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CO Poisoning

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https://www.readbyqxmd.com/read/28938502/-alarming-pregabalin-abuse-in-munich-prevalence-patterns-of-use-and-complications
#1
Nicolas Zellner, Florian Eyer, Tobias Zellner
Background Pregabalin is used e. g. for the treatment of neuropathic pain and anxiety disorder. Recently, its potential for abuse and addiction has become apparent. Methods From 2008 - 2015, we searched our database for the term "Pregabalin", including all patients treated in our department and all calls to the Poison Information Centre (PIC) Munich.From October 2013 to September 2014, all patients were included in a cohort study who either were admitted with a drug intoxication or who presented themselves for a course of detoxification (except ethanol)...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28937694/precision-gas-therapy-using-intelligent-nanomedicine
#2
Qianjun He
Gas therapy is an emerging and promising field, utilizing the unique therapeutic effects of several kinds of gases (NO, CO, H2S and H2) towards many major diseases, including cancer and cardiovascular diseases, and it is also facing challenges relating to enhancing gas therapy efficacy and avoiding gas poisoning risks. Here, we have proposed a new concept for precision gas therapy using a nanomedicine strategy to overcome the challenges. In this perspective, we have addressed a series of existing and potential solutions from the point of view of nanomedicine, and conveyed a collection of opinions about future expandable research into precision gas therapy...
September 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28929754/spectro-electrochemical-examination-of-the-formation-of-dimethyl-carbonate-from-co-and-methanol-at-different-electrode-materials
#3
Marta C Figueiredo, Vinh Trieu, Stefanie Eiden, Marc T M Koper
In this work, we report a fundamental mechanistic study of the electrochemical oxidative carbonylation of methanol with CO for the synthesis of dimethyl carbonate on metallic electrodes at low overpotentials. For the first time, the reaction was shown to take place on the metallic catalysts without need of oxidized metals or additives. Moreover, in situ spectroelectrochemical techniques were applied to this electrosynthesis reaction in order to reveal the reaction intermediates and shed light into the reaction mechanism...
September 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28917804/development-and-validation-of-a-maleimide-based-enzyme-linked-immunosorbent-assay-for-the-detection-of-tetrodotoxin-in-oysters-and-mussels
#4
Laia Reverté, Maria Rambla-Alegre, Sandra Leonardo, Carlos Bellés, Katrina Campbell, Christopher T Elliott, Arjen Gerssen, Mirjam D Klijnstra, Jorge Diogène, Mònica Campàs
The recent detection of tetrodotoxins (TTXs) in puffer fish and shellfish in Europe highlights the necessity to monitor the levels of TTXs in seafood by rapid, specific, sensitive and reliable methods in order to protect human consumers. A previous immunoassay for TTX detection in puffer fish, based on the use of self-assembled monolayers (SAMs) for the immobilization of TTX on maleimide plates (mELISA), has been modified and adapted to the analysis of oyster and mussel samples. Changing dithiol for cysteamine-based SAMs enabled reductions in the assay time and cost, while maintaining the sensitivity of the assay...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28911688/curcumin-inhibits-adenosine-deaminase-and-arginase-activities-in-cadmium-induced-renal-toxicity-in-rat-kidney
#5
Ayodele Jacob Akinyemi, Nora Onyebueke, Opeyemi Ayodeji Faboya, Sunday Amos Onikanni, Adewale Fadaka, Israel Olayide
In this study, the effect of enzymes involved in degradation of renal adenosine and l-arginine was investigated in rats exposed to cadmium (Cd) and treated with curcumin, the principal active phytochemical in turmeric rhizome. Animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, saline/curcumin 25 mg/kg, Cd/vehicle, Cd/curcumin 12.5 mg/kg, and Cd/curcumin 25 mg/kg. The results of this study revealed that the activities of renal adenosine deaminase and arginase were significantly increased in Cd-treated rats when compared with the control (p < 0...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28906147/carbon-monoxide-poisoning-from-waterpipe-smoking-a-retrospective-cohort-study
#6
Lars Eichhorn, Dirk Michaelis, Michael Kemmerer, Björn Jüttner, Kay Tetzlaff
OBJECTIVE: Waterpipe smoking may increasingly account for unintentional carbon monoxide poisoning, a serious health hazard with high morbidity and mortality. We aimed at identifying waterpipe smoking as a cause for carbon monoxide poisoning in a large critical care database of a specialty care referral center. METHODS: This retrospective cohort study included patients with a history of exposure to waterpipe smoking and carbon monoxide blood gas levels >10% or presence of clinical symptoms compatible with CO poisoning admitted between January 2013 and December 2016...
September 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28904004/jadomycins-inhibit-type-ii-topoisomerases-and-promote-dna-damage-and-apoptosis-in-multidrug-resistant-triple-negative-breast-cancer-cells
#7
Steven R Hall, Jay Toulany, Leah G Bennett, Camilo F Martinez-Farina, Andrew W Robertson, David L Jakeman, Kerry B Goralski
Jadomycins are natural products that kill drug-sensitive and multidrug resistant (MDR) breast cancer cells. To date the cytotoxic activity of jadomycins has never been tested in MDR breast cancer cells that are also triple-negative. Additionally, there is only a rudimentary understanding of how jadomycins cause cancer cell death, which includes the induction of intracellular reactive oxygen species (ROS). We first created a paclitaxel-resistant, triple-negative breast cancer cell line (231-TXL) from drug-sensitive MDA-MB-231 cells (231-CON)...
September 13, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28900032/nucleolar-and-spindle-associated-protein-1-nusap1-interacts-with-a-sumo-e3-ligase-complex-during-chromosome-segregation
#8
Christine A Mills, Aussie Suzuki, Anthony Arceci, Jin Yao Mo, Alex Duncan, Edward D Salmon, Michael J Emanuele
The mitotic spindle is composed of dynamic microtubules and associated proteins that together direct chromosome movement during mitosis. The spindle plays a vital role in accurate chromosome segregation fidelity and is a therapeutic target in cancer. Nevertheless, the molecular mechanisms by which many spindle associated proteins function remains unknown. The Nucleolar and Spindle Associated Protein NUSAP1 is a microtubule binding protein implicated in spindle stability and chromosome segregation. We show here that NUSAP1 localizes to dynamic spindle microtubules in a unique chromosome-centric pattern, in the vicinity of overlapping microtubules, during metaphase and anaphase of mitosis...
September 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28888530/economic-implications-of-unintentional-carbon-monoxide-poisoning-in-the-united-states-and-the-cost-and-benefit-of-co-detectors
#9
Tao Ran, Tursynbek Nurmagambetov, Kanta Sircar
BACKGROUND: Unintentional non-fire-related (UNFR) carbon monoxide (CO) poisoning has been among the leading causes of poisoning in the United States. Current estimation of its economic burden is important for an optimal allocation of resources for UNFR CO poisoning prevention. OBJECTIVE: This study was to estimate the morbidity costs of UNFR CO poisoning. We also compared the costs and benefits of installing CO detectors in residences. METHODS: We used 2010-2014 charges and cost data from Healthcare Cost and Utilization Project (HCUP), and Truven© Health MarketScan Commercial Claims and Encounters and Medicare Supplemental data...
August 23, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28884628/the-effect-of-tannic-acid-on-bone-mechanical-and-geometric-properties-bone-density-and-trabecular-histomorphometry-as-well-as-the-morphology-of-articular-and-growth-cartilages-in-rats-co-exposed-to-cadmium-and-lead-is-dose-dependent
#10
Ewa Tomaszewska, Piotr Dobrowolski, Anna Winiarska-Mieczan, Małgorzata Kwiecień, Siemowit Muszyński, Agnieszka Tomczyk
Cadmium (Cd) and lead (Pb) are toxic elements that accumulate to the largest extent in bones. Rats were used to investigate whether tannic acid (TA; 0.5%, 1.0%, 1.5%. 2.0%, or 2.5%) would have a protective effect on the structure and properties of bones in the case of exposure to Cd and Pb (diet: 7 mg Cd/kg and 50 mg Pb/kg) for 6 weeks. The effects of administration of TA in Cd- and Pb-poisoned rats on bone characteristics and the morphology of articular and growth cartilages were determined. All the rats administered Cd and Pb had an enhanced Cd and Pb concentration in blood plasma and bone and reduced bone Ca content irrespective of the TA administration...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28879668/n-acetylcysteine-as-a-chemical-scavenger-for-sulfur-mustard-new-insights-by-mass-spectrometry
#11
Markus Siegert, Andreas Kranawetvogl, Horst Thiermann, Harald John
The vesicant sulfur mustard (SM) is a banned chemical warfare agent. Although, SM was used in combat since WWI there is still no causal therapy currently available. Accordingly, development and investigation of antidotes and scavengers targeting SM are of high clinical relevance. N-acetylcysteine (NAC) was shown to mitigate symptoms of SM intoxications in vitro and in vivo. However, it is still unclear whether the beneficial effects of NAC are only due to physiological processes or also due to chemical scavenging of SM...
September 6, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28874945/pediatric-exposures-to-topical-benzocaine-preparations-reported-to-a-statewide-poison-control-system
#12
Rais Vohra, Serena Huntington, Jennifer Koike, Kevin Le, Richard J Geller
INTRODUCTION: Topical benzocaine is a local anesthetic commonly used to relieve pain caused by teething, periodontal irritation, burns, wounds, and insect bites. Oral preparations may contain benzocaine concentrations ranging from 7.5% to 20%. Pediatric exposure to such large concentrations may result in methemoglobinemia and secondarily cause anemia, cyanosis, and hypoxia. METHODS: This is a retrospective study of exposures reported to a statewide poison control system...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28845896/development-of-a-multiplex-real-time-pcr-assay-for-detection-of-human-enteric-viruses-other-than-norovirus-using-samples-collected-from-gastroenteritis-patients-in-fukui-prefecture-japan
#13
Kazuaki Kowada, Kenji Takeuchi, Eiko Hirano, Miho Toho, Kiyonao Sada
There are many varieties of gastroenteritis viruses, of which norovirus (NoV) accounts for over 90% of the viral food poisoning incidents in Japan. However, protocols for rapidly identifying other gastroenteritis viruses need to be established to investigate NoV-negative cases intensively. In this study, a multiplex real-time PCR assay targeting rotavirus A, rotavirus C, sapovirus, astrovirus, adenovirus, and enterovirus was developed using stool samples collected from gastroenteritis patients between 2010 and 2013 in Fukui Prefecture, Japan...
August 28, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28840967/photocatalytic-conversion-of-co2-to-co-by-a-copper-ii-quaterpyridine-complex
#14
Zhenguo Guo, Fei Yu, Ying Yang, Chi-Fai Leung, Siu-Mui Ng, Chi-Chiu Ko, Claudio Cometto, Tai-Chu Lau, Marc Robert
The invention of efficient systems for the photocatalytic reduction of CO2 comprising earth-abundant metal catalysts is a promising approach for the production of solar fuels. One bottleneck is to design highly selective and robust molecular complexes that are able to transform the CO2 gas. The Cu(II) quaterpyridine complex [Cu(qpy)](2+) (1) is found to be a highly efficient and selective catalyst for visible-light driven CO2 reduction in CH3 CN using [Ru(bpy)3 ](2+) (bpy: bipyridine) as photosensitizer and BIH/TEOA (1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole/triethanolamine) as sacrificial reductant...
August 25, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28833273/reinforcement-of-barrier-function-and-scalp-homeostasis-by-senkyunolide-a-to-fight-against-dandruff
#15
Philippe Mondon, Caroline Ringenbach, Emmanuel Doridot, Viviane Genet, Pascaline Criton
OBJECTIVE: Senkyunolide-A (SENKY) can be isolated from Apium graveolens seed oil obtained using supercritical CO2 extraction. SENKY and its parent compounds, the N-butyl phthalides, have been demonstrated to protect cells from CO poisoning, to prevent diabetes mellitus and to decrease cancer cell proliferation. This study was undertaken to evaluate in vitro and in vivo the effect of SENKY on epidermal function improvement, Malassezia effect control, scalp soothing and dandruff reduction via skin protection related pathways...
August 18, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28829070/homoleptic-iron-ii-and-cobalt-ii-bis-phosphoranimide-complexes-for-the-selective-hydrofunctionalization-of-unsaturated-molecules
#16
Tao Bai, Trevor Janes, Datong Song
Low-coordinate homoleptic bulky M2(NP(t)Bu3)4 (M = Fe (A), Co (B)) complexes were synthesized and characterized as dimeric structures by crystallographic studies. The iron complex A can catalyze the hydroboration reaction of aldehydes and ketones. The cobalt complex B outperformed its iron counterpart in hydrogenations of several typical alkenes and alkynes under mild conditions. Poisoning experiments indicate that the Co(ii)/HBpin catalytic system could be homogeneous.
August 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28820222/quasi-zero-dimensional-cobalt-doped-ceo2-dots-on-pd-catalysts-for-alcohol-electro-oxidation-with-enhanced-poisoning-tolerance
#17
Qiang Tan, Haiyan Zhu, Shengwu Guo, Yuanzhen Chen, Tao Jiang, Chengyong Shu, Shaokun Chong, Benjamin Hultman, Yongning Liu, Gang Wu
Deactivation of an anode catalyst resulting from the poisoning of COad-like intermediates is one of the major problems for methanol and ethanol electro-oxidation reactions (MOR & EOR), and remains a grand challenge towards achieving high performance for direct alcohol fuel cells (DAFCs). Herein, we report a new approach for the preparation of ultrafine cobalt-doped CeO2 dots (Co-CeO2, d = 3.6 nm), which can be an effective anti-poisoning promoter for Pd catalysts towards MOR and EOR in alkaline media. Compared to Pd/CeO2 and pure Pd, the hybrid Pd/Co-CeO2 nanocomposite catalyst exhibited a much enhanced activity and remarkable anti-poisoning ability for both MOR and EOR...
August 31, 2017: Nanoscale
https://www.readbyqxmd.com/read/28812383/evaluation-of-relationship-between-coronary-artery-status-evaluated-by-coronary-computed-tomography-angiography-and-development-of-cardiomyopathy-in-carbon-monoxide-poisoned-patients-with-myocardial-injury-a-prospective-observational-study
#18
Yong Sung Cha, Hyun Kim, Yoonsuk Lee, Woocheol Kwon, Jung-Woo Son, Hyun Youk, Hyung Il Kim, Oh Hyun Kim, Kyung Hye Park, Kyoung-Chul Cha, Kang Hyun Lee, Sung Oh Hwang
OBJECTIVES: Whether coronary artery changes are a main mechanism in the development of carbon monoxide (CO)-induced cardiomyopathy remains unknown. We investigated the effects of coronary artery stenosis on the presence or patterns of cardiomyopathy in CO-poisoned patients with myocardial injury defined as elevation of troponin I. MATERIALS AND METHODS: This prospective observational study collected data from consecutive patients who were diagnosed with CO poisoning and myocardial injury during the 24-month study period...
August 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28812367/the-usefulness-of-diffusion-weighted-magnetic-resonance-imaging-performed-in-the-acute-phase-as-an-early-predictor-of-delayed-neuropsychiatric-sequelae-in-acute-carbon-monoxide-poisoning
#19
Y S Kim, Y S Cha, M S Kim, H J Kim, Y S Lee, H Youk, H I Kim, O H Kim, K-C Cha, H Kim, K H Lee, S O Hwang
Delayed onset of neuropsychiatric symptoms after apparent recovery from acute carbon monoxide (CO) poisoning has been described as delayed neuropsychiatric sequelae (DNS). No previous study has determined whether early use of diffusion-weighted magnetic resonance imaging (DWI) can predict which patients will develop DNS in the acute CO poisoning. This retrospective observational study was performed on adult patients with acute CO poisoning consecutively treated over a 17-month period. All included patients with acute CO poisoning underwent DWI to evaluate brain injury within 72 h after CO exposure...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28807985/inhaled-carbon-monoxide-from-toxin-to-therapy
#20
Dean R Hess
Carbon monoxide (CO) is usually recognized as a toxic gas that can be used to assess lung function in the pulmonary function laboratory. The toxicity of CO relates to its high affinity for hemoglobin and other heme molecules, producing carboxyhemoglobin (HbCO). Despite that blood HbCO levels are commonly measured in patients with CO poisoning, the clinical presentation often does not correlate with the HbCO level, and clinical improvement in the patient's condition does not correlate with HbCO clearance. In patients with CO poisoning, administration of 100% O2 is standard practice...
August 14, 2017: Respiratory Care
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