Read by QxMD icon Read


Baomei Zhang, Yang Wang, Jiyong Liu, Guangxi Zhai
Graphene-based nanomaterials have drawn abundant interest in various fields such as biomedicine in recent years, thanks to their unique physico-chemical properties. Due to the ultra-high surface area of single-layered graphene, higher molecular loading is obtained. In addition, easy modifications are acquired because of its ample oxygen-content functional groups. Based on the above talking advantages, graphene-based nanomaterials have been widely explored as novel nano-vectors for disease theranostics. In this article, we give a comprehensive review about graphene-based nanomaterials, including introduction about different members of graphene family nanomaterials (GFNs), various modifications, toxicity and biomedical applications of graphene-based derivatives...
October 19, 2016: Current Medicinal Chemistry
L Murli, A Thukral, M J Sankar, S Vishnubhatla, A K Deorari, V K Paul, A Sakariah, Dolma, R Agarwal
OBJECTIVE: To determine the agreement between transcutaneous bilirubin (TcB) measured from shielded skin and serum total bilirubin (STB) in infants (34 to 41 weeks of gestation) with hyperbilirubinemia receiving phototherapy (PT). STUDY DESIGN: In this prospective cohort study, we shielded a small area of skin on sternum using a commercial photo-opaque patch (BilEclipseTM, Philips Respironics, Murrysville, PA, USA). The TcB from the shielded skin (TcBs) and STB were measured at four time points-before initiation, 12 and 24 h during and once after (12 h) cessation of PT...
October 20, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Monique Narciso Alba, Marli Gerenutti, Valquíria Miwa Hanai Yoshida, Denise Grotto
Acne vulgaris treatments usually cause sensitivity, teratogenicity and bacterial resistance. Investigations of others therapeutic techniques, such as phototherapy, is highly relevant. Thus, we compared the effectiveness of two Acne vulgaris treatments in adolescents: peeling with salicylic acid and phototherapy. Teens were randomly divided in: group I, treatment with salicylic acid peels (10 %) and group II, treatment with phototherapy (blue LED and red laser lights). Photographs were taken before and after ten sessions of each treatment, carried out weekly, and compared...
October 20, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Ronaldo Custodio de Souza Oliveira, Rodrigo José Corrêa, Raquel Simas Pereira Teixeira, Daniela Dias Queiroz, Rodrigo da Silva Souza, Simon John Garden, Nanci Camara de Lucas, Marcos Dias Pereira, Josué Sebastián Bello Forero, Eric Cardona Romani, Emerson Schwingel Ribeiro
In the present study, SiO2 nanoparticles functionalized with 3-(2-aminoethylamino)propyl group (SiNP-AAP) were used, for the first time, to covalently bond rose bengal (SiNP-AAP-RB) or 9,10-anthraquinone-2-carboxylic acid (SiNP-AAP-OCAq). The functionalized SiNP were characterized by: Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM); elemental analysis (CHN) for determination of the dye concentration; FTIR and UV-vis diffuse reflectance (DR-UV-vis) and a surface area study (BET). The functionalized SiNPs were applied in photodynamic therapy (PDT) against lung cancer cell lines...
October 13, 2016: Journal of Photochemistry and Photobiology. B, Biology
Nayan Patel, Paula Pera, Penny Joshi, Mykhaylo Dukh, Walter A Tabaczynski, Kevin E Siters, Mark Kryman, Ravindra R Cheruku, Farukh Durrani, Joseph R Missert, Ramona Watson, Tymish Y Ohulchanskyy, Erin Tracy, Heinz Baumann, Ravindra K Pandey
We report herein, the synthesis and biological efficacy of near-infrared (NIR), bacteriochlorin analogs: 3-(1'-butyloxy)ethyl-3-deacetyl-bacteriopurpurin-18-N-butylimide methyl ester (3) and the corresponding carboxylic acid 10. In in vitro assays, compared to its methyl ester analog 3, the corresponding carboxylic acid derivative 10 showed higher photosensitizing efficacy. However, due to drastically different pharmacokinetics in vivo, the PS 3 (HPLC purity > 99%) showed higher tumor uptake and long-term tumor cure than 10 (HPLC purity > 96...
October 17, 2016: Journal of Medicinal Chemistry
Annie Liu, Lyne Giroux
An 86-year-old man developed a suspected severe erythroderma during treatment with silodosin (dosage unknown) for benign prostatic enlargement. Two weeks after starting silodosin, he developed a total-body scaling dermatitis. A biopsy was planned but the patient improved at his subsequent visit and it was not taken. Silodosin was discontinued and the patient received UVB phototherapy, clobetasol ointment, and several bland and protective skin-care measures. One week after the initial presentation, the patient demonstrated improvement in his total-body scaling...
December 2015: Drug Saf Case Rep
Min Soo Jang, Dong Young Kang, Jong Bin Park, Joon Hee Kim, Kwi Ae Park, Hark Rim, Kee Suck Suh
BACKGROUND: Pityriasis lichenoides (PL)-like skin lesions rarely appear as a specific manifestation of mycosis fungoides (MF). OBJECTIVE: We investigated the clinicopathological features, immunophenotypes, and treatments of PL-like MF. METHODS: This study included 15 patients with PL-like lesions selected from a population of 316 patients diagnosed with MF at one institution. RESULTS: The patients were between 4 and 59 years of age...
October 2016: Annals of Dermatology
Edyta Biskup, David Gram Naym, Robert Gniadecki
BACKGROUND: Psoralen plus ultraviolet A (PUVA) photochemotherapy is a combination treatment used for inflammatory and neoplastic skin diseases such as mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). However, 30% of MF patients do not respond sufficiently to PUVA and require more aggressive therapies. OBJECTIVE: The aim of this project was to investigate whether inhibition of Ataxia Telangiectasia and Rad3 related kinase (ATR) may enhance efficacy of phototherapy...
September 16, 2016: Journal of Dermatological Science
Alan G Wade, Gordon M Crawford, David Young, Joyce Leman, Neil Pumford
BACKGROUND: Scottish Intercollegiate Guidelines Network and National Institute of Health and Care Excellence guidelines stress the importance of assessing patients with psoriasis for psoriatic arthritis, comorbidities associated with severe disease and quality of life (QoL). The purpose of the study was to evaluate the primary care management of psoriasis in relation to disease severity and QoL from a patient's perspective. METHODS: A cross-sectional survey of adults (≥18 years) with psoriasis managed in primary care was conducted in Scotland over 1-year (2012-2013)...
October 14, 2016: BMC Family Practice
E B Carter, M G Tuuli, A O Odibo, G A Macones, A G Cahill
OBJECTIVE: To investigate the association between the number of prenatal visits (PNVs) and pregnancy outcomes in women with gestational diabetes (GDM) and Type 2 diabetes mellitus (DM). STUDY DESIGN: A 4-year prospective cohort study of women with GDM and DM and was conducted. Patients ⩾75th percentile for number of PNVs were compared with those ⩽25th percentile. The primary outcomes were large for gestational age (LGA) with birth weight >90% and neonatal intensive care unit (NICU) admission for >24 h...
October 13, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Fatma İnci Arıkan, Semra Kara, Hüseyin Bilgin, Fatma Özkan, Yıldız Dallar Bilge
OBJECTIVE: The purpose of the current study was to investigate the possible effects of phototherapy on bone status of term infants evaluated by measurement of tibial bone SOS. MATERIALS AND METHODS: The phototherapy group (n = 30) consisted of children who had undergone phototherapy for at least 24 hours and the control group (n = 30) comprised children who had not received phototherapy. Blood samples were obtained from all infants for serum calcium, phosphorus, magnesium, alkaline phosphatase, parathyroid hormone and vitamin D concentrations...
October 13, 2016: Journal of Maternal-fetal & Neonatal Medicine
Nekma Meah, Ali Alsharqi, Richard M Azurdia, Lynne-Catherine Owens, Richard Parslew, Leena Chularojanamontri
BACKGROUND/OBJECTIVES: The simplified psoriasis index (SPI) is a three-part multidimensional tool incorporating disease severity, psychosocial impact and historical course completed by the health-care professional (professional SPI, [proSPI]) or the patient (self-assessment SPI, [saSPI]). We aimed to assess the validity and response distribution of proSPI and saSPI in patients with psoriasis undergoing phototherapy. METHODS: The validity and response distribution of SPI was assessed by recording saSPI and proSPI in patients with psoriasis before and after a course of phototherapy...
October 12, 2016: Australasian Journal of Dermatology
David M Harris, Lou Reinisch
BACKGROUND AND OBJECTIVE: Selective killing of pathogens by laser is possible due to the difference in absorption of photon energy by pathogens and host tissues. The optical properties of pathogenic microorganisms are used along with the known optical properties of soft tissues in calculations of the laser-induced thermal response of pathogen colonies embedded in a tissue model. The objective is to define the laser parameters that optimize pathogen destruction and depth of the bactericidal effect...
October 10, 2016: Lasers in Surgery and Medicine
Merel van Elk, Bruce P Murphy, Tatiane Eufrásio-da-Silva, Daniel P O'Reilly, Tina Vermonden, Wim E Hennink, Garry P Duffy, Eduardo Ruiz-Hernández
The development of nanomedicines for the treatment of cancer focuses on the local targeted delivery of chemotherapeutic drugs to enhance drug efficacy and reduce adverse effects. The nanomedicines which are currently approved for clinical use are mainly successful in terms of improved bioavailability and tolerability but do not necessarily increase drug performance. Therefore, there is a need for improved drug carrier systems which are able to deliver high doses of anti-cancer drugs to the tumor. Stimuli responsive carriers are promising candidates since drug release can be triggered locally in the tumor via internal (i...
October 7, 2016: International Journal of Pharmaceutics
Y Altuner Torun, U Ertural, A B Ergul, C Karakukcu, M A Akin
OBJECTIVE: Indirect bilirubin exerts an antioxidant effect when increased mildly. This study aimed to investigate whether increased bilirubin levels lead to an oxidant effect in newborns with hyperbilirubinemia requiring phototherapy. PATIENTS AND METHODS: The study included 30 term newborn infants aged 0-7 days with indirect hyperbilirubinemia requiring phototherapy and no comorbid disease as the study group. In addition, 30 term healthy newborn infants aged 0-7 days without indirect hyperbilirubinemia were employed as a control group...
October 11, 2016: Journal of Maternal-fetal & Neonatal Medicine
Wenpei Fan, Peng Huang, Xiaoyuan Chen
Photodynamic therapy (PDT) has been applied to treat a wide range of medical conditions, including wet age-related macular degeneration psoriasis, atherosclerosis, viral infection and malignant cancers. However, the tissue penetration limitation of excitation light hinders the widespread clinical use of PDT. To overcome this "Achilles' heel", deep PDT, a novel type of phototherapy, has been developed for the efficient treatment of deep-seated diseases. Based on the different excitation sources, including near-infrared (NIR) light, X-ray radiation, and internal self-luminescence, a series of deep PDT techniques have been explored to demonstrate the advantages of deep cancer therapy over conventional PDT excited by ultraviolet-visible (UV-Vis) light...
September 26, 2016: Chemical Society Reviews
Jing Tan, Supawadee Namuangruk, Weifu Kong, Nawee Kungwan, Jia Guo, Changchun Wang
An approach to transforming amorphous organic networks into crystalline covalent organic frameworks (COFs) with retention of the colloidal nanosize and uniform morphology is presented. Specifically, Fe3 O4 nanoclusters are encapsulated by a disordering polyimine network via the Schiff-base reaction. The formed imine bonds could be reconstructed under thermodynamic control to reform the polyimine networks into imine-linked COFs in situ. Such a core-shell microsphere exhibits the uniform size and spherical shape, controllable COF shell thickness, accessible surface modification, and improved solution dispersibility as well as maintenance of high surface area, periodic micropores, and superior magnetic responsiveness...
October 6, 2016: Angewandte Chemie
Julia-Tatjana Maul, Lorenz Kretschmer, Florian Anzengruber, Andrew Pink, Carla Murer, Lars E French, Günther F L Hofbauer, Alexander A Navarini
BACKGROUND: Narrowband (TL-01) UVB phototherapy (UVB nb) is effective in treating inflammatory skin disease. The addition of UVA is traditionally advocated to reduce pruritus, but lacks evidence for this recommendation. OBJECTIVES: The aim of this study was to assess the effect of UVB nb and UVA phototherapy in combination compared against UVB nb monotherapy on pruritus, disease activity, and quality of life. METHODS: In this double-blind randomised clinical trial 53 patients suffering from inflammatory skin diseases with pronounced itching (Visual Analogue Scale (VAS) for pruritus ≥ 5) were randomised in to two treatment groups...
October 4, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Surabhi Dayal, Priyadarshini Sahu, Nidhi Gupta
BACKGROUND/OBJECTIVES: A combination of narrowband ultraviolet B (NBUVB) phototherapy plus topical tacrolimus has been used in adult vitiligo but has not yet been explored in children. We therefore sought to highlight the efficacy of this synergistic combination in childhood vitiligo. The objective was to study the clinical efficacy and safety of a combination of NBUVB with topical tacrolimus ointment 0.03% in childhood vitiligo. METHOD: In this open-label study, 20 children, 4 to 14 years of age, with symmetrical vitiligo lesions were enrolled for 24 weeks...
October 4, 2016: Pediatric Dermatology
Ronghua Li, Meng Qiao, Xiaoyan Wang, Xintong Zhao, Qing Sun
BACKGROUND: The treatment of vitiligo is still one of the most difficult dermatological challenges, although there are many therapeutic options. Narrow band ultraviolet B (NB-UVB) phototherapy is considered to be a very important modality for generalized vitiligo. OBJECTIVE: The aim of this study was to explore whether a combination of NB-UVB and topical agents would be superior to NB-UVB alone for treating vitiligo. METHODS: We searched the electronic databases such as PUBMED, EMBASE, Cochrane Library and Web of Science...
October 1, 2016: Photodermatology, Photoimmunology & Photomedicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"