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Rui Kano, Masako Kawasaki, Takashi Mochizuki, Masatarou Hiruma, Atsuhiko Hasegawa
The mating type (-)-specific gene of the alpha-box and the mating type (+)-specific gene of the high-mobility group (HMG) DNA-binding domain were confirmed in zoophilic dematophytes of Arthroderma simii and A. vanbreuseghemii. The sequence of the alpha-box gene was 1,375 bp, containing 2 exons (from 172 to 463 bp and from 513 to 1,375 bp) in the A. simii (-) mating type strain and 1,380 bp, containing 2 exons (from 177 to 468 bp and from 518 to 1,380 bp) in the A. vanbreuseghemii (-) mating type strain. The sequence of the HMG gene was 1,871 bp, containing 2 exons (from 181 to 362 bp and from 426 to 1,440 bp, coding a protein of 398 amino acids) in the A...
March 2012: Mycopathologia
Eliângela C Côbo, Juliano C Silva, Ulisses A Cota, Juliana R Machado, Lucio R Castellano
Here we present a modified protocol for dematophyte diagnosis, utilizing a simple centrifugation step to significantly decrease false-negative results of the original KOH direct microscopy-based technique. Although culture constitutes the gold-standard diagnosis, the time spent for results is a limit. Fast and low-cost techniques are important for infection screening in underdeveloped countries.
May 2010: Journal of Microbiological Methods
Amit Jaiswal, R P Sharma, A P Garg
BACKGROUND: Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts and molds. AIMS: To study the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in onychomycosis. METHODS: A clinical comparative study was undertaken on 96 Patients of onychomycosis during the period between August 2005 to July 2006. Forty-eight patients were randomly assigned in group A to receive oral terbinafine 250 mg, one tablet twice daily for seven days every month (pulse therapy); 24 patients in group B to receive oral terbinafine pulse therapy plus topical ciclopirox olamine 8% to be applied once daily at night on all affected nails; and 24 patients in group C to receive oral terbinafine pulse therapy plus topical amorolfine hydrochloride 5% to be applied once weekly at night on all the affected nails...
November 2007: Indian Journal of Dermatology, Venereology and Leprology
P V Venugopal, T V Venugopal
The allylamine derivatives are a new class of synthetic antifungal agents. The antidermatophytic activity of the two main compounds, naftifine and terbinafine were compared in vitro with those of ketoconazole and itraconazole by agar dilution. Eighty eight clinical isolates of dematophytes comprising of Microsporum canis (50), M. audouinii (5), Trichophyton rubrum (6) T. mentagrophytes (5), T. violaceum (12), T. simii (5), T. verrucosum (1), T. soudanense (1), T. erinacie (1) and Epidermophyton floccosum (2) were tested...
October 1994: Indian Journal of Pathology & Microbiology
R Aho
Hairsamples of domestic and laboratory animals suspected of dermatophytosis were examined for the presence of dermatophytes. A nutritionally poor base-medium developed by the author was successfully used in the isolation and identification of dermatophytes. Casein-medium supplemented with vitamins and Sabouraud-liquid medium were used in special cases. Dermatophytes were isolated in 36 of 331 samples (10.9%). The dermatophytes recovered were Microsporum canis: 13 isolates from cat. 4 from dog. 1 from horse; Trichophyton mentagrophytes var...
April 1980: Acta Pathologica et Microbiologica Scandinavica. Section B, Microbiology
E A Kundsen
The effect of PUVA therapy upon 12 dermatophyte strains, 3 of Candida albicans, and 4 of mould fungi was evaluated by the agar dilution method on Sabouraud agar. 8-MOP, 30 microgram/ml medium plus UVA, 4 Joule/cm2 proved to be fungicidal dose to all the strains studied, with the exception of three of the mould fungi. For dematophytes and Candida albicans the MIC was between 1 and 3 microgram, 8-MOP plus UVA, 4 J; and 3 microgram when the UVA dose was reduced to 1--2 J. For mould fungi it was higher. The MFC varied within the range 2 to 30 microgram, when the UVA dose was fixed at 4 J...
1980: Acta Dermato-venereologica
H Behring
No abstract text is available yet for this article.
May 31, 1980: ZFA. Zeitschrift Für Allgemeinmedizin
R D King, H A Khan, J C Foye, J H Greenberg, H E Jones
The factor present in normal human serum which inhibits growth of dematophytic fungi is characterized and identified. Serum inhibitory factor (SIF) is nondialyzable, heat stable at 56 degrees C. for 4 hours, and fungistatic. SIF was found to be an inhibitor of the dermatophyte genera Trichophyton, Microsporium, and Epidermophyton as well as the dimorphic yeast Candida albicans. SIF activity directly correlated with a serum's unbound iron-binding capacity (UIBC) in that lower UIBC'S were less inhibitory. Addition of iron to serum neutralized the inhibitory activity and this neutrilization was shown to be specific for iron since zinc, magnesium, managnese, and copper failed to alter serum inhibitory activity...
August 1975: Journal of Laboratory and Clinical Medicine
M Otcenásek, B Rosický
Mycotic zoonoses sensu stricto and mycotic infections acquired from animal polluted environment belong to diseases characterized by the phenomenon of natural focality. On a global scale they comprise 16 different diseases caused by yeast-like organisms, dematophytes, dimorphous agents of systemic mycoses and primarily saprophytic fungi as well. Prevalence of mentioned diseases is influenced by a number of factors concerning not only biology and ecology of pathogenic agents and particular hosts, but also character of specific extra-animal substrates which make possible long-term maintenance or active propagation of agents in the environment...
1979: Folia Parasitologica
R Vanbreuseghem
Dematophytes invade hosts when their state is suitable for the production of their pathogenicity. When the host's resistance is reduced, the prevalence of dermatophytoses can be extremely high or the symptomatology can be very unusual. It is suspected that the 'maladie dermatophytique' and pherhaps dermatophytic mycetoma develop in such situations. The fact is that the behaviour of dermatophytes does not differ from that of the so-called opportunistic fungi and in some cases it is possible to speak of dermatophytic asthenomycosis...
1979: Dermatologica
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