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antidepressants and hormone therapy for breast cancer

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https://www.readbyqxmd.com/read/27677719/botanicals-and-their-bioactive-phytochemicals-for-women-s-health
#1
Birgit M Dietz, Atieh Hajirahimkhan, Tareisha L Dunlap, Judy L Bolton
Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber officinale (ginger)...
October 2016: Pharmacological Reviews
https://www.readbyqxmd.com/read/27428195/positive-association-of-female-overactive-bladder-symptoms-and-estrogen-deprivation-a-nationwide-population-based-cohort-study-in-taiwan
#2
Chen-Li Cheng, Jian-Ri Li, Ching-Heng Lin, William C de Groat
OBJECTIVE: Estrogen is considered to be a unique hormone in females that has an impact on voiding function. Animal models and clinical epidemiologic studies showed high correlation between estrogen deficiency and female overactive bladder (OAB) symptoms. We designed a population-based cohort study from a national health database to assess the association of estrogen deprivation therapy and female OAB. MATERIALS AND METHODS: This study examined the records of 16,128 patients ranging in age from 18 to 40 that were included in the Taiwan National Health Insurance Research Database (NHIRD) in the years between 2001 and 2010...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26799406/consequences-of-a-false-positive-mammography-result-drug-consumption-before-and-after-screening
#3
My von Euler-Chelpin, Christina Bæksted, Ilse Vejborg, Elsebeth Lynge
Background Previous research showed women experiencing false-positive mammograms to have greater anxiety about breast cancer than women with normal mammograms. To elucidate psychological effects of false-positive mammograms, we studied impact on drug intake. Methods We calculated the ratio of drug use for women with false-positive versus women with normal mammograms, before and after the event, using population-based registers, 1997-2006. The ratio of the ratios (RRR) assessed the impact. Results Before the test, 40...
May 2016: Acta Oncologica
https://www.readbyqxmd.com/read/26228669/clinical-characteristics-of-japanese-patients-with-severe-hypertriglyceridemia
#4
Hayato Tada, Masa-Aki Kawashiri, Takuya Nakahashi, Kunimasa Yagi, Daisuke Chujo, Azusa Ohbatake, Yukiko Mori, Shunsuke Mori, Mitsuhiro Kometani, Hiroshi Fujii, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi
BACKGROUND: Although of interest, few data exist on the clinical characteristics of Japanese patients with an extremely high triglyceride level (≥ 1000 mg/dL). OBJECTIVE: We assessed the clinical characteristics of Japanese patients with an extremely high triglyceride level. METHODS: We investigated the presence of coronary artery disease, history of pancreatitis, the presence of fatty liver, and the potential causes of elevated triglyceride in Japanese subjects with an extremely high level of fasting triglyceride (≥ 1000 mg/dL) among 70,368 subjects whose serum triglyceride was measured for any reason at Kanazawa University Hospital from April 2004 to March 2014...
July 2015: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/26124682/critical-appraisal-of-paroxetine-for-the-treatment-of-vasomotor-symptoms
#5
REVIEW
Dana G Carroll, Katelin M Lisenby, Tracy L Carter
BACKGROUND: Vasomotor symptoms (VMS), characterized by hot flashes and night sweats, are the most commonly reported symptoms associated with estrogen deficiency during menopause and occur in up to 70% of women. The goal of treatment is to reduce the frequency and severity of symptoms. Although hormone therapy (HT) is generally recommended as first-line treatment, it is not appropriate for all patients. Antidepressants, specifically selective serotonin reuptake inhibitors, have been evaluated and utilized internationally for alternative treatment for VMS...
2015: International Journal of Women's Health
https://www.readbyqxmd.com/read/26033800/predictors-of-discontinuation-of-adjuvant-hormone-therapy-in-patients-with-breast-cancer
#6
Wei He, Fang Fang, Catherine Varnum, Mikael Eriksson, Per Hall, Kamila Czene
PURPOSE: To identify predictors of discontinuation of adjuvant hormone therapy in patients with breast cancer. PATIENTS AND METHODS: We conducted a record-linkage study based on data from Stockholm-Gotland Breast Cancer Register, Swedish Prescribed Drug Register, and self-reported questionnaire. Women diagnosed with breast cancer between 2005 and 2008 in Stockholm, Sweden, were prospectively followed for 5 years until 2013, starting from their first prescription of tamoxifen or aromatase inhibitors (N = 3,395)...
July 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/24852403/treatment-of-climacteric-symptoms-in-breast-cancer-patients-a-retrospective-study-from-a-medication-databank
#7
Caroline Antoine, Lieveke Ameye, Marianne Paesmans, Serge Rozenberg
INTRODUCTION: Women affected by breast cancer (BC) will often go through menopause at an earlier age and display more frequent and severe symptoms than women who have a natural menopause. The safety of hormone replacement therapy (HRT) and vaginal estrogens for BC survivors has been debated over time and remains unclear. Non hormonal therapies such as antidepressants, gabapentine and clonidine may be useful for those patients but there are few data about their safety. AIM: This retrospective study analyses the use by BC patients of treatments known to alleviate climacteric symptoms...
July 2014: Maturitas
https://www.readbyqxmd.com/read/24434530/successful-use-of-agomelatine-in-the-treatment-of-major-depression-in-a-woman-taking-tamoxifen-a-case-report
#8
Domenico De Berardis, Maurizio Brucchi, Nicola Serroni, Alessandro Valchera, Michele Fornaro, Monica Mazza, Giovanni Martinotti, Massimo Di Giannantonio
The selective estrogen receptor modulator, tamoxifen, is extensively used for the endocrine treatment of all stages of hormone receptor-positive breast cancer. Tamoxifen is a mainly inactive prodrug, necessitating metabolism by the cytochrome P450 (CYP450) pathway, predominantly the Cytochrome P450 2D6 (CYP2D6), into the active metabolites 4-hydroxytamoxifen and, in particular, endoxifen to achieve its therapeutic effect. As several women treated with tamoxifen may experience depressive symptoms or may have a previous or actual major depressive episode with ongoing antidepressant treatment or need for a new-onset therapy, the coprescription of an antidepressant drug may be particularly problematic as several antidepressants are potent CYP2D6-inhibiting drugs...
January 2014: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/24313623/hot-flushes-in-women-with-breast-cancer-state-of-the-art-and-future-perspectives
#9
REVIEW
Maddalena Barba, Laura Pizzuti, Domenico Sergi, Marcello Maugeri-Saccà, Cristina Vincenzoni, Francesca Conti, Federica Tomao, Enrico Vizza, Luigi Di Lauro, Franco Di Filippo, Silvia Carpano, Luciano Mariani, Patrizia Vici
Although not life-threatening, vasomotor symptoms might have a detrimental effect on quality of life and represent a major determinant of poor therapeutic compliance in breast cancer patients. Limitations of hormonal therapies have fostered the use of non-estrogenic pharmacological agents, which mainly include centrally acting compounds, antidepressant drugs, serotonin-norepinephrine reuptake inhibitors and serotonin reuptake inhibitors. Integrating therapeutic tools have recently come from a wide range of heterogeneous approaches varying from phytoestrogens use to ganglion block...
February 2014: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/23760858/unjustified-prescribing-of-cyp2d6-inhibiting-ssris-in-women-treated-with-tamoxifen
#10
Lisette Binkhorst, Ron H J Mathijssen, Myrthe P P van Herk-Sukel, Marjolein Bannink, Agnes Jager, Erik A C Wiemer, Teun van Gelder
Tamoxifen is a largely inactive pro-drug, requiring metabolism into its most important metabolite endoxifen. Since the cytochrome P450 (CYP) 2D6 enzyme is primarily involved in this metabolism, genetic polymorphisms of this enzyme, but also drug-induced CYP2D6 inhibition can result in considerably reduced endoxifen formation and as a consequence may affect the efficacy of tamoxifen treatment. Selective serotonin reuptake inhibitors (SSRIs) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs) have been effectively used for the treatment of depression and hot flashes, both of which occur frequently in tamoxifen-treated women...
June 2013: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/23580071/cyp3a4-and-seasonal-variation-in-vitamin-d-status-in-addition-to-cyp2d6-contribute-to-therapeutic-endoxifen-level-during-tamoxifen-therapy
#11
Wendy A Teft, Inna Y Gong, Brian Dingle, Kylea Potvin, Jawaid Younus, Theodore A Vandenberg, Muriel Brackstone, Francisco E Perera, Yun-Hee Choi, Guangyong Zou, Robin M Legan, Rommel G Tirona, Richard B Kim
Tamoxifen is a widely utilized adjuvant anti-estrogen agent for hormone receptor-positive breast cancer, known to undergo CYP2D6-mediated bioactivation to endoxifen. However, little is known regarding additional genetic and non-genetic determinants of optimal endoxifen plasma concentration. Therefore, 196 breast cancer patients on tamoxifen were enrolled in this prospective study over a 24-month period. Blood samples were collected for pharmacogenetic and drug-level analysis of tamoxifen and metabolites. Regression analysis indicated that besides CYP2D6, the recently described CYP3A4*22 genotype, seasonal variation, and concomitant use of CYP2D6-inhibiting antidepressants were significant predictors of endoxifen concentration...
May 2013: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/23408273/botanical-modulation-of-menopausal-symptoms-mechanisms-of-action
#12
REVIEW
Atieh Hajirahimkhan, Birgit M Dietz, Judy L Bolton
Menopausal women suffer from a variety of symptoms, including hot flashes and night sweats, which can affect quality of life. Although it has been the treatment of choice for relieving these symptoms, hormone therapy has been associated with increased breast cancer risk leading many women to search for natural, efficacious, and safe alternatives such as botanical supplements. Data from clinical trials suggesting that botanicals have efficacy for menopausal symptom relief have been controversial, and several mechanisms of action have been proposed including estrogenic, progestogenic, and serotonergic pathways...
May 2013: Planta Medica
https://www.readbyqxmd.com/read/23037499/menopausal-symptoms-in-young-survivors-of-breast-cancer-a-growing-problem-without-an-ideal-solution
#13
REVIEW
Vijayashree Murthy, Ronald S Chamberlain
BACKGROUND: New breast cancers occur in 25% to 30% of women < 50 years of age. These young women undergo ablative surgery, chemotherapy, or hormonal/targeted treatment. These treatments have resulted in increased survival but at the expense of early menopause, marked by distressing vasomotor symptoms, sexual dysfunction, decreased metabolism, and musculoskeletal and cardiovascular effects. METHODS: A comprehensive literature search was performed using PubMed...
October 2012: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/22818586/-effect-of-sub-anaesthetic-doses-of-ketamine-in-the-postoperative-period-in-a-patient-with-uncontrolled-depression
#14
M Cortiñas-Saenz, M B Alonso-Menoyo, C L Errando-Oyonarte, I Alférez-García, M A Carricondo-Martínez
Recent studies indicate that the intravenous infusion of ketamine hydrochloride (an N-methyl-D-aspartate receptor antagonist) leads to a rapid reduction in depressive symptoms. A 42 year-old woman with breast cancer and major depression resistant to medical treatment received a 90 minute intravenous infusion of 0.3 mg/kg ketamine for 5 consecutive days. A significant reduction from 22 to 13 (-41%) was observed in the symptoms assessed using the Hamilton scale, with the effect maintained for 14 days. The possible therapeutic mechanism is discussed...
February 2013: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/22151953/breast-cancer-and-sexuality-multi-modal-treatment-options
#15
REVIEW
Michael L Krychman, Anne Katz
The sexual consequences of breast cancer and its treatments are well known and previously reviewed. Alterations in body image, with or without breast reconstruction, changes in sexual self-esteem and self-efficacy, vulvovaginal atrophy as a result of chemotherapy and/or adjuvant hormone therapy, and loss of libido secondary to dyspareunia and body image issues are common in survivors of breast cancer. Medications that are prescribed for long-term use including those in the class of aromatase inhibitors can have far-reaching implications on quality of life by contributing to vulvar and vaginal atrophic changes...
January 2012: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/22148909/non-estrogen-conventional-and-phytochemical-treatments-for-vasomotor-symptoms-what-needs-to-be-known-for-practice
#16
REVIEW
P Villaseca
OBJECTIVE: Non-hormonal treatment for menopausal vasomotor symptoms (VMS) is needed in women in whom there are medical or personal concerns on the use of hormone therapy. This paper reviews conventional and phytochemical therapies available for the relief of VMS, on their mechanisms of action, their efficacy and safety concerns. METHODS: Medline was searched through Pubmed on the names of the diverse therapies analyzed, up to June 2011. The Cochrane Controlled Clinical Trials Register Database was searched for relevant trials that provided data on treatment of menopausal hot flushes...
April 2012: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/22042786/hot-flashes-a-review-of-pathophysiology-and-treatment-modalities
#17
REVIEW
Phuong Khanh H Morrow, Danielle N Mattair, Gabriel N Hortobagyi
Many therapies are being studied for the treatment of hot flashes for individuals with cancer, yet few studies have demonstrated safe and effective clinical benefit for those who suffer from this distressing symptom. The purpose of this paper is to assess the current options for the management of hot flashes, examining key endpoints from recent clinical trials and reviewing future directions. Hot flashes are a common stressful symptom for individuals with cancer, particularly women with a history of breast cancer and men with prostate cancer...
2011: Oncologist
https://www.readbyqxmd.com/read/21822636/psychotropic-medication-during-endocrine-treatment-for-breast-cancer
#18
Geertruida H de Bock, Regina F Musters, H Jens Bos, Caroline P Schröder, Marian J E Mourits, Lolkje T W de Jong-van den Berg
PURPOSE: Psychological problems are frequently mentioned in women treated for breast cancer in whom depression is mentioned as the most common disorder. The aim was to study the prescription of psychotropic medication in women with endocrine treatment for breast cancer in women in our prospective and consecutive pharmacy database. METHODS: Women (n = 2,172) with at least one prescription of tamoxifen, fulvestrant, anastrazole, letrozole or exemestane were considered as breast cancer patients treated with endocrine therapy...
July 2012: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/21751753/tamoxifen-and-cyp-2d6-inhibitors-caution
#19
(no author information available yet)
Tamoxifen, an oestrogen antagonist, is the standard hormone treatment for breast cancer. It is extensively transformed into its active metabolites by the cytochrome P450 enzyme system, especially into endoxifen by isoenzyme CYP 2D6. Co-administration of tamoxifen with isoenzyme CYP 2D6 inhibitors reduces this metabolism. Selective serotonin reuptake inhibitor (SSRI) antidepressants inhibit isoenzyme CYP 2D6. Paroxetine and fluoxetine reduce the plasma concentration of endoxifen by about 50%. Two epidemiological studies involving about 3700 women have shown a link between the use of SSRI antidepressants and an increased frequency of breast cancer recurrence...
July 2011: Prescrire International
https://www.readbyqxmd.com/read/21424694/identification-of-antidepressant-like-ingredients-in-ginseng-root-panax-ginseng-c-a-meyer-using-a-menopausal-depressive-like-state-in-female-mice-participation-of-5-ht2a-receptors
#20
Noriko Yamada, Hiroaki Araki, Hiroyuki Yoshimura
RATIONALE: After reports of adverse effects with hormone replacement therapy, such as reproductive and breast cancer and coronary heart disease, much attention has been given to the development of new remedies to alleviate menopausal depression in women, but methods for their preclinical evaluation have not been clarified. We previously developed a procedure to predict the drug effect on the menopausal depressive-like state in female mice. OBJECTIVES: We attempted to identify psychoactive components from ginseng root, one of the earliest known materials for menopausal disorder, and to clarify the possible mechanism involved...
August 2011: Psychopharmacology
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