the tru-cut biopsy. METHODOLOGY: 140 patients who were operated due to breast mass following tru-cut biopsy were retrospectively evalu-ated. Patients' demographic characteristics, imaging findings, biopsy and histopathology results were compared. RESULTS: The mean age of 140 patients was 51...
November 29, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29204254/gastric-metastasis-from-ovarian-adenocarcinoma-presenting-as-a-subepithelial-tumor-and-diagnosed-by-endoscopic-ultrasound-guided-tissue-acquisition
#11
Filippo Antonini, Liboria Laterza, Lorenzo Fuccio, Massimo Marcellini, Lucia Angelelli, Sonia Calcina, Corrado Rubini, Giampiero Macarri
We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor (SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy (EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features...
November 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29148091/intrinsic-subtypes-of-breast-cancers-initially-assessed-as-probably-benign-or-of-low-suspicion-on-ultrasonography-differ-according-to-tumor-size
#12
Jieun Koh, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Eun-Kyung Kim
OBJECTIVES: To investigate whether the intrinsic subtypes of breast cancers initially assessed as American College of Radiology Breast Imaging and Reporting System (BI-RADS) category 3 or 4a differ according to tumor size. METHODS: A total of 444 breast cancers in 439 patients initially assessed as BI-RADS 3 or 4a through ultrasound-guided core needle biopsy were included. Tumors were classified by the size criterion of 10 mm or smaller or larger than 10 mm and categorized as the luminal type (estrogen receptor [ER] positive and/or progesterone receptor [PR] positive and human epidermal growth factor receptor 2 [HER2] negative), HER2 type (HER2 positive regardless of ER or PR status), or triple-negative type (ER negative, PR negative, and HER2 negative)...
November 17, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29119620/identification-of-oestrogen-progesterone-receptor-and-human-epidermal-growth-factor-receptor-2-expression-in-mediastinal-metastases-of-breast-cancer-obtained-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#13
P Serra, J Sanz-Santos, E Castellà, B Cirauqui, F Andreo, M Llatjós, M Avila, M Margelí, L Serrano, C Centeno, V Quiroga, M Torky, J Ruiz-Manzano
BACKGROUND: In breast cancer patients, the expression statuses of oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are crucial in the choice of treatment. Receptor expression in metastatic lesions can differ from the primary tumour. The aim of our study was to analyse the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to obtain samples allowing the identification of ER, PR and HER2 expression in patients with mediastinal metastases of breast cancer...
November 9, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29100673/flat-epithelial-atypia-upgrade-rates-and-risk-stratification-approach-to-support-informed-decision-making
#14
Leslie R Lamb, Manisha Bahl, Michele A Gadd, Constance D Lehman
BACKGROUND: Our aim was to determine upgrade rates of pure flat epithelial atypia (FEA) to malignancy and higher-risk lesions and to identify patients with FEA at low risk for upgrade. STUDY DESIGN: Medical chart review from 2007 to 2016 identified 208 consecutive patients with pure FEA diagnosed by image-guided core needle biopsy who underwent surgical excision (96.2% [200 of 208]) or had at least 2 years of imaging follow-up (3.8% [8 of 208]). Medical records were reviewed for risk factors and surgical outcomes...
September 27, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29070987/results-of-short-term-follow-up-in-bi-rads-3-and-4a-breast-lesions-with-a-histological-diagnosis-of-fibroadenoma-at-percutaneous-needle-biopsy
#15
Paola Clauser, Massimo Bazzocchi, Magda Marcon, Viviana Londero, Chiara Zuiani
OBJECTIVE: To evaluate the usefulness of short-term (6 months) follow-up in patients with Breast Imaging Report and Data System (BI-RADS) 3 and 4a lesions, after a diagnosis of fibroadenoma at an image-guided biopsy. PATIENTS AND METHODS: The data of 318 women with 349 biopsy-proven fibroadenomas, a 6-month follow-up, and a follow-up of ≥ 24 months were retrospectively reviewed. Information on clinical history, lesion characteristics on ultrasound (US), mammography, and magnetic resonance imaging (MRI), BI-RADS classification, and follow-up was collected...
September 2017: Breast Care
https://www.readbyqxmd.com/read/29063297/pre-operative-axillary-ultrasound-guided-needle-sampling-in-breast-cancer-comparing-the-sensitivity-of-fine-needle-aspiration-cytology-and-core-needle-biopsy
#16
Ashley R Topps, Simon P Barr, Panagiotis Pikoulas, Susan A Pritchard, Anthony J Maxwell
BACKGROUND: Pre-operative ultrasound-guided needle sampling (UNS) of abnormal axillary lymph nodes in breast cancer can identify patients with axillary metastases and therefore rationalize patient care and inform decision-making. To obtain tissue diagnosis, UNS can be performed by either fine needle aspiration (FNA) or core needle biopsy (CNB). However, few studies have compared the sensitivity of these techniques and the majority show no difference. METHODS: All node-positive patients (those with micro- and macrometastases but not isolated tumor cells) treated at a tertiary referral center between January 2012 and December 2015 were retrospectively identified from pathology records...
October 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29039725/high-risk-breast-lesions-a-machine-learning-model-to-predict-pathologic-upgrade-and-reduce-unnecessary-surgical-excision
#17
Manisha Bahl, Regina Barzilay, Adam B Yedidia, Nicholas J Locascio, Lili Yu, Constance D Lehman
Purpose To develop a machine learning model that allows high-risk breast lesions (HRLs) diagnosed with image-guided needle biopsy that require surgical excision to be distinguished from HRLs that are at low risk for upgrade to cancer at surgery and thus could be surveilled. Materials and Methods Consecutive patients with biopsy-proven HRLs who underwent surgery or at least 2 years of imaging follow-up from June 2006 to April 2015 were identified. A random forest machine learning model was developed to identify HRLs at low risk for upgrade to cancer...
October 17, 2017: Radiology
https://www.readbyqxmd.com/read/28970857/follow-up-outcomes-of-benign-pathology-initially-assigned-as-breast-imaging-reporting-and-data-system-category-4a-and-3
#18
Ji Young You, Hee Jung Suh, Yunju Kim, Jae Kwan Jun, Haydee Ojeda-Fournier, Kyounglan Ko
PURPOSE: This retrospective study investigated if the initially assigned category 4A or 3 in concordant benign lesions, after ultrasound (US)-guided core needle biopsy, could affect follow-up compliance. METHODS: Eight hundred thirty-eight concordant benign lesions, after core needle biopsy (674, initial category 4A group and 164, category 3 group) and follow-up US, were included in our study. If an immediate surgical excision-a surgical excision before the next follow-up-exists, those cases with pathologic reports were collected...
September 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28937373/radiological-tests-versus-pathological-diagnostics-complimentary-or-antagonistic-relationship-the-experience-of-a-tertiary-hospital
#19
Maria A Arafah, Hala M Kfoury
INTRODUCTION: Early detection of breast cancer plays a pivotal role in the outcome of the disease. Diagnostic modalities encompass radiological and pathological findings. The aim of this study is to evaluate the correlation between the results of these two modalities in a tertiary hospital. MATERIALS AND METHODS: From a total of 180 patients, 203 ultrasound-guided breast core needle biopsies (US-CNBs) were included in this study over a period of a year (May 2015 - May 2016)...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28919032/the-role-of-preoperative-axillary-ultrasound-and-fine-needle-aspiration-cytology-in-identifying-patients-with-extensive-axillary-lymph-node-involvement
#20
Robert Maráz, Tamás Zombori, Éva Ambrózay, Gábor Cserni
INTRODUCTION: In the recent past, both clinically node-positive and node-negative but sentinel node-positive patients underwent axillary lymph node dissection (ALND), although the two groups seem to have substantially different degree of nodal involvement. METHODS: Data on consecutive primary breast cancer patients with documented axillary ultrasound (AXUS) results who underwent ALND between January 2003 and December 2015 either because of AXUS-guided fine needle aspiration (A-FNAC) results or because of a positive sentinel lymph node were retrospectively analysed...
August 30, 2017: European Journal of Surgical Oncology
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