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https://www.readbyqxmd.com/read/29792833/self-diffusion-of-water-soluble-fullerene-derivatives-in-mouse-erythrocytes
#1
Irina Avilova, Ekaterina Khakina, Ol''ga Kraevaya, Alexander Kotelnikov, Raisa Kotelnikova, Pavel Troshin, Vitaliy Volkov
Self-diffusion of water-soluble fullerene derivative (WSFD) C60 [S(CH2 )3 SO3 Na]5 H in mouse red blood cells (RBC) was characterized by 1 H pulsed field gradient NMR technique. It was found that a fraction of fullerene molecules (~13% of the fullerene derivative added in aqueous RBC suspension) shows a self-diffusion coefficient of (5.5 ± 0.8)·10-12  m2 /s, which is matching the coefficient of the lateral diffusion of lipids in the erythrocyte membrane (DL  = (5.4 ± 0.8)·10-12  m2 /s). This experimental finding evidences the absorption of the fullerene derivative by RBC...
May 21, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29788704/low-estimated-glomerular-filtration-rate-is-prevalent-among-north-korean-refugees-in-south-korea
#2
Young-Soo Song, Seong-Woo Choi
BACKGROUND: The number of North Korean refugees entering South Korea is rising. Few studies have investigated the risk of non-communicable disease in North Korean refugees. Moreover, kidney insufficiency, a risk factor for cardiovascular disease, has not been studied in this population. We compared the prevalence of non-communicable disease and kidney function in North Korean refugees and South Koreans. METHODS: Our study was conducted using a case-control design...
May 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29788069/inflammatory-bowel-disease-and-parkinson-s-disease-a-nationwide-swedish-cohort-study
#3
Petra Weimers, Jonas Halfvarson, Michael C Sachs, Rachel Saunders-Pullman, Jonas F Ludvigsson, Inga Peter, Johan Burisch, Ola Olén
Background: Few studies have examined the association between inflammatory bowel disease (IBD) and Parkinson's disease (PD). Methods: To estimate the incidence and relative risk of PD development in a cohort of adult IBD, we included all incident IBD patients (n = 39,652) in the Swedish National Patient Register (NPR) between 2002 and 2014 (ulcerative colitis [UC]: n = 24,422; Crohn's disease [CD]: n = 11,418; IBD-unclassified [IBD-U]: n = 3812). Each IBD patient was matched for sex, age, year, and place of residence with up to 10 reference individuals (n = 396,520)...
May 16, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29772880/detection-of-spatial-aggregation-of-cases-of-cancer-from-data-on-patients-and-health-centres-contained-in-the-minimum-basic-data-set
#4
Pablo Fernández-Navarro, Jose-Miguel Sanz-Anquela, Angel Sánchez Pinilla, Rosario Arenas Mayorga, Carmen Salido-Campos, Gonzalo López-Abente
The feasibility of the Minimum Basic Data Set (MBDS) as a tool in cancer research was explored monitoring its incidence through the detection of spatial clusters. Case-control studies based on MBDS and marked point process were carried out with the focus on the residence of patients from the Prince of Asturias University Hospital in Alcalá de Henares (Madrid, Spain). Patients older than 39 years with diagnoses of stomach, colorectal, lung, breast, prostate, bladder and kidney cancer, melanoma and haematological tumours were selected...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29771477/serious-infections-in-rheumatoid-arthritis-offspring-exposed-to-tumour-necrosis-factor-%C3%AE-inhibitors-cohort-study
#5
Évelyne Vinet, Cristiano De Moura, Christian A Pineau, Michal Abrahamowicz, Jeffrey R Curtis, Sasha Bernatsky
OBJECTIVE: To evaluate the risk of serious infections in rheumatoid arthritis (RA) offspring exposed to tumour necrosis factor α inhibitors (TNFi) in the gestational period compared to unexposed RA offspring, as well as to children from the general population. METHODS: We used US claim data (2011-2015) to identify 2 989 RA offspring and a randomly selected group of 14 596 control children, matched ≥4:1 for maternal age, year of delivery, and state of residence...
May 17, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29764527/an-outbreak-of-haemorrhagic-fever-with-renal-syndrome-linked-with-mountain-recreational-activities-in-zagreb-croatia-2017
#6
Z Lovrić, B Kolarić, M L Kosanović Ličina, M Tomljenović, O Đaković Rode, K Danis, B Kaić, V Tešić
In 2017 Zagreb faced the largest outbreak of haemorrhagic fever with renal syndrome (HFRS) to date. We investigated to describe the extent of the outbreak and identify risk factors for infection. We compared laboratory-confirmed cases of Hantavirus infection in Zagreb residents with the onset of illness after 1 January 2017, with individually matched controls from the same household or neighbourhood. We calculated adjusted matched odds ratios (amOR) using conditional logistic regression. During 2017, 104 cases were reported: 11-81 years old (median 37) and 71% (73) male...
May 16, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29758330/human-liver-infiltrating-%C3%AE-%C3%AE-t-cells-are-composed-of-clonally-expanded-circulating-and-tissue-resident-populations
#7
Stuart Hunter, Carrie Willcox, Martin Davey, Sofya Kasatskaya, Hannah Jeffery, Dmitriy Chudakov, Ye Oo, Benjamin Willcox
BACKGROUND & AIM: γδ T-cells comprise a substantial proportion of tissue-associated lymphocytes. However, our current understanding of human γδ T-cells is primarily based on peripheral blood subsets, while the immunobiology of tissue-associated subsets remains largely unclear. METHODS: To address this, we characterised the TCR diversity, immunophenotype and function of human liver infiltrating γδ T-cells, focussing on the predominant tissue-associated Vδ2neg γδ subset, which is implicated in liver immunopathology...
May 11, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29751859/-lack-of-measurable-clinical-or-knowledge-gains-from-resident-participation-in-noon-conference
#8
Nathaniel B Meyer, Kara Gaetke-Udager, Kimberly L Shampain, Amy Spencer, Richard H Cohan, Matthew S Davenport
RATIONALE AND OBJECTIVES: The objective of this study was to determine whether noon conference attendance by diagnostic radiology residents is predictive of measurable performance. METHODS: This single-center retrospective Health Insurance and Portability and Accountability Act (HIPAA)-compliant cross-sectional study was considered "not regulated" by the institutional review board. All diagnostic radiology residents who began residency training from 2008 to 2012 were included (N = 54)...
June 2018: Academic Radiology
https://www.readbyqxmd.com/read/29751856/how-does-the-current-generation-of-medical-students-view-the-radiology-match-an-analysis-of-the-auntminnie-and-student-doctor-network-online-forums
#9
Paul H Yi, Sherwin Novin, Taylor L Vander Plas, Eric Huh, Donna Magid
RATIONALE AND OBJECTIVES: The AuntMinnie (AM) and the Student Doctor Network (SDN) online forums are popular resources for medical students applying for residency. The purpose of this study was to describe medical student radiology-related posts on AM and SDN to better understand the medical student perspective on the application and Match process. MATERIALS AND METHODS: We reviewed all posts made on the AM and SDN online forums over 5 consecutive academic years from July 2012 to July 2017...
June 2018: Academic Radiology
https://www.readbyqxmd.com/read/29751516/engineering-a-3d-bioprinted-model-of-human-heart-valve-disease-using-nanoindentation-based-biomechanics
#10
Dewy C van der Valk, Casper F T van der Ven, Mark C Blaser, Joshua M Grolman, Pin-Jou Wu, Owen S Fenton, Lang H Lee, Mark W Tibbitt, Jason L Andresen, Jennifer R Wen, Anna H Ha, Fabrizio Buffolo, Alain van Mil, Carlijn V C Bouten, Simon C Body, David J Mooney, Joost P G Sluijter, Masanori Aikawa, Jesper Hjortnaes, Robert Langer, Elena Aikawa
In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro models as a result of complex valvular biomechanical features surrounding resident mechanosensitive valvular interstitial cells (VICs). We measured layer-specific mechanical properties of the human AV and engineered a three-dimensional (3D)-bioprinted CAVD model that recapitulates leaflet layer biomechanics for the first time...
May 3, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29747937/timing-and-stability-of-fellowship-choices-during-pediatric-residency-a-longitudinal-survey
#11
Michelle L Macy, Laurel K Leslie, Debra Boyer, Keaton D Van, Gary L Freed
OBJECTIVES: To determine, among pediatric residents, the timing and stability of decisions to pursue fellowship training and select a specific subspecialty, which can be used to inform strategies to better match the distribution of pediatric subspecialist with the needs of children. STUDY DESIGN: A longitudinal survey administered with the General Pediatrics In-training Exam to pediatric residents in the US and Canada, 2010-2014. The study included residents who responded in each of their first 3 years of residency and indicated plans to enter fellowship or matriculated, 2013-2016, into 1 of the 14 medical subspecialty fellowships for which the American Board of Pediatrics grants a certificate...
May 7, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29746299/suppressive-antiretroviral-therapy-associates-with-effective-treatment-of-high-grade-cervical-intraepithelial-neoplasia
#12
Christina Carlander, Philippe Wagner, Astrid van Beirs, Aylin Yilmaz, Kristina Elfgren, Joakim Dillner, Anders Sönnerborg, Pär Sparén
OBJECTIVES: To assess if women living with HIV (WLWH) have poorer outcome after treatment of cervical intraepithelial neoplasia (CIN2+) than HIV-negative women and to identify predictors of CIN2+ treatment failure and recurrence in WLWH. DESIGN: Population-based cohort study with follow-up between 1983 and 2015. METHODS: The Swedish National HIV Registry, the Swedish Population Registry and the Swedish National Cervical Screening Registry were linked to identify all women in Stockholm and Gothenburg counties (Sweden) living with HIV and diagnosed with CIN2+ (n = 179) sometime between 1983 and 2014...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29745817/impaired-mineral-quality-in-dentin-in-x-linked-hypophosphatemia
#13
Benjamin R Coyac, Guillaume Falgayrac, Guillaume Penel, Alain Schmitt, Thorsten Schinke, Agnès Linglart, Marc D McKee, Catherine Chaussain, Claire Bardet
X-linked hypophosphatemia (XLH) is a skeletal disorder arising from mutations in the PHEX gene, transmitted in most cases as an X-linked dominant trait. PHEX deficiency leads to renal phosphate wasting and hypophosphatemia, as well as impaired mineralization of bone and dentin, resulting in severe skeletal and dental complications. Dentin mineralization defects appear as characteristic, large interglobular spaces resulting from the lack of fusion of calculospherites in the circumpulpal region during the mineralization process...
December 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29743325/trajectories-of-disposable-income-among-people-of-working-ages-diagnosed-with-multiple-sclerosis-a-nationwide-register-based-cohort-study-in-sweden-7-years-before-to-4-years-after-diagnosis-with-a-population-based-reference-group
#14
Chantelle Murley, Olof Mogard, Michael Wiberg, Kristina Alexanderson, Korinna Karampampa, Emilie Friberg, Petter Tinghög
OBJECTIVES: To describe how disposable income (DI) and three main components changed, and analyse whether DI development differed from working-aged people with multiple sclerosis (MS) to a reference group from 7 years before to 4 years after diagnosis in Sweden. DESIGN: Population-based cohort study, 12-year follow-up (7 years before to 4 years after diagnosis). SETTING: Swedish working-age population with microdata linked from two nationwide registers...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29741291/epidemiological-characteristics-and-associated-factors-of-acute-hepatitis-a-outbreak-among-hiv-coinfected-men-who-have-sex-with-men-in-taiwan-june-2015-december-2016
#15
Chien-Yu Cheng, Hao-Hsin Wu, Huachun Zou, Yi-Chun Lo
In Taiwan, an outbreak of acute hepatitis A (AHA) infection has been identified since June 2015. Approximately half of the cases occurred in HIV-infected men who have sex with men (MSM). We used the Taiwan Centers for Disease Control (TCDC)-operated National Disease Surveillance Systems (NDSS) to identify the incidence of AHA during 2011-2016. Between June 2015 and December 2016, a total of 1,268 AHA cases were documented, and 601 cases (47.4%) were co-infected with HIV; the majority of whom were MSM (98.4%)...
May 9, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29732718/impact-of-treatment-with-pioglitazone-on-stroke-outcomes-a-real-world-database-analysis
#16
Christopher Ll Morgan, Silvio E Inzucchi, Jorge Puelles, Sara Jenkins-Jones, Craig J Currie
AIMS: Randomised controlled trials have reported an association between pioglitazone and reduced incidence of stroke in type 2 diabetic (T2DM) and insulin-resistant populations. We investigated this association within a real-world database. MATERIALS AND METHODS: T2DM patients initiating pioglitazone between 2000-2012 were extracted from the Clinical Practice Research Datalink (CPRD); a UK routine. Two non-exposed control cohorts were matched on age, gender, HbA1c, diabetes duration, stroke history, co-morbidities and prior T2DM regimen...
May 7, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29725559/trapped-as-a-group-escape-as-a-team-applying-gamification-to-incorporate-team-building-skills-through-an-escape-room-experience
#17
Xiao Chi Zhang, Hyunjoo Lee, Carlos Rodriguez, Joshua Rudner, Teresa M Chan, Dimitrios Papanagnou
Teamwork, a skill critical for quality patient care, is recognized as a core competency by the Accreditation Council for Graduate Medical Education (ACGME). To date, there is no consensus on how to effectively teach these skills in a forum that engages learners, immerses members in life-like activities, and builds both trust and rapport. Recreational 'Escape Rooms' have gained popularity in creating a life-like environment that rewards players for working together, solving puzzles, and completing successions of mind-bending tasks in order to effectively 'escape the room' in the time allotted...
March 2, 2018: Curēus
https://www.readbyqxmd.com/read/29724386/comorbidities-and-risk-of-mortality-among-hospitalized-patients-with-idiopathic-pulmonary-fibrosis-in-spain-from-2002-to-2014
#18
Fernando Pedraza-Serrano, Rodrigo Jiménez-García, Ana López-de-Andrés, Valentín Hernández-Barrera, Jesús Esteban-Hernández, Gema Sánchez-Muñoz, Luis Puente-Maestu, Javier de-Miguel-Díez
BACKGROUND: To describe and compare the comorbid conditions, the in-hospital mortality (IHM) and the length of hospital stay (LOHS) among idiopathic pulmonary fibrosis (IPF) patients and non-IPF-matched patients hospitalized in Spain. We assess the performance of the Charlson Comorbidity Index[CCI] and the Elixhauser Comorbidity Index[ECI] to predict IHM in IPF and we identify the specific predictive factors of IHM in patients suffering IPF. METHODS: We identified patients with IPF hospitalized in years 2002, 2006, 2010 and 2014...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29720915/resource-use-evaluation-of-tobramycin-formulations-in-a-state-medicaid-program
#19
Shellie L Keast
OBJECTIVE: Patients with cystic fibrosis (CF) often suffer from chronic infection with Pseudomonas aeruginosa. For patients with CF, 6 years of age and older, with P aeruginosa persistently present in cultures of the airways, the Cystic Fibrosis Foundation recommends the chronic use of inhaled tobramycin to reduce exacerbations. To ease treatment burden, a new dry powder formulation was developed. The objective of this research was to compare resource utilization between tobramycin inhaled solution (TIS) and a new tobramycin dry powder (TIP) formulation in a state Medicaid program...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29719030/improving-underrepresented-minority-in-medicine-representation-in-medical-school
#20
Kendall M Campbell, Naomi C Brownstein, Helen Livingston, José E Rodríguez
OBJECTIVES: Despite the efforts of various leading organizations in medical education, representation of black students in US medical schools has declined since the mid-1990s. The Florida State University College of Medicine (FSUCOM) has undertaken efforts to increase black and other underrepresented minority in medicine (URMM) representation in medical school through the Bridge to Clinical Medicine Program. This program is described and analyzed by the authors. METHODS: Demographic information, Medical College Admission Test scores, undergraduate grade point average, US Medical Licensing Examination (USMLE) scores (Steps 1 and 2), residency match information, and current practice location from 2006 to 2015 were collected from the FSUCOM...
April 2018: Southern Medical Journal
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