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https://www.readbyqxmd.com/read/28436152/multispecialty-involvement-in-the-management-of-type-b-aortic-dissections-in-the-endovascular-era-implications-for-training-cardiothoracic-residents
#1
Corbin Muetterties, Rohan Menon, William Moser, Nels Carroll, Kathleen Marulanda, Myunghan Choi, Grayson H Wheatley
PURPOSE: Involvement of qualified specialists with proficiency in endovascular therapies has created flux regarding the role of cardiothoracic surgeons, vascular surgeons, and other catheter-skilled specialists in the management of type B aortic dissections. We used manuscript authorship trends and recent match data in order to study how multi-specialty involvement in treating aortic dissections has changed in the endovascular era. METHODS: A PubMed review of published literature between 1998 and 2015 was performed with "aortic dissection" in the title...
April 23, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28435870/nanoparticles-that-do-not-adhere-to-mucus-provide-uniform-and-long-lasting-drug-delivery-to-airways-following-inhalation
#2
Craig S Schneider, Qingguo Xu, Nicholas J Boylan, Jane Chisholm, Benjamin C Tang, Benjamin S Schuster, Andreas Henning, Laura M Ensign, Ethan Lee, Pichet Adstamongkonkul, Brian W Simons, Sho-Yu S Wang, Xiaoqun Gong, Tao Yu, Michael P Boyle, Jung Soo Suk, Justin Hanes
Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that avoid mucoadhesion and have diameters smaller than mucus mesh spacings rapidly penetrate mucus layers [mucus-penetrating particles (MPP)], which we hypothesized would provide prolonged lung retention compared to MAP...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28435488/clinician-performed-bedside-ultrasound-in-improving-diagnostic-accuracy-in-patients-presenting-to-the-ed-with-acute-dyspnea
#3
Dimitrios Papanagnou, Michael Secko, John Gullett, Michael Stone, Shahriar Zehtabchi
INTRODUCTION: Diagnosing acute dyspnea is a critical action performed by emergency physicians (EP). It has been shown that ultrasound (US) can be incorporated into the work-up of the dyspneic patient; but there is little data demonstrating its effect on decision-making. We sought to examine the impact of a bedside, clinician-performed cardiopulmonary US protocol on the clinical impression of EPs evaluating dyspneic patients, and to measure the change in physician confidence with the leading diagnosis before and after US...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28435377/frequency-of-impacted-teeth-and-categorization-of-impacted-canines-a-retrospective-radiographic-study-using-orthopantomograms
#4
Hassan Al-Zoubi, Abdulgader Abdullatif Alharbi, Donald J Ferguson, Muhammad Sohail Zafar
OBJECTIVE: The objective of this study is to determine the frequency of impacted maxillary canines using seven subtype classification system. For this purpose, impacted maxillary canines have been divided into seven various subtypes. MATERIALS AND METHODS: This is a descriptive, cross-sectional, and retrospective study conducted using radiographic data of residents of Madinah, Al Munawwarah. Radiographic data of 14,000 patients, who attended College of Dentistry, Taibah University, from January 2011 to February 2015, were screened against the selection criteria for the presence of impacted teeth...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28434249/pulmonary-tuberculosis-is-associated-with-biomass-fuel-use-among-rural-women-in-pakistan-an-age-and-residence-matched-case-control-study
#5
Unaib Rabbani, Ambreen Sahito, Asaad Ahmed Nafees, Ambreen Kazi, Zafar Fatmi
Facility-based, age- and residential area-matched case-control study was conducted in Sindh, Pakistan to determine association between biomass fuel use for cooking and pulmonary tuberculosis (TB). Cases were women with pulmonary TB, and controls were those suffering from other diseases. Current users of biomass fuel were at higher risk of pulmonary TB (adjusted matched odds ratio [mOR] = 3.0; 95% CI = 1.1-4.9) compared with nonusers. In comparison with former biomass users (women not using biomass for >10 years), recent biomass users (women who switched from biomass to nonbiomass ≤10 years ago), and current (lifetime) users were at a higher risk in a dose-response manner (adjusted mOR = 2...
April 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28432494/primary-prevention-and-screening-practices-among-long-term-breast-cancer-survivors
#6
Lori Mandelzweig, Angela Chetrit, Tova Amitai, Barbara Silverman, Nava Siegelmann-Danieli, Siegal Sadetzki
PURPOSE: Parallel to increasing survival of breast cancer (BC) patients, a need has arisen to characterize the follow-up required to improve and maintain their health. Our study aimed to assess changes in lifestyle habits over time among the study population, compare compliance rates of selected primary and secondary prevention practices between long-term BC survivors and an age-matched comparison group, and identify factors associated with compliance to these practices. METHODS: The study population comprised 250 Israeli BC survivors, diagnosed with BC between 1999 and 2003, without evidence of disease after 8-12 years, and 250 women with no cancer history, individually matched to survivors by age and area of residence...
April 21, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28431391/serum-levels-of-lead-mercury-and-cadmium-in-relation-to-coronary-artery-disease-in-the-elderly-a-cross-sectional-study
#7
Sedigheh Asgary, Ahmad Movahedian, Mahtab Keshvari, Mahsa Taleghani, Amirhossein Sahebkar, Nizal Sarrafzadegan
BACKGROUND: There is a continuing attempt to identify novel factors that can predict the risk of cardiovascular disease beyond the established coronary risk factors. It has been suggested that serum levels of lead, mercury and cadmium are associated with the risk of coronary artery disease (CAD). In the present study, we aimed to evaluate serum concentrations of lead (s-Pb), mercury (s-Hg) and cadmium (s-Cd) in patients with CAD in comparison with those of healthy individuals. The correlation between serum levels of these heavy metals and lipid profile parameters was also investigated...
March 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28430820/cardiovascular-safety-of-tiotropium-respimat-vs-handihaler-in-the-routine-clinical-practice-a-population-based-cohort-study
#8
Francesco Trotta, Stefania Spila-Alegiani, Roberto Da Cas, Maja Rajevic, Valentino Conti, Mauro Venegoni, Mariangela Rossi, Giuseppe Traversa
The cardiovascular safety of tiotropium Respimat formulation in the routine clinical practice is still an open issue. Our aim was to compare the risk of acute myocardial infarction and heart rhythm disorders in incident users of either tiotropium Respimat or HandiHaler. The study population comprises patients aged ≥45 years, resident in two Italian regions with a first prescription of tiotropium (HandiHaler or Respimat) between 01/07/2011-30/11/2013. The cohort was identified through the database of prescriptions reimbursed by the Italian National Health Service...
2017: PloS One
https://www.readbyqxmd.com/read/28427334/the-impact-of-the-mode-of-survey-administration-on-estimates-of-daily-smoking-for-mobile-phone-only-users
#9
Joseph Hanna, Damien V Cordery, David G Steel, Walter Davis, Timothy C Harrold
BACKGROUND: Over the past decade, there have been substantial changes in landline and mobile phone ownership, with a substantial increase in the proportion of mobile-only households. Estimates of daily smoking rates for the mobile phone only (MPO) population have been found to be substantially higher than the rest of the population and telephone surveys that use a dual sampling frame (landline and mobile phones) are now considered best practice. Smoking is seen as an undesirable behaviour; measuring such behaviours using an interviewer may lead to lower estimates when using telephone based surveys compared to self-administered approaches...
April 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28426980/hormonal-and-reproductive-risk-factors-of-papillary-thyroid-cancer-a-population-based-case-control-study-in-france
#10
Emilie Cordina-Duverger, Christophe Leux, Monica Neri, Catherine Tcheandjieu, Anne-Valérie Guizard, Claire Schvartz, Thérèse Truong, Pascal Guénel
The three times higher incidence of thyroid cancer in women compared to men points to a role of female sex hormones in its etiology. However the effects of these factors are poorly understood. We analyzed the association between thyroid cancer and hormonal and reproductive factors among women enrolled in CATHY, a population-based case-control study conducted in France. The study included 430 cases of papillary thyroid cancer and 505 controls frequency-matched on age and area of residence. The odds ratios for thyroid cancer increased with age at menarche (p trend 0...
April 17, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28424361/computed-tomographic-findings-in-subjects-who-died-from-respiratory-disease-in-the-national-lung-screening-trial
#11
Esther Pompe, Pim A de Jong, David A Lynch, Nikolas Lessmann, Ivana Išgum, Bram van Ginneken, Jan-Willem J Lammers, Firdaus A A Mohamed Hoesein
We evaluated the prevalence of significant lung abnormalities on computed tomography (CT) in patients who died from a respiratory illness other than lung cancer in the National Lung Screening Trial (NLST).In this retrospective case-control study, NLST participants in the CT arm who died of respiratory illness other than lung cancer were matched for age, sex, pack-years and smoking status to a surviving control. A chest radiologist and a radiology resident blinded to the outcome independently scored baseline CT scans visually and qualitatively for the presence of emphysema, airway wall thickening and fibrotic lung disease...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28423324/resolving-subcellular-mirna-trafficking-and-turnover-at-single-molecule-resolution
#12
Sethuramasundaram Pitchiaya, Laurie A Heinicke, Jun I Park, Elizabeth L Cameron, Nils G Walter
Regulation of microRNA (miRNA) localization and stability is critical for their extensive cytoplasmic RNA silencing activity and emerging nuclear functions. Here, we have developed single-molecule fluorescence-based tools to assess the subcellular trafficking, integrity, and activity of miRNAs. We find that seed-matched RNA targets protect miRNAs against degradation and enhance their nuclear retention. While target-stabilized, functional, cytoplasmic miRNAs reside in high-molecular-weight complexes, nuclear miRNAs, as well as cytoplasmic miRNAs targeted by complementary anti-miRNAs, are sequestered stably within significantly lower-molecular-weight complexes and rendered repression incompetent...
April 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28418775/research-101-an-initiative-to-encourage-and-facilitate-quality-resident-research-in-a-military-setting
#13
Kathryn E Marshall, Tanisha L Hammill
Objective Describe and evaluate a structured research program initiated at a tertiary Department of Defense (DOD) Medical Training Facility (MTF) to encourage and facilitate the conduct of research investigations, specifically among residents and junior or inexperienced investigators, but applicable for all DOD otolaryngology (ENT) and audiology providers. Methods A new comprehensive program was deployed in the ENT clinic at Madigan Army Medical Center (MAMC) to help improve the research program. Identified gaps in research methods and regulatory training were incorporated into the existing graduate medical education program along with structured mentorship between residents and senior staff...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28416127/experimental-and-modelling-of-arthrospira-platensis-cultivation-in-open-raceway-ponds
#14
Panneerselvam Ranganathan, J C Amal, S Savithri, Ajith Haridas
In this study, the growth of Arthrospira platensis was studied in an open raceway pond. Furthermore, dynamic model for algae growth and CFD modelling of hydrodynamics in open raceway pond were developed. The dynamic behaviour of the algal system was developed by solving mass balance equations of various components, considering light intensity and gas-liquid mass transfer. A CFD modelling of the hydrodynamics of open raceway pond was developed by solving mass and momentum balance equations of the liquid medium...
March 27, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28415992/women-epidemiology-lung-cancer-welca-study-reproductive-hormonal-occupational-risk-factors-and-biobank
#15
Isabelle Stücker, Diane Martin, Monica Neri, Pierre Laurent-Puig, Hélène Blons, Martine Antoine, Anne Guiochon-Mantel, Sylvie Brailly-Tabard, Marianne Canonico, Marie Wislez, Jean Trédaniel
BACKGROUND: Lung cancer aetiology and clinical aspects have been mainly studied in men, although specific risk factors probably exist in women. Here we present the rationale, design and organization of the WELCA study (Women Epidemiology Lung CAncer) that has been launched to investigate lung cancer in women, focusing particularly on hormonal and occupational factors. METHODS/DESIGN: WELCA is a population based case-control study and planned to recruit 1000 cases and 1000 controls in three years, based on study power calculation...
April 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28414686/severe-sepsis-and-septic-shock-cases-meeting-guidelines-among-patients-in-a-university-hospital-setting
#16
J A Charrier, C L Steen, E Borrero
BACKGROUND: A diagnosis of severe sepsis or septic shock has been shown to significantly increase mortality rate independent of other factors. Research has revealed all cause hospital case fatality rates have declined yet the percentage of severe sepsis cases continues to increase and age-adjusted mortality rates from severe sepsis and septic shock has significantly increased during the same time period. Patients with severe sepsis demonstrate ongoing mortality rate increases for up to 2 years following hospitalization when compared to aged matched controls of nonseptic patients...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28411120/effectiveness-and-safety-of-rivaroxaban-and-warfarin-in-patients-with-unprovoked-venous-thromboembolism-a-propensity-matched-nationwide-cohort-study
#17
Torben B Larsen, Flemming Skjøth, Jette N Kjældgaard, Gregory Y H Lip, Peter B Nielsen, Mette Søgaard
BACKGROUND: Deep vein thrombosis (DVT) and pulmonary embolism are collectively known as venous thromboembolism (VTE), which is a common vascular disease and a major cause of morbidity and mortality worldwide. We compare effectiveness and safety of rivaroxaban versus warfarin in a prospective cohort of routine care patients with incident unprovoked VTE. METHODS: In this propensity-matched cohort study, we linked nationwide Danish health registries to identify all patients with a first hospital diagnosis of unprovoked VTE who were new users of rivaroxaban or warfarin...
April 11, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28410022/intraspecific-competition-and-inbreeding-depression-increased-competitive-effort-by-inbred-males-is-costly-to-outbred-opponents
#18
Jon Richardson, Per T Smiseth
A recent theoretical model suggests that intraspecific competition is an important determinant of the severity of inbreeding depression. The reason for this is that intraspecific competition is density dependent, leading to a stronger negative effect on inbred individuals if they are weaker competitors than outbred ones. In support of this prediction, previous empirical work shows that inbred individuals are weaker competitors than outbred ones and that intraspecific competition often exacerbates inbreeding depression...
May 2017: American Naturalist
https://www.readbyqxmd.com/read/28409666/evaluating-the-feasibility-of-single-incision-laparoscopic-appendectomy-performed-by-a-resident-based-on-propensity-score-matching
#19
Sung Min Lee, Dong Jin Park, Jong Hee Yoon, Soon Young Tae, Song Soo Yang, Yeong Cheol Im
PURPOSE: Conventional laparoscopic appendectomy (CLA) has been considered the standard for the treatment of acute appendicitis. Recently, single incision laparoscopic appendectomy (SILA) has become an alternative option. There are few reports on the results of SILA performed by residents during the training period. The present study, we report our residents' experience. MATERIALS AND METHODS: We reviewed clinical characteristics and outcomes of 1005 patients who underwent appendectomy between October 2013 and April 2016...
April 14, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28409421/the-impact-of-microenvironment-on-the-synovial-sarcoma-transcriptome
#20
Huifeng Jin, Jared J Barrott, Matthew G Cable, Michael J Monument, Daniel M Lerman, Kyllie Smith-Fry, Dakota Nollner, Kevin B Jones
Synovial sarcoma (SS) is initiated by a t(X;18) chromosomal translocation and resultant SS18-SSX fusion oncogene. Only a few SS cell lines exist. None has been compared to its source tumor. In order to compare matched tumor and cell line pairs, we performed RNAseq on 3 tumor/cell line pairs from a genetically engineered mouse model of SS, as well as 2 pairs from human SS tumors. Transcriptomes of mouse tumors and derivative cell lines deviated significantly. Differentially expressed genes highlighted inflammatory infiltrates and metabolism...
April 13, 2017: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
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