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hearing loss exposure to toxins

Matthew Kruger, Robert Boney, Alexander J Ordoobadi, Thomas F Sommers, Josef G Trapani, Allison B Coffin
Moderate to severe hearing loss affects 360 million people worldwide and most often results from damage to sensory hair cells. Hair cell damage can result from aging, genetic mutations, excess noise exposure, and certain medications including aminoglycoside antibiotics. Aminoglycosides are effective at treating infections associated with cystic fibrosis and other life-threatening conditions such as sepsis, but cause hearing loss in 20-30% of patients. It is therefore imperative to develop new therapies to combat hearing loss and allow safe use of these potent antibiotics...
2016: Frontiers in Cellular Neuroscience
Maki Niihori, Terry Platto, Suzu Igarashi, Audriana Hurbon, Allison M Dunn, Phi Tran, Hung Tran, Jordan A Mudery, Marvin J Slepian, Abraham Jacob
Hearing loss is one of the most common human sensory disabilities, adversely affecting communication, socialization, mood, physical functioning, and quality of life. In addition to age and noise-induced damage, ototoxicity is a common cause of sensorineural hearing loss with chemotherapeutic agents, for example, cisplatin, being a major contributor. Zebrafish (Danio rerio) are an excellent model to study hearing loss as they have neurosensory hair cells on their body surface that are structurally similar to those within the human inner ear...
November 2015: Translational Research: the Journal of Laboratory and Clinical Medicine
Phillip M Uribe, Leen H Kawas, Joseph W Harding, Allison B Coffin
Loss of sensory hair cells from exposure to certain licit drugs (e.g., aminoglycoside antibiotics, platinum-based chemotherapy agents) can result in permanent hearing loss. Here we ask if allosteric activation of the hepatocyte growth factor (HGF) cascade via Dihexa, a small molecule drug candidate, can protect hair cells from aminoglycoside toxicity. Unlike native HGF, Dihexa is chemically stable and blood-brain barrier permeable. As a synthetic HGF mimetic, it forms a functional ligand by dimerizing with endogenous HGF to activate the HGF receptor and downstream signaling cascades...
2015: Frontiers in Cellular Neuroscience
Angela Wenzel, Bryan K Ward, Michael C Schubert, Amir Kheradmand, David S Zee, Georgios Mantokoudis, John Patrick Carey
OBJECTIVE: To propose an etiology for a syndrome of bilateral vestibular hypofunction and sound and/or pressure-evoked eye movements with normal hearing thresholds. DESIGN: Retrospective case series. SETTING: Tertiary care referral center. PATIENTS: Four patients with bilateral vestibular hypofunction, sound and/or pressure-evoked nystagmus and normal hearing thresholds were identified over a 3-year period. No evidence of other known vestibular disorders was identified...
June 2014: Otology & Neurotology
Jing Zou, Ya Zhang, Weikai Zhang, Dennis Poe, Suoqiang Zhai, Shiming Yang, Ilmari Pyykkö
The different cell types within the cochlea may have a specific contribution to the pathological changes during metabolism failure, which may provide clues for developing novel strategies for inner ear therapy. In order to evaluate activity-correlated cell death during metabolism failure in the cochlea, 3-nitropropionic acid was used to irreversibly inhibit the respiratory chain. Dose-response of the cochlear cells to 3-nitropropionic acid was analyzed in vitro. 3-Nitropropionic acid was administered onto the round window of guinea pigs...
September 2013: European Archives of Oto-rhino-laryngology
Adnan Lidian, Monika Stenkvist-Asplund, Birgitta Linder, Matti Anniko, Leif Nordang
CONCLUSION: Brain-derived neurotrophic factor (BDNF) protects the inner ear from PaExoA (exotoxin A from Pseudomonas aeruginosa)-induced sensory neural hearing loss when administered 12 h after exotoxin, but not after 72 h. OBJECTIVE: BDNF is a peptide in the neurotrophin family with protective effects against noise-induced hair cell loss and toxic inner ear damage following exposure to cisplatin. The exotoxin A (PaExoA) from P. aeruginosa, the most common microorganism in chronic suppurative otitis media, induces sensorineural hearing loss in rats...
January 2013: Acta Oto-laryngologica
Adnan Lidian, Birgitta Linder, Matti Anniko, Leif Nordang
CONCLUSION: Brain-derived neurotrophic factor (BDNF) can prevent auditory brainstem response (ABR) threshold shift changes caused by Pseudomonas aeruginosa exotoxin A (PaExoA). OBJECTIVE: Peptides of the neurotrophin family are known to prevent neuronal death during embryonic development by interacting with specific membrane receptors. The purpose of this study was to investigate whether a single dose of BDNF is an effective protectant against toxic effects of PaExoA-induced ABR threshold shifts...
January 2013: Acta Oto-laryngologica
Peter C Grayson, J Mark Sloan, John L Niles, Paul A Monach, Peter A Merkel
OBJECTIVES: Reports of an association between antineutrophil cytoplasmic antibodies (ANCA) and autoimmune neutropenia have rarely included cases of proven vasculitis. A case of ANCA-associated vasculitis (AAV) with recurrent neutropenia is described and relevant literature on the association between ANCA, neutropenia, and vasculitis is reviewed. METHODS: Longitudinal clinical assessments and laboratory findings are described in a patient with AAV and recurrent episodes of profound neutropenia from December 2008 to October 2010...
December 2011: Seminars in Arthritis and Rheumatism
Paula V Phongsamran, Jiwon W Kim, Jennifer Cupo Abbott, Angela Rosenblatt
Hepatic encephalopathy (HE) is a challenging clinical complication of liver dysfunction with a wide spectrum of neuropsychiatric abnormalities that range from mild disturbances in cognitive function and consciousness to coma and death. The pathogenesis of HE in cirrhosis is complex and multifactorial, but a key role is thought to be played by circulating gut-derived toxins of the nitrogenous compounds, most notably ammonia. Therapeutic treatment options for HE are currently limited and have appreciable risks and benefits associated with their use...
June 18, 2010: Drugs
A L Smit, R J Stokroos, S G H Litjens, B Kremer, B W Kramer
Congenital sensorineural hearing loss (SNHL) is common. In the Western world, the incidence is 1-3 per 1000 live births. The aetiology encompasses genetic and non-genetic factors accounting for 55 % and 45 % of cases, respectively. Reports that describe the contribution of intrauterine infection to the occurrence of congenital SNHL are limited, and comparative analysis of the different pathogens is lacking. Lipopolysaccharide (LPS), a product of bacteriolysis, has been demonstrated to be associated with inner ear damage in experimental studies...
April 2010: Journal of Medical Microbiology
Kelly N Owens, Felipe Santos, Brock Roberts, Tor Linbo, Allison B Coffin, Anna J Knisely, Julian A Simon, Edwin W Rubel, David W Raible
Inner ear sensory hair cell death is observed in the majority of hearing and balance disorders, affecting the health of more than 600 million people worldwide. While normal aging is the single greatest contributor, exposure to environmental toxins and therapeutic drugs such as aminoglycoside antibiotics and antineoplastic agents are significant contributors. Genetic variation contributes markedly to differences in normal disease progression during aging and in susceptibility to ototoxic agents. Using the lateral line system of larval zebrafish, we developed an in vivo drug toxicity interaction screen to uncover genetic modulators of antibiotic-induced hair cell death and to identify compounds that confer protection...
February 2008: PLoS Genetics
Andrew P Kurmis, Stacey A Apps
OBJECTIVES: Occupational noise-induced hearing loss (ONIHL) describes an acquired hearing deficiency directly attributable to excessive workplace noise exposure. Data suggest that excessive noise attributes to approximately 37% of all adult causes of hearing loss and remains a significant contributor to employment-related morbidity internationally. Typically insidiously-acquired, often without frank progressive symptomatology, regional medical agencies continue to struggle with this potentially debilitating condition...
2007: International Journal of Occupational Medicine and Environmental Health
Masaya Takumida, Matti Anniko
CONCLUSION: Our findings suggest that edaravone can protect against cochlear damage caused by Pseudomonas aeruginosa exotoxin A (PaExoA). OBJECTIVE: To analyze the protective effect of a free radical scavenger, edaravone, against the ototoxicity resulting from exposure of the middle ear to PaExoA. MATERIAL AND METHODS: In nine groups of albino rats the following solutions were instilled either via the tympanic membrane into the round window niche [intratympanically (i...
January 2006: Acta Oto-laryngologica
Yasuhide Okamoto, Noriyuki Hoya, Kazusaku Kamiya, Masato Fujii, Kaoru Ogawa, Tatsuo Matsunaga
Mitochondrial dysfunction in the cochlea is thought to be an important cause of sensorineural hearing loss. Recently, we have established a novel rat model with acute hearing impairment caused by exposure to the mitochondrial toxin 3-nitropropionic acid (3-NP) to analyze the mechanism of cochlear mitochondrial dysfunction. Both permanent and temporary threshold shifts were observed in this model depending on the amount of 3-NP used to induce hearing impairment. In this study, we demonstrate cochlear morphological changes in the permanent threshold shift model...
July 2005: Audiology & Neuro-otology
Monika Stenqvist, Matti Anniko
OBJECTIVE: To ascertain whether the severity of toxin-related hearing loss and the interval between instillation of toxin and surgical trauma affect hearing recovery capacity following semicircular canal (SCC) surgery in the rat. MATERIAL AND METHODS: Twelve rats were injected with Pseudomonas aeruginosa exotoxin A (PaExoA). Auditory brainstem responses (ABRs) were measured 72 h and 3 weeks later. Depending on the severity of hearing loss, the rats were divided into two groups: those with moderate (Group A; n = 6) and severe (Group B; n = 6) hearing loss...
January 2004: Acta Oto-laryngologica
Manabu Maeta, Matti Anniko
OBJECTIVE: The protective effect of brain-derived neurotrophic factor (BDNF) against the ototoxicity resulting from exposure of Pseudomonas aeruginosa exotoxin A (PaExoA) to the middle ear was analyzed. The combined effect of BDNF and N(G)-nitro-L-arginine methyl ester (L-NAME) was also investigated. MATERIAL AND METHODS: Six groups of albino rats were instilled through the tympanic membrane into the round window niche with the following solutions: saline; PaExoA; BDNF; L-NAME; PaExoA + BDNF; and PaExoA + BDNF + L-NAME...
January 2003: Acta Oto-laryngologica
Z Lu, S M Tomchik
Red tides are formed from blooms of marine algae. Among them, the dinoflagellate ( Karenia brevis) that is responsible for Florida red tides can release many types of natural toxins, which cause massive kills of marine animals, including endangered species, and threaten human health. This study was to investigate whether or not a neurotoxin, brevetoxin-3, purified from Florida red tides affects hearing sensitivity of a teleost fish, the goldfish ( Carassius auratus). LD(50) of the goldfish that were intraperitoneally injected with brevetoxin-3 was 0...
November 2002: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
J B Leikin, A Davis, D A Klodd, T Thunder, G A Kelafant, D L Paquette, M J Rothe, R Rubin
The auditory and nonauditory effects of noise can be quite profound, affecting approximately 15 to 20 million Americans. As with most occupational toxins, recognition and careful assessment of noise exposure are the foundation on which preventive measures and treatment are based. Dosimeters can measure noise exposure over specific time periods. Pure tone air conduction audiometric monitoring should be performed on an annual basis in workers at risk for significant noise exposure. Occupational infectious disease involves far more than hepatitis and tuberculosis...
April 2000: Disease-a-month: DM
M Stenqvist, H Rask-Andersen, M Anniko
One group of Sprague-Dawley rats (group A, n = 6) was treated by instilling Pseudomonas aeruginosa exotoxin A (PaExoA), and another (group B, n = 6) treated similarly with Haemophilus influenzae type b endotoxin (HiBEndo). In group A a 20 dB hearing loss was observed, predominantly in the high-frequency region, which was reversible within 1 month. In group B no significant hearing impairment was noted. Between 1 and 6 months later, the lateral and posterior semicircular canals (SCCs) were ablated unilaterally...
September 1997: Acta Oto-laryngologica
M Stenqvist, M Anniko, A Pettersson
Electrophysiological changes were studied in the albino rat following instillation of Pseudomonas aeruginosa exotoxin A into the middle ear cavity through the tympanic membrane. Hearing threshold was measured by a burst-elicited, frequency-specific auditory brainstem response (ABR) technique prior to exposure, then 24 and 48 h, 5 days, 2 and 4 weeks after the toxin instillation. A single dose (1 microgram/20 microliters) of Pseudomonas aeruginosa exotoxin A raised the ABR threshold over the whole frequency range, by 5-25 dB, particularly in the high tones...
January 1997: Acta Oto-laryngologica
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