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https://www.readbyqxmd.com/read/29332137/variation-in-guideline-concordant-care-for-elderly-patients-with-metastatic-breast-cancer-in-the-united-states
#1
Philip D Poorvu, Ines Vaz-Luis, Rachel A Freedman, Nancy U Lin, William T Barry, Eric P Winer, Michael J Hassett
PURPOSE: Prior studies have identified shortcomings in the quality of care for early-stage breast cancer. Guidelines recommend systemic therapy for metastatic breast cancer (MBC), but few studies have examined guideline concordance for these patients. METHODS: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data to identify patients aged ≥ 66 diagnosed in 2010-2011 with de novo MBC who were continuously enrolled in fee-for-service Medicare...
January 13, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29330754/systematic-review-of-mammography-screening-educational-interventions-for-hispanic-women-in-the-united-states
#2
REVIEW
John S Luque, Ayaba Logan, Grace Soulen, Kent E Armeson, Danielle M Garrett, Caroline B Davila, Marvella E Ford
In the United States (U.S.), Hispanics experience breast cancer disparities. Breast cancer is the leading cause of cancer-related death among Hispanic women, and Hispanic women receive mammography screening at lower rates than some other ethnic groups. This low rate of screening mammography is associated with increased risk for possible late-stage diagnosis and lower survival rates. Educational interventions could play a role in increasing screening mammography rates among Hispanic women. This systematic review synthesized the current literature on educational interventions to increase mammography screening among Hispanic women...
January 12, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29330268/pelvic-and-buttock-hypoplasia-reconstructed-with-anatomical-breast-implants
#3
Felicity Page, Ayad Harb, Garth Titley
Radiation therapy is used in the management of a number of childhood cancers and can have significant effects on skeletal growth. We present the case of a 35-year-old woman who developed a hypoplastic pelvis and buttocks following radiotherapy for rhabdomyosarcoma of the vagina at the age of 2. At the age of 25, the patient underwent bilateral buttock augmentation with a two-stage reconstruction using tissue expansion followed by definitive augmentation with anatomical breast implant insertion. The patient continues to have a satisfactory outcome 10 years following reconstruction, having undergone a single uplift procedure and exchange of implants through the original incision 9 years postoperatively...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29330212/early-and-locally-advanced-metaplastic-breast-cancer-presentation-and-survival-by-receptor-status-in-surveillance-epidemiology-and-end-results-seer-2010-2014
#4
Mary C Schroeder, Priya Rastogi, Charles E Geyer, Lance D Miller, Alexandra Thomas
BACKGROUND: Metaplastic breast cancer (MBC) is a rare disease subtype characterized by an aggressive clinical course. MBC is commonly triple negative (TN), although hormone receptor (HR) positive and human epidermal growth receptor 2 (HER2) positive cases do occur. Previous studies have reported similar outcomes for MBC with regard to HR status. Less is known about outcomes for HER2 positive MBC. MATERIALS AND METHODS: Surveillance, Epidemiology, and End Results Program data were used to identify women diagnosed 2010-2014 with MBC or invasive ductal carcinoma (IDC)...
January 12, 2018: Oncologist
https://www.readbyqxmd.com/read/29329697/ageing-perceptions-and-non-adherence-to-aromatase-inhibitors-among-breast-cancer-survivors
#5
Moriah J Brier, Dianne L Chambless, Jinbo Chen, Jun J Mao
PURPOSE: Aromatase inhibitors (AIs) are a potentially life-saving treatment for breast cancer survivors, yet poor adherence to treatment is a prevalent problem. A common adverse effect of AI treatment is arthralgia, which is identified by survivors as a major reason for treatment discontinuation. Women who experience arthralgia on AIs often report feeling they have aged rapidly while on the treatment. In the present study, we examined whether arthralgia-associated ageing perceptions predicted non-adherence...
January 9, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29329582/when-do-patient-reported-quality-of-life-indicators-become-prognostic-in-breast-cancer
#6
Chee Khoon Lee, Malcolm Hudson, John Simes, Karin Ribi, Jürg Bernhard, Alan S Coates
BACKGROUND: Various patient reported quality-of-life indicators are independently prognostic for survival in metastatic breast cancer and other cancers. The same measures recorded at first diagnosis of early breast cancer carry no corresponding prognostic information. The present study aims to assess at what time in the disease evolution the prognostic association appears. METHODS: Among 8024 patients enrolled in one of seven randomized controlled trials in early-stage breast cancer 3247 had a breast cancer relapse after a median follow-up of 12...
January 12, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29328397/aberrant-expression-of-il-23-il-23r-in-patients-with-breast-cancer-and-its-clinical-significance
#7
Shuhai Sheng, Jinji Zhang, Jianzhong Ai, Xueli Hao, Ruishen Luan
Breast cancer tissues and adjacent tissues were collected from 32 patients who were treated in The Third Hospital of Chengde City. Reverse transcription‑quantitative polymerase chain reaction results demonstrated that, compared with the adjacent tissues, interleukin (IL)‑23/IL‑23 receptor (R) gene expression levels were notably higher in breast cancer tissues. Furthermore, IL‑23 and IL‑23R expression levels were positively correlated with patients' tumor size, TNM stage and metastasis. Recombinant human (rh) IL‑23 (10 ng/ml) was used for the stimulation of the MCF‑7 cell line...
January 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29325566/male-breast-cancer-diagnosis-stages-treatment-and-survival-in-a-country-with-limited-resources-burkina-faso
#8
Nayi Zongo, Smaïla Ouédraogo, Nina Korsaga-Somé, Ollo Roland Somé, Naïma Go, Edgar Ouangré, Maurice Zida, Gilbert Bonkoungou, Aimé Sosthène Ouédraogo, Aboubacar Hirrum Bambara, Bambara Augustin Tozoula, Si Simon Traoré, Ahmadou Dem, Pascal Niamba, Adama Traoré, Adama Sanou, Danielé Grazziotin Soares, Jean-Pierre Lotz
BACKGROUND: Male breast cancer is a rare and less known disease. Therapeutic modalities affect survival. In Burkina Faso, male breast cancers are diagnosed in everyday practice, but the prognosis at short-, middle-, and long-term remains unknown. The objective of this study is to study the diagnosis stages, therapeutic modalities, and 5-year survival in male breast cancer at the General Surgery Unit of Yalgado Ouedraogo University Hospital from 1990 to 2009. METHODS: A cohort longitudinal study concerning cases of breast cancer diagnosed in man...
January 11, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29325355/-comparison-of-prognosis-between-invasive-micropapillary-carcinoma-and-invasive-ductal-carcinoma-of-breast-a-single-center-retrospective-case-control-study
#9
B Hua, X Lu, W Z Xiao, X Yang, S R He, Z Wang
Objective: To elucidate the clinicopathological characters and prognostic factors of invasive micropapillary carcinoma of the breast (IMPC) by compared with invasive ductal carcinoma, not otherwise specified of the breast (IDC). Methods: The retrospective study was performed with female patients who had undergone curative resection for breast cancer without neoadjuvant chemotherapy from June 2008 to April 2016 in Breast Center of Beijing Hospital. Forty-seven mixed or pure IMPC patients and 93 pure IDC patients(admitted in the same center from October 2008 to January 2016 ) were matched for tumor stage, nodal status and age...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29321957/high-expression-of-palb2-predicts-poor-prognosis-in-patients-with-advanced-breast-cancer
#10
Jingquan Li, Mian Li, Peizhan Chen, Qian Ba
PALB2 mutation is associated with increased breast cancer risk; however, PALB2 mutation is rare in sporadic breast cancer cases and little is known about PALB2 expression in breast cancer. Here, we evaluated the prognostic effects of PALB2 with tissue microarray specimens of 117 female breast cancer patients, and determined the potential underlying mechanisms in cell models. In immunohistochemical analysis, we found increased expression of PALB2 in breast cancer tissues compared with the adjacent normal ductal epithelium (P < 0...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29321821/the-influence-of-glyoxalase-1-gene-polymorphism-on-its-expression-at-different-stages-of-breast-cancer-in-egyptian-women
#11
Rehab S Abdul-Maksoud, Walid Sh Elsayed, Rasha S Elsayed
Aim: To assess the association of GLO1 C332C gene polymorphism with breast cancer risk at different stages of the disease and to investigate the effect of this gene polymorphism on its mRNA expression and enzyme activity. Methods: GLO1 C332C gene polymorphism was analyzed by PCR-RFLP in 100 healthy controls and 200 patients with breast cancer (100 patients with stage I & II and 100 patients with stage III & IV). GLO1 mRNA expression was measured by real time PCR...
November 2017: Genes & Cancer
https://www.readbyqxmd.com/read/29320969/differential-expression-of-tgf%C3%AE-isoforms-in-breast-cancer-highlights-different-roles-during-breast-cancer-progression
#12
Mahmood Y Hachim, Ibrahim Y Hachim, Meiou Dai, Suhad Ali, Jean-Jacques Lebrun
While TGFβ plays a critical role in tumor formation and progression, the role and contribution of its three different isoforms remain unclear. In this study, we aimed at elucidating the prognostic value of the TGFβ isoforms and assessed their expression levels in breast cancer patients at different stages of the disease. We found higher levels of TGFβ1 and TGFβ3 in cancer patients compared to normal tissues, with no significant changes in TGFβ2 expression. Similarly, TGFβ1 and TGFβ3, but not TGFβ2, showed higher expression levels in advanced lymph node-positive and metastatic tumors, suggesting different roles for the different isoforms in tumor progression and the metastatic process, while in the least aggressive molecular subtype (luminal A), expression of the three TGFβ isoforms significantly correlated with expression of both TGFβ receptors, such correlation only occurred between TGFβ1 and TGFβ3 and the TGFβ type II receptor (TβRII) in the highly aggressive basal-like subtype...
January 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29319722/pain-and-quality-of-life-in-breast-cancer-patients
#13
Weruska Alcoforado Costa, Michelly Nóbrega Monteiro, Janice França Queiroz, Ana Katherine Gonçalves
OBJECTIVE: To evaluate the influence of pain on quality of life in breast cancer patients. METHODS: A cross-sectional study of 400 patients, including 118 without metastasis, 160 with loco-regional metastasis and 122 with distant metastasis. The instruments used were the European Organization for Research and Treatment for Cancer Quality of Life Questionnaire-Core 30 and the Breast Cancer-specific 23 and short McGill Pain Questionnaire. RESULTS: In total, 71...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319143/prognostic-factors-of-breast-cancer-survival-in-the-islamic-republic-of-iran-an-additive-empirical-bayesian-approach
#14
Samane Nematolahi, Abbas Rezaianzadeh, Najaf Zare, Majid Akrami, Sedighe Tahmasebi
Breast cancer is a public health challenge in the Islamic Republic of Iran. Relatively few studies have dealt with large dataset and advanced statistical methods. Therefore, we aimed to investigate the role of prognostic factors on breast cancer survival using Additive Empirical Bayesian model with large data set. Breast cancer data set included 1574 women diagnosed with breast cancer from 2002 to 2012 that registered from Cancer Registry in Fars Province, Islamic Republic of Iran. Overall survival rates at 2, 3, 5 and 10 years were 0...
January 2, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29317553/safety-profile-of-biosimilar-filgrastim-zarzio-zarxio-a-combined-analysis-of-phase-iii-studies
#15
Nadia Harbeck, Pere Gascón, Andriy Krendyukov, Nadja Hoebel, Sreekanth Gattu, Kimberly Blackwell
BACKGROUND: Evaluation of adverse events (AEs) in pivotal registration trials and ongoing postmarketing surveillance is important for all biologics, including biosimilars. A combined analysis of two pivotal registration studies was performed to strengthen evidence on safety for biosimilar filgrastim EP2006 in patients with breast cancer receiving myelosuppressive chemotherapy, a sensitive clinical setting to confirm biosimilarity of filgrastim. MATERIALS AND METHODS: Data were combined from two phase III studies of biosimilar filgrastim EP2006...
January 9, 2018: Oncologist
https://www.readbyqxmd.com/read/29315955/prevalence-of-physical-problems-detected-by-the-distress-thermometer-and-problem-list-in-patients-with-breast-cancer
#16
Daniel C McFarland, Kelly M Shaffer, Amy Tiersten, Jimmie Holland
BACKGROUND: Patients with breast cancer have high rates of physical symptoms that negatively impact their quality of life. The relationship between women's perceptions of these physical symptoms and patient demographic and breast cancer characteristics is less well known. This study describes breast cancer patients' physical symptoms and their relationship with patient characteristics. METHODS: Patients (n=125) with breast cancer (Stage 0-IV) completed questionnaires in a dedicated academic medical center breast cancer clinic...
January 5, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29315062/invasive-breast-cancer-prognostic-value-of-peritumoral-edema-identified-at-preoperative-mr-imaging
#17
Hyejin Cheon, Hye Jung Kim, Tae Hun Kim, Hun-Kyu Ryeom, Jongmin Lee, Gab Chul Kim, Jin-Sung Yuk, Won Hwa Kim
Purpose To determine the prognostic value of peritumoral edema identified at preoperative breast magnetic resonance (MR) imaging for disease recurrence in patients with invasive breast cancer. Materials and Methods Between January 2011 and December 2012, 353 women (median age, 49 years; range, 27-77 years) with invasive breast cancer who had undergone preoperative MR imaging and mastectomy or breast-conserving surgery were identified. Two radiologists independently reviewed peritumoral edema on the basis of the degree of the signal intensity surrounding the tumor on T2-weighted images...
January 9, 2018: Radiology
https://www.readbyqxmd.com/read/29313215/association-of-mitochondrial-dna-content-in-peripheral-blood-with-cancer-related-fatigue-and-chemotherapy-related-cognitive-impairment-in-early-stage-breast-cancer-patients-a-prospective-cohort-study
#18
Jung-Woo Chae, Peh Siang Chua, Terence Ng, Angie Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Sreemanee Dorajoo, Koon Mian Foo, Kiley Wei-Jen Loh, Si-Lin Koo, Wen Yee Chay, Tira Jing Ying Tan, Sok Yuen Beh, Elaine Hsuen Lim, Guek Eng Lee, Rebecca Dent, Yoon Sim Yap, Raymond Ng, Han Kiat Ho, Alexandre Chan
PURPOSE: Cancer-related fatigue (CRF) and chemotherapy-related cognitive impairment (CRCI) are reported to be associated with mitochondrial dysfunction. Hence, mitochondrial DNA (mtDNA) content, a biomarker of mitochondrial dysfunction, is hypothesized to correlate with the onset of CRF and CRCI. This study aims to evaluate the association between peripheral blood mtDNA content reduction and severity of CRF and CRCI in patients receiving chemotherapy. METHODS: This was a prospective cohort study...
January 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29312562/downregulation-of-mir-221-3p-and-upregulation-of-its-target-gene-parp1-are-prognostic-biomarkers-for-triple-negative-breast-cancer-patients-and-associated-with-poor-prognosis
#19
Ling Deng, Qianqian Lei, Yu Wang, Zhu Wang, Guiqin Xie, Xiaorong Zhong, Yanping Wang, Nianyong Chen, Yan Qiu, Tianjie Pu, Hong Bu, Hong Zheng
The purpose of this study was to identify microRNAs (miRNAs) closely associated with the prognosis of triple-negative breast cancer (TNBC) and their possible targets. This study recruited 125 early-stage TNBC patients, including 40 cases in the experimental group (20 cases with poor prognoses vs. 20 cases with good prognoses) and 85 cases in the validation group (27 cases with poor prognoses vs. 58 cases with good prognoses). In the experimental group, miRNA microarray showed 34 differentially expressed miRNAs in patients with different prognoses...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310836/circulating-long-non-coding-rna-malat1-expression-as-molecular-biomarker-in-egyptian-patients-with-breast-cancer
#20
Haidy E Zidan, Rehab A Karam, Omnia S El-Seifi, Tamer M Abd Elrahman
The abnormal contribution of long non-coding RNA (lncRNAs) expression to human tumorigenesis is still a matter of debate. Breast cancer is the most common cancer in females; it represents a terrible problem in our country. The aim of this research was to assess the role of MALAT1, as one of lncRNAs, as a potential biomarker in breast cancer. This study comprised 80 patients with breast cancer and 80 controls. MALAT1 expression was measured by RT-quantitative polymerase chain reaction (qPCR). CA15-3 was estimated using chemiluminescence immunoassay (CLIA)...
January 2018: Cancer Genetics
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