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https://www.readbyqxmd.com/read/29913535/thrombocytopenia-and-platelet-dysfunction-in-acute-tropical-infectious-diseases
#1
Indri Hapsari Putri, Rahajeng N Tunjungputri, Philip G De Groot, Andre J van der Ven, Quirijn de Mast
Thrombocytopenia is a well-known manifestation of acute tropical infectious diseases. The role of platelets in infections has received much attention recently because of their emerging activities in modulation of inflammatory responses, host defense, and vascular integrity. However, while many studies have addressed thrombocytopenia in tropical infections, abnormalities in platelet function have been largely overlooked. This is an important research gap, as platelet dysfunction may contribute to the bleeding tendency that characterizes some tropical infections...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29911521/integrated-perinatal-mental-health-care-a-national-model-of-perinatal-primary-care-in-vulnerable-populations
#2
Kimberly C Lomonaco-Haycraft, Jennifer Hyer, Britney Tibbits, Jennifer Grote, Kelly Stainback-Tracy, Claire Ulrickson, Alison Lieberman, Lies van Bekkum, M Camille Hoffman
IntroductionPerinatal mood and anxiety disorders (PMADs) are the most common complication of pregnancy and have been found to have long-term implications for both mother and child. In vulnerable patient populations such as those served at Denver Health, a federally qualified health center the prevalence of PMADs is nearly double the nationally reported rate of 15-20%. Nearly 17% of women will be diagnosed with major depression at some point in their lives and those numbers are twice as high in women who live in poverty...
June 18, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29911435/systemic-analysis-of-medication-administration-omission-errors-in-a-tertiary-care-hospital-in-quebec
#3
Thomas G Poder, Serge Maltais
OBJECTIVE: Medication administration omission errors (MAOEs) occur frequently in hospitals and can significantly affect patient health. An interdisciplinary committee was formed in summer 2012 to analyse incident/accident reports (AH-223-1 forms) of MAOEs for the 2011-2012 fiscal year in order to identify contributing factors and to propose preventive solutions. Special attention was paid to events with consequences for patients. METHOD: An aggregate data analysis involving four major steps was conducted: sampling, categorisation, identification of contributing factors, and seeking preventive solutions...
January 1, 2018: Health Information Management: Journal of the Health Information Management Association of Australia
https://www.readbyqxmd.com/read/29911318/generalized-information-theory-meets-human-cognition-introducing-a-unified-framework-to-model-uncertainty-and-information-search
#4
Vincenzo Crupi, Jonathan D Nelson, Björn Meder, Gustavo Cevolani, Katya Tentori
Searching for information is critical in many situations. In medicine, for instance, careful choice of a diagnostic test can help narrow down the range of plausible diseases that the patient might have. In a probabilistic framework, test selection is often modeled by assuming that people's goal is to reduce uncertainty about possible states of the world. In cognitive science, psychology, and medical decision making, Shannon entropy is the most prominent and most widely used model to formalize probabilistic uncertainty and the reduction thereof...
June 17, 2018: Cognitive Science
https://www.readbyqxmd.com/read/29910733/preclinical-models-of-traumatic-brain-injury-emerging-role-of-glutamate-in-the-pathophysiology-of-depression
#5
REVIEW
Darik A O'Neil, Melissa A Nicholas, Naima Lajud, Anthony E Kline, Corina O Bondi
More than 10 million people worldwide incur a traumatic brain injury (TBI) each year, with two million cases occurring in the United States. TBI survivors exhibit long-lasting cognitive and affective sequelae that are associated with reduced quality of life and work productivity, as well as mental and emotional disturbances. While TBI-related disabilities often manifest physically and conspicuously, TBI has been linked with a "silent epidemic" of psychological disorders, including major depressive disorder (MDD)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29909163/update-on-multiple-endocrine-neoplasia-type-1-and-2
#6
Abdallah Al-Salameh, Camille Baudry, Régis Cohen
Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. Multiple endocrine neoplastic type 2 is a rare genetic syndrome, characterized by the familial occurrence of medullary thyroid carcinoma either isolated or associated with pheochromocytoma, primary hyperparathyroidism, or typical features (Marfanoid habitus, mucosal neuromas)...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29908781/-impact-of-cardiovascular-risk-factors-on-the-consumption-of-resources-in-primary-care-according-to-clinical-risk-groups
#7
Magdalena Millá Perseguer, Natividad Guadalajara Olmeda, David Vivas Consuelo
OBJECTIVE: To analyze the prevalence of Cardiovascular Risk Factors (CVRF) in the context of a Basic Health Area and the impact they generate on morbidity and consumption of healthcare resources in the stratified population according to the Clinical System Risk Groups (CRG) in Primary Care, with the purpose of identifying the population with multimorbidity to apply preventive measures, as well as the one that generates the highest care burden and social needs. DESIGN: Observational, cross-sectional and population-based study for a basic health area during 2013...
June 13, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29908632/urologic-complications-after-phalloplasty-or-metoidioplasty
#8
REVIEW
Dmitriy Nikolavsky, Michael Hughes, Lee C Zhao
In the past decade, issues facing transgender individuals have come to the forefront of popular culture, political discourse, and medical study. The evaluating physician should have knowledge of the reconstructed anatomy, as well as potential postoperative complications. This knowledge will aid in providing appropriate care and recognizing issues that may require specialized urologic care. Transgender anatomic definitions and a synopsis of common urologic complications specific to transmen, including urethrocutaneous fistulae, neourethral strictures, and persistent vaginal cavities are discussed...
July 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29908002/shielding-a-high-sensitivity-digital-detector-from-electromagnetic-interference
#9
David E Hintenlang, Xia Jiang, Kevin J Little
PURPOSE: To document a study in shielding a high-sensitivity digital mammography system detector from AC magnetic fields of magnitudes great enough to induce imaging artifacts. METHODS/MATERIALS: Preliminary evaluation of AC magnetic fields at a site designated for a digital breast tomosynthesis (DBT) system raised concerns that the magnetic component of electromagnetic interference (EMI) may be great enough to induce imaging artifacts. Subsequent measurements using digital detector arrays from two separate manufacturers verified this concern, and AC magnetic fields were mapped, spatially and temporally, throughout the area of concern...
June 15, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29907900/-anesthesia-ventilation-and-pain-treatment-in-thoracic-trauma
#10
REVIEW
M Weigeldt, M Paul, S Schulz-Drost, M D Schmittner
The management of anesthesia plays a central role in the treatment of thoracic trauma, both in the initial phase when safeguarding the difficult airway and in the intensive care unit. A rapid transfer to a trauma center should be considered in order to recognize and treat organ dysfunction in time. Development of atelectasis, pneumonia and acute lung failure are common pulmonary complications. Non-invasive ventilation combined with physiotherapy and respiratory training can help to minimize these pulmonary complications...
June 15, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29907898/inpatient-glycemic-management-of-non-cardiac-cvd-focus-on-stroke-and-pvd
#11
REVIEW
Estelle Everett, Nestoras Mathioudakis
PURPOSE OF REVIEW: Hyperglycemia occurs frequently in hospitalized patients with stroke and peripheral vascular disease (PVD). Guidelines for inpatient glycemic management are not well established for this patient population. We will review the clinical impact of hyperglycemia in this acute setting and review the evidence for glycemic control. RECENT FINDINGS: Hyperglycemia in acute stroke is associated with poor short and long-term outcomes, and perioperative hyperglycemia in those undergoing revascularization for PVD is linked to increased post-surgical complications...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29907380/monoclonal-gammopathies-of-unknown-significance-and-smoldering-myeloma-assessment-and-management-of-the-elderly-patients
#12
Verónica González-Calle, María Victoria Mateos
Monoclonal gammopathy of unknown significance (MGUS) is the most frequent plasma cell disorder that commonly affects elderly patients. Although it is an asymptomatic condition, as well as smoldering myeloma (SMM), the risk of progression to multiple myeloma requiring therapy or other B-cell disorders varies greatly for individual patients, remaining low for MGUS (1% per year), while higher and not uniform for SMM patients (10% per year). This scenario implies some special considerations regarding assessment and follow-up, especially in the elderly...
June 12, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29905358/-molecular-understanding-of-hearing-how-does-this-matter-to-the-hearing-impaired
#13
Tobias Moser
This review addresses the advances of our molecular understanding of hearing and how this benefits the hearing impaired. Classical biochemical methods usually fall short in contributing to the analysis of the molecular mechanisms of hearing e. g. in the cochlea, the auditory part of the inner ear, due to the scarcity of the cells of interest. Genetics, molecular cell biology, and physiology, on the other hand, have elucidated the intricate molecular and cellular mechanisms that bring about the outstanding performance of the auditory system...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29905134/problems-and-costs-that-could-be-addressed-by-improved-burn-and-wound-care-training-in-health-professions-education
#14
Patrick T Delaplain, Victor C Joe
The current system of burn care delivery attempts to meet the needs of the nearly 500 000 patients in the United States who require medical treatment annually. However, specialization of care and lack of fundamental burn and wound care knowledge among graduating medical trainees has unintended consequences, leaving the system inefficient, with inherent inequities in care delivery and with the potential to be overwhelmed in a mass casualty event. While increasing accessibility to specialty burn centers through technology could mitigate some of these problems, increased education is more practical...
June 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29904621/flexible-nanopillar-based-electrochemical-sensors-for-genetic-detection-of-foodborne-pathogens
#15
Yoo Min Park, Sun Young Lim, Soon Woo Jeong, Younseong Song, Nam Ho Bae, Seok Bok Hong, Bong Gill Choi, Seok Jae Lee, Kyoung G Lee
Flexible and highly ordered nanopillar arrayed electrodes have brought great interest for many electrochemical applications, especially to the biosensors, because of its unique mechanical and topological properties. Herein, we report an advanced method to fabricate highly ordered nanopillar electrodes produced by soft-/photo-lithography and metal evaporation. The highly ordered nanopillar array exhibited the superior electrochemical and mechanical properties in regard with the wide space to response with electrolytes, enabling the sensitive analysis...
2018: Nano Convergence
https://www.readbyqxmd.com/read/29904370/vitamin-d-supplementation-guidelines-for-general-population-and-groups-at-risk-of-vitamin-d-deficiency-in-poland-recommendations-of-the-polish-society-of-pediatric-endocrinology-and-diabetes-and-the-expert-panel-with-participation-of-national-specialist-consultants
#16
REVIEW
Agnieszka Rusińska, Paweł Płudowski, Mieczysław Walczak, Maria K Borszewska-Kornacka, Artur Bossowski, Danuta Chlebna-Sokół, Justyna Czech-Kowalska, Anna Dobrzańska, Edward Franek, Ewa Helwich, Teresa Jackowska, Maria A Kalina, Jerzy Konstantynowicz, Janusz Książyk, Andrzej Lewiński, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska, Artur Mazur, Izabela Michałus, Jarosław Peregud-Pogorzelski, Hanna Romanowska, Marek Ruchała, Piotr Socha, Mieczysław Szalecki, Mirosław Wielgoś, Danuta Zwolińska, Arkadiusz Zygmunt
Introduction: Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professionals in Poland, an updated recommendation for the prevention, diagnosis and treatment of vitamin D deficiency. Methods: A systematic literature search examining the prevention and treatment strategies for vitamin D deficiency was conducted...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29903924/detection-and-characteristics-of-temporal-encephaloceles-in-patients-with-refractory-epilepsy
#17
Z M Campbell, J M Hyer, S Lauzon, L Bonilha, M V Spampinato, M Yazdani
BACKGROUND AND PURPOSE: Temporal encephaloceles are increasingly visualized during neuroimaging assessment of individuals with refractory temporal lobe epilepsy, and their identification could indicate an intracranial abnormality that may be related to a potential seizure focus. Careful review by an experienced neuroradiologist may yield improved detection of TEs, and other clinical, neurophysiologic, and radiologic findings may predict their presence. MATERIALS AND METHODS: Data were reviewed retrospectively in patients at our institution who were presented at a multidisciplinary conference for refractory epilepsy between January 1, 2010, and December 31, 2016...
June 14, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29903786/comorbidities-and-the-use-of-comedications-in-people-living-with-hiv-on-antiretroviral-therapy-in-japan-a-cross-sectional-study-using-a-hospital-claims-database
#18
Daniel J Ruzicka, Kentaro Imai, Kenichi Takahashi, Toshio Naito
OBJECTIVES: To investigate the prevalence of chronic comorbidities and the use of comedications in people living with HIV (PLWH) and on antiretrovirals in Japan, by using a hospital claims database. DESIGN: Observational, retrospective, cross-sectional study. SETTING: A hospital claims database of Japanese hospitals that have advanced medical treatment capabilities (ie, advanced treatment hospitals, general hospitals, acute care hospitals), which include those providing acute and chronic care (excluding nursing homes or hospices)...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29903540/the-role-of-the-nurse-at-the-end-of-the-life-of-a-critically-ill-patient
#19
M González-Rincón, P Díaz de Herrera-Marchal, M L Martínez-Martín
OBJECTIVE: Analyze the role of the nurse at the end of the life of a critically ill patient. METHOD: Bibliographic review from a search of the health science databases such as PubMed, CINAHL, Cuiden, Scopus, Cochrane, as well as specialized platforms, general and thematic browsers. The limits were language (English or Spanish) and publication date (2005-2015). RESULTS: 180 articles met the inclusion criteria, and 16 of them were selected for analysis...
June 11, 2018: Enfermería Intensiva
https://www.readbyqxmd.com/read/29903444/genetics-of-cerebellar-disorders
#20
Enza Maria Valente, Sara Nuovo, Dan Doherty
The approach to identifying a genetic cause in patients with cerebellar disorders relies on history, examination, consultation, and testing, combined with specialized expertise because they are rare and genetically diverse. Cerebellar disorders can be caused by a variety of DNA alterations including single-nucleotide changes, small insertions or deletions, larger copy number variants, and nucleotide repeat expansions, exhibiting autosomal-recessive, autosomal-dominant (inherited and de novo), X-linked, and mitochondrial modes of inheritance...
2018: Handbook of Clinical Neurology
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