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CO Poisoning

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https://www.readbyqxmd.com/read/29161647/simple-synthesis-of-self-supported-hierarchical-aupd-alloyed-nanowire-networks-for-boosting-electrocatalytic-activity-toward-formic-acid-oxidation
#1
Tao Yuan, Hong-Yan Chen, Xiaohong Ma, Jiu-Ju Feng, Pei-Xin Yuan, Ai-Jun Wang
Herein, self-supported hierarchical AuPd alloyed interconnected nanowire networks (AuPd NCNs) were fabricated by a one-pot co-reduction method. Theophylline was acted as the capping and structure-directing agents. The product was mainly characterized by a series of techniques such as transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The hierarchical nanostructures had the enlarged electrochemically active surface area (EASA), and the enhanced catalytic activity toward formic acid oxidation reaction (FAOR) and strengthened poisoning tolerance for poisoning CO-like intermediates by cyclic voltammetry and chronoamperometry, which outperformed commercial Pd black catalyst...
November 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29151273/post-treatment-with-methylene-blue-is-effective-against-delayed-encephalopathy-after-acute-carbon-monoxide-poisoning
#2
Ningjun Zhao, Pengchong Liang, Xiaoying Zhuo, Chenglei Su, Xuemei Zong, Bingnan Guo, Han Dong, Xianliang Yan, Shuqun Hu, Quanguang Zhang, Xu Tie
Delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP) is the most severe and clinically intractable complication that occurs following acute carbon monoxide poisoning. Unfortunately, the mechanism of DEACMP is still vague. Growing evidence indicates that delayed cerebral damage following CO poisoning is related to oxidative stress, abnormal neuro-inflammation, apoptosis and immune-mediated injury. Our recent report indicated that methylene blue (MB) may be a promising therapeutic agent in the prevention of neuronal cell death and cognitive deficits following transient global cerebral ischaemia (GCI)...
November 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29129815/biological-effects-of-adipocytes-in-sulfur-mustard-induced-toxicity
#3
Hua Xu, Zhongcai Gao, Peng Wang, Bin Xu, Yajiao Zhang, Long Long, Cheng Zong, Lei Guo, Weijian Jiang, Qinong Ye, Lili Wang, Jianwei Xie
Sulphur mustard (2,2'-dichloroethyl sulfide; SM) is a vesicant chemical warfare agent whose mechanism of acute or chronic action is not known with any certainty and to date there is no effective antidote. SM accumulation in adipose tissue (AT) has been originally verified in our previous study. To evaluate the biological effect caused by the presence of abundant SM in adipocyte and assess the biological role of AT in SM poisoning, in vitro and in vivo experiments were performed. High content analysis revealed multi-cytotoxicity in SM exposed cells in a time and dose dependent manner, and adipocytes showed a relative moderate damage compared with non-adipocytes...
November 10, 2017: Toxicology
https://www.readbyqxmd.com/read/29122100/occupational-carbon-monoxide-poisoning-associated-with-diesel-motor-operation-in-an-air-raid-shelter-in-june-2015-jinan-city-china-an-epidemiological-investigation
#4
Liang Liang Cui, Jing Wen Zhou, Xing Yi Geng, Xin Wei Li, Zhong Liu, George A Conway, Ji Zhang
Occupational carbon monoxide (CO) poisoning related to diesel motor fumes in an air-raid shelter (ARS) was first identified in Jinan City, China, in June 2015. A total of 17 cases were identified, including 14 possible cases of firemen and 3 confirmed cases of water channel clean-up workers. The overall attack rate (AR) of firemen was 42% (14/33). The firemen had a significantly higher AR with a longer exposure and more protracted time of rescue in the ARS (P < 0.05). All the cases stated that they did not realize the potentially high level of exposure to CO in the ARS...
October 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29116693/cost-effectiveness-of-residential-carbon-monoxide-alarms
#5
Neil B Hampson
BACKGROUND: While residential carbon monoxide (CO) alarms are now required in a majority of states, the cost effectiveness of the devices is unknown. This analysis was performed to determine the degree of prevention efficacy necessary from home carbon monoxide alarms for their expense to be cost-effective. METHODS: Data regarding numbers of individuals affected in the United States annually from accidental, non-fire, residential non-fatal and fatal carbon monoxide poisoning were obtained from published literature...
2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29081331/immediate-and-delayed-neuropsychological-effects-of-carbon-monoxide-poisoning-a-meta-analysis
#6
Stephanie Watt, Catherine E Prado, Simon F Crowe
BACKGROUND: Carbon monoxide (CO) poisoning is the leading cause of accidental poisoning worldwide. This study undertook a meta-analysis to examine differences in neuropsychological functioning in patients with CO poisoning as compared to healthy controls, and examined the longer-term neuropsychological effects of CO poisoning. METHODS: Studies performed between the years 1995 and 2016 were identified through a search of the electronic databases Medline and PsycInfo...
October 30, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29080523/fatal-poisonings-involving-propoxyphene-before-and-after-voluntary-withdrawal-from-the-united-states-market-an-analysis-from-the-state-of-florida
#7
Chris Delcher, Guanming Chen, Yanning Wang, Svetla Slavova, Bruce A Goldberger
The synthetic opioid propoxyphene was a schedule IV controlled substance with multiple reported health risks before the US Food and Drug Administration issued a request for voluntary market withdrawal in November 2010. The purpose of this study is to investigate the characteristics and occurrences of propoxyphene-related deaths in Florida before and after voluntary market removal. Decedent-level toxicology data from Florida's Medical Examiners Commission was used to compare the temporal, polysubstance use, sociodemographic, and geographic profiles associated with propoxyphene-involved deaths for a pre-withdrawal (November 2008-November 2010) and post-withdrawal (December 2010-December 2012) period...
October 14, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29077293/-characteristics-of-emergency-poisoning-cases-in-elderly-versus-younger-patients
#8
August Supervía Caparrós, Oriol Pallàs Villaronga, Carlos Clemente Rodríguez, María Dolores Aranda Cárdenas, María Pi-Figueras Valls, Isabel Cirera Lorenzo
OBJECTIVES: To compare cases of poisoning according to age to detect differences in frequency of visits to the emergency department, patient characteristics, case management, and immediate outcome in terms of related mortality. MATERIAL AND METHODS: Descriptive study of a retrospective series of patients who visited a university hospital emergency department for treatment of poisoning between 2009 and 2014. We collected patient characteristics and data related to the event, case management, and poisoning-related death...
October 2017: Emergencias
https://www.readbyqxmd.com/read/29067847/serum-n-terminal-probnp-not-troponin-i-at-presentation-predicts-long-term-neurologic-outcome-in-acute-charcoal-burning-carbon-monoxide-intoxication
#9
Jeong Mi Moon, Byeong Jo Chun, Min Ho Shin, Seung Do Lee
OBJECTIVE: This study aimed to investigate whether the serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin I levels at emergency department (ED) presentation predict long-term neurologic outcomes after acute charcoal-burning carbon monoxide (CO) poisoning. METHODS: This retrospective study included 220 patients suffering from charcoal-burning CO poisoning. The demographics, serum NT-proBNP and troponin I levels at ED presentation, treatment, clinical course during hospitalization, and long-term neurologic outcomes were collected...
October 25, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29027621/use-of-carboxyhemoglobin-as-a-biomarker-of-environmental-co-exposure-critical-evaluation-of-the-literature
#10
Agnese Veronesi, Valentina Pecoraro, Stefano Zauli, Marta Ottone, Giovanni Leonardi, Paolo Lauriola, Tommaso Trenti
Carbon monoxide (CO) poisoning is the primary cause for access to emergency department (ED) services for more than 50,000 persons in Europe and the USA every year. CO poisoning diagnosis is based on multiple factors and is usually confirmed by high carboxyhemoglobin (COHb) levels in the blood. We conducted a systematic evaluation of literature to investigate the usefulness of COHb as a biomarker of environmental CO exposure. We conducted an electronic search in Medline, Embase, and the Cochrane Library databases...
October 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29025057/nqo2-inhibition-relieves-reactive-oxygen-species-effects-on-mouse-oocyte-meiotic-maturation-and-embryo-development
#11
Dandan Chen, Xin Li, Xiaoyun Liu, Xiaoyu Liu, Xiuying Jiang, Juan Du, Qian Wang, Yuanjing Liang, Wei Ma
NRH: quinone oxidoreductase 2 (NQO2) is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone to hydroquinones. Herein, we assessed the protein expression, subcellular localization, and possible functions of NQO2 in mouse oocyte meiotic maturation and embryo development. Western blot analysis detected high and stable protein expression of NQO2 in mouse oocytes during meiotic progression. Immunofluorescence illustrated NQO2 distribution on nuclear membrane, chromosomes, and meiotic spindles...
October 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29023394/carbon-based-oxamate-cobalt-iii-complexes-as-bioenzyme-mimics-for-contaminant-elimination-in-high-backgrounds-of-complicated-constituents
#12
Nan Li, Yun Zheng, Xuemei Jiang, Ran Zhang, Kemei Pei, Wenxing Chen
Complex wastewater with massive components is now a serious environmental issue facing humanity. Selective removal of low-concentration contaminants in mixed constituents holds great promise for increasing water supplies. Bioenzymes like horseradish peroxidase exhibit oxidizing power and selectivity. Here, we manufactured its mimic through immobilizing non-heme oxamate anionic cobalt(III) complex ([Co(III)(opba)](-), opba = o-phenylenebis(oxamate)) onto pyridine (Py) modified multiwalled carbon nanotubes ([Co(III)(opba)](-)-Py-MWCNTs, MWCNTs = multiwalled carbon nanotubes), where MWCNTs captured substrates and Py functioned as the fifth ligand...
October 12, 2017: Materials
https://www.readbyqxmd.com/read/29016863/a-tubb6-mutation-is-associated-with-autosomal-dominant-non-progressive-congenital-facial-palsy-bilateral-ptosis-and-velopharyngeal-dysfunction
#13
Walid Fazeli, Peter Herkenrath, Barbara Stiller, Antje Neugebauer, Julia Fricke, Ruth Lang-Roth, Gudrun Nürnberg, Michaela Thoenes, Jutta Becker, Janine Altmüller, Alexander E Volk, Christian Kubisch, Raoul Heller
Congenital cranial dysinnervation disorders (CCDDs) comprise a heterogeneous spectrum of diseases characterized by congenital, non-progressive impairment of eye, eyelid and/or facial movements including Möbius syndrome, Duane retraction syndrome, congenital ptosis, and congenital fibrosis of the extraocular muscles. Over the last 20 years, several CCDDs have been identified as neurodevelopmental disorders that are caused by mutations of genes involved in brain and cranial nerve development, e.g. KIF21A and TUBB3 that each plays a pivotal role for microtubule function...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28994363/mass-casualty-triage-in-the-case-of-carbon-monoxide-poisoning-lessons-learned
#14
Mathieu Pasquier, Fabrice Dami, Pierre-Nicolas Carron, Bertrand Yersin, Rodrigue Pignel, Olivier Hugli
Carbon monoxide (CO) can cause mass intoxication, but no standard triage algorithm specifically addresses CO poisoning. The roles of some recent diagnostic tools in triage as well as treatment with hyperbaric oxygen are controversial. We describe a mass casualty case of CO poisoning involving 77 patients, with a focus on the triage and treatment options decided on-site. The reasons for choosing these options are reviewed, and the pitfalls that occurred and the lessons learned from this major incident are described...
October 10, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28986777/predicting-cardiotoxic-effects-of-carbon-monoxide-poisoning-using-speckle-tracking-echocardiography
#15
Erhan Saraçoğlu, Ertan Vuruşkan, Salih Kılıç, Yusuf Çekici, Bahaeddin Onur, Yavuz Arslan, Ertuğrul Kılıç, Ömer Aykut
Carbon monoxide (CO) poisoning could cause significant cardiac injury. This study aimed to evaluate patients with CO poisoning by using speckle tracking echocardiography (STE), a potentially more sensitive technique, to identify left systolic ventricular dysfunction for the first time in the literature. Seventy-two patients who were exposed to CO poisoning were studied. Blood collection and echocardiography were performed at admission and after patients' discharge on days 10-15 (mean 12 days). Global longitudinal strain (GLS) and global circumferential strain (GCS) were calculated using STE...
October 6, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28980109/seasonal-variation-of-heavy-metals-in-water-and-sediments-in-the-halda-river-chittagong-bangladesh
#16
Md Simul Bhuyan, Muhammad Abu Bakar
The present study was carried out to assess the contamination levels of heavy metals (Pb, Cd, Cr, Cu, Hg, Al, Ni, Co, Zn, Mn) in surface water and sediment of the Halda River. The observed order of heavy metal concentration in water for Al > Ni > Zn > Mn > Cu > Cd > Pb > Cr > Co > Hg (mg/l) and for sediments Al > Mn > Zn > Ni > Cr > Pb > Cu > Co > Cd > Hg (mg/kg), respectively. The concentrations of Pb, Cd, Cr, Cu, Hg, Al, Ni, Co, Zn, and Mn in water, whereas in sediment Pb, Cu, Al, Ni, Co, Zn, and Mn were found above the permissible limit (WHO 2004; USEPA 2006; EPA 1986, 2002 and ECR 1997)...
October 5, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28974933/gaseous-mediators-and-mitochondrial-function-the-future-of-pharmacologically-induced-suspended-animation
#17
REVIEW
Clair Hartmann, Benedikt Nussbaum, Enrico Calzia, Peter Radermacher, Martin Wepler
The role of nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) as poisonous gases is well-established. However, they are not only endogenously produced but also, at low concentrations, exert beneficial effects, such as anti-inflammation, and cytoprotection. This knowledge initiated the ongoing debate, as to whether these molecules, also referred to as "gaseous mediators" or "gasotransmitters," could serve as novel therapeutic agents. In this context, it is noteworthy, that all gasotransmitters specifically target the mitochondria, and that this interaction may modulate mitochondrial bioenergetics, thereby subsequently affecting metabolic function...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28973660/high-susceptibility-of-lrig1-sebaceous-stem-cells-to-tcdd-in-mice
#18
F Fontao, L Barnes, G Kaya, J H Saurat, O Sorg
We have previously shown that CYP1A1 was highly induced for a long period of time in a patient who had been poisoned by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a compound known to activate the aryl hydrocarbon receptor (AhR). During that period of time no sebaceous glands could be observed in the skin of this patient. In the present study, starting from observations in the patient exposed to TCDD, we analysed the seboatrophy induced by dioxins in mice. We observed a very different pattern of AhR and CYP1A1 immunostaining in skin biopsies of the patient...
August 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28967016/first-principles-investigation-of-h2s-adsorption-and-dissociation-on-titanium-carbide-surfaces
#19
Shiyan Wang, Xilin Zhang, Yanxing Zhang, Jianjun Mao, Zongxian Yang
The adsorption and dissociation reactions of H2S on TiC(001) are investigated using first-principles density functional theory calculations. The geometric and electronic structures of the adsorbed S-based species (including H2S, SH and S) on TiC(001) are analyzed in detail. It is found that the H2S is bound weakly, while SH and atomic S are bound strongly on the TiC(001) surface. The transition state calculations show that the formation of SH from H2S (H2S → SH + H) is very easy, while the presence of a co-adsorbed H will inhibit the further dissociation of SH (SH + H → S + H + H)...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28952172/bio-inspired-carbon-monoxide-sensors-with-voltage-activated-sensitivity
#20
Suchol Savagatrup, Vera Schroeder, Xin He, Sibo Lin, Maggie He, Omar Yassine, Khaled N Salama, Xi-Xiang Zhang, Timothy M Swager
Carbon monoxide (CO) outcompetes oxygen when binding to the iron center of hemeproteins, leading to a reduction in blood oxygen level and acute poisoning. Harvesting the strong specific interaction between CO and the iron porphyrin provides a highly selective and customizable sensor. We report the development of chemiresistive sensors with voltage-activated sensitivity for the detection of CO comprising iron porphyrin and functionalized single-walled carbon nanotubes (F-SWCNTs). Modulation of the gate voltage offers a predicted extra dimension for sensing...
November 6, 2017: Angewandte Chemie
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