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https://www.readbyqxmd.com/read/29153714/polyphosphonate-ligands-from-synthesis-to-design-of-hybrid-pegylated-nanoparticles-toward-phototherapy-studies
#1
Maelle Monteil, Hanane Moustaoui, Gennaro Picardi, Fatima Aouidat, Nadia Djaker, Marc Lamy de La Chapelle, Marc Lecouvey, Jolanda Spadavecchia
The use of phosphonate ligands to modify the nanoparticle (NPs) surface has attracted a strong interest in the last years for the design of highly functional hybrid materials. Here, we applied a methodology to synthesize bisphosphonates having functionalized PEG side chains with a specific length in order to design a novel class of hybrid nanomaterials composed by tetraphosphonate-complex-gold COOH-terminated PEG-coated NPs (Bis-PO-PEG-AuNPs). The synthetic approach consist in three steps: (1) Complexation between new phosphonate ligands (Bis PO) and tetrachloroauric acid (HAuCl4) to form gold clusters; (2) adsorption of COOH-terminated PEG molecules (PEG) onto Bis PO-Au complex; (3) reduction of metal ions in that vicinity, growth of gold particles and colloidal stabilization...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29153050/factors-influencing-irradiance-of-locally-fabricated-phototherapy-devices-in-jos-north-central-nigeria
#2
Udochukwu M Diala, Akinyemi Od Ofakunrin, Bose O Toma, David D Shwe, Christopher S Yilgwan, Fidelia Bode-Thomas
Locally fabricated phototherapy devices (LFPDs) are widely used in Nigeria for the treatment of neonatal jaundice. Ours was a cross-sectional observational study of all LFPDs in major hospitals in Jos between January and March 2015. We evaluated a total of 24 LFPDs. The irradiance at the level of the baby was in the range of 2-23.9 µW/cm(2)/nm. Fourteen devices had the recommended irradiance of ≥10 µW/cm(2)/nm and none had irradiance in the intensive range. Decreasing distance from the baby, presence of reflectors and increasing number of flourecent tubes significantly contributed to higher irradiance...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29152718/an-extension-of-a-multicenter-randomized-split-face-clinical-trial-evaluating-the-efficacy-and-safety-of-chromophore-gel-assisted-blue-light-phototherapy-for-the-treatment-of-acne
#3
Andreas Nikolis, Stéphane Fauverghe, Giovanni Scapagnini, Dimitrios Sotiriadis, George Kontochristopoulos, Athanasios Petridis, Dimitrios Rigopoulos, Clio Dessinioti, Konstantinos Kalokasidis, Christina Antoniou
A variety of laser/light-based devices have been reported to be effective for the treatment of acne, yet no long-term data on efficacy and safety have been published. A first 12-week clinical trial ("Main trial") recently demonstrated that the KLOX BioPhotonic System, an LED blue light device using photo-converter chromophores, can significantly improve moderate and severe facial acne vulgaris with an excellent safety profile. This Extension trial followed the Main trial, using the same BioPhotonic System, with the same dose and instructions for use, on patients having already completed treatment in the Main trial...
November 20, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29152226/an-overview-of-the-cutaneous-porphyrias
#4
REVIEW
Robert Dawe
This is an overview of the cutaneous porphyrias. It is a narrative review based on the published literature and my personal experience; it is not based on a formal systematic search of the literature. The cutaneous porphyrias are a diverse group of conditions due to inherited or acquired enzyme defects in the porphyrin-haem biosynthetic pathway. All the cutaneous porphyrias can have (either as a consequence of the porphyria or as part of the cause of the porphyria) involvement of other organs as well as the skin...
2017: F1000Research
https://www.readbyqxmd.com/read/29150336/urinary-tract-infections-in-neonates-with-unexplained-pathological-indirect-hyperbilirubinemia-prevalence-and-significance
#5
Elif Bahat Ozdogan, Mehmet Mutlu, Secil Arslansoyu Camlar, Gülcin Bayramoglu, Sebnem Kader, Yakup Aslan
BACKGROUND: It is controversial to test for urinary tract infection (UTI) in patients with unexplained indirect hyperbilirubinemia in the first 2 weeks of life. We aimed to study the prevalence and significance of UTIs in such neonates who were requiring phototherapy. METHODS: Subjects were 2- to 14-day-old neonates with indirect bilirubin levels above phototherapy limit with no other abnormality in their bilirubinaemia-related etiologic workup. UTI was diagnosed by 2 consecutive positive cultures obtained by catheterisation, documenting growth of >10,000 colonies of the same microorganism with consistent antibiograms...
October 28, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29147708/advanced-sensing-imaging-and-therapy-nanoplatforms-based-on-nd-3-doped-nanoparticle-composites-exhibiting-upconversion-induced-by-808-nm-near-infrared-light
#6
REVIEW
Ming-Hsien Chan, Ru-Shi Liu
Malignant tumors are currently the leading cause of death worldwide, followed by cardiovascular and cerebrovascular diseases. Although various methods, such as blood examination, tissue biopsy, and radiography, for tumor detection, exist, these techniques still require further refinement. Researchers have recently explored the use of novel adjuvant methods, specifically luminescence imaging detection, for the detection of tumors. The light-triggered approach is less invasive and induces fewer side effects than traditional detection methods...
November 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/29145270/study-on-the-adverse-effects-following-chemotherapy-for-breast-cancer-diagnosis-during-pregnancy-the-first-case-report-in-china
#7
Xin Ye, Qi He, Xiaoyun Zhou
RATIONALE: Treatment of breast cancer during pregnancy (BCP) remains a challenge to physicians. Surgery and chemotherapy during pregnancy are widely used for the treatment of BCP. Herein, we reported 3 Chinese patients with BCP who underwent chemotherapy during pregnancy and were followed up for adverse effects. PATIENT CONCERNS: Three female patients (case 1, case 2, and case 3) of 37-, 32-, and 28-year-old with breast masses were enrolled. Case 1 had been pregnant for over 4 months, case 2 over 7 months, and case 3 for 7 months...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144101/perspective-on-the-real-life-use-of-phototherapy-in-early-stage-mycosis-fungoides-from-the-cutaneous-lymphoma-commission-of-fondazione-italiana-linfomi-results-from-a-web-based-survey
#8
Vieri Grandi, Paolo Fava, Serena Rupoli, Silvia A Violetti, Lucia Canafoglia, Emilio Berti, Pietro Quaglino
No abstract text is available yet for this article.
November 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29134951/iron-based-radiochromic-systems-for-uv-dosimetry-applications
#9
Hannah Jungeun Lee, Mamdooh Alqathami, Anton Blencowe, Geoffrey S Ibbott
Phototherapy treatment using ultraviolet (UV) A and B light sources has long existed as a treatment option for various skin conditions. Quality control for phototherapy treatment recommended by the British Association of Dermatologists and British Photodermatology Group generally focused on instrumentation-based dosimetry measurements. The purpose of this study was to present an alternative, easily prepared dosimeter system for the measurement of UV dose and as a simple quality assurance technique for phototherapy treatments...
November 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29134822/treating-moderate-to-severe-plaque-psoriasis-with-guselkumab-a-review-of-phase-ii-and-phase-iii-trials
#10
Seth T Howell, Leah A Cardwell, Steven R Feldman
OBJECTIVE: Guselkumab, an anti-interleukin-23 monoclonal antibody was recently approved for the treatment of patients with moderate-to-severe plaque psoriasis. This article will review the available phase II and phase III guselkumab clinical trial data. DATA SOURCES: A PubMed search was conducted using the terms guselkumab, interleukin-23, psoriasis, adalimumab, and ustekinumab (January 2014 to August 2017). STUDY SELECTION AND DATA EXTRACTION: Articles detailing the results of phase II and phase III clinical trials were selected for review...
November 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29131033/adverse-reactions-to-biologics-in-psoriasis
#11
Stephen J Lockwood, Lisette M Prens, Alexa B Kimball
Psoriasis is a chronic autoimmune disease which affects millions of people worldwide. Not only can psoriasis itself be debilitating and significantly reduce an individual's quality of life, but it is also a risk factor for other systemic disorders, such as metabolic syndrome, cardiovascular disease, and malignancy. Tremendous strides were made in the treatment of psoriasis during the mid-to-late-20th century, including the emergence of topical corticosteroids and vitamin D analogs, methotrexate, systemic retinoids, and phototherapy...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29130829/comparison-of-conventional-phototherapy-and-phototherapy-along-with-kangaroo-mother-care-on-cutaneous-bilirubin-of-neonates-with-physiological-jaundice
#12
Laleh Goudarzvand, Akram Dabirian, Manizheh Nourian, Hadi Jafarianesh, Mehdi Ranjbaran
BACKGROUND: One of the adjuvant and desirable therapies is skin contact between mother and baby or Kangaroo mother care (KMC) that is a cheap, accessible, relaxing, noninvasive and easy method. This study aimed to compare the effect of conventional phototherapy method and phototherapy along with KMC on cutaneous bilirubin in neonates with physiological jaundice. MATERIALS AND METHODS: In this randomized clinical trial, all infants with physiological jaundice who referred for phototherapy to Mofid Hospital of Shahid Beheshti University of Medical Sciences, Tehran, Iran were selected by convenience sampling based on inclusion criteria and were randomly assigned into two groups of conventional phototherapy (n = 35) and phototherapy along with KMC (n = 35)...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29124714/dose-quantification-in-uv-phototherapy
#13
David Robert Grimes
Ultraviolet light has long been used to alleviate a number of skin conditions, and its efficacy is well known. However, over-exposure to ultraviolet radiation has a number of detrimental effects and thus it is vital to maintain a dose to skin within the therapeutic window. To maximise treatment gain whilst circumventing potential side-effects of over-exposure requires accurate determination of irradiance and skin-dose. This is complicated by the fact that ultraviolet radiation is essentially absorbed at the skin surface, which means that changing orientation of the patient and source can modulate dose received...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124712/safety-and-efficacy-of-phototherapy-in-the-management-of-eczema
#14
Annalisa Patrizi, Beatrice Raone, Giulia Maria Ravaioli
Atopic Dermatitis (AD), a common skin disease, can occur in patients of all age, gender and ethnicity. It is an inflammatory affection, characterized by chronic and highly debilitating behavior. First-line interventions against AD include environmental measures and topical emollients, corticosteroids or calcineurin inhibitors. When these measures are not sufficient, phototherapy represents an efficient second-line option of treatment; it can be administered on its own, or in the most severe cases combined with systemic medicaments such as corticosteroids...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124709/phototherapy-of-psoriasis-a-chronic-inflammatory-skin-disease
#15
Emőke Rácz, Errol P Prens
Phototherapy is an effective treatment modality for several skin diseases which has been in use from the era of the Egyptians. Insight into its mode of action has gradually accumulated over the past decades. A crucial biological effect of ultraviolet radiation is the induction of apoptosis in T lymphocytes and in keratinocytes in the epidermis. Via this mechanism inflammation-induced pathological changes characteristic of psoriasis are counteracted.Phototherapy remains the only therapeutic option for certain patient groups where modification of the systemic immune reactions is contraindicated, such as by HIV, internal malignancy or pregnancy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124708/phototherapy-in-atopic-dermatitis
#16
José María Ortiz-Salvador, Amparo Pérez-Ferriols
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Currently management of AD includes avoidance of triggering factors, skin care aiming to compensate the skin barrier defects, anti-inflammatory therapy (mostly topical corticosteroids and topical calcineurin inhibitors). When these first-line approaches are unsuccessful, systemic treatment or phototherapy ought to be carried out as next line of defence. Current phototherapy modalities for AD include broadband UVB (290-320 nm), narrowband UVB (311-313 nm), UVA-1 therapy (340-400 nm), UVA therapy plus 8-methoxypsoralens (PUVA), 308 nm excimer laser (EL) and Full spectrum light (FSL)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124694/ultraviolet-a-1-in-dermatological-diseases
#17
Torello M Lotti, Serena Gianfaldoni
The exposure to ultraviolet radiations and visible light, or phototherapy, is a well-known therapeutic tool available for the treatment of many dermatological disorders. The continuos medical and technological progresses, of the last 50 years, have involved the field of phototherapy, which evolved from UVA and PUVA in its various forms, to the development of narrowband UVB (NB-UVB) and NB-UVB micro-focused phototherapies. Further advances in technology have now permitted the introduction of a new device emitting UVA-1 radiations...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29123631/comparison-between-311-312-nm-narrow-band-ultraviolet-b-phototherapy-and-308-nm-monochromatic-excimer-light-phototherapy-in-treatment-of-vitiligo-a-histopathological-study
#18
Manal Mohamed Salah Eldin, Nevein Ahmed Sami, Dalia Gamal Aly, Noha Sami Hanafy
Introduction: Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for the treatment of vitiligo. To histopathologically compare the early effects of NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using H&E and HMB-45. Methods: Thirty subjects with non-segmental vitiligo lesions were treated twice a week for 6 weeks with 308-nm MEL, while NB-UVB was used to treat lesions contra laterally. Skin biopsies were taken from lesional areas before and after 6 weeks of treatment by either modality...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29122805/impact-of-uv-irradiation-on-electrical-impedance-spectroscopy-of-benign-nevi-study-protocol-for-a-prospective-controlled-clinical-study
#19
Christine Fink, Anissa Schweizer, Lorenz Uhlmann, Holger A Haenssle
INTRODUCTION: The clinical and histological changes of nevi after ultraviolet (UV) irradiation have been studied in detail. In contrast, the impact of UV irradiation on electrical impedance spectroscopy scores of nevi has not been investigated. However, for physicians, it is essential to know the extent to which changes in electrical impedance spectroscopy scores of nevi may be attributed to seasonal effects of UV irradiation. METHODS: This is a prospective, controlled, clinical study evaluating the impact of UV irradiation on the electrical impedance spectroscopy scores of benign nevi in 50 patients undergoing phototherapy...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29121124/atopic-dermatitis-prevention-and-treatment
#20
Nanette B Silverberg
Atopic dermatitis (AD) is the cause of substantial morbidity including severe pruritus and impaired personal and familial quality of life. Furthermore, the rising incidence and familial association of AD have highlighted the need for disease prevention. It is largely genetic in nature and cannot be avoided in all cases. However, low-risk prevention strategies have been attempted to reduce triggering of first onset of AD in predisposed individuals. Therapeutics for active disease include trigger avoidance, barrier repair, topical medicaments including topical corticosteroids (TCs) and nonsteroidal agents, phototherapy, and antibacterial interventions...
September 2017: Cutis; Cutaneous Medicine for the Practitioner
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