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https://www.readbyqxmd.com/read/27909636/imatinib-induced-ototoxicity-in-a-patient-with-gastrointestinal-stromal-tumor-gist
#1
Komal Wasif, Nawal Wasif, Muhammad W Saif
Imatinib (Gleevec) is a biological agent that is approved for the treatment of chronic myeloid leukemia (CML) as well as gastrointestinal stromal tumor (GIST). The most frequently seen adverse effects in patients treated with imatinib include superficial edema, muscle cramps, musculoskeletal pain, rash, fatigue, headache, abdominal pain, and joint pain. Ototoxicity has rarely been reported except in two cases. We report a case of bilateral irreversible sensorineural hearing loss (SNHL) caused by imatinib in a patient receiving this agent in the adjuvant setting...
October 26, 2016: Curēus
https://www.readbyqxmd.com/read/27908491/clinical-outcomes-of-botox-injections-for-chronic-temporomandibular-disorders-do-we-understand-how-botox-works-on-muscle-pain-and-the-brain
#2
S T Connelly, J Myung, R Gupta, G M Tartaglia, A Gizdulich, J Yang, R Silva
The main objective of this retrospective review was to analyze the clinical outcomes following the use of botulinum toxin (onabotulinumtoxinA, Botox) injections to relieve the symptoms of chronic temporomandibular disorders (TMD). Seventy-one patients with a diagnosis of TMD (according to the RDC/TMD international consortium) associated with or without bruxism and refractory to conventional treatment (e.g. oral appliances, physiotherapy, etc.) received Botox injections into the temporalis and masseter muscles...
November 28, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27904817/transitional-vertebra-and-spina-bifida-occulta-related-with-chronic-low-back-pain-in-a-young-patient
#3
Maryam Kundi, Maham Habib, Sumbal Babar, Asif K Kundi, Salman Assad, Amjad Sheikh
Bertolotti's syndrome (BS) must be considered as a differential diagnosis in a young patient presenting with low back pain (LBP). We present a case of a 26-year-old male complaining of mild chronic LBP for six years, radiating to his left thigh for the past six months. He has been taking non-steroidal anti-inflammatory drugs (NSAIDs) with skeletal muscle relaxants for pain relief. The X-ray and computed tomography (CT) imagings showed congenital enlargement of the left transverse process of the fifth lumbar (L5) vertebra forming pseudo-articulation with the sacrum and unilateral pars interarticularis defect at the L4 level on the left side, respectively...
October 19, 2016: Curēus
https://www.readbyqxmd.com/read/27896920/fusion-of-ssm6a-with-a-protein-scaffold-retains-selectivity-on-nav-1-7-and-improves-its-therapeutic-potential-against-chronic-pain
#4
Chuan Wang, Bin Shan, Qiong Wang, Qunyuan Xu, Hailin Zhang, Huimeng Lei
Voltage gated sodium channel NaV 1.7 serves an attractive target for chronic pain treatment. Several venom peptides were found to selectively inhibit NaV 1.7 but with intrinsic problems. Among them, Ssm6a, a recently discovered centipede venom peptide, shows the greatest selectivity against NaV 1.7, but dissociates from the target too fast and loses bioactivity in synthetic forms. As a disulfide-rich venom peptide, it is difficult to optimize Ssm6a by artificial mutagenesis and produce the peptide with common industrial manufacturing methods...
November 29, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27894876/long-term-functional-outcomes-after-primary-surgical-repair-of-acute-and-chronic-patellar-tendon-rupture-series-of-25%C3%A2-patients
#5
K Belhaj, H El Hyaoui, A Tahir, S Meftah, L Mahir, A Rafaoui, F Lmidmani, M Arsi, M Rahmi, M Rafai, A Garch, M Fadili, M Nechad, A El Fatimi
OBJECTIVE: We aimed to evaluate the clinical outcomes after surgical repair of patellar tendon rupture (PTR) and compare the evolution of 2 types of rupture (acute and chronic) after the same rehabilitation protocol. METHODS: This was a prospective cohort study of patients with PTR treated between January 2006 and January 2014 in the department of trauma surgery, Ibn Rochd university hospital, Casablanca. RESULTS: We evaluated 25 patients (21 men) after a median follow-up of 75 months (range 29-120)...
November 25, 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27889489/the-drug-candidate-adx71441-is-a-novel-potent-and-selective-positive-allosteric-modulator-of-the-gabab-receptor-with-a-potential-for-treatment-of-anxiety-pain-and-spasticity
#6
Mikhail Kalinichev, Françoise Girard, Hasnaà Haddouk, Mélanie Rouillier, Eric Riguet, Isabelle Royer-Urios, Vincent Mutel, Robert Lütjens, Sonia Poli
Positive allosteric modulation of the GABAB receptor is a promising alternative to direct activation of the receptor as a therapeutic approach for treatment of addiction, chronic pain, anxiety, epilepsy, autism, Fragile X syndrome, and psychosis. Here we describe in vitro and in vivo characterization of a novel, potent and selective GABAB positive allosteric modulator (PAM) N-(5-(4-(4-chloro-3-fluorobenzyl)-6-methoxy-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)-2-fluorophenyl)acetamide (ADX71441). In vitro, Schild plot and reversibility tests at the target confirmed PAM properties of the compound...
November 23, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27888852/medial-sided-ankle-pain-deltoid-ligament-and-beyond
#7
REVIEW
Julia Crim
Abnormalities of the medial ligaments and posterior tibial tendon can occur because of acute injury or chronic instability or malalignment. Medial ankle injuries may occur because of pronation or supination-external rotation injuries. Deltoid ligament injuries have a significant impact on lateral ankle instability but can be overlooked in patients with lateral ligament injuries. Posterior tibial tendon dysfunction is usually associated with spring ligament or flexor retinaculum injury. Tarsal tunnel syndrome, accessory flexor muscles, and subtalar coalition should be considered as well as ligament and tendon tears in differential diagnosis of chronic medial ankle pain...
February 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27888843/normal-variants-accessory-muscles-about-the-ankle
#8
REVIEW
Yvonne Cheung
Accessory muscles around the ankle are commonly encountered as incidental findings on cross-sectional imaging. Mostly asymptomatic, accessory muscles sometimes mimic mass lesions. They have been implicated as the cause of tarsal tunnel syndrome, impingement of surrounding structures, and chronic pain. Distinguishing these muscles can be challenging, because some travel along a similar path. This article describes these accessory muscles in detail, including their relationships to the aponeurosis of the lower leg...
February 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27885474/comparison-of-mri-defined-back-muscles-volume-between-patients-with-ankylosing-spondylitis-and-control-patients-with-chronic-back-pain-age-and-spinopelvic-alignment-matched-study
#9
Doo Hee Bok, Jihye Kim, Tae-Hwan Kim
PURPOSE: To compare MRI-defined back muscle volume between AS patients and age, and spinopelvic alignment matched control patients with chronic back pain. METHODS: 51 male patients with AS were enrolled. Age and spinopelvic alignment matched controls (male) were found among non-AS patients with chronic back pain. After matching procedure, fully matched controls were found in 31 of 51 AS patients (60.8%), who represent AS patients without deformity. However, matched controls were not found in 20 of 51 AS patients (39...
November 24, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27884690/conditioned-pain-modulation-and-pressure-pain-sensitivity-in-the-adult-danish-general-population-the-danfund-study
#10
S Skovbjerg, T Jørgensen, L Arendt-Nielsen, J F Ebstrup, T Carstensen, T Graven-Nielsen
: Increased pressure pain sensitivity and impaired descending pain control have been associated with chronic pain, but knowledge on the variability in the adult general population is lacking. Pressure pain thresholds (PPTs) and descending pain control as assessed by conditioning pain modulation (CPM) were recorded in a randomly selected sample (n=2199, 53% females) of the Danish adult general population aged 18-70 years. PPTs were recorded over the tibialis anterior muscle and the upper trapezius muscle...
November 21, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27875630/eosinophilic-fasciitis-with-subjacent-myositis
#11
Julia B Whitlock, Elliot L Dimberg, Duygu Selcen, Devon I Rubin
Introduction Eosinophilic fasciitis (EF) is a rare disorder that can present with muscle symptoms that mimic other neuromuscular diseases. Methods We report a 43-year-old woman with chronic muscle aches, tightness, and stiffness with hypertrophied, well-defined muscles despite physical inactivity, and thickened skin with reduced elasticity and discoloration. Results Except for mild peripheral eosinophilia, laboratory studies, including blood count, electrolytes, paraneoplastic panel, muscle enzymes, thyroid function, and serum protein electrophoresis were normal...
November 22, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27872005/the-role-of-pelvic-floor-muscles-in-male-sexual-dysfunction-and-pelvic-pain
#12
REVIEW
Deborah Cohen, Joshua Gonzalez, Irwin Goldstein
INTRODUCTION: Sexual function is essential to good health and well-being in men. The relationship between male sexual function, pelvic floor function, and pelvic pain is complex and only beginning to be appreciated. AIM: The objectives of the current review are to examine these complex relationships, and to demonstrate how pelvic floor physical therapy can potentially improve the treatment of various male sexual dysfunctions, including erectile dysfunction and dysfunction of ejaculation and orgasm...
January 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27866992/comorbidities-that-cause-pain-and-the-contributors-to-pain-in-individuals-with-chronic-obstructive-pulmonary-disease
#13
Yi-Wen Chen, Pat G Camp, Harvey O Coxson, Jeremy D Road, Jordan A Guenette, Michael A Hunt, W Darlene Reid
OBJECTIVE: To determine comorbidities that cause pain and the potential contributors to pain in individuals with COPD. DESIGN: Prospective cross-sectional survey study. SETTING: Pulmonary rehabilitation programs of six centers. PARTICIPANTS: A convenience sample of individuals with COPD who attended pulmonary rehabilitation programs (n=137). In total, 100 (73%) returned the survey packages. Of those responders, 96 (70%) participants were included in the analyses...
November 17, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27862166/association-between-temporomandibular-disorders-and-pain-in-other-regions-of-the-body
#14
Letícia Ladeira Bonato, Valquiria Quinelato, Patrícia Cataldo de Felipe Cordeiro, Eduardo Branco de Sousa, Ricardo Tesch, Priscila Ladeira Casado
: The pain from temporomandibular disorder (TMD) is often associated on physical symptoms of other chronic pain disorders and comorbidities, such as generalized muscle and joint pain. However, this association is not widely studied. OBJECTIVE: To evaluate the prevalence of comorbid pain in joints, specifically in the the knees, hips, ankles, shoulders, wrists and elbows, in individuals with and without TMD. MATERIALS AND METHOD: We evaluated 337 patients from a public hospital in the city of Rio de Janeiro, Brazil...
November 10, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27861839/widespread-pressure-pain-hypersensitivity-is-similar-in-women-with-frequent-episodic-and-chronic-tension-type-headache-a-blinded-case-control-study
#15
María Palacios Ceña, Matteo Castaldo, Kelun Wang, Paola Torelli, Paolo Pillastrini, César Fernández-de-Las-Peñas, Lars Arendt-Nielsen
OBJECTIVE: To investigate differences in widespread pressure pain hyperalgesia in the trigemino-cervical and extra-trigeminal (distant pain-free) regions in women with frequent episodic (FETTH) and chronic (CTTH) tension-type headache. BACKGROUND: It seems that people with tension-type headache exhibit central sensitization. No study has investigated differences between FETTH and CTTH in terms of widespread pressure pain hypersensitivity. METHODS: Forty-three women with FETTH, 42 with CTTH, and 45 women without headache diagnosis were recruited...
November 11, 2016: Headache
https://www.readbyqxmd.com/read/27854207/long-term-oral-dantrolene-improved-muscular-symptoms-in-a-malignant-hyperthermia-susceptible-individual
#16
Brian N Butala, Audry Kang, Jasmeen Guron, Barbara W Brandom
This case report describes a female with p.Lys4876Arg amino acid change in the ryanodine receptor type 1 (RYR1) and a sibling who died of malignant hyperthermia (MH) during anesthesia. After her diagnosis as MH susceptible, this patient was administered low-dose dantrolene daily for greater than 25 years for treatment of chronic muscle spasm and pain in her lower extremities and back limiting sleep. Her creatine phosphokinase (CPK) was as high as 2390 IU/L during labor and 900 IU at rest. With 25 mg dantrolene daily, muscle cramps were eliminated, and sleep was improved...
March 3, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27849460/a-narrative-review-of-the-prevalence-and-risk-factors-associated-with-development-of-knee-osteoarthritis-after-traumatic-unilateral-lower-limb-amputation
#17
Shawn Farrokhi, Brittney Mazzone, Adam Yoder, Kristina Grant, Marilynn Wyatt
INTRODUCTION: Young military Service Members with traumatic unilateral lower limb amputations may be at a high risk for developing knee osteoarthritis (OA). There is growing evidence for potential influence and predictive value of nonsystemic risk factors on development and progression of primary knee OA in older adults. Proposed factors include chronic knee pain, obesity, abnormal knee joint mechanics, muscle weakness, previous knee trauma, and altered physical activity level. However, there is limited information available regarding whether such nonsystemic risk factors could also be responsible for the increased risk of knee OA after traumatic, unilateral lower limb amputation in young military Service Members...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27847987/the-side-of-chronic-low-back-pain-matters-evidence-from-the-primary-motor-cortex-excitability-and-the-postural-adjustments-of-multifidi-muscles
#18
Hugo Massé-Alarie, Louis-David Beaulieu, Richard Preuss, Cyril Schneider
Hemispheric lateralization of pain processing was reported with overactivation of the right frontal lobe. Specifically in chronic low back pain (CLBP), functional changes in the left primary motor cortex (M1) with impaired anticipatory postural activation (APA) of trunk muscles have been observed. Given the connections between frontal and M1 areas for motor planning, it is hypothesized that the pain side could differently influence M1 function and APA of paravertebral multifidus (MF) muscles. This study aimed at testing whether people with right- versus left-sided CLBP showed different M1 excitability and APA...
November 15, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27836771/differential-activation-of-the-dorsal-neck-muscles-during-a-light-arm-elevation-task-in-patients-with-chronic-nonspecific-neck-pain-and-asymptomatic-controls-an-ultrasonographic-study
#19
Raziyeh Baghi, Leila Rahnama, Noureddin Karimi, Fereshte Goodarzi, Asghar Rezasoltani, Shapour Jaberzadeh
BACKGROUND: Disturbance in neck muscle function is a well-known complication of chronic nonspecific neck pain (CNNP). It is, however, unclear which muscles are more susceptible to functional impairment in patients with CNNP during upper limb tasks. OBJECTIVES: To compare ultrasonographic changes in dorsal neck muscles thickness in patients with CNNP and asymptomatic controls while they performed a light load upper-limb movement. DESIGN: Case control...
November 9, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27834407/-painful-temporomandibular-dysfunctions-diagnosis-and-treatment
#20
F Lobbezoo, G Aarab, W Knibbe, M Koutris, C J Warnsinck, P Wetselaar, C M Visscher
Painful temporomandibular disorders (TMD pain) are common among the general population. The most common sub diagnoses are myalgia (jaw-muscle pain) and arthralgia (temporomandibular joint pain). The aetiology of TMD pain has a multifactorial nature, and its diagnosis and possible treatment often require a multidisciplinary approach. The most recent insights in the diagnosis and treatment of TMD pain are based on the multidisciplinary guideline 'Chronic Orofacial Pain' that was developed by the Dutch Society of Headache Patients and was published in 2013...
November 2016: Nederlands Tijdschrift Voor Tandheelkunde
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