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https://www.readbyqxmd.com/read/27931262/glymphatic-distribution-of-csf-derived-apoe-into-brain-is-isoform-specific-and-suppressed-during-sleep-deprivation
#1
Thiyagaragan M Achariyar, Baoman Li, Weiguo Peng, Philip B Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takana, David M Holtzman, Maiken Nedergaard, Rashid Deane
BACKGROUND: Apolipoprotein E (apoE) is a major carrier of cholesterol and essential for synaptic plasticity. In brain, it's expressed by many cells but highly expressed by the choroid plexus and the predominant apolipoprotein in cerebrospinal fluid (CSF). The role of apoE in the CSF is unclear. Recently, the glymphatic system was described as a clearance system whereby CSF and ISF (interstitial fluid) is exchanged via the peri-arterial space and convective flow of ISF clearance is mediated by aquaporin 4 (AQP4), a water channel...
December 8, 2016: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/27929097/aerosol-effect-on-the-evolution-of-the-thermodynamic-properties-of-warm-convective-cloud-fields
#2
Guy Dagan, Ilan Koren, Orit Altaratz, Reuven H Heiblum
Convective cloud formation and evolution strongly depend on environmental temperature and humidity profiles. The forming clouds change the profiles that created them by redistributing heat and moisture. Here we show that the evolution of the field's thermodynamic properties depends heavily on the concentration of aerosol, liquid or solid particles suspended in the atmosphere. Under polluted conditions, rain formation is suppressed and the non-precipitating clouds act to warm the lower part of the cloudy layer (where there is net condensation) and cool and moisten the upper part of the cloudy layer (where there is net evaporation), thereby destabilizing the layer...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929055/in-situ-size-sorting-in-cvd-synthesis-of-si-microspheres
#3
M Garín, R Fenollosa, L Kowalski
Silicon microspheres produced in gas-phase by hot-wall CVD offer unique quality in terms of sphericity, surface smoothness, and size. However, the spheres produced are polydisperse in size, which typically range from 0.5 μm to 5 μm. In this work we show through experiments and calculations that thermophoretic forces arising from strong temperature gradients inside the reactor volume effectively sort the particles in size along the reactor. These temperature gradients are shown to be produced by a convective gas flow...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27925736/electron-cooling-in-a-magnetically-expanding-plasma
#4
J M Little, E Y Choueiri
Electron cooling in a magnetically expanding plasma, which is a fundamental process for plasma flow and detachment in magnetic nozzles, is experimentally investigated using a radio frequency plasma source and magnetic nozzle (MN). Probe measurements of the plasma density, potential, and electron temperature along the center line of the MN indicate that the expansion follows a polytropic law with exponent γ_{e}=1.15±0.03. This value contradicts isothermal electron expansion, γ_{e}=1, which is commonly assumed in MN models...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925434/thermo-driven-evaporation-self-assembly-and-dynamic-analysis-of-homocentric-carbon-nanotube-rings
#5
Hu Li, Han Ouyang, Min Yu, Nan Wu, Xinxin Wang, Wen Jiang, Zhuo Liu, Jingjing Tian, Yiming Jin, Hongqin Feng, Yubo Fan, Zhou Li
MWCNTs self-assemble into various homocentric rings in a thermo-driven self-assembly system. Closely packed and scatteredly packed MWCNT rings self-assemble on a Si-SiO2 substrate, whereas on a Au substrate smoothly packed MWCNT rings, rings with waviness, and rings with shuttle-like holes are seen to self-assemble. The dynamic self-assembly process includes convection flow and swirling flow.
December 7, 2016: Small
https://www.readbyqxmd.com/read/27924163/highly-effective-auger-electron-therapy-in-an-orthotopic-glioblastoma-xenograft-model-using-convection-enhanced-delivery
#6
Helge Thisgaard, Bo Halle, Charlotte Aaberg-Jessen, Birgitte Brinkmann Olsen, Anne Sofie Nautrup Therkelsen, Johan Hygum Dam, Niels Langkjær, Sune Munthe, Kjell Någren, Poul Flemming Høilund-Carlsen, Bjarne Winther Kristensen
Glioblastoma, the most common and malignant primary brain tumor, always recurs after standard treatment. Therefore, promising new therapeutic approaches are needed. Short-range Auger-electron-emitters carry the ability of causing highly damaging radiation effects in cells. The aim of this study was to test the effect of [(125)I]5-Iodo-2'-deoxyuridine ((125)I-UdR, a radioactive Auger-electron-emitting thymidine analogue) Auger-therapy on immature glioblastoma spheroid cultures and orthotopic xenografted glioblastoma-bearing rats, the latter by means of convection-enhanced delivery (CED)...
2016: Theranostics
https://www.readbyqxmd.com/read/27921304/hyperthermia-thermal-injuries-and-death-from-a-forced-convection-heat-source-a-case-report-and-experimental-model
#7
Amanda O Fisher-Hubbard, LokMan Sung, Sean A Hubbard, Leigh Hlavaty
Heat-related deaths of children are most often encountered in the context of enclosed vehicles in summer months. Deviating from this, a 16-month-old boy was found unresponsive in a stroller that was placed adjacent to a space heater during mid-winter. The cause of death was hyperthermia and thermal injuries. Manner of death determination was difficult due to alleged surrounding circumstances. To understand the time-course of this child's injuries, a child death scene investigation was performed; the stroller and space heater were recovered...
December 6, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27921289/slip-driven-electroosmotic-transport-through-porous-media
#8
Harshad Gaikwad, Pranab Kumar Mondal
We investigate the slip driven transport of a Newtonian fluid through porous media under electrical double layer effect. We employ a semi-analytical framework to obtain the underlying electro-hydrodynamics for different configurations of porous media. We bring out an alteration in flow dynamics, stemming from interplay among the geometrical feature of the models and the interfacial slip as modulated by the electrical forcing. Further, we show the consequent effects of the underlying flow dynamics on the volumetric transport rate through different models...
December 6, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27921285/spatiotemporal-distribution-modeling-of-pet-tracer-uptake-in-solid-tumors
#9
Madjid Soltani, Mostafa Sefidgar, Hossein Bazmara, Michael E Casey, Rathan M Subramaniam, Richard L Wahl, Arman Rahmim
OBJECTIVE: Distribution of PET tracer uptake is elaborately modeled via a general equation used for solute transport modeling. This model can be used to incorporate various transport parameters of a solid tumor such as hydraulic conductivity of the microvessel wall, transvascular permeability as well as interstitial space parameters. This is especially significant because tracer delivery and drug delivery to solid tumors are determined by similar underlying tumor transport phenomena, and quantifying the former can enable enhanced prediction of the latter...
December 5, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27921028/two-year-results-after-convective-radiofrequency-water-vapor-thermal-therapy-of-symptomatic-benign-prostatic-hyperplasia
#10
Christopher M Dixon, Edwin Rijo Cedano, Dalibor Pacik, Vítězslav Vit, Gabriel Varga, Lennart Wagrell, Thayne R Larson, Lance A Mynderse
OBJECTIVE: The objective of this study was to assess the effectiveness and safety of convective radiofrequency (RF) water vapor thermal therapy in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH); a pilot study design with 2-year follow-up evaluations. PATIENTS AND METHODS: Men aged ≥45 years with an International Prostate Symptom Score ≥13, a maximum urinary flow rate (Qmax) ≤15 mL/s, and prostate volume 20-120 cc were enrolled in a prospective, open-label pilot study using convective RF water vapor energy with the Rezūm System...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27918023/reactive-convective-dissolution-in-a-porous-medium-the-storage-of-carbon-dioxide-in-saline-aquifers
#11
Parama Ghoshal, Min Chan Kim, Silvana S S Cardoso
We quantify the destabilising effect of a first-order chemical reaction on the fingering instability of a diffusive boundary layer in a porous medium. Using scaling, we show that the dynamics of such a reactive boundary layer is fully determined by two dimensionless groups: Da/Ra(2), which measures the timescale for convection compared to those for reaction and diffusion; and βC/βA, which reflects the density change induced by the product relative to that of the diffusing solute. Linear stability and numerical results for βC/βA in the range 0-10 and Da/Ra(2) in the range 0-0...
December 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27917861/submillimetre-network-formation-by-light-induced-hybridization-of-zeptomole-level-dna
#12
Takuya Iida, Yushi Nishimura, Mamoru Tamura, Keisuke Nishida, Syoji Ito, Shiho Tokonami
Macroscopic unique self-assembled structures are produced via double-stranded DNA formation (hybridization) as a specific binding essential in biological systems. However, a large amount of complementary DNA molecules are usually required to form an optically observable structure via natural hybridization, and the detection of small amounts of DNA less than femtomole requires complex and time-consuming procedures. Here, we demonstrate the laser-induced acceleration of hybridization between zeptomole-level DNA and DNA-modified nanoparticles (NPs), resulting in the assembly of a submillimetre network-like structure at the desired position with a dramatic spectral modulation within several minutes...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913958/the-effect-of-mass-transfer-parameterization-and-ice-retention-on-the-scavenging-and-redistribution-of-so2-by-a-deep-convective-cloud
#13
Vladan Vučković, Dragana Vujović
A chemistry module with the aqueous chemistry coupled with the complex 3D nonhydrostatic atmospheric model is used to investigate how the representation of gas-aqueous mass transfer and ice retention affect the SO2 redistribution in the presence of a convective cloud. Gas uptake to the liquid water is calculated using both Henry's law equilibrium (HE) and kinetic mass transport (KMT). The constant retention coefficients for SO2 (k ret = 0.46) and for H2O2 (k ret = 0.64) are used. It is shown that the amount of SO2 in the air at higher altitudes (10-12 km) is greater when partial retention (PR) is included...
December 2, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27911802/aerosol-indirect-effect-from-turbulence-induced-broadening-of-cloud-droplet-size-distributions
#14
Kamal Kant Chandrakar, Will Cantrell, Kelken Chang, David Ciochetto, Dennis Niedermeier, Mikhail Ovchinnikov, Raymond A Shaw, Fan Yang
The influence of aerosol concentration on the cloud-droplet size distribution is investigated in a laboratory chamber that enables turbulent cloud formation through moist convection. The experiments allow steady-state microphysics to be achieved, with aerosol input balanced by cloud-droplet growth and fallout. As aerosol concentration is increased, the cloud-droplet mean diameter decreases, as expected, but the width of the size distribution also decreases sharply. The aerosol input allows for cloud generation in the limiting regimes of fast microphysics ([Formula: see text]) for high aerosol concentration, and slow microphysics ([Formula: see text]) for low aerosol concentration; here, [Formula: see text] is the phase-relaxation time and [Formula: see text] is the turbulence-correlation time...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27900374/spatially-resolved-microfluidic-stimulation-of-lymphoid-tissue-ex-vivo
#15
Ashley E Ross, Maura C Belanger, Jacob F Woodroof, Rebecca R Pompano
The lymph node is a structurally complex organ of the immune system, whose dynamic cellular arrangements are thought to control much of human health. Currently, no methods exist to precisely stimulate substructures within the lymph node or analyze local stimulus-response behaviors, making it difficult to rationally design therapies for inflammatory disease. Here we describe a novel integration of live lymph node slices with a microfluidic system for local stimulation. Slices maintained the cellular organization of the lymph node while making its core experimentally accessible...
November 30, 2016: Analyst
https://www.readbyqxmd.com/read/27898853/cookery-method-and-endpoint-temperature-can-affect-the-warner-bratzler-shear-force-cooking-loss-and-internal-cooked-color-of-beef-semimembranosus-and-infraspinatus-steaks
#16
J W S Yancey, J K Apple, M D Wharton
Steaks from USDA Select inside rounds (Exp. 1) and shoulder clods (Exp. 2) were used to test the interactive effect of cookery method and endpoint temperature on Warner-Bratzler shear force (WBSF) and internal cooked color. Pairs of 2.5-cm-thick semimembranosus (SM) or infraspinatus (INF) steaks ( = 360/muscle) were cut from each subprimal, labeled, vacuum packaged, and frozen at -30°C in the dark for approximately 60 d before being cooked to 65.5, 71.1, or 76.6°C using 1) a forced-air convection oven (FAC); 2) a forced-air impingement oven (IMP); 3) a gas-fired, open-hearth charbroiler (CHAR); 4) an electric countertop griddle (GRID); or 5) a clam-shell grill (CLAM)...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896789/mhd-natural-convection-flow-of-casson-nanofluid-over-nonlinearly-stretching-sheet-through-porous-medium-with-chemical-reaction-and-thermal-radiation
#17
Imran Ullah, Ilyas Khan, Sharidan Shafie
In the present work, the effects of chemical reaction on hydromagnetic natural convection flow of Casson nanofluid induced due to nonlinearly stretching sheet immersed in a porous medium under the influence of thermal radiation and convective boundary condition are performed numerically. Moreover, the effects of velocity slip at stretching sheet wall are also examined in this study. The highly nonlinear-coupled governing equations are converted to nonlinear ordinary differential equations via similarity transformations...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27893932/density-driven-free-convection-model-for-isotopically-fractionated-geogenic-nitrate-in-sabkha-brine
#18
Warren W Wood, J K Böhlke
Subsurface brines with high nitrate (NO3(-) ) concentration are common in desert environments as atmospheric nitrogen is concentrated by the evaporation of precipitation and little nitrogen uptake. However, in addition to having an elevated mean concentration of ∼525 mg/L (as N), NO3- in the coastal sabkhas of Abu Dhabi is enriched in (15) N (mean δ(15) N ∼17‰), which is an enigma. A NO3(-) solute mass balance analysis of the sabkha aquifer system suggests that more than 90% of the nitrogen is from local atmospheric deposition and the remainder from ascending brine...
November 28, 2016: Ground Water
https://www.readbyqxmd.com/read/27893186/the-relative-influence-of-hematocrit-and-red-blood-cell-velocity-on-oxygen-transport-from-capillaries-to-tissue
#19
Adrien Lücker, Timothy W Secomb, Bruno Weber, Patrick Jenny
OBJECTIVE: Oxygen transport to parenchymal cells occurs mainly at the microvascular level, and depends on convective red blood cell (RBC) flux, which is proportional in an individual capillary to the product of capillary hematocrit and red blood cell velocity. This study investigates the relative influence of these two factors on tissue oxygen partial pressure (PO2 ). METHODS: A simple analytical model is used to quantify the respective influences of hematocrit, RBC velocity and flow on tissue oxygenation around capillaries...
November 28, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27888924/triangular-node-for-transmission-line-modeling-tlm-applied-to-bio-heat-transfer
#20
Hugo F M Milan, Kifle G Gebremedhin
Transmission-Line Modeling (TLM) is a numerical method used to solve complex and time-domain bio-heat transfer problems. In TLM, rectangles are used to discretize two-dimensional problems. The drawback in using rectangular shapes is that instead of refining only the domain of interest, a large additional domain will also be refined in the x and y axes, which results in increased computational time and memory space. In this paper, we developed a triangular node for TLM applied to bio-heat transfer that does not have the drawback associated with the rectangular nodes...
December 2016: Journal of Thermal Biology
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