Antonio Rafael Quadros Gomes, Natasha Costa da Rocha Galucio, Kelly Cristina Oliveira de Albuquerque, Heliton Patrick Cordovil Brígido, Everton Luiz Pompeu Varela, Ana Laura Gadelha Castro, Valdicley Vieira Vale, Marcelo Oliveira Bahia, Rommel Mario Rodriguez Burbano, Fábio Alberto de Molfeta, Liliane Almeida Carneiro, Sandro Percario, Maria Fâni Dolabela
Eleutherine plicata has been shown to be a promising medicinal plant, and its activity has been associated with naphthoquinones. The present study aimed at evaluating the cytotoxicity, genotoxicity, and oral toxicity of the ethanol extract (EEEp), dichloromethane fraction (FDMEp) of E. plicata , and isoeleutherin. For the cytotoxicity evaluation, the viability test (MTT) was used. Genotoxicity was accessed through the Comet assay (alkaline version), acute and subacute oral toxicities were also evaluated. The antioxidant capacity of the samples in the wells where the cells were treated with E...
2021: Toxicology Reports