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CO oximetry

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https://www.readbyqxmd.com/read/29734568/carboxyhemoglobin-a-primer-for-clinicians
#1
Neil B Hampson
One of carbon monoxide's several mechanisms of toxicity is binding with circulating hemoglobin to form carboxyhemoglobin, resulting in a functional anemia. While patients with carbon monoxide poisoning are often said to be "cherry-red," such discoloration is rarely seen. Carboxyhemoglobin levels cannot be measured with conventional pulse oximetry, can be approximated with pulse CO-oximetry, and are most accurately measured with a laboratory CO-oximeter. Carboxyhemoglobin levels are quite stable and can be accurately measured on a transported blood sample...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29705429/technical-note-evaluation-of-a-wireless-pulse-oximeter-for-measuring-arterial-oxygen-saturation-and-pulse-rate-in-newborn-holstein-friesian-calves
#2
P Kanz, S Krieger, M Drillich, M Iwersen
Pulse oximetry is a well-established technique in human and veterinary medicine. In farm animals, it could also be a useful tool for the detection of critical conditions relating to oxygen supply and the cardiovascular system. Among other uses, an innovative application could be the monitoring of fetuses during birth. This could help in the early identification of critical situations and support farmers and veterinarians in their decision to start obstetric or life-support interventions. Until now, however, its use in ruminant medicine was still limited to experimental applications...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29673798/transcutaneous-co-oximetry-differentiates-asthma-exacerbation-and-convalescence-in-children
#3
David B Kantor, Carter R Petty, Wanda Phipatanakul, Jonathan M Gaffin
This study reports that transcutaneous carboxyhemoglobin (SpCO), measured with a pulse CO-Oximetry device, is a marker of asthma exacerbation in children presenting for emergency care.
April 16, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29666878/-methemoglobinemia-after-inhalation-of-poppers
#4
U Janssens, S Hillen, T Janssens, J Grafe
BACKGROUND: This case report presents a case of symptomatic methemoglobinemia (MetHb 31.6%) after inhalation of volatile nitrites (poppers). METHODS: The patient's medical history and symptoms are discussed together with pathophysiology of methemoglobinemia, diagnostics, and antidote therapy. Pulse oxymetry, arterial blood gas analysis, and CO-oximetry receive particular attention as well as antidote therapy with methylene blue. RESULTS: The patient was treated successfully with intravenous methylene blue...
April 17, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29655987/overcoming-safety-challenges-in-co-therapy-extracorporeal-co-delivery-under-precise-feedback-control-of-systemic-carboxyhemoglobin-levels
#5
Jakob Wollborn, Cornelius Hermann, Ulrich Goebel, Benjamin Merget, Christian Wunder, Sven Maier, Thomas Schäfer, Dominik Heuler, Klaus Müller-Buschbaum, Hartmut Buerkle, Lorenz Meinel, Martin A Schick, Christoph Steiger
Carbon monoxide (CO) has demonstrated therapeutic potential in multiple inflammatory conditions including intensive care applications such as organ transplantation or sepsis. Approaches to translate these findings into future therapies, however, have been challenged by multiple hurdles including handling and toxicity issues associated with systemic CO delivery. Here, we describe a membrane-controlled Extracorporeal Carbon Monoxide Release System (ECCORS) for easy implementation into Extracorporeal Membrane Oxygenation (ECMO) setups, which are being used to treat cardiac and respiratory diseases in various intensive care applications...
April 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29627919/acquired-methemoglobinemia-associated-with-topical-lidocaine-administration-a-case-report
#6
Hawkins C Gay, Ansel Philip Amaral
A 55-year-old male was admitted to the hospital with pneumonia. During an intubation procedure, the patient received an application of endobronchial lidocaine (4% gel). Within 2 h of intubation, the patient developed worsening hypoxia, and investigation of arterial blood gasses revealed a pH of 7.21, carbon dioxide partial pressure (PaCO2 ) of 3.3 kPa, oxygen partial pressure (PaO2 ) of 55.1 kPa, and measured oxygen saturation of 49%. Co-oximetry of this sample returned a methemoglobin level of 53%. Intravenous methylthioninium chloride (1% solution at 1 mg/kg) was delivered, and subsequent arterial blood gasses, at 30 min and 1 h post administration, showed methemoglobin levels of 12 and 9%, respectively, with return of oxygen saturation to > 90%...
April 7, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29519718/local-anesthetic-induced-methemoglobinemia-during-pregnancy-a-case-report-and-evaluation-of-treatment-options
#7
Andrew C Faust, Emily Guy, Nidhu Baby, Anthony Ortegon
BACKGROUND: Methemoglobinemia is a well-recognized adverse drug reaction related to the use of certain local anesthetic agents. The mainstay of treatment for methemoglobinemia is i.v. methylene blue, along with provision of supplemental oxygen; however, methylene blue is listed as a category X teratogen. This poses an issue should methemoglobinemia develop during pregnancy. CASE REPORT: A 35-year-old, 20-week and 5-day gravid female was transferred from an outpatient oral surgeon's office for hypoxia...
May 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29476876/changes-and-clinical-consequences-of-smoking-cessation-in-patients-with-copd-a-prospective-analysis-from-the-chain-cohort
#8
Cristina Martínez-González, Ciro Casanova, Juan P de-Torres, José M Marín, Pilar de Lucas, Antonia Fuster, Borja G Cosío, Myriam Calle, Germán Peces-Barba, Ingrid Solanes, Ramón Agüero, Nuria Feu-Collado, Inmaculada Alfageme, Amparo Romero Plaza, Eva Balcells, Alfredo de Diego, Margarita Marín Royo, Amalia Moreno, Antonia Llunell Casanovas, Juan B Galdiz, Rafael Golpe, Celia Lacárcel Bautista, Carlos Cabrera, Alicia Marin, Joan B Soriano, Jose Luis Lopez-Campos
BACKGROUND: Despite the existing evidence-based smoking cessation interventions, chances of achieving that goal in real life are still low among patients with COPD. We sought to evaluate the clinical consequences of changes in smoking habits in a large cohort of patients with COPD. METHODS: CHAIN (COPD History Assessment in Spain) is a Spanish multicenter study carried out at pulmonary clinics including active and former smokers with COPD. Smoking status was certified by clinical history and co-oximetry...
February 22, 2018: Chest
https://www.readbyqxmd.com/read/29445475/endogenous-carbon-monoxide-production-in-extracorporeal-membrane-oxygenation-related-hemolysis-potential-use-of-point-of-care-co-oximetry-carboxyhemoglobin-to-detect-hemolysis
#9
Chan Kai Man, Lam Koon Ngai
Extracorporeal membrane oxygenation (ECMO)-related hemolysis is a rare but devastating condition. Death is inevitable without early recognition and prompt management. Endogenous carbon monoxide production, as an epiphenomenon of hemolysis, potentially allows rapid detection of such condition by use of point-of-care CO-oximetry carboxyhemoglobin.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29435715/clinical-chameleons-an-emergency-medicine-focused-review-of-carbon-monoxide-poisoning
#10
REVIEW
Patrick Chow Yuen Ng, Brit Long, Alex Koyfman
Carbon monoxide (CO) is a colorless, odorless gas that is found in the environment, in the home, and in the human body as a normal part of mammalian metabolism. Poisoning from CO, a common exposure, is associated with significant morbidity and mortality if not recognized and treated in a timely manner. This review evaluates the signs and symptoms of CO poisoning, conditions that present similar to CO poisoning, and an approach to the recognition and management for CO poisoning. CO poisoning accounts for thousands of emergency department visits annually...
March 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29404717/pulse-oximetry-findings-in-newborns-with-antenatally-diagnosed-congenital-heart-disease
#11
Isabel E Mawson, Pratusha L Babu, John M Simpson, Grenville F Fox
A retrospective review of admission preductal oxygen saturations of neonates with antenatally diagnosed critical congenital heart disease (CCHD) was performed to investigate the differences in newborn pulse oximetry (Pulsox) by specific CCHD diagnosis. Saturations were recorded at median of < 1 h (range < 1-9 h) after delivery. Data was stratified by CCHD diagnosis and analysed according to the three different admission Pulsox thresholds, ≤ 90, ≤ 92 and ≤ 95%. Of the 276 neonates studied, 208 were clinically well at admission, with no co-morbidities, gestation > 34 weeks and birth weight > 1...
May 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29402444/comparison-of-nasal-and-forehead-oximetry-accuracy-and-pressure-injury-in-critically-ill-patients
#12
Marilyn Schallom, Donna Prentice, Carrie Sona, Cassandra Arroyo, John Mazuski
BACKGROUND: In critically ill patients, clinicians can have difficulty obtaining accurate oximetry measurements. OBJECTIVE: To compare the accuracy of nasal alar and forehead sensor measurements and incidence of pressure injury. METHODS: 43 patients had forehead and nasal alar sensors applied. Arterial samples were obtained at 0, 24, and 120 hours. Oxygen saturations measured by co-oximetry were compared to sensor values. Skin was assessed every 8 hours...
March 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/29382114/utility-of-non-invasive-monitoring-of-cardiac-output-and-cerebral-oximetry-during-pain-management-of-children-with-sickle-cell-disease-in-the-pediatric-emergency-department
#13
Pradeep Padmanabhan, Chikelue Oragwu, Bibhuti Das, John A Myers, Ashok Raj
Pain crisis in children with sickle cell disease (SCD) is typically managed with intravenous fluids and parenteral opioids in the pediatric emergency department. Electrical cardiometry (EC) can be utilized to measure cardiac output (CO) and cardiac index (CI) non-invasively. Near-infrared spectroscopy (NIRS) measuring cerebral (rCO₂) and splanchnic regional (rSO₂) mixed venous oxygenation non-invasively has been utilized for monitoring children with SCD. We studied the value and correlation of NIRS and EC in monitoring hemodynamic status in children with SCD during pain crisis...
January 29, 2018: Children
https://www.readbyqxmd.com/read/29359090/camera-based-pulse-oximetry-validated-risks-and-opportunities-from-theoretical-analysis
#14
Mark Van Gastel, Sander Stuijk, Gerard De Haan
Camera-based pulse-oximetry has recently shown to be feasible, even when the signal is corrupted by noise and motion artifacts. Earlier work showed that using three instead of the common two wavelengths improves robustness of the measurement, however without a thorough investigation on the optimal wavelength selection. We therefore performed a search to identify these wavelengths to further improve the robustness of the measurement. Besides motion, it is empirically known that there are several other factors that influence the measurement leading to falsely-low or falsely-high SpO2 readings...
January 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29339078/analytical-and-pre-analytical-performance-characteristics-of-a-novel-cartridge-type-blood-gas-analyzer-for-point-of-care-and-laboratory-testing
#15
Matthijs Oyaert, Tom Van Maerken, Silke Bridts, Silvi Van Loon, Heleen Laverge, Veronique Stove
BACKGROUND: Point-of-care blood gas test results may benefit therapeutic decision making by their immediate impact on patient care. We evaluated the (pre-)analytical performance of a novel cartridge-type blood gas analyzer, the GEM Premier 5000 (Werfen), for the determination of pH, partial carbon dioxide pressure (pCO2 ), partial oxygen pressure (pO2 ), sodium (Na+ ), potassium (K+ ), chloride (Cl- ), ionized calcium (i Ca2+ ), glucose, lactate, and total hemoglobin (tHb). METHODS: Total imprecision was estimated according to the CLSI EP5-A2 protocol...
March 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29335914/accuracy-and-trending-of-non-invasive-hemoglobin-measurement-during-different-volume-and-perfusion-statuses
#16
Abdelmoneim Adel, Wael Awada, Bassant Abdelhamid, Heba Omar, Omnia Abd El Dayem, Ahmed Hasanin, Ashraf Rady
The evolution of non-invasive hemoglobin measuring technology would save time and improve transfusion practice. The validity of pulse co-oximetry hemoglobin (SpHb) measurement in the perioperative setting was previously evaluated; however, the accuracy of SpHb in different volume statuses as well as in different perfusion states was not well investigated. The aim of this work is to evaluate the accuracy and trending of SpHb in comparison to laboratory hemoglobin (Lab-Hb) during acute bleeding and after resuscitation...
January 15, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29302896/comparison-of-the-accuracy-of-noninvasive-hemoglobin-monitoring-for-preoperative-evaluation-between-adult-and-pediatric-patients-a-retrospective-study
#17
Yong-Hee Park, Seho Lim, Hyun Kang, Hwa-Yong Shin, Chong Wha Baek, Young Cheol Woo
We measured noninvasive hemoglobin (SpHb) levels during the pre-anesthesia visit in patients planning elective surgery. Differences between SpHb and laboratory-measured hemoglobin (Hblab ) were compared between adult and pediatric patients. In the pre-anesthesia visiting office, we routinely monitor noninvasive Hb levels with oxygen saturation and heart rate using Masimo Radical-7® Pulse CO-Oximetry (Masimo Corp., Irvine, CA, USA). We attached the R1 20 (body weight, 10-50 kg) or R1 25 (body weight > 30 kg) probe on the index finger...
January 4, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29285649/carboxyhemoglobin-levels-induced-by-cigarette-smoking-outdoors-in-smokers
#18
Jonathan Schimmel, Naomi George, John Schwarz, Sami Yousif, Selim Suner, Jason B Hack
INTRODUCTION: Non-invasive screening of carboxyhemoglobin saturation (SpCO) in the emergency department to detect occult exposure is increasingly common. The SpCO threshold to consider exposure in smokers is up to 9%. The literature supporting this cutoff is inadequate, and the impact of active smoking on SpCO saturation remains unclear. The primary objective was to characterize baseline SpCO in a cohort of smokers outdoors. Secondary objectives were to explore the impact of active smoking on SpCO and to compare SpCO between smokers and non-smokers...
March 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29284341/cerebral-perfusion-monitoring-in-adult-patients-following-cardiac-surgery-an-observational-study
#19
Tammy Slater, Julie Stanik-Hutt, Patricia Davidson
BACKGROUND: Following adult cardiac surgery, often difficult to detect fluctuations in regional cerebral perfusion can contribute to strokes. Optimal cerebral perfusion remains elusive and traditional monitoring strategies do not consistently identify acute changes. Non-invasive cerebral oximetry may detect perfusion variations. OBJECTIVE: To assess the feasibility of postoperative non-invasive cerebral oximetry monitoring. METHODS: Non-invasive cerebral oximetry was performed on adult aortic valve surgery patients in a cardiac surgical intensive care unit...
December 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/29274316/comparative-evaluation-of-neonatal-bilirubin-using-radiometer-whole-blood-co-oximetry-and-plasma-bilirubin-methods-from-roche-diagnostics-and-ortho-clinical-diagnostics
#20
Ian Marie Lano, Andrew W Lyon, Li Wang, Rob Ruskin, Martha E Lyon
BACKGROUND: Clinically significant variation has been reported within and between plasma and whole blood total bilirubin methods used to identify neonates for whom clinical intervention for hyperbilirubinemia may be required. OBJECTIVE: To evaluate total bilirubin measurements between the Radiometer whole blood co-oximeter and plasma bilirubin methods from Roche Diagnostics and Ortho Clinical Diagnostics using neonatal specimens. METHODS: Total bilirubin levels were analyzed by whole blood co-oximetry (Radiometer® ABL90)...
March 2018: Clinical Biochemistry
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