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https://www.readbyqxmd.com/read/29053896/quality-and-reporting-of-guidelines-on-the-diagnosis-and-management-of-dystonia
#1
Gertrúd Tamás, Catarina Abrantes, Anabela Valadas, Péter Radics, Alberto Albanese, Marina A J Tijssen, Joaquim J Ferreira
BACKGROUND: The quality of clinical practice guidelines on dystonia has not yet been assessed. Our aim was to appraise the methodological quality of guidelines worldwide and analyze the consistency of their recommendations. METHODS: We searched for clinical practice guidelines on dystonia diagnosis/treatment in the National Guideline Clearinghouse, PubMed, National Institute for Health and Care Excellence, Guidelines International Network and Web of Science databases...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053003/detoxification-of-cancerogenic-compounds-by-lactic-acid-bacteria-strains
#2
Zhao Lili, Wei Junyan, Zhao Hongfei, Zhu Baoqing, Zhang Bolin
Carcinogens in food are an important issue that threat people's health right now. Lactic acid bacteria (LAB) strains as well-known probiotics have shown numerous perspectives in being used as a good food additive to confront cancerogenic compounds in recent years. Some LAB strains can remove cancerogenic compounds from medium environment via direct physical binding and avoid re-pollution of poisonous secondary metabolites which are generated from degradation of cancerogenic compounds. This article presents a whole overview of the physical-binding of LAB strains to such common cancerogenic compounds existed in food and feed environments as mycotoxins, polycyclic aromatic hydrocarbons (PAHs), heterocyclic amines (HAs) and pthalic acid esters (PAEs)...
October 20, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29052944/differential-expression-of-the-three-alcanivorax-borkumensis-sk2-genes-coding-for-the-p450-cytochromes-involved-in-the-assimilation-of-hydrocarbons
#3
Emma Sevilla, Luis Yuste, Renata Moreno, Fernando Rojo
Alcanivorax borkumensis, a marine bacterium highly specialized in degrading linear and branched alkanes, plays a key ecological role in the removal of marine oil spills. It contains several alternative enzyme systems for terminal hydroxylation of alkanes, including three P450 cytochromes (P450-1, P450-2 and P450-3). The present work shows cytochrome P450-1 to be expressed from the promoter of the upstream gene fdx. Promoter Pfdx was more active when C8 -C18 n-alkanes or pristane were assimilated than when pyruvate was available...
October 20, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29052664/a-qualitative-study-exploring-models-of-supportive-care-in-men-and-their-partners-caregivers-affected-by-metastatic-prostate-cancer
#4
Charlotte Primeau, Catherine Paterson, Ghulam Nabi
PURPOSE/OBJECTIVES: To explore the experiences of patients with metastatic prostate cancer and their partners/caregivers, as well as an interprofessional team, with a nurse-led multimodality supportive care intervention. 
. RESEARCH APPROACH: Qualitative study. 
. SETTING: National Health Service (NHS), Tayside, Scotland.
. PARTICIPANTS: 19 patients, 7 partners/caregivers, and 7 interprofessional members from four hospitals in NHS, Tayside, Scotland...
November 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29052427/the-joint-ispor-ispe-special-task-force-on-real-world-evidence-in-health-care-decision-making-an-interview-with-marc-berger
#5
Marc L Berger
Marc L Berger, MD, is a retired, part-time consultant. He recently became Chair of the Real World Evidence Advisory Board for SHYFT Analytics. Over a 25-year industry career, Marc has held senior-level positions at Pfizer, Inc., OptumInsight, Eli Lilly and Company, and Merck & Co., Inc. His professional activities have included serving on committees for Center for Medicare and Medicaid Services (CMS), Agency for Healthcare Research and Quality (AHRQ), Patient-Centered Outcomes Research Institute (PCORI), the International Society for Pharmacoeconomics and Outcomes Research (ISPOR), Drug Information Association (DIA), and the editorial advisory boards of several journals...
October 20, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29052137/malignancies-in-hiv-infected-and-aids-patients
#6
Yongjia Ji, Hongzhou Lu
Currently, HIV infection and AIDS are still one of the most important epidemic diseases around the world. As early in the initial stage of HIV epidemic, the high incidence of ADCs including Kaposi sarcoma and non-Hodgkin's lymphoma was the substantial amount of disease burden of HIV infection and AIDS. With the increasing accessibility of HAART and improving medical care for HIV infection and AIDS, AIDS-related illness including ADCs has dramatically decreased. Meanwhile, the incidence of NADCs rises in PLWH...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29051780/sensitivity-of-postnatal-fasting-plasma-glucose-in-identifying-impaired-glucose-tolerance-in-women-with-gestational-diabetes-25-years-data
#7
Habiba Kapaya, Lucy May, Richard Jacques, Priya Madhuvrata
OBJECTIVE: To assess the uptake of postnatal oral glucose tolerance test and to determine the sensitivity of fasting postnatal blood sugar in predicting 2-h impaired glucose tolerance. METHODS: Retrospective study of 1961 women diagnosed with gestational diabetes mellitus. All women were offered oral glucose tolerance test six weeks post-delivery. RESULTS: Of 1961 women, 1090 (56%) returned for postpartum oral glucose tolerance test. A fasting plasma glucose of ≥6...
September 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29051208/redefining-the-pulvinar-sign-in-fabry-disease
#8
S Cocozza, C Russo, A Pisani, G Olivo, E Riccio, A Cervo, G Pontillo, S Feriozzi, M Veroux, Y Battaglia, D Concolino, F Pieruzzi, R Mignani, P Borrelli, M Imbriaco, A Brunetti, E Tedeschi, G Palma
BACKGROUND AND PURPOSE: The pulvinar sign refers to exclusive T1WI hyperintensity of the lateral pulvinar. Long considered a common sign of Fabry disease, the pulvinar sign has been reported in many pathologic conditions. The exact incidence of the pulvinar sign has never been tested in representative cohorts of patients with Fabry disease. The aim of this study was to assess the prevalence of the pulvinar sign in Fabry disease by analyzing T1WI in a large Fabry disease cohort, determining whether relaxometry changes could be detected in this region independent of the pulvinar sign positivity...
October 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29051092/a-study-on-the-targeted-surveillance-of-nosocomial-infection-in-intensive-care-units-of-177-hospitals-in-jiangsu-province-of-china
#9
Yang Li, Xiao-Li Cao, Hai Ge, Yi-Hong Jiang, Hong Zhou, Wei Zheng
BACKGROUND: Nosocomial infections (NIs) impact care and costs in hospitals across the globe. There are minimal data on targeted surveillance of NI in intensive care units (ICUs), and data specific to the risk factors for NI are especially limited. METHODS: One hundred seventy-seven secondary and tertiary hospitals performed NI targeted surveillance in their ICUs. The data were collected and summarized by Minke software, then fed back once per quarter. RESULTS: The incidence of NI appeared to decrease, and the incidence of NI per 1000 patient-days and adjusted incidence were 25...
October 16, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29050932/characteristics-of-patients-using-specialty-medications
#10
Taehwan Park, Scott K Griggs, Paul D Chung
BACKGROUND: Specialty medications include innovative drugs and biologic agents requiring special handling and close monitoring. Although specialty medications have been widely used for various chronic conditions, increased use of these medications has contributed a growing share of total health care expenditures. OBJECTIVE: The aim of this study was to examine patient characteristics related to specialty medication use. METHODS: Using Medical Expenditure Panel Survey (MEPS) data from 2000 through 2013, this study identified U...
October 14, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29050886/disparities-in-access-to-emergency-general-surgery-care-in-the-united-states
#11
Jasmine A Khubchandani, Connie Shen, Didem Ayturk, Catarina I Kiefe, Heena P Santry
BACKGROUND: As fewer surgeons take emergency general surgery call and hospitals decrease emergency services, a crisis in access looms in the United States. We examined national emergency general surgery capacity and county-level determinants of access to emergency general surgery care with special attention to disparities. METHODS: To identify potential emergency general surgery hospitals, we queried the database of the American Hospital Association for "acute care general hospital," with "surgical services," and "emergency department," and ≥1 "operating room...
October 16, 2017: Surgery
https://www.readbyqxmd.com/read/29049526/incorporating-patient-and-caregiver-experiences-into-cardiovascular-clinical-trial-design
#12
Sean P Collins, Phillip D Levy, Jane L Holl, Javed Butler, Yosef Khan, Tiffany L Israel, Gregg C Fonarow, Jacqueline Alikhaani, Eric Sarno, Alison Cook, Clyde W Yancy
Patient centeredness is a concept that is increasingly being viewed as essential for clinical research. A core principle involves a comprehensive assessment and integration of patient and caregiver perspectives into trial design. Importantly, this involves more than just soliciting feedback. Patients and caregivers are now considered vital members of the study team, even serving as coinvestigators who may help to conceive, plan, and develop the study; continue to direct the day-to-day conduct of the study; and fully participate in the dissemination of the study results...
October 11, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29049466/breast-implant-associated-anaplastic-large-cell-lymphoma-a-systematic-review
#13
Ashley N Leberfinger, Brittany J Behar, Nicole C Williams, Kevin L Rakszawski, John D Potochny, Donald R Mackay, Dino J Ravnic
Importance: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare peripheral T-cell lymphoma, is increasing in incidence. However, many practitioners who treat patients with breast cancer are not aware of this disease. Objectives: To assess how BIA-ALCL develops, its risk factors, diagnosis, and subsequent treatment and to disseminate information about this entity to the medical field. Evidence Review: A literature review was performed in an academic medical setting...
October 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049115/an-evidence-based-approach-to-the-prescription-opioid-epidemic-in-orthopedic-surgery
#14
Ellen M Soffin, Seth A Waldman, Roberta J Stack, Gregory A Liguori
Orthopedic surgery is associated with significant perioperative pain. Providing adequate analgesia is a critical component of patient care and opioids play a vital role in the acute postoperative setting. However, opioid prescribing for patients undergoing orthopedic procedures has recently been identified as a major contributor to the current opioid epidemic. As opioid usage and related morbidity and mortality continue to rise nationwide, opioid-prescribing practices are under increased scrutiny. Here, we update the evidence base and recommendations behind a set of interventions developed at the Hospital for Special Surgery to address the national epidemic at the local level...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29048982/symptom-relief-and-palliative-care-during-the-last-week-of-life-among-patients-with-heart-failure-a-national-register-study
#15
Kristofer Årestedt, Anette Alvariza, Kurt Boman, Joakim Öhlén, Ida Goliath, Cecilia Håkanson, Carl Johan Fürst, Margareta Brännström
BACKGROUND: Heart failure is a disease with high morbidity, mortality, and physical and psychological burden. More knowledge about the care provided for patients with heart failure close to death is needed. OBJECTIVE: The aim was to describe key aspects of palliative care during the last week of life in patients with heart failure, as reported by healthcare professionals. DESIGN: This is a national register study. SETTING/SUBJECTS: The study included 3981 patients with diagnosed heart failure as the underlying cause of death...
October 19, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29048449/emergency-medical-service-information-system-the-ares-118-experience
#16
D A Ientile, M A Cardinale, S Cataldi, M Parafati, A Pasquarella, N Trani, M P Corradi
BACKGROUND: In this paper we describe ARES 118, the prehospital Emergency Medical Service of the Region Lazio, Italy, focusing on its data system used to populate a data warehouse and to create ad hoc reports. ARES 118 is a regional public mono-specialized health company, established in 2004, that manages the emergency care throughout the Region Lazio. METHODS: Being a peculiar company in its kind, and being the first experience of this kind in Italy, ARES 118 has begun to equip itself, in an autonomous way, with a corporate information system, starting from what already existed as data collection from the individual provincial operating Centers and then by activating a unique information system at a regional and company level by deploying a data warehouse...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29048365/integrating-autism-care-through-a-school-based-intervention-model-a-pilot-study
#17
Katherine Dang, Stephen Bent, Brittany Lawton, Tracy Warren, Felicia Widjaja, Michael G McDonald, Michael Breard, Whitney O'Keefe, Robert L Hendren
The purpose of this pilot study is to determine the feasibility of monitoring the progress of children with an autism spectrum disorder (ASD) both in school and at home to promote a school-based integrated care model between parents, teachers, and medical providers. This is a prospective cohort study. To monitor progress, outcome measures were administered via an online platform developed for caregivers and teachers of children (n = 30) attending a school specializing in neurodevelopmental disorders and using an integrated medical and education program...
October 19, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29046809/hospital-resuscitation-teams-a-review-of-the-risks-to-the-healthcare-worker
#18
REVIEW
Stephen M Vindigni, Juan N Lessing, David J Carlbom
BACKGROUND: "Code blue" events and related resuscitation efforts involve multidisciplinary bedside teams that implement specialized interventions aimed at patient revival. Activities include performing effective chest compressions, assessing and restoring a perfusing cardiac rhythm, stabilizing the airway, and treating the underlying cause of the arrest. While the existing critical care literature has appropriately focused on the patient, there has been a dearth of information discussing the various stresses to the healthcare team...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/29046408/-smart-diagnosis-of-parasites-using-smartphones
#19
Muhammad A Saeed, Abdul Jabbar
Accurate and rapid diagnosis is crucial in combating parasitic diseases that cause millions of deaths worldwide. However, the scarcity of specialized diagnostic equipment in low-to-middle income countries is one of the barriers in effective management of parasitic diseases, which warrants the need for alternative, inexpensive and point-of-care diagnostic tools. Due to their multiple built-in sensors, smartphones offer cost-effective alternative to expensive diagnostic devices. However, the use of smartphones in parasitic diagnoses remains in its infancy...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29046196/-disaster-response-plans-in-the-neonatal-intensive-care-unit
#20
Yuan Shi
Newborns in the neonatal intensive care unit (NICU) are highly vulnerable in disasters due to their need for specialized and highly technical support. It is strongly encouraged to prepare for the most likely disaster scenarios for the NICU. During a disaster, neonatal care providers should maintain situational awareness for decision-making, including available equipment, medication, and staffing. Neonatal care providers also should consider the ethical issues and the psychosocial needs of the families and neonatal care staff...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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