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https://www.readbyqxmd.com/read/29452112/molecular-diagnosis-of-protozoan-parasites-by-recombinase-polymerase-amplification
#1
A Castellanos-Gonzalez, A C White, P Melby, B Travi
Infections caused by protozoan parasites affect millions of people around the world. Traditionally, diagnosis was made by microscopy, which is insensitive and in some cases not specific. Molecular methods are highly sensitive and specific, but equipment costs and personnel training limit its availability only to specialized centers, usually far from populations with the highest risk of infection. Inexpensive methods that can be applied at the point of care (POC), especially in places with limited health infrastructure, would be a major advantage...
February 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29451406/cancer-costs-and-outcomes-for-common-cancer-sites-in-the-finnish-population-between-2009-2014
#2
Paulus Torkki, Riikka-Leena Leskelä, Miika Linna, Suvi Mäklin, Jukka-Pekka Mecklin, Petri Bono, Vesa Kataja, Sakari Karjalainen
BACKGROUND: The cost of cancer and outcomes of cancer care have been discussed a lot since cancer represents 3-6% of total healthcare costs and cost estimations have indicated growing costs. There are studies considering the cost of all cancers, but studies focusing on the cost of disease and outcomes in most common cancer sites are limited. The objective of this study was to analyze the development of the costs and outcomes in Finland between 2009 and 2014 per cancer site. METHODS: The National cost, episode and outcomes data were obtained from the National register databases based on International Statistical Classification of Diseases (ICD)-10 diagnosis codes...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29451088/a-marginalized-two-part-model-with-heterogeneous-variance-for-semicontinuous-data
#3
Valerie A Smith, John S Preisser
Semicontinuous data, characterized by a point mass at zero followed by a positive, continuous distribution, arise frequently in medical research. These data are typically analyzed using two-part mixtures that separately model the probability of incurring a positive outcome and the distribution of positive values among those who incur them. In such a conditional specification, however, standard two-part models do not provide a marginal interpretation of covariate effects on the overall population. We have previously proposed a marginalized two-part model that yields more interpretable effect estimates by parameterizing the model in terms of the marginal mean...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29450395/investigating-the-perception-of-romanian-adults-on-ophthalmology-services-from-an-experiential-marketing-perspective
#4
Consuela-Mădălina Gheorghe, Iuliana-Raluca Gheorghe, Victor Lorin Purcărea
Nowadays, we live in a world in which we are daily bombed by hundreds of advertisements. Specialists have to discover other channels or embed attractive elements in the advertisements' messages to cut through the clutter and catch the consumers' attention. The evolution of the concept of service has changed from the commercial status to determining a lifestyle. Buying a service has led to a change in the consumer behavior. Consumers want to buy services that dazzle their senses, touch their hearts, and stimulate their minds, not as before, excellent or satisfying...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29449581/dyslipidemia-and-risk-of-renal-replacement-therapy-or-death-in-incident-pre-dialysis-patients
#5
Pauline W M Voskamp, Merel van Diepen, Friedo W Dekker, Ellen K Hoogeveen
Globally the number of patients on renal replacement therapy (RRT) is rising. Dyslipidemia is a potential modifiable cardiovascular risk factor, but its effect on risk of RRT or death in pre-dialysis patients is unclear. The aim of this study was to assess the association between dyslipidemia and risk of RRT or death among patients with CKD stage 4-5 receiving specialized pre-dialysis care, an often under represented group in clinical trials. Of the 502 incident pre-dialysis patients (>18 y) in the Dutch PREPARE-2 study, lipid levels were available in 284 patients and imputed for the other patients...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448766/escape-rate-for-nonequilibrium-processes-dominated-by-strong-non-detailed-balance-force
#6
Ying Tang, Song Xu, Ping Ao
Quantifying the escape rate from a meta-stable state is essential to understand a wide range of dynamical processes. Kramers' classical rate formula is the product of an exponential function of the potential barrier height and a pre-factor related to the friction coefficient. Although many applications of the rate formula focused on the exponential term, the prefactor can have a significant effect on the escape rate in certain parameter regions, such as the overdamped limit and the underdamped limit. There have been continuous interests to understand the effect of non-detailed balance on the escape rate; however, how the prefactor behaves under strong non-detailed balance force remains elusive...
February 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29447221/how-does-the-interaction-radius-affect-the-performance-of-intervention-on-collective-behavior
#7
Caiyun Wang, Jing Han
The interaction radius r plays an important role in the collective behavior of many multi-agent systems because it defines the interaction network among agents. For the topic of intervention on collective behavior of multi-agent systems, does r also affect the intervention performance? In this paper we study whether it is easier to change the convergent heading of the group by adding some special agents (called shills) into the Vicsek model when r is larger (or smaller). Two kinds of shills are considered: fixed-heading shills (like leaders that never change their headings) and evolvable-heading shills (like normal agents but with carefully designed initial headings)...
2018: PloS One
https://www.readbyqxmd.com/read/29446855/associations-between-enteral-nutrition-and-acute-respiratory-infection-among-patients-in-new-york-metropolitan-region-pediatric-long-term-care-facilities
#8
Marissa Burgermaster, Meghan Murray, Lisa Saiman, David S Seres, Elaine L Larson
BACKGROUND: Pediatric long-term care facilities (pLTCF) serve a complicated and resource-intensive patient population with high usage of nutrition support. However, the relationship between nutrition support and outcomes among pLTCF residents is not well understood. We described this relationship in three metropolitan New York pLTCF and a subsample of infants from one of these facilities with a feeding disorders unit. METHODS: In this prospective cohort study, we used logistic regression to assess relationships between enteral nutrition (EN), and acute respiratory infections (ARI) among residents (n = 720, 50% male, mean age = 5...
February 15, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29446808/private-public-partnership-a-solution-for-the-development-of-health-system-in-tunisia
#9
Jihen Jdidi, Yosra Mejdoub, Sourour Yaich, Houda Ben Ayed, Mondher Kassis, Habib Fki, Ines Ayadi, Jamel Damak
In a context of economic difficulties, the Tunisian government is required to find solutions to meet the expectations of the population. Health sector is one of the critical areas requiring radical reform. The objective of this paper is to find the place of public private partnership project in the harmonious development of both public and private sectors in Tunisia. Indeed, the Tunisian health system consists of two main sectors: the public sector, and the private sector, booming since the 90s. Tunisian infrastructure and staff resources distribution is characterised by a very significant regional disparity, to the detriment of the interior regions, which is more pronounced in the private sector...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29445982/care-coordination-empowering-families-a-promising-practice-to-facilitate-medical-home-use-among-children-and-youth-with-special-health-care-needs
#10
Lisa Gorman Ufer, Julie A Moore, Kristen Hawkins, Gina Gembel, David N Entwistle, David Hoffman
Introduction This paper describes the care coordination training program and results of an evaluation from its pilot in seven states. Despite the importance of practice-based care coordination, only 42.3% of children with special health care needs (CYSHCN) met all needed components of care coordination as defined by the Maternal Child Health Bureau. Recognizing that children with medically complex conditions often have lower rates of achieving care coordination within a medical home, the Region 4 Midwest Genetics Collaborative worked with families to develop a training to empower families in care coordination...
February 14, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29445831/using-a-sequential-explanatory-mixed-method-to-evaluate-the-therapeutic-window-of-opportunity-for-initiating-osteoporosis-treatment-following-fragility-fractures
#11
S Roux, I Gaboury, N Gionet-Landry, M-P Garant, M-C Beaulieu, N Carrier, F Cabana, G Boire
Interventions targeting patients with recent fragility fracture and their physician were most successful at initiating osteoporosis treatment during the first 12 months. This window of opportunity had already closed after 1 year. The reasons for declining or accepting the intensive intervention were explored in patients still untreated at 12 months. INTRODUCTION: A fragility fracture (FF) event identifies patients most likely to benefit from osteoporosis treatment. Nonetheless, most FF patients go untreated...
February 14, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29445626/catastrophic-health-expenditure-in-iran-a-review-article
#12
REVIEW
Aidin Aryankhesal, Manal Etemadi, Mohammad Mohseni, Saber Azami-Aghdash, Majid Nakhaei
Background: One of the main challenges of healthcare systems is to protect people from consequences of health expenditures. Such expenditures may lead to catastrophic financial loss in families so that many people deny demanding necessary healthcare services, which results in harms to their health status. The aim of this systematic review was to investigate the catastrophic health expenditures trend and its related factors in Iran. Methods: This systematic review and meta-analysis was conducted on studies conducted between 1984 and 2014...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29444816/quality-improvement-effort-to-reduce-hypothermia-among-high-risk-infants-on-a-mother-infant-unit
#13
Christine Andrews, Colleen Whatley, Meaghan Smith, Emily Caron Brayton, Suzanne Simone, Alison Volpe Holmes
BACKGROUND AND OBJECTIVE: Neonatal hypothermia is common in low birth weight (LBW) (<2500 g) and late-preterm infants (LPIs) (34 0/7-36 6/7 weeks' gestation). It can be a contributory factor for newborn admission to a NICU, resulting in maternal-infant separation and increased resource use. Our objective was to study the efficacy of a quality-improvement bundle of hypothermia preventive measures for LPIs and/or LBW infants in a mother-infant unit. METHODS: We conducted plan-do-study-act (PDSA) cycles aimed at decreasing environmental hypothermia for LPIs and/or LBW infants in a mother-infant unit with no other indications for NICU-level care...
February 14, 2018: Pediatrics
https://www.readbyqxmd.com/read/29444666/analysis-of-total-knee-arthroplasty-revision-causes
#14
Anne Postler, Cornelia Lützner, Franziska Beyer, Eric Tille, Jörg Lützner
BACKGROUND: The number of revision Total Knee Arthroplasty (TKA) is rising in many countries. The aim of this study was the prospective assessment of the underlying causes leading to revision TKA in a tertiary care hospital and the comparison of those reasons with previously published data. METHODS: In this study patients who had revision TKA between 2010 and 2015 were prospectively included. Revision causes were categorized using all available information from patients' records including preoperative diagnostics, intraoperative findings as well as the results of the periprosthetic tissue analysis...
February 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29444340/antipsychotics-delirium-and-acute-respiratory-distress-syndrome-what-is-the-link
#15
Heather Torbic, Abhijit Duggal
Acute respiratory distress syndrome (ARDS) is an acute inflammatory process that impairs the ability of the lungs to oxygenate and ultimately leads to respiratory failure. Patients who develop ARDS often have prolonged and complicated hospital courses putting them at risk for intensive care unit (ICU) delirium. Patients with ICU delirium often need chemical sedation, mechanical ventilation, prolonged duration of ICU and hospital stays, long-term cognitive impairment, and increased mortality. In a patient with ARDS, ICU delirium further complicates the hospital course and increases the risk of morbidly and mortality...
February 14, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29442341/the-influence-of-hospitalisation-on-the-initiation-continuation-and-discontinuation-of-benzodiazepines-and-z-drugs-an-observational-study
#16
Thomas Grimmsmann, Markus Harden, Thomas Fiß, Wolfgang Himmel
BACKGROUND AND OBJECTIVES: Hospitalisation influences drug therapy in ambulatory care and this influence is generally negatively perceived. The few studies that have explored changes in benzodiazepine or sleep medication use as a function of hospitalisation failed to precisely determine the hospital's role in initiating, continuing and discontinuing these drugs on a valid basis. The aim of the study was to ascertain the overall influence of hospitalisation on the prescription of benzodiazepines and Z-drugs in outpatient care with a special focus on the role of different hospital departments and drug classes...
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29442333/cost-benefit-analysis-of-telemedicine-systems-units-in-greek-remote-areas
#17
Marios-Nikolaos Kouskoukis, Charalambos Botsaris
BACKGROUND: Telemedicine units and information technology systems provide special healthcare services to remote populations using telecommunication technology, in order to reduce or even remove the usual and typical face-to-face contact between doctor and patient. This innovative approach to medical care delivery has been expanding for several years and currently covers various medical specialties. OBJECTIVE: To facilitate installation of telemedicine systems/units in Greek remote areas, this article presents results of a cost-benefit analysis for two Greek islands, Patmos and Leros, using specific economic criteria...
June 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29441454/chemotherapy-and-immunotherapy-for-recurrent-and-metastatic-head-and-neck-cancer-a-systematic-review
#18
REVIEW
Alessandro Guidi, Carla Codecà, Daris Ferrari
Head and neck cancer (HNC) is a fatal malignancy with an overall long-term survival of about 50% for all stages. The diagnosis is not rarely delayed, and the majority of patients present with loco-regionally advanced disease. The rate of second primary tumors after a diagnosis of HNC is about 3-7% per year, the highest rate among solid tumors. Currently, a single-modality or a combination of surgery, radiotherapy and chemotherapy (CHT), is the standard treatment for stage III-IV HNC. For the recurrent/metastatic setting, in the last 40 years great efforts have been made in order to develop a more effective CHT regimen, from the use of methotrexate alone, to the combination of cisplatin (CDDP) and 5-fluorouracile (5FU) or paclitaxel...
February 13, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29441184/revised-risk-priority-number-in-failure-mode-and-effects-analysis-model-from-the-perspective-of-healthcare-system
#19
Fatemeh Rezaei, Mohmmad H Yarmohammadian, Abbas Haghshenas, Ali Fallah, Masoud Ferdosi
Background: Methodology of Failure Mode and Effects Analysis (FMEA) is known as an important risk assessment tool and accreditation requirement by many organizations. For prioritizing failures, the index of "risk priority number (RPN)" is used, especially for its ease and subjective evaluations of occurrence, the severity and the detectability of each failure. In this study, we have tried to apply FMEA model more compatible with health-care systems by redefining RPN index to be closer to reality...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29440963/heritage-of-stanis%C3%A5-aw-ostrowski-the-only-one-medical-doctor-who-became-state-polish-president-patriae-semper-fidelis
#20
Martyna Woltanowska, Piotr Woltanowski, Andrzej Wincewicz, Magdalena Woltanowska
Aim: Our purpose was to write a biography of Stanisław Ostrowski that would address in the first place the medical aspect of his professional life, with a comprehensive approach of others fields of his activity. Methods: We essentially grounded the paper on primary resources that were papers authored by Ostrowski including his scientific publications, memories, speeches as well as contemporaneous official documents that referred to Ostrowski. Second resources were also used to double check some data from primary resources and to place the biography of Stanisław Ostrowski in a proper background with special care to social, professional and political context...
2018: Clujul Medical (1957)
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