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Methylene Chloride

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https://www.readbyqxmd.com/read/28704725/simultaneous-estimation-of-lisofylline-and-pentoxifylline-in-rat-plasma-by-high-performance-liquid-chromatography-photodiode-array-detector-and-its-application-to-pharmacokinetics-in-rat
#1
Kishan S Italiya, Saurabh Sharma, Ishit Kothari, Deepak Chitkara, Anupama Mittal
Lisofylline (LSF) is an anti-inflammatory and immunomodulatory agent with proven activity in serious infections associated with cancer chemotherapy, hyperoxia-induced acute lung injury, autoimmune disorders including type-1 diabetes (T1DM) and islet rejection after islet transplantation. It is also an active metabolite of another anti-inflammatory agent, Pentoxifylline (PTX). LSF bears immense therapeutic potential in multiple pharmacological activities and hence appropriate and accurate quantification of LSF is very important...
June 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28686036/synthesis-of-thieno-fused-five-and-six-membered-nitrogen-and-oxygen-heterocycles-via-intramolecular-heteroannulation-of-4-5-substituted-3-amino-or-3-hydroxy-2-functionalized-thiophenes
#2
Anand Acharya, Vibha Gautam, Hiriyakkanavar Ila
Diverse general high-yield routes for novel thieno-fused five- and six-membered nitrogen and oxygen heterocycles such as thieno[3,2-b]pyrroles, thieno[3,2-b]furans, thieno[3,2-b]indoles, thieno[3,2-b]benzofurans, thieno[3,2-b]pyridine-5-ones, thieno[3,2-b]pyran-5-ones, thieno[3,2-b]isoquinolin-5-ones, thieno[3,2-b]chromen-5-ones, thieno[3,2-b]quinolin-9-ones, and thieno[3,2-b]chromen-9-ones have been developed via in situ or stepwise intramolecular heteroannulation of newly synthesized 4,5-substituted 3-amino- or 3-hydroxy 2-functionalized thiophenes...
July 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28676661/tailoring-hydrophobic-branch-in-polyzwitterionic-resin-for-simultaneous-capturing-of-hg-ii-and-methylene-blue-with-response-surface-optimization
#3
Tawfik A Saleh, Ihsan Budi Rachman, Shaikh A Ali
A new highly efficient cross-linked polymer was synthesized via cyclotetrapolymerization of hydrophilic [(diallylamino)propyl]phosphonic acid hydrochloride (72 mol%), hydrophobic N,N-diallyl-1-[6-(biphenyl-4-yloxy)hexylammonium chloride (18 mol%), cross-linker 1,1,4,4-tetraallylpiperazinium dichloride (10 mol%) with an equivalent amount of alternating SO2 units (100 mol%). The pH-responsive resin chemically tailored with the aminopropylphosphonate chelating ligand and hydrophobic chain of (CH2)6OC6H4-C6H5 is designed to capture toxic metal ions and organic contaminants simultaneously...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28669229/cytotoxic-activity-of-alkyl-benzoate-and-fatty-acids-from-the-red-sea-sponge-hyrtios-erectus
#4
Usama W Hawas, Lamia T Abou El-Kassem, Mohamed S Abdelfattah, Mohammed I Y Elmallah, Mennat Allah G Eid, Marwa Monier, M Nithiyanandam
The chemical investigation of the methylene chloride fraction of marine sponge Hyrtios erectus led to the isolation of the known oxysterol (2) along with a new alkyl benzoate compound identified by spectroscopic methods (NMR and MS) as 4'-methylheptyl benzoate (1), whilst the n-butanol fraction afforded the known indole 3-carbaldehyde and β-carboline derivatives. Moreover, the hexane fraction was analysed by GC-MS for their fatty acids (FAs). A total of 17 FAs with chain lengths between 14 and 25 carbons were identified...
July 3, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28665001/nmr-spectroscopic-conformational-analysis-of-4-methylene-cyclohexyl-pivalate-the-effect-of-sp-2-hybridization
#5
Erich Kleinpeter, Matthias Heydenreich, Andreas Koch, Angela Krtitschka, Tobias Krüger, Torsten Linker
The conformational equilibrium of the axial/equatorial conformers of 4-methylene-cyclohexyl pivalate is studied by dynamic NMR spectroscopy in a methylene chloride/freon mixture. At 153 K the ring interconversion gets slow on the NMR time scale, the conformational equilibrium (-ΔG°) can be examined and the barrier to ring interconversion (ΔG(#) ) can be determined. The structural influence of sp(2) hybridization on both ΔG° and ΔG(#) of the cyclohexyl moiety can be quantified.
June 30, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28660262/pyrene-tagged-carbohydrate-based-mixed-p-s-ligand-spacer-effect-on-the-rh-i-catalyzed-hydrogenation-of-methyl-%C3%AE-acetamidocinnamate
#6
Juan Francisco Moya, Christian Rosales, Inmaculada Fernández, Noureddine Khiar
The post-functionalization of a chiral catalyst offers the advantage of providing it with additional physical characteristics that, together with its enantioselective capacity, increase its overall synthetic value. Taking advantage of the modularity and polyfunctionality of carbohydrate-derived ligands, herein we report the synthesis of two mixed P/S catalysts functionalized with a pyrene group through the 6 position of the sugar by carbon chains of different lengths. Using the hydrogenation of methyl (Z)-α-acetamidocinnamate as the model reaction has shown that the proximity of the pyrenyl group to the catalytic center is detrimental to the activity and enantioselectivity of the hydrogenation process, the most efficient catalyst being the complex derived from pyrenebutyric acid 12...
June 29, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28644688/intraosseous-administration-of-antidotes-a-systematic-review
#7
Audrée Elliott, Pierre-André Dubé, Amélie Cossette-Côté, Laura Patakfalvi, Eric Villeneuve, Martin Morris, Sophie Gosselin
CONTEXT: Intraosseous (IO) access is an established route of administration in resuscitation situations. Patients with serious poisoning presenting to the emergency department may require urgent antidote therapy. However, intravenous (IV) access is not always readily available. OBJECTIVE: This study reviews the current evidence for IO administration of antidotes that could be used in poisoning. The primary outcome was mortality as a surrogate of efficacy. Secondary outcomes included hemodynamic variables, electrocardiographic variables, neurological status, pharmacokinetics outcomes, and adverse effects as defined by each article...
June 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28634802/alkaline-treated-sawdust-as-an-effective-material-for-cationic-dye-removal-from-textile-effluents-under-dynamic-conditions-breakthrough-curve-prediction-and-mechanism-exploration
#8
Ahmed Amine Azzaz, Salah Jellali, Rahma Souissi, Karim Ergaieg, Latifa Bousselmi
This paper deals with the methylene blue molecule (MB) removal from synthetic and real textile wastewaters by alkali-treated orange tree sawdust (ATOS) under different dynamic conditions. Experimental results showed that MB removal efficiencies by ATOS increased when increasing initial dye concentrations and bed depths but decreased with the increase of the applied flow rates with a maximum adsorption capacity of about 110 mg g(-1). Moreover, various empirical models were applied to predict the experimental breakthrough curves (BTCs) and to determine the characteristic adsorption parameters...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28571111/occupational-solvent-exposure-and-adult-chronic-lymphocytic-leukemia-no-risk-in-a-population-based-case-control-study-in-four-nordic-countries
#9
Madar Talibov, Anssi Auvinen, Elisabete Weiderpass, Johnni Hansen, Jan-Ivar Martinsen, Kristina Kjaerheim, Laufey Tryggvadottir, Eero Pukkala
The aim of this study was to assess the effect of occupational solvent exposure on the risk of adult chronic lymphocytic leukemia (CLL). The current case-control study was nested in the Nordic Occupational Cancer Study (NOCCA) cohort. 20,615 CLL cases diagnosed in 1961-2005 in Finland, Iceland, Norway, and Sweden, and 103,075 population-based controls matched by year of birth, sex, and country were included. Occupational histories for cases and controls were obtained from census records in 1960, 1970, 1980/1981, and 1990...
June 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28494432/synthesis-and-evaluation-of-mucoadhesive-acryloyl-quaternized-pdmaema-nanogels-for-ocular-drug-delivery
#10
Ruairí P Brannigan, Vitaliy V Khutoryanskiy
Poly((2-dimethylamino)ethyl methacrylate) (PDMAEMA) nanogels were synthesized via surfactant-free free-radical polymerization technique in aqueous conditions utilizing N,N'-methylene-bis-acrylamide (MBA) as a crosslinking agent. The PDMAEMA nanogels were subsequently quaternized with acryloyl chloride in order to yield mucoadhesive materials which incorporate two mucoadhesive concepts; electrostatic interactions and covalent bond forming acrylate groups. The native PDMAEMA nanogels were found to exhibit good mucoadhesive properties on ex vivo bovine conjunctival tissues, which was found to increase proportionally with the degree of quaternization...
April 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28476961/poly-vinyl-alcohol-poly-acrylamide-co-diallyldimethyl-ammonium-chloride-semi-ipn-hydrogels-for-ciprofloxacin-hydrochloride-drug-delivery
#11
Siva Sankar Sana, Vijaya Kumar Naidu Boya
Herein, the authors developed a new and potential semi-interpenetrating polymer network (semi-IPN) hydrogels of poly vinyl alcohol (PVA), acryl amide and diallyldimethyl ammonium chloride employing chemical cross-linker N, N'-methylene bisacrylamide (NNMBA) and ammonium persulphate as an initiator by radical polymerisation. To analyse the copolymer formation between two monomers and IPN cross-linking reaction, the resulting hydrogel was characterised by Fourier transform infrared spectroscopy and the surface morphology was analysed using scanning electron microscopy...
February 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28452738/development-of-lc-ms-ms-method-for-determination-of-the-olanzapine-in-human-plasma
#12
K Sivsivadze, M Jokhadze, P Tushurashvili, T Murtazashvili, N Imnadze
The study aim was to develop a validated selective, reproducible and sensitive Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) method for qualitative and quantitative determination of olanzapin (OLZ ) in human plasma. For isolation was used solid phase extraction with the Gilson GX-271 ASPEC Solid phase extraction system, cartridge Supelclean LC-18 SPE 500mg. Elution solvent contained 40mL of isopropanol, 4mL of concentrated ammonium hydroxide and 156mL of freshly prepared methylene chloride. Samples containing OLZ and IS were chromatographed on AGILENT TECHNOLOGIES 1290 Infinity AGILENT TECHNOLOGIES 6460 Triple quad LC-MS/MS system...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28445629/n-acetonitrile-functionalized-nitropyrazoles-precursors-to-insensitive-asymmetric-n-methylene-c-linked-azoles
#13
Dheeraj Kumar, Gregory H Imler, Damon A Parrish, Jean'ne M Shreeve
Properties of energetic compounds obtained by linking energetic pyrazoles to tetrazoles by means of N-methylene-C bridges can be fine-tuned. Reactions of pyrazole derivatives with chloroacetonitrile followed by conversion of the cyano group to tetrazole using click reactions in the presence of zinc chloride result in asymmetric N-methylene-C bridged azole-based energetic compounds. All the compounds were thoroughly characterized by IR and NMR [(1) H, (13) C {(1) H}, (15) N] spectroscopy, elemental analysis, and differential scanning calorimetry (DSC), and for two compounds, further supported by single-crystal X-ray diffraction studies...
April 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28439909/effect-of-thermally%C3%A2-deposited-siloxane-methacrylate-coating-on-bonding-to-glass-fibre-posts
#14
F P Silva, A L Faria-E-Silva, R R Moraes, A O Ogliari, G R Reis, A R F Oliveira, M S Menezes
AIM: To evaluate the alterations promoted by a thermally deposited siloxane-methacrylate coating on the surface of glass-fibre posts and its effect on the bond strength of resin-core materials to the posts. METHODOLOGY: Fibre post surfaces were treated with experimental thermally deposited siloxane-methacrylate coatings or clinically available treatments (i.e., hydrogen peroxide and methylene chloride); non-treated posts were used as controls. The contact angles formed between the post surface and the water/adhesive were measured with a tensiometer...
April 25, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28388335/agreement-between-two-methods-for-retrospective-assessment-of-occupational-exposure-intensity-to-six-chlorinated-solvents-data-from-the-national-birth-defects-prevention-study
#15
Candice Y Johnson, Carissa M Rocheleau, Misty J Hein, Martha A Waters, Patricia A Stewart, Christina C Lawson, Jennita Reefhuis
The wide variety of jobs encountered in population-based studies makes retrospective exposure assessment challenging in occupational epidemiology. In this analysis, two methods for estimating exposure intensity to chlorinated solvents are compared: rated (assigned by an expert rater) and modeled (assigned using statistical models). Estimates of rated and modeled intensities were compared for jobs held by mothers participating in the National Birth Defects Prevention Study with possible exposure to six chlorinated solvents: carbon tetrachloride, chloroform, methylene chloride, perchloroethylene, 1,1,1-trichloroethane, and trichloroethylene...
May 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28382365/methylene-bridged-intramolecular-donor-acceptor-systems-based-on-rare-earth-metals-and-phosphinomethanides
#16
Martin Pieper, Jan-Hendrik Lamm, Beate Neumann, Hans-Georg Stammler, Norbert W Mitzel
New geminally bonded intramolecular donor-acceptor systems, Cp2LnCH2PR2 (Ln = Y, Ho, Er, R = CHMe2, CMe3), were prepared by salt elimination reactions between the dicyclopentadienyl-element chlorides (Cp2LnCl, Ln = Y, Ho, Er) and diorganylphosphinomethanides (R2PCH2Li; R = CHMe2, CMe3). These compounds, 1-6, were characterized by elemental analyses, mass spectrometry and X-ray diffraction experiments and the yttrium species additionally by NMR spectroscopy. In the solid state the molecular structures differ from each other, depending on the steric demand of the phosphorus substituents...
April 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28375686/biological-synthesis-of-gold-and-silver-chloride-nanoparticles-by-glycyrrhiza-uralensis-and-in-vitro-applications
#17
Yue Huo, Priyanka Singh, Yeon Ju Kim, Veronika Soshnikova, Jongpyo Kang, Josua Markus, Sungeun Ahn, Verónica Castro-Aceituno, Ramya Mathiyalagan, Mohan Chokkalingam, Kwi-Sik Bae, Deok Chun Yang
The current study highlights the rapid biosynthesis of gold nanoparticles (Gu-AuNps) and silver chloride nanoparticles (Gu-AgClNps) by aqueous root extract of Glycyrrhiza uralensis, a medicinal plant. G. uralensis has been reported for anticancer and hepatoprotective effects. The reduction of chloroauric acid and silver nitrate by the Glycyrrhiza root extract prompted the formation of Gu-AuNps and Gu-AgClNps within 4 and 40 min at 80 °C, respectively. The complete reaction did not require supplemental reducing and stabilizing agents, which demonstrated green synthesis...
April 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28281370/nortirucallane-a-a-new-tirucallane-type-nortriterpenoid-isolated-from-lonicerae-japonicae-flos
#18
Xu Wang, Jing Zhang, Ya-Qun Li, Bao-Xiang Du, Qi-Hui Sun, Yun-Jiao Cao, Hai-Qiang Jiang, Yu-Hong Liu, Hong-Lei Zhou, Rong Rong
One new tirucallane-type nortriterpenoid Nortirucallane A (1), together with Chrysoeriol (2) and Isorhamnetin (3), was isolated from the methylene chloride part of Lonicerae japonicae flos. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compound 3 was isolated from the genus of Lonicera for the first time. The significance of 1 for the study of phytochemical taxonomy was discussed.
March 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28269766/methylene-blue-tetramethylthionine-chloride-influences-the-mobility-of-adult-neural-stem-cells-a-potentially-novel-therapeutic-mechanism-of-a-therapeutic-approach-in-the-treatment-of-alzheimer-s-disease
#19
Amelie T van der Ven, Julius C Pape, Dirk Hermann, Robert Schloesser, Just Genius, Nadine Fischer, Rainald Mößner, Norbert Scherbaum, Jens Wiltfang, Dan Rujescu, Jens Benninghoff
An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects of tetramethylthionine chloride (methylene blue, MB) on properties of adult murine neural stem cells. Based on recent clinical studies, MB has increasingly been discussed as a potential treatment for Alzheimer's disease. While no differences in the proliferative capacity were identified, a general potential of MB in modulating the migratory capacity of adult neural stem cells was indicated in a cell mobility assay...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28266352/preparation-of-carotenoid-extracts-and-nanoemulsions-from-lycium-barbarum-l-and-their-effects-on-growth-of-ht-29-colon-cancer-cells
#20
H J Hsu, R F Huang, T H Kao, B S Inbaraj, B H Chen
Lycium barbarum L., a traditional Chinese herb widely used in Asian countries, has been demonstrated to be protective against chronic diseases such as age-related macular degeneration. The objectives of this study were to determine the carotenoid content in L. barbarum by high-performance liquid chromatography-mass spectrometry, followed by preparation of a carotenoid nanoemulsion to evaluate the mechanism of inhibition on HT-29 colon cancer cells. The highest extraction yield of carotenoids was attained by employing a solvent system of hexane-ethanol-acetone (1:1:1, v/v/v)...
March 7, 2017: Nanotechnology
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