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https://www.readbyqxmd.com/read/29241061/scfv-modified-graphene-coated-ide-arrays-for-label-free-screening-of-cardiovascular-disease-biomarkers-in-physiological-saline
#1
Lotta E Delle, Vivek Pachauri, Shikha Sharma, Olena Shaforost, Hui Ma, Mohammad Adabi, Rainer Lilischkis, Patrick Wagner, Ronald Thoelen, Norbert Klein, Richard O'Kennedy, Sven Ingebrandt
Fatty-acid binding proteins (FABP) and myeloperoxidases (MPO) are associated with many chronic conditions in humans and considered to be important biomarkers for diagnosis of cardiac diseases. Here we assemble a new electrical biosensor platform based on graphene-coated interdigitated electrode arrays (IDE-arrays) towards ultrafast, label-free screening of heart type-FABP and MPO. Arrays of nanoscale (nanoIDE) and microscale (microIDE) electrode-arrays were fabricated on wafer-scale by combining nanoimprint and photolithography processes...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29240836/is-quality-of-life-different-between-diabetic-and-non-diabetic-people-the-importance-of-cardiovascular-risks
#2
L M Peña-Longobardo, B Rodríguez-Sánchez, M Mata-Cases, L Rodríguez-Mañas, M Capel, J Oliva-Moreno
BACKGROUND: To analyse and compare the impact of cardiovascular risk factors and disease on health-related quality of life (HRQoL) in people with and without diabetes living in the community. METHODS: We used data of 1,905 people with diabetes and 19,031 people without diabetes from the last Spanish National Health Survey (years 2011-2012). The HRQoL instrument used was the EuroQol 5D-5L, based on time trade-off scores. Matching methods were used to assess any differences in the HRQoL in people with and without diabetes with the same characteristics (age, gender, education level, and healthy lifestyle), according to cardiovascular risk factors and diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29240727/health-and-development-at-age-19-24-months-of-19-children-who-were-born-with-microcephaly-and-laboratory-evidence-of-congenital-zika-virus-infection-during-the-2015-zika-virus-outbreak-brazil-2017
#3
Ashley Satterfield-Nash, Kim Kotzky, Jacob Allen, Jeanne Bertolli, Cynthia A Moore, Isabela Ornelas Pereira, André Pessoa, Flavio Melo, Ana Carolina Faria E Silva Santelli, Coleen A Boyle, Georgina Peacock
In November 2015, the Brazilian Ministry of Health (MOH) declared the Zika virus outbreak a public health emergency after an increase in microcephaly cases was reported in the northeast region of the country (1). During 2015-2016, 15 states in Brazil with laboratory-confirmed Zika virus transmission reported an increase in birth prevalence of microcephaly (2.8 cases per 10,000 live births), significantly exceeding prevalence in four states without confirmed transmission (0.6 per 10,000) (2). Although children with microcephaly and laboratory evidence of Zika virus infection have been described in early infancy (3), their subsequent health and development have not been well characterized, constraining planning for the care and support of these children and their families...
December 15, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29240510/equipment-needs-for-premature-babies-in-special-care-or-intensive-care
#4
Aysha Mendes
Neonates who require additional care, be it in a special care baby unit, neonatal intensive care unit or just on the labour ward, may need specific equipment to allow the team to care for them accurately and safely. This article outlines some of the specific types of equipment which may be needed.
December 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29240341/finland-establishing-the-internet-of-genomics-and-health-data
#5
Aarno Palotie, Samuli Ripatti
Genomic data, i.e. measurement of variation in the complete genome has revolutionized genetic research and changed our understanding of the pathogenetic mechanisms of diseases. Genomic data in combination with Finnish special strengths - population history, the nation's comprehensive health records and a strong research tradition in genetic epidemiology - has made Finland a testing laboratory for diseases of public health importance. At the same time, genomic research has changed into statistical evaluation of large masses of data - big data...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29240317/inflammations-of-the-mammary-gland
#6
Tuomo Meretoja, Hanna Ihalainen, Marjut Leidenius
Breast inflammation, i.e. mastitis is an entity with a variable etiology and severity, typically affecting women of fertile age. In most cases, anamnesis reveals the etiology of the disease, bacterial puerperal mastitis associated with breastfeeding being the most common. Periductal mastitis is a breast inflammation typically associated with smoking in women of 40 to 50 years of age, localized to the region of the areola. Granulomatous mastitis and other rare breast inflammations usually require specialized care...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239957/american-college-of-surgeons-children-s-surgery-verification-quality-improvement-program-what-anesthesiologists-need-to-know-now
#7
Melissa Brooks Peterson, Constance S Houck, Jayant K Deshpande, Randall P Flick
A task force of pediatric surgical specialists with the support of The American College of Surgeons recently launched a verification program for pediatric surgery, the Children's Surgery Verification quality improvement program, with the goal of improving pediatric surgical, procedural, and perioperative care. Included in this program are specific standards for the delivery of pediatric anesthesia care across a variety of practice settings. We review the background, available evidence, requirements for verification, and verification process and its implications for the practice of pediatric anesthesia across the country...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239814/surgical-considerations-and-challenges-in-the-pediatric-and-adolescent-gynecologic-patient
#8
REVIEW
Serena H Chan, Eduardo Lara-Torre
It is important for practitioners to recognize that there are special considerations when performing gynecologic surgery in a pediatric or adolescent patient. A provider must be familiar with differences in anatomy, physiology, surgical technique, and psychosocial concerns. This can be challenging for a provider who does not routinely operate on patients in this population. A minimally invasive surgical approach is preferred in the pediatric and adolescent patient whenever possible. While a good command of laparoscopy in the adult patient is certainly a useful skill when operating on pediatric and adolescent patients, there are technical adaptations and challenges to consider...
October 17, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29239772/does-a-program-based-on-cognitive-behavioral-therapy-affect-kinesiophobia-in-patients-following-total-knee-arthroplasty-a%C3%A2-randomized-controlled-trial-with-a-6-month-follow-up
#9
Libai Cai, Huanhuan Gao, Huiping Xu, Yanyan Wang, Peihua Lyu, Yanjin Liu
BACKGROUND: To evaluate the effects of a cognitive behavioral therapy (CBT) program on kinesiophobia, knee function, pain and pain catastrophizing in patients following total knee arthroplasty (TKA). METHODS: This was a parallel-group, randomized, controlled pilot study in which 100 patients who exhibited kinesiophobia after TKA were randomly assigned to participate in a CBT (experimental group) or standard care (control group) program. Each group included 50 patients...
October 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29239222/minimal-incision-minimally-invasive-medializing-displacement-calcaneal-osteotomy
#10
Thomas I Sherman, Gregory P Guyton
Minimally invasive techniques are readily applicable to calcaneal osteotomies and have the potential to accomplish hindfoot correction equivalent to open procedures with less morbidity and pain. Use of a guidance jig makes the procedure more predictable. While most anatomic features of the procedure are the same as those with open techniques, special care must be taken to avoid neurovascular injury because there is no open exposure. Anatomic guidelines have been established for appropriately localizing the osteotomy...
December 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29238725/the-accuracy-of-new-and-aged-mechanical-torque-devices-employed-in-five-dental-implant-systems
#11
Mehmet Ali Erdem, Burcin Karatasli, Onur Dinçer Kose, Taha Emre Kose, Erhan Çene, Serhan Aydın Aya, Abdulkadir Burak Cankaya
Purpose: Friction-style and spring-style torque wrenches are used to tighten implant abutments and prosthetic screws. The mechanical stability of these torque wrenches is crucial for the implant-abutment connection. The purposes of this study were to assess the performance of five brands (Straumann, Zimmer, Implant KA, Bredent, and Biohorizons) of wrench and to evaluate possible changes in applied torque values of aged wrenches. Materials and Methods: Five new and aged wrenches that had been used approximately 250 times in a 1-year period were tested...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29238687/status-of-otorhinolaryngology-as-specialty-of-choice-among-female-medical-graduates
#12
Sunil Garg, Rubeena Arora, Sunil Kumar, Gautam Bir Singh
Specialty choices among medical graduates have undergone changes over time. We aimed to analyze status of otorhinolaryngology as specialty of choice among female medical graduates and factors affecting it. A total of 123 female medical graduates were surveyed during their internship over a period of 1 year in a tertiary-care hospital. Each intern was assessed using a questionnaire at the end of otorhinolaryngology rotation. The survey included nine questions about future career choices with special focus on ENT as a choice for specialization...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29238519/how-to-manage-anaphylaxis-in-primary-care
#13
REVIEW
Alberto Alvarez-Perea, Luciana Kase Tanno, María L Baeza
Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different combinations of symptoms and apparently mild signs and can progress to fatal anaphylactic shock unpredictably. The difficulty in recognizing anaphylaxis is due, in part, to the variability of diagnostic criteria, which in turn leads to a delay in administration of appropriate treatment, thus increasing the risk of death...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29237858/humans-as-a-model-for-understanding-biological-fundamentals
#14
REVIEW
Sarah F Brosnan, Erik Postma
How special are humans? This question drives scholarly output across both the sciences and the humanities. Whereas some disciplines, and the humanities in particular, aim at gaining a better understanding of humans per se, most biologists ultimately aim to understand life in general. This raises the question of whether and when humans are acceptable, or even desirable, models of biological fundamentals. Especially for basic biological processes, non-human species are generally accepted as a relevant model to study topics for which studying humans is impractical, impossible, or ethically inadvisable, but the reverse is controversial: are humans 'too unique' to be informative with respect to biological fundamentals relevant to other species? Or are there areas where we share key components, or for which our very uniqueness serves to allow novel explorations? In this special feature, authors from disciplines including biology, psychology, anthropology, neuroscience and philosophy tackle this question...
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29237557/erepo-orp-exploring-the-opportunity-space-to-combat-orphan-diseases-with-existing-drugs
#15
Michal Brylinski, Misagh Naderi, Rajiv Gandhi Govindaraj, Jeffrey Lemoine
About 7000 rare, or orphan, diseases affect more than 350 million people worldwide. Although these conditions collectively pose significant health care problems, drug companies seldom develop drugs for orphan diseases due to extremely limited individual markets. Consequently, developing new treatments for often life-threatening orphan diseases is primarily contingent on financial incentives from governments, special research grants, and private philanthropy. Computer-aided drug repositioning is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research...
December 10, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29236965/management-errors-in-adults-with-congenital-heart-disease-prevalence-sources-and-consequences
#16
Rachael Cordina, Subha Nasir Ahmad, Irina Kotchetkova, Gry Eveborn, Lynne Pressley, Julian Ayer, Richard Chard, David Tanous, Peter Robinson, Jens Kilian, John E Deanfield, David S Celermajer
Aims: Improved survival has resulted in increasing numbers and complexity of adults with congenital heart disease (ACHD). International guidelines recommend specialized care but many patients are still not managed at dedicated ACHD centres. This study analysed referral sources and appropriateness of management for patients referred to our tertiary ACHD Centre over the past 3 years. Methods and results: We compared differences in care between patients referred from paediatric/ACHD-trained vs...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29236882/narratives-of-family-members-on-the-suicide-of-older-adults-in-an-amazonian-metropolis
#17
André Luis Sales da Costa, Maximiliano Loiola Ponte de Souza
OBJECTIVE: To analyze the narratives of family members on the suicide of older adults in Manaus, State of Amazonas, Brazil. METHODS: This is a qualitative study of the narratives of eight older adults, who committed suicide in the period of 2001-2012. In the analytic-interpretative process, we have tried to perform the hermeneutic double exercise: to interpret the interpretation of narrators. We have used as theoretical references authors who have investigated suicide from the perspective of gender and its correlations with the sociofamiliar context and with mental disorders...
December 11, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29235934/learning-from-guidelines-on-the-sexual-healthcare-of-men-who-have-sex-with-men
#18
Dan Clutterbuck
The British Association for Sexual Health and HIV (BASHH) United Kingdom national guideline on the sexual health care of men who have sex with men (MSM) was published in electronic format in this journal in 2017. In common with other BASHH guidelines, the document fulfils the dual role of scrutinising and evaluating the available evidence according to the accredited Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, as well as the often more challenging job of codifying and summarising expert opinion in areas where the evidence base is incomplete or lacking...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29235740/thalassemia-major-and-intermedia-in-patients-older-than-35-years-a-single-center-experience
#19
Liat Shargian-Alon, Oren Pasvolsky, Pia Raanani
BACKGROUND: During the past decades, beta thalassemia major (TM) and beta thalassemia intermedia (TI) have transformed from a universally fatal disease at a young age into a chronic disease. This advancement is attributed to improved chelation therapy as well as enhanced management strategies, with focused attention on disease and treatment-related complications. OBJECTIVES: To describe characteristics of adults with thalassemia as well as treatment modalities, disease and treatment-related complications, and socioeconomic information of the patients...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29235437/impact-of-a-in-situ-laboratory-on-physician-expectancy
#20
Romain Brulé, Marianne Sarazin, Nicole Tayeb, Martine Roubille, Anton Szymanowicz
Biological examinations are essential for clinicians' medical care. The aim of this study is to assess clinicians' expectations in healthcare facilities and their perception of medical biology in different types of organization. We performed a prospective transversal study by electronic questionnaire conducted among 242 practitioners in four healthcare facilities. The aspects explored were as follows: quality, reliability, rendering time of examination results and biology platform support. Analyses were conducted after rectification of the sample by weight...
December 13, 2017: Annales de Biologie Clinique
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