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https://www.readbyqxmd.com/read/28343106/a-structure-based-plasma-protein-pre-fractionation-using-conjoint-immobilized-metal-chelate-affinity-ima-system
#1
Karan Karkra, Kishore K R Tetala, M A Vijayalakshmi
The potential of immobilized metal/chelate affinity (IMA) in a continuous fashion, referred as conjoint approach, to pre-fractionate plasma proteins (in their native state) prior to LC-MS analysis was investigated in this study. Four transition metal-ions (Co (II), Zn (II), Ni (II) and Cu (II)) were individually chelated with IDA (iminodiacetic acid) coated CIM (Convective Interaction Media) disks and placed in a single housing in the following sequential order: IDA-Co (II)→IDA-Zn (II)→IDA-Ni (II)→IDA-Cu (II)...
March 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28340526/an-experimental-study-on-flow-and-heat-transfer-characteristics-of-ethanol-polyalphaolefin-nanoemulsion-flowing-through-circular-minichannels
#2
Vu Trinh, Jiajun Xu
This work experimentally studied the convective flow and heat transfer characteristics of a novel nanostructured heat transfer fluid: "ethanol/polyalphaolefin nanoemulsion" flowing through 12 circular minichannels of 1-mm diameter each. Ethanol/polyalphaolefin nanoemulsion is a thermodynamically stable system formed by dispersing ethanol into a mixture of "polyalphaolefin (PAO)" and surfactants. In this study, ethanol/PAO nanoemulsion is used as the working fluid to study the effect of ethanol nanodroplets on its convective flow and heat transfer characteristics...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28339826/the-importance-of-considering-competing-treatment-affecting-prognosis-in-the-evaluation-of-therapy-in-trials-the-example-of-renal-transplantation-in-hemodialysis-trials
#3
C Marijn Hazelbag, Sanne A E Peters, Peter J Blankestijn, Michiel L Bots, Bernard Canaud, Andrew Davenport, Muriel P C Grooteman, Fatih Kircelli, Francesco Locatelli, Francisco Maduell, Marion Morena, Menso J Nubé, Ercan Ok, Ferran Torres, Arno W Hoes, Rolf H H Groenwold
Background.: During the follow-up in a randomized controlled trial (RCT), participants may receive additional (non-randomly allocated) treatment that affects the outcome. Typically such additional treatment is not taken into account in evaluation of the results. Two pivotal trials of the effects of hemodiafiltration (HDF) versus hemodialysis (HD) on mortality in patients with end-stage renal disease reported differing results. We set out to evaluate to what extent methods to take other treatments (i...
February 27, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28337767/impact-of-drying-and-micronization-on-the-physico-chemical-properties-and-antioxidant-activities-of-celery-stalk
#4
Karna Ramachandraiah, Koo Bok Chin
BACKGROUND: The influence of convective drying and ball-mill treatment of celery stalk on particle size distribution, physicochemical properties, bioactive compounds and antioxidant activities were analyzed in this study. RESULTS: Ball-milling of celery stalk dried at the temperatures of 50, 75 and 100 °C resulted in decreasing average particle sizes of 48.8, 10.5 and 7.2 µm, respectively. Bulk density was increased with reduced particle size. Darker (L*) and reddish (a*) powders were formed at higher temperatures while ball-milling increased greenness (-a*) of powders dried at 50 and 75 °C...
March 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28337716/long-term-variation-of-serum-levels-of-uremic-toxins-in-patients-treated-by-post-dilution-high-volume-on-line-hemodiafiltration-in-comparison-to-standard-low-flux-bicarbonate-dialysis-results-from-the-redert-study
#5
Vincenzo Panichi, Maria Teresa Rocchetti, Alessia Scatena, Alberto Rosati, Massimiliano Migliori, Francesco Pizzarelli, Loreto Gesualdo
PURPOSE OF THE STUDY: Little information have been provided till now regarding the effect of high volume HDF (hv-OL-HDF) in respect to standard bicarbonate dialysis (BHD) in medium-long term protein-bound toxins removal. PROCEDURES: A randomised cross-over multicentre study (REDERT study) was designed to compare the effects of hv-OL-HDF and low-flux BHD on uremic toxins serum levels in 36 chronic dialysis patients followed for 13 months. Group 1 patients were treated with BHD (Treatment A) for 6 months, and afterwards, they were transferred to hv-OL-HDF for a further 6 months (Treatment B)...
March 24, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28325927/temperature-fluctuations-in-a-changing-climate-an-ensemble-based-experimental-approach
#6
Miklós Vincze, Ion Dan Borcia, Uwe Harlander
There is an ongoing debate in the literature about whether the present global warming is increasing local and global temperature variability. The central methodological issues of this debate relate to the proper treatment of normalised temperature anomalies and trends in the studied time series which may be difficult to separate from time-evolving fluctuations. Some argue that temperature variability is indeed increasing globally, whereas others conclude it is decreasing or remains practically unchanged. Meanwhile, a consensus appears to emerge that local variability in certain regions (e...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325440/mixed-convection-peristaltic-motion-of-copper-water-nanomaterial-with-velocity-slip-effects-in-a-curved-channel
#7
T Hayat, S Farooq, A Alsaedi
BACKGROUND AND OBJECTIVE: The primary objective of present analysis is to model the peristalsis of copper-water based nanoliquid in the presence of first order velocity and thermal slip conditions in a curved channel. Mixed convection, viscous dissipation and heat generation/absorption are also accounted. METHOD: Mathematical formulation is simplified under the assumption of small Reynolds number and large wavelength. Regular perturbation technique is employed to find the solution of the resulting equations in terms of series for small Brinkman number...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28324690/e-coli-interactions-adhesion-and-transport-in-alumino-silica-clays
#8
Houzhen Wei, Guang Yang, Boya Wang, Runwei Li, Gang Chen, Zhenze Li
Bacterial adhesion and transport in the geological formation are controlled by their mutual complex interactions, which have been quantified by the traditional and extended Derjaguin-Landau-Verwey-Overbeek (DLVO) theory as well as direct atomic force microscopy (AFM) measurements. In this research, the DLVO forces calculated based on the independently determined bacterial and porous media surface thermodynamic properties were compared with those of AFM measurements. Although differences in the order of several magnitudes existed, forces obtained from both ways could explain the observations of E...
March 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28324641/preparation-of-a-non-woven-poly-%C3%AE%C2%B5-caprolactone-fabric-with-partially-embedded-apatite-surface-for-bone-tissue-engineering-applications-by-partial-surface-melting-of-poly-%C3%AE%C2%B5-caprolactone-fibers
#9
In Ae Kim, Sang-Hoon Rhee
This paper describes a novel method for the preparation of a biodegradable non-woven poly(ε-caprolactone) fabric with a partially-embedded apatite surface designed for application as a scaffold material for bone tissue engineering. The non-woven poly(ε-caprolactone) fabric was generated by the electro-spinning technique and then apatite was coated in simulated body fluid after coating the PVA solution containing CaCl2 ·2H2 O. The apatite crystals were partially- or fully-embedded into the thermoplastic poly(ε-caprolactone) fibers by controlling the degree of poly(ε-caprolactone) fiber surface melting in a convection oven...
March 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28319082/passive-phloem-loading-and-long-distance-transport-in-a-synthetic-tree-on-a-chip
#10
Jean Comtet, Kaare H Jensen, Robert Turgeon, Abraham D Stroock, A E Hosoi
Vascular plants rely on differences in osmotic pressure to export sugars from regions of synthesis (mature leaves) to sugar sinks (roots, fruits). In this process, known as Münch pressure flow, the loading of sugars from photosynthetic cells to the export conduit (the phloem) is crucial, as it sets the pressure head necessary to power long-distance transport. Whereas most herbaceous plants use active mechanisms to increase phloem sugar concentration above that of the photosynthetic cells, in most tree species, for which transport distances are largest, loading seems, counterintuitively, to occur by means of passive symplastic diffusion from the mesophyll to the phloem...
March 20, 2017: Nature Plants
https://www.readbyqxmd.com/read/28318624/treatment-tolerance-and-patient-reported-outcomes-favor-online-hemodiafiltration-compared-to-high-flux-hemodialysis-in-the-elderly
#11
Marion Morena, Audrey Jaussent, Lotfi Chalabi, Hélène Leray-Moragues, Leila Chenine, Alain Debure, Damien Thibaudin, Lynda Azzouz, Laure Patrier, Francois Maurice, Philippe Nicoud, Claude Durand, Bruno Seigneuric, Anne-Marie Dupuy, Marie-Christine Picot, Jean-Paul Cristol, Bernard Canaud
Large cohort studies suggest that high convective volumes associated with online hemodiafiltration may reduce the risk of mortality/morbidity compared to optimal high-flux hemodialysis. By contrast, intradialytic tolerance is not well studied. The aim of the FRENCHIE (French Convective versus Hemodialysis in Elderly) study was to compare high-flux hemodialysis and online hemodiafiltration in terms of intradialytic tolerance. In this prospective, open-label randomized controlled trial, 381 elderly chronic hemodialysis patients (over age 65) were randomly assigned in a one-to-one ratio to either high-flux hemodialysis or online hemodiafiltration...
March 15, 2017: Kidney International
https://www.readbyqxmd.com/read/28317083/numerical-simulation-of-reactive-extraction-of-benzoic-acid-from-wastewater-via-membrane-contactors
#12
Mehdi Ghadiri, Saeed Shirazian
Membrane-based non-dispersive solvent extraction is used in many chemical processes due to its significant benefits such as straightforward scale-up and low energy consumption. A mechanistic model was developed to predict recovery of benzoic acid (BA) from wastewater using membrane contactors. Model equations were derived for benzoic acid transport in the membrane module, and solved using FEM. The model findings were compared with experimental results, and an average deviation of 4% was observed between experimental and simulation results...
March 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28315390/quantifying-the-dynamic-density-driven-convection-in-high-permeability-packed-beds
#13
Ying Teng, Lanlan Jiang, Yingting Fan, Yu Liu, Dayong Wang, Abuliti Abudula, Yongchen Song
The density driven convection phenomenon is expected to have a significant and positive role in CO2 geological storage capacity and safety. The onset and development of density-driven convective on the core scale is critical to understand the mass transfer mechanism. In this paper, laboratory experiments were conducted to investigate the density-driven convective in a vertical tube. The deuterium oxide (D2O)/manganese chloride (MnCl2) water solution in water or brine were as an analog for CO2-rich brine in original brine...
March 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28299724/convection-enhanced-delivery
#14
REVIEW
A M Mehta, A M Sonabend, J N Bruce
Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics directly through the interstitial spaces of the central nervous system. It addresses and offers solutions to many limitations of conventional techniques, allowing for delivery past the blood-brain barrier in a targeted and safe manner that can achieve therapeutic drug concentrations. CED is a broadly applicable technique that can be used to deliver a variety of therapeutic compounds for a diversity of diseases, including malignant gliomas, Parkinson's disease, and Alzheimer's disease...
March 15, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28299470/onset-and-non-linear-regimes-of-soret-induced-convection-in-binary-mixtures-heated-from-above
#15
T Lyubimova, N Zubova, V Shevtsova
The paper deals with the investigation of the onset and non-linear regimes of convection of liquid binary mixtures with negative Soret effect heated from above. The linear stability of a convectionless state in a horizontal layer is studied by the numerical solution of the linearized problem on the temporal evolution of small perturbations of the unsteady base state. Non-linear regimes of convection are investigated by the numerical solution of the non-linear unsteady equations for a horizontally elongated rectangular cavity...
March 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28297919/scaling-of-velocity-and-scalar-structure-functions-in-ac-electrokinetic-turbulence
#16
Wei Zhao, Guiren Wang
Electrokinetic (EK) turbulence or electrohydrodynamic (EHD) turbulence has been recently achieved in different fluids under both ac [G. Wang et al., Lab Chip 14, 1452 (2014)10.1039/C3LC51403J; Phys. Rev. E 93, 013106 (2016)10.1103/PhysRevE.93.013106] and dc electric fields [A. Varshney et al., Soft Matter 12, 1759 (2016)10.1039/C5SM02316E]. Here, through dimensional analysis, scaling laws of both velocity and electric conductivity structure functions in the forced cascade region of ac EK turbulence can be predicated (similar to Bolgiano-Obukhov scaling law in turbulent Rayleigh-Bénard convection), in either macroscale or microscale flows...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28294186/a-scientific-report-on-heat-transfer-analysis-in-mixed-convection-flow-of-maxwell-fluid-over-an-oscillating-vertical-plate
#17
Ilyas Khan, Nehad Ali Shah, L C C Dennis
This scientific report investigates the heat transfer analysis in mixed convection flow of Maxwell fluid over an oscillating vertical plate with constant wall temperature. The problem is modelled in terms of coupled partial differential equations with initial and boundary conditions. Some suitable non-dimensional variables are introduced in order to transform the governing problem into dimensionless form. The resulting problem is solved via Laplace transform method and exact solutions for velocity, shear stress and temperature are obtained...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28292763/oxygen-delivery-and-the-restoration-of-the-muscle-energetic-balance-following-exercise-implications-for-delayed-muscle-recovery-in-patients-with-copd
#18
Gwenael Layec, Corey R Hart, Joel D Trinity, Oh-Sung Kwon, Matthew J Rossman, Ryan M Broxterman, Yann Le Fur, Eun-Kee Jeong, Russell S Richardson
Patients with chronic obstructive pulmonary disease (COPD) experience a delayed recovery from skeletal muscle fatigue following exhaustive exercise that likely contributes to their progressive loss of mobility. As this phenomenon is not well understood, this study sought to examine post-exercise peripheral oxygen (O2) transport and muscle metabolism dynamics in patients with COPD, two important determinants of muscle recovery. Twenty four subjects, 12 non-hypoxemic patients with COPD and 12 healthy subjects with a sedentary lifestyle, performed dynamic plantar flexion exercise at 40% of maximal work rate (WRmax) with phosphorus magnetic resonance spectroscopy ((31)P-MRS), near-infrared spectroscopy (NIRS), and vascular Doppler ultrasound assessments...
March 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28292516/speedy-standing-wave-design-optimization-and-scaling-rules-of-simulated-moving-bed-systems-with-linear-isotherms
#19
George S Weeden, Nien-Hwa Linda Wang
Simulated Moving Bed (SMB) systems with linear adsorption isotherms have been used for many different separations, including large-scale sugar separations. While SMBs are much more efficient than batch operations, they are not widely used for large-scale production because there are two key barriers. The methods for design, optimization, and scale-up are complex for non-ideal systems. The Speedy Standing Wave Design (SSWD) is developed here to reduce these barriers. The productivity (PR) and the solvent efficiency (F/D) are explicitly related to seven material properties and 13 design parameters...
February 22, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28291783/oesophageal-heat-exchangers-with-a-diameter-of-11mm-or-14-7mm-are-equally-effective-and-safe-for-targeted-temperature-management
#20
Daniel C Schroeder, Maria Guschlbauer, Alexandra C Maul, Daniel A Cremer, Ingrid Becker, David de la Puente Bethencourt, Peter Paal, Stephan A Padosch, Wolfgang A Wetsch, Thorsten Annecke, Bernd W Böttiger, Anja Sterner-Kock, Holger Herff
BACKGROUND: Targeted temperature management (TTM) is widely used in critical care settings for conditions including hepatic encephalopathy, hypoxic ischemic encephalopathy, meningitis, myocardial infarction, paediatric cardiac arrest, spinal cord injury, traumatic brain injury, ischemic stroke and sepsis. Furthermore, TTM is a key treatment for patients after out-of-hospital cardiac-arrest (OHCA). However, the optimal cooling method, which is quick, safe and cost-effective still remains controversial...
2017: PloS One
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