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CO Poisoning

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https://www.readbyqxmd.com/read/27921441/re-methemoglobin-measurements-are-underestimated-by-the-radical-7-co-oximeter-experience-from-a-series-of-moderate-to-severe-propanil-poisonings
#1
Nasim Zamani, Hossein Hassanian-Moghaddam
No abstract text is available yet for this article.
December 6, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27919173/carbon-monoxide-poisoning-during-camping-in-korea
#2
Youn-Jung Kim, Chang Hwan Sohn, Bum Jin Oh, Kyoung Soo Lim, Won Young Kim
OBJECTIVE: The aim of this study was to evaluate the epidemiology and characteristics of unintentional carbon monoxide (CO) poisoning during camping in Korea. METHODS: We performed a retrospective observational study on patients with unintentional camping-related CO poisoning who were admitted to the emergency department (ED) from 1 January 2010 to 31 December 2014. News reports about incidents of camping-related CO poisoning were collected using news search engines...
December 5, 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27906402/one-step-synthesis-of-ultrathin-ptxpb-nerve-like-nanowires-as-robust-catalysts-for-enhanced-methanol-electrooxidation
#3
Liang Huang, Yujie Han, Xueping Zhang, Youxing Fang, Shaojun Dong
Ultrathin PtxPb nerve-like nanowires (NNWs) with a diameter of only around 3.6 nm were synthesized by a one-step wet-chemical strategy, and they served as robust catalysts for greatly enhancing methanol electrooxidation both under acidic and alkaline conditions. Due to the high CO-poisoning tolerance, superior electrocatalytic activity and stability endowed by the Pt-Pb alloyed composition and the unique structure, the Pt3.5Pb NNWs showed the highest specific activity of 2.78 mA cm(-2) in acidic media and 6...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27893431/dysregulated-human-tyrosyl-dna-phosphodiesterase-i-acts-as-cellular-toxin
#4
Selma M Cuya, Evan Q Comeaux, Keith Wanzeck, Karina J Yoon, Robert C A M van Waardenburg
Tyrosyl-DNA phosphodiesterase I (TDP1) hydrolyzes the drug-stabilized 3'phospho-tyrosyl bond formed between DNA topoisomerase I (TOPO1) and DNA. TDP1-mediated hydrolysis uses a nucleophilic histidine (Hisnuc) and a general acid/base histidine (Hisgab). A Tdp1Hisgab to Arg mutant identified in patients with the autosomal recessive neurodegenerative disease SCAN1 causes stabilization of the TDP1-DNA intermediate. Based on our previously reported Hisgab-substitutions inducing yeast toxicity (Gajewski et al. J...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27890445/acute-carbon-monoxide-poisoning-mr-imaging-findings-with-clinical-correlation
#5
D M Kim, I H Lee, J Y Park, S-B Hwang, D S Yoo, C J Song
PURPOSE: To assess the magnetic resonance imaging (MRI) findings, including diffusion-weighted imaging (DWI) in patients with acute carbon monoxide (CO) poisoning and correlate MRI findings with carboxyhemoglobin levels. MATERIALS AND METHODS: The MRI examinations and medical records of seven men with a mean age of 43±16.0years (SD) (range: 25-63 years) with acute CO poisoning were reviewed. MRI examinations were analyzed with respect to lesion location, imaging presentation on T1- and T2-weighted images, and diffusion characteristics on DWI and apparent diffusion coefficient (ADC) maps...
November 24, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27867479/donor-pretreatment-with-carbon-monoxide-prevents-ischemia-reperfusion-injury-following-heart-transplantation-in-rats
#6
Noritomo Fujisaki, Keisuke Kohama, Takeshi Nishimura, Hayato Yamashita, Michiko Ishikawa, Akihiro Kanematsu, Taihei Yamada, Sungsoo Lee, Tetsuya Yumoto, Kohei Tsukahara, Joji Kotani, Atsunori Nakao
Because inhaled carbon monoxide (CO) provides potent anti-inflammatory and antioxidant effects against ischemia reperfusion injury, we hypothesized that treatment of organ donors with inhaled CO would decrease graft injury after heart transplantation. Hearts were heterotopically transplanted into syngeneic Lewis rats after 8 hours of cold preservation in University of Wisconsin solution. Donor rats were exposed to CO at a concentration of 250 parts per million for 24 hours via a gas-exposure chamber. Severity of myocardial injury was determined by total serum creatine phosphokinase and troponin I levels at three hours after reperfusion...
July 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27867475/characteristics-of-exogenous-carbon-monoxide-deliveries
#7
REVIEW
Hui-Jun Hu, Qiang Sun, Zhou-Heng Ye, Xue-Jun Sun
Carbon monoxide (CO) has long been considered an environmental pollutant and a poison. Exogenous exposure to amounts of CO beyond the physiologic level of the body can result in a protective or adaptive response. However, as a gasotransmitter, endogenous CO is important for multiple physiologic functions. To date, at least seven distinct methods of delivering CO have been utilized in animal and clinical studies. In this mini-review, we summarize the exogenous CO delivery methods and compare their advantages and disadvantages...
April 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27861257/pulmonary-phototherapy-to-treat-carbon-monoxide-poisoning-in-rats
#8
Luca Zazzeron, Chen Liu, Walfre Franco, Akito Nakagawa, William A Farinelli, Donald B Bloch, R Rox Anderson, Warren M Zapol
BACKGROUND: Carbon monoxide (CO) poisoning is a common cause of poison-related mortality. CO binds to hemoglobin in the blood to form carboxyhemoglobin (COHb), impairing oxygen delivery to peripheral tissues. Current treatment of CO poisoned patients involves oxygen administration to rapidly remove CO and restore oxygen delivery. Light dissociates CO from COHb with high efficiency. Exposure of murine lungs to visible laser-generated light improved the CO elimination rate in vivo. The aims of this study were to apply pulmonary phototherapy to a larger animal model of CO poisoning, to test novel approaches to light delivery, and to examine the effect of chemiluminescence-generated light on the CO elimination rate...
November 16, 2016: Shock
https://www.readbyqxmd.com/read/27849445/deaths-due-to-carbon-monoxide-poisoning-in-aydin-western-turkey
#9
Musa Dirlik, Başak Bostancıoğlu
The purpose of this study was to retrospectively investigate cases of death due to carbon monoxide (CO) poisoning in the province of Aydın in western Turkey. The study investigated the cases of death due to CO poisoning that were autopsied at the Adnan Menderes University Department of Forensic Medicine from 2002 to 2012. The mean age of the 33 autopsied cases of fatal CO poisoning was 60.30 ± 4.082 years, and 75.8% of the cases were men. The highest level of CO in blood was 79.7%. It was found that most of the CO poisoning deaths were related to accidents...
November 16, 2016: Death Studies
https://www.readbyqxmd.com/read/27833554/n-butylphthalide-alleviates-blood-brain-barrier-impairment-in-rats-exposed-to-carbon-monoxide
#10
Mingjun Bi, Mingwei Zhang, Dadong Guo, Weikang Bi, Bin Liu, Yong Zou, Qin Li
Carbon monoxide (CO) poisoning is one of the most important health concerns and may result in neuropathologic changes and neurologic sequelae. However, few studies have addressed the correlation between CO poisoning and blood-brain barrier (BBB) impairment. In this study, we investigated the effects of N-butylphthalide (NBP) on the expressions of zonula occludens-1 (ZO-1), claudin-5 and aquaporin-4 (AQP-4) proteins in a CO poisoning rat model. The results indicated that the brain water content was obviously increased, and the tight junctions between endothelial cells were disrupted, resulting in significant cerebral edema and BBB dysfunction in a rat model of CO poisoning...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27827957/screening-of-cytotoxic-b-cereus-on-differentiated-caco-2-cells-and-in-co-culture-with-mucus-secreting-ht29-mtx-cells
#11
Virginie Castiaux, Laurie Laloux, Yves-Jacques Schneider, Jacques Mahillon
B. cereus is an opportunistic foodborne pathogen able to cause diarrhoea. However, the diarrhoeal potential of a B. cereus strain remains difficult to predict, because no simple correlation has yet been identified between the symptoms and a unique or a specific combination of virulence factors. In this study, 70 B. cereus strains with different origins (food poisonings, foods and environment) have been selected to assess their enterotoxicity. The B. cereus cell-free supernatants have been tested for their toxicity in vitro, on differentiated (21 day-old) Caco-2 cells, using their ATP content, LDH release and NR accumulation...
November 5, 2016: Toxins
https://www.readbyqxmd.com/read/27824191/nitrogen-and-sulfur-co-doping-of-3d-hollow-structured-carbon-spheres-as-an-efficient-and-stable-metal-free-catalyst-for-the-oxygen-reduction-reaction
#12
Zexing Wu, Rong Liu, Jie Wang, Jing Zhu, Weiping Xiao, Cuijuan Xuan, Wen Lei, Deli Wang
Three-dimensional, hollow-structured carbon sphere nanocomposites (N,S-hcs) doped with nitrogen and sulfur were prepared using a soft template approach followed by a high-temperature treatment. The synthesized N,S-hcs nanomaterials exhibited favourable catalytic activity for the oxygen reduction reaction (ORR) compared to carbon spheres doped solely with nitrogen (N-hcs), polypyrrole (PPY) solid nanoparticles and irregular fragments of polyaniline (PAN). These results demonstrated the co-doping of N/S and the relatively large surface area of the mesoporous carbon structure that enhanced the catalytic activity of the resulting material...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27819312/relation-between-brain-temperature-and-white-matter-damage-in-subacute-carbon-monoxide-poisoning
#13
Shunrou Fujiwara, Yoshichika Yoshioka, Tsuyoshi Matsuda, Hideaki Nishimoto, Akira Ogawa, Kuniaki Ogasawara, Takaaki Beppu
In the previous studies, carbon monoxide (CO) poisoning showed an imbalance between cerebral perfusion and metabolism in the acute phase and the brain temperature (BT) in these patients remained abnormally high from the acute to the subacute phase. As observed in chronic ischemic patients, BT can continuously remain high depending on impairments of cerebral blood flow and metabolism; this is because heat removal and production system in the brain may mainly be maintained by the balance of these two factors; thus, cerebral white matter damage (WMD) affecting normal metabolism may affect the BT in patients with CO poisoning...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27785820/central-nervous-system-toxicity-of-mefenamic-acid-overdose-compared-to-other-nsaids-an-analysis-of-cases-reported-to-the-united-kingdom-national-poisons-information-service
#14
A Kamour, S Crichton, G Cooper, D J Lupton, M Eddleston, J A Vale, J P Thompson, S H L Thomas
AIMS: Case reports and small case series suggest increased Central Nervous System (CNS) toxicity especially convulsions, after overdose of mefenamic acid, compared with other NSAIDs, but comparative epidemiological studies have not been conducted. This study compared rates of CNS toxicity after overdose between mefenamic acid, ibuprofen, diclofenac and naproxen, as reported in telephone enquiries to the United Kingdom National Poisons Information Service (NPIS). METHODS: NPIS telephone enquiries related to the four NSAIDs received between January 2007 and December 2013 were analysed, comparing the frequency of reported CNS toxicity (convulsions, altered conscious level, agitation or aggression, confusion or disorientation) using multivariable logistic regression...
October 26, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27779839/hepatitis-b-in-poland-in-2014
#15
Małgorzata Stępień, Katarzyna Piwowarow, Mirosław P Czarkowski
OBJECTIVE: The aim of the study was to assess the epidemiological situation of hepatitis B in Poland in 2014 in comparison with the previous years. MATERIAL AND METHODS: The evaluation of the epidemiological situation was carried out on a basis of analysis of data from case-based reports on acute hepatitis B registered by sanitary and epidemiological stations, aggregate data derived from annual bulletins “Infectious diseases and poisonings in Poland”, data from annual bulletin “Vaccinations in Poland” and data on locally registered HBsAg carriers...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27778147/effects-of-acute-carbon-monoxide-poisoning-on-ecg-and-echocardiographic-parameters-in-children
#16
Abdullah Ozyurt, Derya Karpuz, Aydin Yucel, Mehtap Durukan Tosun, Ayse Esin Kibar, Olgu Hallioglu
The aim of the current study is to investigate the effects of CO (carbon monoxide) on the cardiovascular system via electrocardiographic, echocardiographic and biochemical findings in children. This prospective study included 22 children with CO poisoning and 24 healthy children as a control group. The CO-intoxicated children were evaluated via electrocardiography and echocardiography 1 h after admission to the emergency department and daily until their discharge from the hospital. Blood gasses, complete blood account, troponin I and creatinine kinase-MB(CK-MB) were assessed daily...
October 24, 2016: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/27773993/toxico-neurological-effects-of-piroxicam-in-monogastric-animals
#17
Saganuwan Alhaji Saganuwan, Orinya Agbaji Orinya
Piroxicam is a benzothiazine compound with anti-inflammatory, antipyretic, and analgesic properties. Because of the very high efficacy of piroxicam and its increasing use in the treatment of carcinomas in dogs and cats, there is a need for acute toxicity study of piroxicam in monogastric animals and its potential for causing secondary poisoning in puppies. Piroxicam manufactured by Shanxi Federal Pharmaceutical Co, Ltd. was used for this study. Revised up-and-down procedure was used for the estimation of median lethal dose in mouse (259...
2016: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/27753502/carbon-monoxide-poisoning-pathogenesis-management-and-future-directions-of-therapy
#18
Jason J Rose, Ling Wang, Qinzi Xu, Charles F McTiernan, Sruti Shiva, Jesus Tejero, Mark T Gladwin
Carbon monoxide (CO) poisoning affects 50,000 people a year in the United States. The clinical presentation runs a spectrum, ranging from headache and dizziness to coma and death, with a mortality rate ranging from 1-3%. A significant number of patients who survive CO poisoning suffer from long term neurologic and affective sequelae. The neurologic deficits do not necessarily correlate with blood CO levels, but likely result from the pleiotropic effects of CO on cellular mitochondrial respiration, cellular energy utilization, inflammation and free radical generation, especially in the brain and heart...
October 18, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27752660/co-tolerance-of-pt-feox-catalyst-in-both-thermal-catalytic-h2-oxidation-and-electrochemical-co-oxidation-the-effect-of-pt-deficit-electron-state
#19
Lequan Liu, Feng Zhou, Rajesh Kodiyath, Shigenori Ueda, Hideki Abe, Defa Wang, Youquan Deng, Jinhua Ye
CO poisoning of Pt catalysts is one of the major challenges to the commercialization of proton exchange membrane fuel cells. One promising solution is to develop CO-tolerant Pt-based catalysts. A facilely synthesized Pt/FeOx catalyst exhibited outstanding CO tolerance in the oxidation of H2 and electrochemical CO stripping. Light-off temperature of H2O formation over Pt/FeOx was achieved even below 30 °C in the presence of 3000 ppm CO at a space velocity of 18 000 mL g(-1)cat h(-1). For the electrochemical oxidation of CO, the onset and peak potentials decreased by 0...
October 18, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27752625/treatment-of-acute-carbon-monoxide-poisoning-with-induced-hypothermia
#20
Byoung-Joon Oh, Yong-Gyun Im, Eunjung Park, Young-Gi Min, Sang-Cheon Choi
OBJECTIVE: The effect of induced hypothermia on severe acute carbon monoxide (CO) poisoning remains to be addressed further. We investigated the effect of induced hypothermia on severe acute CO poisoning. METHODS: Retrospective chart review was conducted for patients who diagnosed as severe acute CO poisoning in emergency department and underwent induced hypothermia from May 2013 to May 2014. Hospital courses with critical medication and major laboratory results were investigated through the chart review...
June 2016: Clinical and Experimental Emergency Medicine
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