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https://www.readbyqxmd.com/read/27873173/comparison-of-non-invasive-peripheral-venous-saturations-with-venous-blood-co-oximetry
#1
A M Belhaj, J P Phillips, P A Kyriacou, R M Langford
The estimation of venous oxygen saturations using photoplethysmography (PPG) may be useful as a noninvasive continuous method of detecting changes in regional oxygen supply and demand (e.g. in the splanchnic circulation). The aim of this research was to compare PPG-derived peripheral venous oxygen saturations directly with venous saturation measured from co-oximetry blood samples, to assess the feasibility of non-invasive local venous oxygen saturation. This paper comprises two similar studies: one in healthy spontaneously-breathing volunteers and one in mechanically ventilated anaesthetised patients...
November 21, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27870644/analysis-of-physiological-respiratory-variable-alarm-alerts-among-laboring-women-receiving-remifentanil
#2
Carolyn F Weiniger, Brendan Carvalho, Daniel Stocki, Sharon Einav
BACKGROUND: Remifentanil may be used by laboring women for analgesia, despite controversy because of potential apneas. We evaluated candidate variables as early warning alerts for apnea, based on prevalence, positive predictive rate, sensitivity for apnea event detection, and early warning alert time intervals (lead time) for apnea. METHODS: We performed a secondary analysis of respiratory physiological data that had been collected during a prospective IRB-approved study of laboring women receiving IV patient-controlled boluses of remifentanil 20 to 60 μg every 1 to 2 minutes...
November 18, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27847557/thoracic-ultrasound-a-complementary-diagnostic-tool-in-cardiology
#3
REVIEW
Guglielmo M Trovato
Clinical assessment and workup of patients referred to cardiologists may need an extension to chest disease. This requires more in-depth examination of respiratory co-morbidities due to uncertainty or severity of the clinical presentation. The filter and integration of ecg and echocardiographic information, addressing to the clues of right ventricular impairment, pulmonary embolism and pulmonary hypertension, and other less frequent conditions, such as congenital, inherited and systemic disease, usually allow more timely diagnosis and therapeutic choice...
October 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27814710/methemoglobin-and-nitric-oxide-therapy-in-ugandan-children-hospitalized-for-febrile-illness-results-from-a-prospective-cohort-study-and-randomized-double-blind-placebo-controlled-trial
#4
Andrea L Conroy, Michael Hawkes, Kyla Hayford, Laura Hermann, Chloe R McDonald, Suparna Sharma, Sophie Namasopo, Robert O Opoka, Chandy C John, W Conrad Liles, Christopher Miller, Kevin C Kain
BACKGROUND: Exposure of red blood cells to oxidants increases production of methemoglobin (MHb) resulting in impaired oxygen delivery to tissues. There are no reliable estimates of methemoglobinemia in low resource clinical settings. Our objectives were to: i) evaluate risk factors for methemoglobinemia in Ugandan children hospitalized with fever (study 1); and ii) investigate MHb responses in critically ill Ugandan children with severe malaria treated with inhaled nitric oxide (iNO), an oxidant that induces MHb in a dose-dependent manner (study 2)...
November 4, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27807379/validation-of-noninvasive-hemoglobin-measurements-using-co-oximetry-in-anesthetized-dogs
#5
Matt R Read, Jenna Rondeau, Grace P S Kwong
New technology allows noninvasive measurement of total hemoglobin (Hb) in humans through use of multiple wavelength co-oximetry. This monitor is now available to the veterinary market but no studies have been performed to validate its use in animals. This study investigated the use of co-oximetry to measure Hb in anesthetized dogs by comparing "gold standard" Hb measurements from a laboratory (LabHb) with those measured by the co-oximeter (SpHb). Bland-Altman analysis showed that the monitor had a bias of -3...
November 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/27549603/methemoglobin-measurements-are-underestimated-by-the-radical-7-co-oximeter-experience-from-a-series-of-moderate-to-severe-propanil-poisonings
#6
Elspeth Hulse, Fathima Shihana, Nicholas A Buckley
INTRODUCTION: In Asia methemoglobinemia (MetHb) is commonly caused through self-poisoning with the pesticide propranil. MetHb can cause hypoxia, coma and death, but usually responds to methylene blue. It is therefore vital to have accurate methods to measure blood MetHb to guide appropriate treatments. The gold standard to measure MetHb utilizes a spectrophotometer, but recent bedside tests have been developed e.g., pulse co-oximeter probe and blood color chart. METHODS: Nine propanil poisoned patients had data collected from hospitals in Sri Lanka during 2008...
November 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27547917/carbon-monoxide-poisoning-in-children-diagnosis-and-management-in-the-emergency-department
#7
Theodore E Macnow, Mark L Waltzman
Approximately 5000 children present to the emergency department annually with unintentional carbon monoxide poisoning. Children may be more vulnerable to carbon monoxide poisoning because of their increased metabolic demand and their inability to vocalize symptoms or recognize a dangerous exposure, and newborn infants are more vulnerable to carbon monoxide poisoning because of the persistence of fetal hemoglobin. Mild carbon monoxide poisoning may present as viral symptoms in the absence of fever. While headache, nausea, and vomiting are the most common presenting symptoms in children, the most common symptom in infants is consciousness disturbance...
September 2016: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/27531200/new-porcine-test-model-reveals-remarkable-differences-between-algorithms-for-spectrophotometrical-haemoglobin-saturation-measurements-with-vls
#8
John Gade, Gorm Greisen
UNLABELLED: The study created an 'ex vivo' model to test different algorithms for measurements of mucosal haemoglobin saturation with visible light spectrophotometry (VLS). The model allowed comparison between algorithms, but it also allowed comparison with co-oximetry using a 'gold standard' method. This has not been described before. Seven pigs were used. They were perfused with cold Haemaxel, and thus killed, chilled and becoming bloodless. The bronchial artery was perfused with cold blood with known saturation and spectrophotometrical measurements were made through a bronchoscope...
September 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27475734/noninvasively-measured-hemoglobin-concentration-reflects-arterial-hemoglobin-concentration-before-but-not-after-cardiopulmonary-bypass-in-patients-undergoing-coronary-artery-or-valve-surgery
#9
Matthias L Riess, Paul S Pagel
OBJECTIVE: This study compared noninvasively measured hemoglobin and arterial hemoglobin before and after cardiopulmonary bypass in patients undergoing coronary artery or valve surgery. DESIGN: Observational study with retrospective data analysis. SETTING: Veterans Affairs hospital. PARTICIPANTS: Thirty-five men. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Hemoglobin values were measured noninvasively by co-oximetry to corresponding arterial hemoglobin concentrations taken at clinically relevant time points chosen at the discretion of the cardiac anesthesiologist...
October 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27290327/effects-of-cardiopulmonary-bypass-on-the-accuracy-of-non-invasive-hemoglobin-measurement-by-pulse-co-oximetry
#10
K Tokuda, K Yamaura, M Higashi, S Hoka
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27172152/photoacoustic-imaging-for-the-detection-of-hypoxia-in-the-rat-femoral-artery-and-skeletal-muscle-microcirculation
#11
Lane Smith, Jasmina Varagic, Liliya Yamaleyeva
Photoacoustic (PA) imaging is an emerging technology that combines structural and functional imaging of tissues using laser and ultrasound energy. We evaluated the ability of PA imaging system to measure real-time systemic and microvascular mean oxygen saturation (mSAO2) in a rat model of hypoxic shock. Male Sprague Dawley rats (n = 6) underwent femoral artery catherization and were subjected to acute hypoxia by lowering the fraction of inspired oxygen (FiO2) from 1.0 to 0.21, and then to 0.08. PA measurements of mSaO2 were taken in the femoral artery near the catheter tip using the Vevo 2100 LAZR at each FiO2 and compared to co-oximetry on blood removed from the femoral catheter...
May 11, 2016: Shock
https://www.readbyqxmd.com/read/27164204/research-comparison-of-the-accuracy-of-a-pocket-versus-standard-pulse-oximeter
#12
COMPARATIVE STUDY
João Cordeiro da Costa, Paula Faustino, Ricardo Lima, Inês Ladeira, Miguel Guimarães
BACKGROUND: Pulse oximetry has become an essential tool in clinical practice. With patient self-management becoming more prevalent, pulse oximetry self-monitoring has the potential to become common practice in the near future. This study sought to compare the accuracy of two pulse oximeters, a high-quality standard pulse oximeter and an inexpensive pocket pulse oximeter, and to compare both devices with arterial blood co-oximetry oxygen saturation. METHODS: A total of 95 patients (35...
May 2016: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/27098765/failing-blood-gas-measurement-due-to-methemoglobin-forming-hemoglobin-variants-a-case-report-and-review-of-the-literature
#13
Toon Schiemsky, Joris Penders, Davy Kieffer
INTRODUCTION: We present a case of an arterial blood gas sample analysis from a 33-year old woman where no oximetry results could be obtained using the Radiometer ABL800 FLEX device. Clinical history of this patient learned that she was carrier of a methemoglobin forming hemoglobin variant type Hyde Park (HbM Hyde Park) and raised the question whether or not this variant could be the cause of the errors obtained during analysis. MATERIALS AND METHODS: A literature search was performed, focusing on methemoglobin forming hemoglobin variants and their influence on oxygenation measurements...
June 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27095814/diagnosis-of-a-rare-fetal-haemoglobinopathy-in-the-age-of-next-generation-sequencing
#14
Thomas A Hooven, Ellen M Hooper, Sandeep N Wontakal, Richard O Francis, Rakesh Sahni, Margaret T Lee
Neonatal cyanosis resulting from a fetal methaemoglobin variant is rare. Most such variants are only described in a few published case reports. We present the case of a newborn with unexplained persistent cyanosis, ultimately determined to have a γ-chain mutation causing Hb FM-Fort Ripley. This neonatal haemoglobinopathy can be challenging to diagnose, as significant oxygen desaturation may result from barely detectable levels of the mutant haemoglobin and co-oximetry studies may show a falsely normal methaemoglobin level...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27036112/a-randomized-clinical-trial-to-determine-the-effectiveness-of-co-oximetry-and-anti-smoking-brief-advice-in-a-cohort-of-kidney-transplant-patients-who-smoke-study-protocol-for-a-randomized-controlled-trial
#15
Salvador Pita-Fernández, Rocío Seijo-Bestilleiro, Sonia Pértega-Díaz, Ángel Alonso-Hernández, Constantino Fernández-Rivera, Mercedes Cao-López, Teresa Seoane-Pillado, Beatriz López-Calviño, Cristina González-Martín, Francisco Valdés-Cañedo
BACKGROUND: The cardiovascular risk in renal transplant patients is increased in patients who continue to smoke after transplantation. The aim of the study is to measure the effectiveness of exhaled carbon monoxide (CO) measurement plus brief advisory sessions, in comparison to brief advice, to reduce smoking exposure and smoking behavior in kidney transplant recipients who smoke. The effectiveness will be measured by: (1) abandonment of smoking, (2) increase in motivation to stop smoking, and (3) reduction in the number of cigarettes smoked per day...
2016: Trials
https://www.readbyqxmd.com/read/27007078/the-relationship-between-oxygen-reserve-index-and-arterial-partial-pressure-of-oxygen-during-surgery
#16
Richard L Applegate, Ihab L Dorotta, Briana Wells, David Juma, Patricia M Applegate
BACKGROUND: The use of intraoperative pulse oximetry (SpO2) enhances hypoxia detection and is associated with fewer perioperative hypoxic events. However, SpO2 may be reported as 98% when arterial partial pressure of oxygen (PaO2) is as low as 70 mm Hg. Therefore, SpO2 may not provide advance warning of falling arterial oxygenation until PaO2 approaches this level. Multiwave pulse co-oximetry can provide a calculated oxygen reserve index (ORI) that may add to information from pulse oximetry when SpO2 is >98%...
September 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27000014/inaccurate-pulse-co-oximetry-of-carboxyhemoglobin-due-to-digital-clubbing-case-report
#17
Nicole Harlan, Lindell K Weaver, Kayla Deru
Newer pulse CO-oximeters provide a non-invasive and quick means of measuring oxyhemoglobin, carboxyhemoglobin and methemoglobin. Clubbing has been reported to cause inaccuracy in pulse oximeters. We present a case of inaccurate carboxy-hemoglobin measurement by pulse CO-oximetry due to digital clubbing. An 18-year-old man with a history of cystic fibrosis presented after a suicide attempt by inhalation of exhaust. At the initial emergency department evaluation, his blood carboxyhemoglobin was 33%. He was intubated, placed on 100% oxygen and transferred to our facility...
January 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/26978143/oxygen-reserve-index-a-novel-noninvasive-measure-of-oxygen-reserve-a-pilot-study
#18
Peter Szmuk, Jeffrey W Steiner, Patrick N Olomu, Roxana P Ploski, Daniel I Sessler, Tiberiu Ezri
BACKGROUND: Pulse oximetry provides no indication of downward trends in PaO2 until saturation begins to decrease. The Oxygen Reserve Index (ORI) is a novel pulse oximeter-based nondimensional index that ranges from 1 to 0 as PaO2 decreases from about 200 to 80 mmHg and is measured by optically detecting changes in SvO2 after SaO2 saturates to the maximum. The authors tested the hypothesis that the ORI provides a clinically important warning of impending desaturation in pediatric patients during induction of anesthesia...
April 2016: Anesthesiology
https://www.readbyqxmd.com/read/26914626/accuracy-of-pulse-oximeters-intended-for-hypoxemic-pediatric-patients
#19
Bronwyn U Harris, Danton S Char, Jeffrey A Feinstein, Archana Verma, Stephen C Shiboski, Chandra Ramamoorthy
OBJECTIVES: Prior studies have shown inaccuracies in pulse oximetry readings at saturations less than 85%; however, no large studies have evaluated new sensors marketed for these low saturations. This study's purpose was to evaluate two sensors with claims of improved accuracy in children with saturations less than 85%. DESIGN: Prospective observational study. SETTING: Single institution; cardiac catheterization laboratory, and operating room...
April 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26899262/elevated-carboxyhaemoglobin-concentrations-by-pulse-co-oximetry-is-associated-with-severe-aluminium-phosphide-poisoning
#20
Mohammad Mashayekhian, Hossein Hassanian-Moghaddam, Mitra Rahimi, Nasim Zamani, Abbas Aghabiklooei, Shahin Shadnia
In pulse CO-oximetry of aluminium phosphide (ALP)-poisoned patients, we discovered that carboxyhaemoglobin (CO-Hb) level was elevated. We aimed to determine whether a higher CO level was detected in patients with severe ALP poisoning and if this could be used as a prognostic factor in these patients. In a prospective case-control study, 96 suspected cases of ALP poisoning were evaluated. In the ALP-poisoned group, demographic characteristics, gastric and exhalation silver nitrate test results, average CO-Hb saturation, methaemoglobin saturation, and blood pressure and blood gas analysis until death/discharge were recorded...
September 2016: Basic & Clinical Pharmacology & Toxicology
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