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enalapril ev

Toshihiro Shimizu, Hiroshi Okamoto, Satoru Chiba, Yutaka Matsui, Takeshi Sugawara, Hisao Onozuka, Taisei Mikami, Hideki Kumamoto, Akira Kitabatake
The efficacy of ACE inhibitors (ACEIs) in the treatment of chronic heart failures is well documented. However, ACEIs may provide incomplete blockade of the renin-angiotensin system (RAS) because of the alternative pathways for angiotensin II (All) production. We hypothesized that more complete blockade of RAS by adding an AT1 receptor blocker (ARB) may have greater potential to decrease mortality associated with heart failure and improve cardiac function than monotherapy with ACEIs. The objective of this study was to evaluate the effect of combined therapy on cardiac functions and survival in cardiomyopathic hamsters...
September 2002: Japanese Heart Journal
C Emanueli, E F Grady, P Madeddu, M Figini, N W Bunnett, D Parisi, D Regoli, P Geppetti
The use of angiotensin-converting enzyme (ACE) has been associated with the occurrence of adverse effects, including cough and angioneurotic edema. Accumulation of kinins has been suggested to play a major role in these adverse effects of ACE inhibitor, although conclusive evidence for such a role is lacking. We investigated whether ACE inhibition increases plasma extravasation in mice (Swiss, C57Bl/6J, and J129Sv/Ev strains) via inhibition of bradykinin metabolism and stimulation of neurogenic inflammatory mechanisms...
June 1998: Hypertension
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